{"product_id":"neuroinflammation-9781118732823","title":"Neuroinflammation","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eNeuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eNeuroinflammation: New Insights into Beneficial and Detrimental Functions\u003c\/i\u003e provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eNeuroinflammation: New Insights into Beneficial and Detrimental Functions\u003c\/i\u003e opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves,\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eList of Contributors xi\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePreface xvii\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Immune Response in the Human Central Nervous System in Multiple Sclerosis and Stroke 3\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eHans Lassmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 3\u003c\/p\u003e \u003cp\u003eThe Concept of Neuroinflammation 3\u003c\/p\u003e \u003cp\u003eBasic Principles of Immune Surveillance and Inflammation by Adaptive Immune Responses 4\u003c\/p\u003e \u003cp\u003eInflammation in the Central Nervous System of Patients with Multiple Sclerosis 7\u003c\/p\u003e \u003cp\u003eInflammation in Stroke Lesions 11\u003c\/p\u003e \u003cp\u003eMicroglia Activation and Macrophage Response 12\u003c\/p\u003e \u003cp\u003eGranulocyte Infiltration 12\u003c\/p\u003e \u003cp\u003eConclusions 15\u003c\/p\u003e \u003cp\u003eReferences 15\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2\u003c\/b\u003e \u003cb\u003e\u003ci\u003eIn Vivo\u003c\/i\u003e\u003c\/b\u003e \u003cb\u003eImaging of Glial and Immune Cell Responses in Central Nervous System Injury and Disease 21\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAlexandre Paré and Steve Lacroix\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 21\u003c\/p\u003e \u003cp\u003eIntravital Microscopy in the CNS and Its Challenges 22\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIn Vivo\u003c\/i\u003e Imaging of the CNS Following Sterile Injury 24\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIn Vivo\u003c\/i\u003e Imaging of the CNS in Disorders with an Inflammatory Component 27\u003c\/p\u003e \u003cp\u003eConclusion 32\u003c\/p\u003e \u003cp\u003eAcknowledgments 33\u003c\/p\u003e \u003cp\u003eReferences 33\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II Detrimental Aspects of Inflammation 39\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Roles of CD4 and CD8 T Lymphocytes in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis 41\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eNathalie Arbour and Alexandre Prat\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 41\u003c\/p\u003e \u003cp\u003eT Lymphocytes: Central Immune Cells 42\u003c\/p\u003e \u003cp\u003eAutoreactive T Lymphocytes 42\u003c\/p\u003e \u003cp\u003eFrom Peripheral Activation to CNS Extravasation 45\u003c\/p\u003e \u003cp\u003eRole of CD4 T Lymphocytes in MS and EAE: Th1 versus Th17 46\u003c\/p\u003e \u003cp\u003eRole of CD8 T Lymphocytes in MS and EAE 47\u003c\/p\u003e \u003cp\u003eRegulatory T Lymphocytes in MS and EAE 48\u003c\/p\u003e \u003cp\u003eConclusions 49\u003c\/p\u003e \u003cp\u003eAcknowledgements 49\u003c\/p\u003e \u003cp\u003eReferences 49\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Microglia and Macrophage Responses and Their Role after Spinal Cord Injury 53\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAntje Kroner, Andrew D. Greenhalgh, and Samuel David\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 53\u003c\/p\u003e \u003cp\u003eMicroglial Responses to Injury 54\u003c\/p\u003e \u003cp\u003eInteractions between Microglia and Other Cell Types in Signaling Responses to Injury 57\u003c\/p\u003e \u003cp\u003eEntry of Peripheral Macrophages and Differences with Microglia 59\u003c\/p\u003e \u003cp\u003eDiverse