{"product_id":"neurostereology-9781118444214","title":"Neurostereology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eStereological methods provide researchers with unparalleled quantitative data from tissue samples and allow for well-evidenced research advances in a broad range of scientific fields. Presenting a concise introduction to the methodology and application of stereological research in neuroscience,\u003ci\u003eNeurostereology\u003c\/i\u003eprovides a fuller understanding of the use of these methods in research and a means for replicating successful scientific approaches. Providing sound footing for future research,\u003ci\u003eNeurostereology\u003c\/i\u003eis a useful tool for basic and clinical researchers and advanced students looking to integrate these methods into their research.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eContributors ix\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePreface xiii\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Stereological Estimation of Brain Volume and Surface Area from MR Images 3\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNiyazi Acer and Mehmet Turgut\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 3\u003c\/p\u003e \u003cp\u003eThe Cavalieri Principle 3\u003c\/p\u003e \u003cp\u003eVolume Estimation Using Spatial Grid of Points 7\u003c\/p\u003e \u003cp\u003eSurface Area Estimation 8\u003c\/p\u003e \u003cp\u003eIsotropic Cavalieri Design 14\u003c\/p\u003e \u003cp\u003eSections Analyzed with Independent Grid Design 14\u003c\/p\u003e \u003cp\u003eSurface Area Using the Invariator 16\u003c\/p\u003e \u003cp\u003eVolume and Surface Area Estimation Using Segmentation Method 17\u003c\/p\u003e \u003cp\u003eDiscussion 18\u003c\/p\u003e \u003cp\u003eReferences 19\u003c\/p\u003e \u003cp\u003eWebliography 21\u003c\/p\u003e \u003cp\u003eAppendix A: R Commands for Point Counting Method 21\u003c\/p\u003e \u003cp\u003eAppendix B: R Commands for Vertical Section to Estimate Surface Area 23\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Cell Proliferation in the Brains of Adult Rats Exposed to Traumatic Brain Injury 27\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSandra A. Acosta, Naoki Tajiri, Paula C. Bickford, and Cesar V. Borlongan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 27\u003c\/p\u003e \u003cp\u003eMaterials and Methods 28\u003c\/p\u003e \u003cp\u003eResults 29\u003c\/p\u003e \u003cp\u003eDiscussion 33\u003c\/p\u003e \u003cp\u003eAcknowledgments 37\u003c\/p\u003e \u003cp\u003eReferences 37\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Age Effects in Substantia Nigra of Asian Indians 39\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePhalguni Anand Alladi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 39\u003c\/p\u003e \u003cp\u003eMaterials and Methods 40\u003c\/p\u003e \u003cp\u003eDiscussion 43\u003c\/p\u003e \u003cp\u003eAcknowledgments 48\u003c\/p\u003e \u003cp\u003eReferences 49\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Design-Based Stereology in the Brain Bank Setting 53\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMark W. Burke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 53\u003c\/p\u003e \u003cp\u003eSpecimen Preparation 53\u003c\/p\u003e \u003cp\u003eA Practical Application of Design-Based Stereology 57\u003c\/p\u003e \u003cp\u003eResults 59\u003c\/p\u003e \u003cp\u003eConclusion 60\u003c\/p\u003e \u003cp\u003eReferences 61\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Practical Stereology for Preclinical Neurotoxicology 63\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMark T. Butt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 63\u003c\/p\u003e \u003cp\u003eSpecimen Quality 64\u003c\/p\u003e \u003cp\u003ePractical Stereology 70\u003c\/p\u003e \u003cp\u003eSoftware Validation\/Verifi cation 70\u003c\/p\u003e \u003cp\u003eReferences 72\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 An Overabundance of Prefrontal Cortex Neurons Underlies Early Brain Overgrowth in Autism 73\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eEric Courchesne, Peter R. Mouton, Michael E. Calhoun, Clelia Ahrens-Barbeau, Melodie J. Hallet, Cynthia Carter Barnes, Karen Pierce, and Katarina Semendeferi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 73\u003c\/p\u003e \u003cp\u003eMethods 74\u003c\/p\u003e \u003cp\u003eResults 78\u003c\/p\u003e \u003cp\u003eDiscussion 80\u003c\/p\u003e \u003cp\u003eAcknowledgments 81\u003c\/p\u003e \u003cp\u003eReferences 82\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Order in Chaos: Stereological Studies of Nervous Tissue 85\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePeter Dockery\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 85\u003c\/p\u003e \u003cp\u003eThe Stereological Approach 85\u003c\/p\u003e \u003cp\u003eAxonal Number and Composition in the Murine Optic Nerve 91\u003c\/p\u003e \u003cp\u003eAxonal and Fiber Size Distributions 92\u003c\/p\u003e \u003cp\u003eThe Myelin Sheath 93\u003c\/p\u003e \u003cp\u003eConclusion 94\u003c\/p\u003e \u003cp\u003eReferences 95\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Comparative Stereology Studies of Brains from Marine Mammals 99\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNina Eriksen and Bente Pakkenberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 99\u003c\/p\u003e \u003cp\u003eDescription of Different Marine Mammalian Brains 99\u003c\/p\u003e \u003cp\u003eParts of the Brain 102\u003c\/p\u003e \u003cp\u003eReferences 