{"product_id":"neonatal-haematology-9781119371588","title":"Neonatal Haematology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eNeonatal Haematology This unique handbook contains comprehensive coverage of neonatal haematology and aids diagnosis via high-quality images, diagnostic algorithms, case studies, and tables. With illustrations accompanying the diagnosis at each stage and clear explanations provided throughout, the book is ideal for trainees and experts alike. Authored by two of the world's leading haematologists, Professor Irene Roberts and Professor Barbara Bain, this book provides a depth of knowledge that is unequalled in other texts. To aid in reader comprehension, it is neatly organised by clinical problems and covers sample topics such as:  Red cells: morphology, membrane, enzymes, and changes over the first 4 weeks of life Haemolytic anaemias: causes of neonatal haemolysis, diagnostic clues, and immune haemolysis (haemolytic disease of the newborn) Neonatal anaemia due to blood loss: causes of blood loss, diagnostic clues, feto-maternal haemorrhage, and twin-to-twin transfusion Haematological si\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface viii\u003c\/p\u003e \u003cp\u003eAbbreviations x\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The full blood count and blood film in healthy term and preterm neonates 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 1\u003c\/p\u003e \u003cp\u003eBrief outline of the ontogeny of haemopoiesis 1\u003c\/p\u003e \u003cp\u003eProperties of fetal haemopoietic stem and progenitor cells 2\u003c\/p\u003e \u003cp\u003eRed blood cell production and development in the fetus and neonate 5\u003c\/p\u003e \u003cp\u003eErythropoietin production in the fetus and neonate 6\u003c\/p\u003e \u003cp\u003eHaemoglobin synthesis and red blood cell production in the fetus and newborn 6\u003c\/p\u003e \u003cp\u003eRed blood cell lifespan and the red blood cell membrane in the fetus and neonate 9\u003c\/p\u003e \u003cp\u003eRed blood cell metabolism in the fetus and neonate 10\u003c\/p\u003e \u003cp\u003eIron metabolism in the fetus and neonate 11\u003c\/p\u003e \u003cp\u003eNormal values for red blood cell parameters in the fetus and neonate 12\u003c\/p\u003e \u003cp\u003eLeucocytes in the fetus and newborn 17\u003c\/p\u003e \u003cp\u003eLeucocyte production and function in the fetus and neonate 18\u003c\/p\u003e \u003cp\u003ePlatelets and megakaryocytes in the fetus and neonate 23\u003c\/p\u003e \u003cp\u003eDevelopmental megakaryopoiesis and thrombopoiesis 23\u003c\/p\u003e \u003cp\u003ePlatelet numbers in the neonate and fetus – normal values 24\u003c\/p\u003e \u003cp\u003eNeonatal platelet function 25\u003c\/p\u003e \u003cp\u003ePractical problems in interpreting neonatal blood counts and films 25\u003c\/p\u003e \u003cp\u003eSample quality\/artefacts 25\u003c\/p\u003e \u003cp\u003eSite of sampling 26\u003c\/p\u003e \u003cp\u003eGestational age and postnatal age 27\u003c\/p\u003e \u003cp\u003ePregnancy-associated complications and mode of delivery 28\u003c\/p\u003e \u003cp\u003eReferences 28\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Red cell disorders: Anaemia, jaundice, polycythaemia and cyanosis 38\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNeonatal anaemia 38\u003c\/p\u003e \u003cp\u003eDefinition and clinical significance of neonatal anaemia 38\u003c\/p\u003e \u003cp\u003eNeonatal anaemia due to reduced red cell production 39\u003c\/p\u003e \u003cp\u003eNeonatal anaemia due to increased red cell destruction 47\u003c\/p\u003e \u003cp\u003eNeonatal anaemia due to haemoglobinopathies and other microcytic anaemias 67\u003c\/p\u003e \u003cp\u003eNeonatal anaemia due to blood loss 76\u003c\/p\u003e \u003cp\u003eAnaemia of prematurity 81\u003c\/p\u003e \u003cp\u003eA simple diagnostic approach to neonatal anaemia 83\u003c\/p\u003e \u003cp\u003eNeonatal polycythaemia 85\u003c\/p\u003e \u003cp\u003eHaematological causes of cyanosis 86\u003c\/p\u003e \u003cp\u003ePrinciples of red cell transfusion in neonates 86\u003c\/p\u003e \u003cp\u003eIllustrative cases 88\u003c\/p\u003e \u003cp\u003eAbbreviations used in the illustrative cases 110\u003c\/p\u003e \u003cp\u003eReferences 110\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Neonatal infection and leucocyte disorders 128\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eLeucocyte abnormalities in neonatal systemic disease 128\u003c\/p\u003e \u003cp\u003eIncreases in leucocyte numbers 128\u003c\/p\u003e \u003cp\u003eNeonatal infection and its differential diagnosis: clues from the blood count and blood film 135\u003c\/p\u003e \u003cp\u003eStorage disorders: diagnostic clues from the blood film 144\u003c\/p\u003e \u003cp\u003eNeonatal neutropenia 145\u003c\/p\u003e \u003cp\u003eDefinition and causes of neutropenia 145\u003c\/p\u003e \u003cp\u003eImmune neutropenia 148\u003c\/p\u003e \u003cp\u003eInherited congenital or neonatal neutropenia 150\u003c\/p\u003e \u003cp\u003eHaematological features of neonates with Down syndrome 154\u003c\/p\u003e \u003cp\u003eCongenital leukaemia 154\u003c\/p\u003e \u003cp\u003eLeukaemia and preleukaemia in neonates with Down syndrome 156\u003c\/p\u003e \u003cp\u003eAcute leukaemia in neonates without Down syndrome 160\u003c\/p\u003e \u003cp\u003eJuvenile myelomonocytic leukaemia and Noonan syndrome myeloproliferative disorder 168\u003c\/p\u003e \u003cp\u003eIllustrative cases 169\u003c\/p\u003e \u003cp\u003eAbbreviations used in the illustrative cases 176\u003c\/p\u003e \u003cp\u003eReferences 176\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Disorders of platelets and coagulation, thrombosis and blood transfusion 190\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThrombocytopenia overview 190\u003c\/p\u003e \u003cp\u003eCauses of neonatal thrombocytopenia: a practical classification based on age at onset 192\u003c\/p\u003e \u003cp\u003eFetal thrombocytopenia 194\u003c\/p\u003e \u003cp\u003eEarly-onset neonatal thrombocytopenia (presenting at \u0026lt;72 hours of age) 194\u003c\/p\u003e \u003cp\u003eLate-onset neonatal thrombocytopenia (presenting at \u0026gt;72 hours of age) 196\u003c\/p\u003e \u003cp\u003eConditions leading to clinically significant thrombocytopenia in the neonate 197\u003c\/p\u003e \u003cp\u003eFetal\/neonatal alloimmune thrombocytopenia 197\u003c\/p\u003e \u003cp\u003eNeonatal thrombocytopenia due to maternal autoimmune disease 200\u003c\/p\u003e \u003cp\u003eThrombocytopenia due to congenital infections 201\u003c\/p\u003e \u003cp\u003eNeonatal thrombocytopenia associated with chromosomal abnormalities 205\u003c\/p\u003e \u003cp\u003eInherited thrombocytopenia 206\u003c\/p\u003e \u003cp\u003eInvestigation of neonatal thrombocytopenia 215\u003c\/p\u003e \u003cp\u003eManagement of neonatal thrombocytopenia 215\u003c\/p\u003e \u003cp\u003eIndications for platelet transfusion 216\u003c\/p\u003e \u003cp\u003ePlatelet function disorders 217\u003c\/p\u003e \u003cp\u003eInherited platelet function disorders with normal platelet counts presenting in the neonate 218\u003c\/p\u003e \u003cp\u003eThrombocytosis 218\u003c\/p\u003e \u003cp\u003eAbnormalities of coagulation 220\u003c\/p\u003e \u003cp\u003eDevelopmental haemostasis 220\u003c\/p\u003e \u003cp\u003eLaboratory investigation of coagulation disorders in the neonate 220\u003c\/p\u003e \u003cp\u003eAcquired coagulation abnormalities 221\u003c\/p\u003e \u003cp\u003eInherited coagulation disorders 223\u003c\/p\u003e \u003cp\u003eThrombosis 224\u003c\/p\u003e \u003cp\u003eScreening tests for thrombophilia in neonates 224\u003c\/p\u003e \u003cp\u003eAcquired thrombotic abnormalities 225\u003c\/p\u003e \u003cp\u003eInherited thrombotic abnormalities 225\u003c\/p\u003e \u003cp\u003eGeneral principles of neonatal platelet and plasma component transfusion 226\u003c\/p\u003e \u003cp\u003ePlatelet transfusion 226\u003c\/p\u003e \u003cp\u003eFresh frozen plasma 226\u003c\/p\u003e \u003cp\u003eCryoprecipitate 227\u003c\/p\u003e \u003cp\u003eProthrombin complex and recombinant factor VIIa 227\u003c\/p\u003e \u003cp\u003eIllustrative cases 227\u003c\/p\u003e \u003cp\u003eAbbreviations used in the illustrative cases 233\u003c\/p\u003e \u003cp\u003eReferences 234\u003c\/p\u003e \u003cp\u003eIndex 254\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default 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