Roles of Macrophages\/Microglia in CNS Injury and Disease 60\u003c\/p\u003e \u003cp\u003eMacrophage Polarization in SCI 61\u003c\/p\u003e \u003cp\u003eConcluding Remarks 66\u003c\/p\u003e \u003cp\u003eAcknowledgements 66\u003c\/p\u003e \u003cp\u003eReferences 66\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The Complexity of the Innate Immune System Activation in Stroke Pathogenesis 71\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMaría Isabel Cuartero, Ignacio Lizasoain, María Ángeles Moro, and Ivan Ballesteros\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eActivation of the Brain Innate Immunity After Stroke 71\u003c\/p\u003e \u003cp\u003eMyeloid Heterogeneity in Brain Ischemia 76\u003c\/p\u003e \u003cp\u003eConcluding Remarks 81\u003c\/p\u003e \u003cp\u003eReferences 81\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Neuroinflammation in Aging 87\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAshley M. Fenn, Diana M. Norden, and Jonathan P. Godbout\u003c\/i\u003e Increased CNS Inflammation in Response to Immune Challenge is Adaptive and Beneficial 87\u003c\/p\u003e \u003cp\u003eThe CNS Microenvironment Shifts to a Proinflammatory State with Aging 88\u003c\/p\u003e \u003cp\u003eMicroglial Priming 88\u003c\/p\u003e \u003cp\u003eMicroglial Regulation 90\u003c\/p\u003e \u003cp\u003eImmune Reactivity of Glia Contributes to Cognitive and Behavioral Deficits 97\u003c\/p\u003e \u003cp\u003eConclusions 100\u003c\/p\u003e \u003cp\u003eReferences 100\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Peripheral and Central Immune Mechanisms in Neuropathic Pain 107\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJi Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 107\u003c\/p\u003e \u003cp\u003eInflammation in Neuropathic Pain 108\u003c\/p\u003e \u003cp\u003eContribution of Peripheral Immune Cells to the Pathogenesis of Neuropathic Pain 109\u003c\/p\u003e \u003cp\u003eCritical Roles of Spinal Glial Activation in Neuropathic Pain 111\u003c\/p\u003e \u003cp\u003eSignificance of Neural Barriers in Inflammatory Response along Pain Transmission Pathway 114\u003c\/p\u003e \u003cp\u003eImbalance of Pro- and Anti-inflammatory Responses in Neuropathic Pain 115\u003c\/p\u003e \u003cp\u003eChallenges in Translating Anti-inflammatory Therapeutic Strategies for the Relief of Neuropathic Pain 115\u003c\/p\u003e \u003cp\u003eAcknowledgement 117\u003c\/p\u003e \u003cp\u003eReferences 117\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Inflammation in the Pathogenesis of Inherited Peripheral Neuropathies 123\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJanos Groh, Dennis Klein, Antje Kroner, and Rudolf Martini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eInherited Peripheral Neuropathies 123\u003c\/p\u003e \u003cp\u003eSubtype-Specific Molecular Patterns of CMT1 124\u003c\/p\u003e \u003cp\u003eMolecular Commonalities of CMT1 Subtypes–a Link to Inflammation 125\u003c\/p\u003e \u003cp\u003eThe Impact of Innate Immune Reactions in Mouse Models of CMT1 126\u003c\/p\u003e \u003cp\u003eThe Impact of Adaptive Immune Reactions in Mouse Models of CMT1 129\u003c\/p\u003e \u003cp\u003eImplications for Putative Therapeutic Approaches 130\u003c\/p\u003e \u003cp\u003eSynopsis 132\u003c\/p\u003e \u003cp\u003eAcknowledgements 132\u003c\/p\u003e \u003cp\u003eReferences 133\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Obesity- and Neuroinflammation-Associated Mood and Cognitive Disorders 139\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eNathalie Castanon, Giamal Luheshi, and Sophie Layé\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 139\u003c\/p\u003e \u003cp\u003eNeuropsychiatric Comorbidity in Obesity 140\u003c\/p\u003e \u003cp\u003eAnimal Models of Obesity and MetS 140\u003c\/p\u003e \u003cp\u003eMechanisms Underlying the Association between Obesity\/MetS