109\u003c\/p\u003e \u003cp\u003eAppendix: Cited Stereological Approaches 110\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Quantitative Assessment of Hippocampus Architecture Using the Optical Disector 113\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eShozo Jinno\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 113\u003c\/p\u003e \u003cp\u003eThe Hippocampus 114\u003c\/p\u003e \u003cp\u003eConclusion 123\u003c\/p\u003e \u003cp\u003eReferences 123\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 The Possible Applications (and Pitfalls!) of Stereological Analysis in Postmortem Brain Research 129\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAhmad A. Khundakar and Alan J. Thomas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 129\u003c\/p\u003e \u003cp\u003eThe Legacy of Two-Dimensional (2D) Analysis 129\u003c\/p\u003e \u003cp\u003eDensity: A Necessary Evil 130\u003c\/p\u003e \u003cp\u003e“Come on, Feel the Noise”: Recognizing Confounding Factors 130\u003c\/p\u003e \u003cp\u003e“I Am Not a Number”: The Importance of Sound Patient Clinical History 131\u003c\/p\u003e \u003cp\u003eLessons Learned from Stereology: Toward a More Unifi ed Approach to Brain Banking and Postmortem Tissue Research (and Beyond!) 132\u003c\/p\u003e \u003cp\u003eObtain the Full Reference Volume or “Make Do and Mend” 133\u003c\/p\u003e \u003cp\u003eTurn Down the “Noise” 134\u003c\/p\u003e \u003cp\u003e“Check the Information, Expand the Knowledge” 135\u003c\/p\u003e \u003cp\u003eShow Your Work! 135\u003c\/p\u003e \u003cp\u003eConclusion 136\u003c\/p\u003e \u003cp\u003eAcknowledgments 136\u003c\/p\u003e \u003cp\u003eReferences 136\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Visualization of Blood Vessels in Two-Dimensional and Three-Dimensional Environments for Vascular Stereology in the Brain 139\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eZerina Lokmic\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 139\u003c\/p\u003e \u003cp\u003eVascular Stereology of Tissue Sections 139\u003c\/p\u003e \u003cp\u003eVisualization of Brain Blood Vessels 142\u003c\/p\u003e \u003cp\u003eConclusion 149\u003c\/p\u003e \u003cp\u003eAcknowledgment 149\u003c\/p\u003e \u003cp\u003eReferences 149\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Blood Flow Analysis in Epilepsy Using a Novel Stereological Approach 153\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRocio Leal-Campanario, Luis Alarcon-Martinez, Susana Martinez-Conde, Michael Calhoun, and Stephen Macknik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 153\u003c\/p\u003e \u003cp\u003eMaterials and Methods 155\u003c\/p\u003e \u003cp\u003eResults 166\u003c\/p\u003e \u003cp\u003eDiscussion 172\u003c\/p\u003e \u003cp\u003eReferences 173\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 AD-Type Neuron Loss in Transgenic Mouse Models 177\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKebreten F. Manaye and Peter R. Mouton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 177\u003c\/p\u003e \u003cp\u003eMaterials and Methods 179\u003c\/p\u003e \u003cp\u003eResults 182\u003c\/p\u003e \u003cp\u003eDiscussion 185\u003c\/p\u003e \u003cp\u003eAcknowledgments 187\u003c\/p\u003e \u003cp\u003eReferences 188\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Quantification in Populations of Nonuniformly Distributed Cells in the Human Cerebral Cortex 191\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eWilliam L. Maxwell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 191\u003c\/p\u003e \u003cp\u003eMaterials and Methods 191\u003c\/p\u003e \u003cp\u003eResults 196\u003c\/p\u003e \u003cp\u003eDiscussion 205\u003c\/p\u003e \u003cp\u003eReferences 208\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 The Effects of High-Fat Diet on the Mouse Hypothalamus: A Stereological Study 211\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMohammad Reza Namavar, Samira Raminfard, Zahra Vojdani Jahromi, and Hassan Azari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 211\u003c\/p\u003e \u003cp\u003eMaterials and Methods 212\u003c\/p\u003e \u003cp\u003eResults 213\u003c\/p\u003e \u003cp\u003eDiscussion 215\u003c\/p\u003e \u003cp\u003eAcknowledgments 217\u003c\/p\u003e \u003cp\u003eReferences 218\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 2D and 3D Morphometric Analyses Comparing Three Rodent Models 221\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJiHyuk Park and S. Omar Ahmad\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 221\u003c\/p\u003e \u003cp\u003eMaterials and Methods 221\u003c\/p\u003e \u003cp\u003eResults 226\u003c\/p\u003e \u003cp\u003eDiscussion 230\u003c\/p\u003e \u003cp\u003eReferences 235\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 A Stereologic Perspective on Autism Neuropathology 237\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNeha Uppal and Patrick R. Hof\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 237\u003c\/p\u003e \u003cp\u003eCortical Areas 237\u003c\/p\u003e \u003cp\u003eHippocampus 248\u003c\/p\u003e \u003cp\u003eNoncortical Areas 249\u003c\/p\u003e \u003cp\u003eConclusions 253\u003c\/p\u003e \u003cp\u003eReferences 254\u003c\/p\u003e \u003cp\u003eIndex 257\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49406870815063,"sku":"9781118444214","price":107.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118444214.jpg?v=1730497397","url":"https:\/\/bookcurl.com\/products\/neurostereology-9781118444214","provider":"Book Curl","version":"1.0","type":"link"}