{"product_id":"natural-products-9781118298060","title":"Natural Products","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003ci\u003eNatural Products: Discourse, Diversity and Design\u003c\/i\u003eprovides an informative and accessible overview of discoveries in the area of natural products in the genomic era, bringing together advances across the kingdoms. As genomics data makes it increasingly clear that the genomes of microbes and plants contain far more genes for natural product synthesis than had been predicted from the numbers of previously identified metabolites, the potential of these organisms to synthesize diverse natural products is likely to be far greater than previously envisaged.\u003ci\u003eNatural Products\u003c\/i\u003eaddresses not only the philosophical questions of the natural role of these metabolites, but also the evolution of single and multiple pathways, and how these pathways and products may be harnessed to aid discovery of new bioactives and modes of action.\u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003eEdited by recognized leaders in the fields of plant and microbial biology, bioorganic chemistry and natural products chemistry, and with contri\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSECTION I NATURAL PRODUCTS IN THE NATURAL WORLD 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Role and Reason 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The Role of Phytochemicals in Relationships of Plants with Other Organisms 5\u003cbr\u003e\u003ci\u003ePaweł Bednarek\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Designer Microbial Ecosystems – Toward Biosynthesis with Engineered Microbial Consortia 23\u003cbr\u003e\u003ci\u003eDavid M. Babson, Mark Held, and Claudia Schmidt-Dannert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Marine Natural Products – Chemical Defense\/Chemical Communication in Sponges and Corals 39\u003cbr\u003e\u003ci\u003eElodie Quévrain, Isabelle Domart-Coulon, and Marie-Lise Bourguet-Kondracki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Self-Protection – Avoiding Autotoxicity 67\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 How Plants Avoid the Toxicity of Self-Produced Defense Bioactive Compounds 69\u003cbr\u003e\u003ci\u003eSupaart Sirikantaramas, Mami Yamazaki, and Kazuki Saito\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Fishing and Pharming 83\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5 Marine Bioprospecting 85\u003cbr\u003e\u003ci\u003eAmanda M. Fenner and William H. Gerwick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Myxobacteria: Chemical Diversity and Screening Strategies 103\u003cbr\u003e\u003ci\u003eAlberto Plaza and Rolf Müller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Fungal Endophytes of Grasses and Morning Glories, and their Bioprotective Alkaloids 125\u003cbr\u003e\u003ci\u003eChristopher L. Schardl, Li Chen, and Carolyn A. Young\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Fungal-Actinomycete Interactions –Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions 147\u003cbr\u003e\u003ci\u003eVolker Schroeckh, Hans-Wilhelm Nützmann, and Axel A. Brakhage\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Secondary Metabolites Produced by Plant Pathogens 159\u003cbr\u003e\u003ci\u003eBarbara J. Howlett\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION II FROM GENES TO MOLECULES 171\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Reading the Genome 173\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10 Analyzing Fungal Secondary Metabolite Genes and Gene Clusters 175\u003cbr\u003e\u003ci\u003eYi-Ming Chiang, Clay C. C. Wang, and Berl R. Oakley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Biosynthesis and Heterologous Expression 195\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11 RiPPs: Ribosomally Synthesized and Posttranslationally Modified Peptides 197\u003cbr\u003e\u003ci\u003eNoah A. Bindman and Wilfred A. Van Der Donk\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Polyketide Synthase: Sequence, Structure, and Function 219\u003cbr\u003e\u003ci\u003eJoel Bruegger, Grace Caldara, Joris Beld, Michael D. Burkart and Shiou-Chuan (Sheryl) Tsai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Manipulation of Fungal Natural Product Pathways 245\u003cbr\u003e\u003ci\u003eRussell J. Cox and Katherine Williams\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Production of Therapeutic Products 261\u003cbr\u003e\u003ci\u003eGuojian Zhang and Blaine A. Pfeifer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Regulation: Waking Sleeping Pathways 277\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15 Waking Sleeping Pathways in Filamentous Fungi 279\u003cbr\u003e\u003ci\u003eJoe Spraker and Nancy Keller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION III EVOLVING ENZYMES, EVOLVING PATHWAYS: SYNTHETIC BIOLOGY 293\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Chemical Diversification 295\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16 The Oxidosqualene Cyclases: One Substrate, Diverse Products 297\u003cbr\u003e\u003ci\u003eIkuro Abe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Harnessing Sugar Biosynthesis and Glycosylation to Redesign Natural Products and to Increase Structural Diversity 317\u003cbr\u003e\u003ci\u003eCarlos Olano, Carmen M\u003c\/i\u003e\u003ci\u003endez, and José A. Salas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Evolving Pathways 341\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18 Evolutionary Mechanisms Involved in Development of Fungal Secondary Metabolite Gene Clusters 343\u003cbr\u003e\u003ci\u003eGeromy G. Moore, Jérôme Collemare, Marc-Henri Lebrun, and Rosie E. Bradshaw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Synthetic Biology 357\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19 Synthetic Biology of Natural Products 359\u003cbr\u003e\u003ci\u003eRainer Breitling and Eriko Takano\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION IV SCREENING FOR BIOACTIVITY 371\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e20 Image-Based Screening Approaches to Natural Products Discovery 373\u003cbr\u003e\u003ci\u003eChristopher J. Schulze and Roger G. Linington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Making Sense of Structures by Utilizing Mother Nature’s Chemical Libraries as Leads to Potential Drugs 397\u003cbr\u003e\u003ci\u003eDavid J. Newman and Gordon M. Cragg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Is There an Ideal Database for Natural Products Research? 413\u003cbr\u003e\u003ci\u003eJohn W. Blunt and Murray H. G. Munro\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION V TO APPLICATION 433\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCase Studies 435\u003c\/p\u003e \u003cp\u003e23 Daptomycin and A54145: Structure–Activity Relationship (SAR) Studies Enabled by Combinatorial Biosynthesis 437\u003cbr\u003e\u003ci\u003eRichard H. Baltz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Discovery and Development of NVB302, a Semisynthetic Antibiotic for Treatment of Clostridium difficile Infection 455\u003cbr\u003e\u003ci\u003eSteven Boakes and Michael J. Dawson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 ILS-920: A Rapamycin Analog for Ischemic Stroke 469\u003cbr\u003e\u003ci\u003eEdmund I. Graziani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 BC265: A Nonquinone Ansamycin Hsp90 Inhibitor Developed Using Biosynthetic Medicinal Chemistry 483\u003cbr\u003e\u003ci\u003eMatthew A. Gregory, Steven J. Moss, and Barrie Wilkinson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Discovery and Development of Caspofungin (CANCIDAS): Concept to Clinic 497\u003cbr\u003e\u003ci\u003eJames M. Balkovec, David L. Hughes, Prakash S. Masurekar, Carole A. Sable, Robert E. Schwartz, and Sheo B. Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 523\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49406847779159,"sku":"9781118298060","price":999.99,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/natural-products-9781118298060","provider":"Book Curl","version":"1.0","type":"link"}