and Neuropsychiatric Symptoms 142\u003c\/p\u003e \u003cp\u003eNeuroinflammation, Sickness Behavior, and Neuropsychiatric Symptoms 143\u003c\/p\u003e \u003cp\u003eRole of Neuroinflammation in Neuropsychiatric Symptoms Associated with Obesity and MetS 146\u003c\/p\u003e \u003cp\u003eConclusions 148\u003c\/p\u003e \u003cp\u003eReferences 149\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Viral Infections of the Central Nervous System: Pathogenic and Protective Effects of Neuroinflammation 155\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJohn G. Walsh and Christopher Power\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 155\u003c\/p\u003e \u003cp\u003eNervous System Infection and Inflammation 157\u003c\/p\u003e \u003cp\u003eHIV-1 Infection: Neurological and Neuropathological Features 158\u003c\/p\u003e \u003cp\u003eWNV Infection and Neuropathology 162\u003c\/p\u003e \u003cp\u003eFuture Perspectives 166\u003c\/p\u003e \u003cp\u003eReferences 167\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III Beneficial Aspects of Inflammation 173\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 The Interplay between the Peripheral and Local Immune Response in Recovery from Acute Central Nervous System Injuries 175\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eCatarina Raposo and Michal Schwartz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eParadigm of Protective Autoimmunity 175\u003c\/p\u003e \u003cp\u003eDichotomy between Microglia and Infiltrating Monocyte-Derived Macrophages 176\u003c\/p\u003e \u003cp\u003eInfiltrating Macrophages Promote Inflammation Resolution and Axonal Regeneration 177\u003c\/p\u003e \u003cp\u003eThe Two Faces of Tregs in CNS Repair 178\u003c\/p\u003e \u003cp\u003eProtective Autoimmunity Works at the Specialized Choroid Plexus Gate 179\u003c\/p\u003e \u003cp\u003eInflammation, the Old Villain in Spinal Cord Repair 181\u003c\/p\u003e \u003cp\u003eComprehensive View of the Protective Autoimmune Network: the Link between Autoimmune T Cells and Inflammation-Resolving Cells 181\u003c\/p\u003e \u003cp\u003eAcknowledgments 183\u003c\/p\u003e \u003cp\u003eReferences 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Inflammation and Optic Nerve Regeneration 189\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eLukas Andereggen, Ephraim F. Trakhtenberg, Yin Yuqin, and Larry I. Benowitz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 189\u003c\/p\u003e \u003cp\u003eBackground 190\u003c\/p\u003e \u003cp\u003eEffects of inflammation on RGC survival and Optic Nerve Regeneration 192\u003c\/p\u003e \u003cp\u003eOncomodulin as a Key Mediator of Inflammation-Induced Regeneration 193\u003c\/p\u003e \u003cp\u003eSynergistic Effects of Combinatorial Treatments 198\u003c\/p\u003e \u003cp\u003eConclusions 200\u003c\/p\u003e \u003cp\u003eAcknowledgments 200\u003c\/p\u003e \u003cp\u003eReferences 200\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Effects of Macrophages and Monocytes in Remyelination of the CNS 205\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMuktha Natrajan, Bibiana Bielekova, and Robin J.M. Franklin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 205\u003c\/p\u003e \u003cp\u003eMyelin Debris Inhibits OPC Differentiation and Remyelination 207\u003c\/p\u003e \u003cp\u003eMonocyte-Derived Macrophages are the Main Actors in Myelin Debris Phagocytosis 209\u003c\/p\u003e \u003cp\u003eSwitching from M1 to M2 Macrophages Promotes CNS Remyelination 211\u003c\/p\u003e \u003cp\u003eAgeing Impairs Macrophage Function, Myelin Debris Clearance, and Remyelination 212\u003c\/p\u003e \u003cp\u003eMacrophages Release Growth and Neurotrophic Factors that Promote Remyelination 213\u003c\/p\u003e \u003cp\u003eConcluding Remarks 215\u003c\/p\u003e \u003cp\u003eReferences 215\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Microglia Involvement in Rett Syndrome 221\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eNoël C. Derecki, James C. Cronk, and Jonathan Kipnis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction to Rett Syndrome and MeCP2 221\u003c\/p\u003e \u003cp\u003eExperimental Mouse Models Used in the Study of Rett Syndrome 222\u003c\/p\u003e \u003cp\u003eThe Cellular Players in Central Nervous System Pathology of Rett Syndrome 223\u003c\/p\u003e \u003cp\u003eMicroglia: From Footnote to First-Line 224\u003c\/p\u003e \u003cp\u003eMicroglia: the Tissue-Resident Macrophages of the Brain 225\u003c\/p\u003e \u003cp\u003eReplacement\/Augmentation of MICROGLIA as A potential therapy in Rett Syndrome 228\u003c\/p\u003e \u003cp\u003eGene Therapy 229\u003c\/p\u003e \u003cp\u003eConclusions 230\u003c\/p\u003e \u003cp\u003eReferences 230\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 The Role of Regulatory T Cells and Microglia in Amyotrophic Lateral Sclerosis 235\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDavid R. Beers, Weihua Zhao, Kristopher G. Hooten, and Stanley H. Appel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview of Amyotrophic Lateral Sclerosis 235\u003c\/p\u003e \u003cp\u003eOverview of ALS Animal Models 237\u003c\/p\u003e \u003cp\u003eOverview of Regulatory T Cells 238\u003c\/p\u003e \u003cp\u003eImmunologic Aspects of Microglia and Tregs in ALS 240\u003c\/p\u003e \u003cp\u003eT Cells and ALS 242\u003c\/p\u003e \u003cp\u003eTregs and ALS 243\u003c\/p\u003e \u003cp\u003eCytokines and ALS 244\u003c\/p\u003e \u003cp\u003eConclusions 245\u003c\/p\u003e \u003cp\u003eReferences 247\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 An Adaptive Role for TNF\u003c\/b\u003e\u003cb\u003ein Synaptic Plasticity and Neuronal Function 251\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRenu Heir and David Stellwagen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 251\u003c\/p\u003e \u003cp\u003eDevelopmental Roles of TNFα 252\u003c\/p\u003e \u003cp\u003eTNFα in Presynaptic Function 252\u003c\/p\u003e \u003cp\u003eTNFα effects on postsynaptic receptor trafficking 252\u003c\/p\u003e \u003cp\u003eTNFα and Synaptic Plasticity 255\u003c\/p\u003e \u003cp\u003eGlial Release of TNFα During Plasticity 256\u003c\/p\u003e \u003cp\u003eTNFα-mediated homeostatic plasticity \u003ci\u003ein vivo\u003c\/i\u003e 258\u003c\/p\u003e \u003cp\u003eTNFα-Mediated Plasticity in the Striatum 258\u003c\/p\u003e \u003cp\u003eImplications of TNFα-Mediated Synaptic Regulation 259\u003c\/p\u003e \u003cp\u003eReferences 260\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Resolution of Inflammation in the Lesioned Central Nervous System 265\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJan M. Schwab, Harald Prüss, and Charles N Serhan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 265\u003c\/p\u003e \u003cp\u003eMechanisms of Resolution 267\u003c\/p\u003e \u003cp\u003eResolution Deficit Following CNS Lesions 268\u003c\/p\u003e \u003cp\u003eImmunobiology of Resolution in CNS Lesions–Impaired Resolution Contributes to Neuropathology 269\u003c\/p\u003e \u003cp\u003eLate Degeneration\/“Tertiary” Injury and Autoimmunity as a Consequence of Failed Resolution of Inflammation in CNS Lesions? 271\u003c\/p\u003e \u003cp\u003eEvidence for the Effectiveness of Pro-resolution Mediators in CNS Lesions 273\u003c\/p\u003e \u003cp\u003eConclusion 274\u003c\/p\u003e \u003cp\u003eAcknowledgement 275\u003c\/p\u003e \u003cp\u003eReferences 275\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex 281\u003c\/b\u003e\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49406913118551,"sku":"9781118732823","price":117.85,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118732823.jpg?v=1730497537","url":"https:\/\/bookcurl.com\/products\/neuroinflammation-9781118732823","provider":"Book Curl","version":"1.0","type":"link"}