{"product_id":"modern-nucleophilic-aromatic-substitution-9783527318612","title":"Modern Nucleophilic Aromatic Substitution","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThis book provides a comprehensive overview of nucleophilic aromatic substitutions, focusing on the mechanistic and synthetic features that govern these reactions. \u003cbr\u003e\u003cbr\u003eThe first chapter presents a detailed mechanistic analysis of the factors determining the feasibility of SNAr substitutions, providing decisive information to predict regioselectivity of many reactions and to define the conditions for concerted SNAr processes. Reflecting the key role played by these species as intermediates in most SNAr reactions, chapter 2 then discusses the chemistry of anionic sigma-complexes. Chapter 3 describes the concept of superelectrophilicity in SNAr substitutions, as it has recently emerged from the reactivity of strongly electron-deficient aromatic and heteroaromatic structures. The numerous synthetic applications are considered in depth in the chapters 4 and 5 that follow on intermolecular and intramolecular nucleophilic aromatic substitutions. Then, chapter 6 focuses on substitutions proceeding formally through displacement of a hydride ion, a hot topic in the field. The final chapter brings together concise yet comprehensive discussions surrounding SNAr photosubstitutions, radical substitutions, and ANRORC substitutions.\u003c\/p\u003e \u003cp\u003eAuthored by a highly respected chemist who has contributed greatly to the field over the past two decades, this is a valuable information source for all organic chemists working in academia or the pharmaceutical and agrochemical industries.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eTHE SNAr REACTIONS: MECHANISTIC ASPECTS\u003cbr\u003e Introduction\u003cbr\u003e Activation of the Aromatic System: Driving Force for SNAr Reactions\u003cbr\u003e Leaving Group, Nucleophile, Solvent, and Medium Effects\u003cbr\u003e Effects of Specific Structural Variations in the Activated Ring\u003cbr\u003e Spectral Evidence for the Intermediacy of sigma-Complexes in SNAr Reactions\u003cbr\u003e Base Catalysis in SNAr Reactions\u003cbr\u003e Regioselectivity in SNAr Reactions\u003cbr\u003e Asymmetric SNAr Substitutions\u003cbr\u003e Concerted SNAr Substitutions\u003cbr\u003e Conclusion\u003cbr\u003e \u003cbr\u003e STRUCTURE AND REACTIVITY OF ANIONIC SIGMA-COMPLEXES\u003cbr\u003e Introduction\u003cbr\u003e Structural Features of sigma-Complexes\u003cbr\u003e Thermodynamics and Kinetics of sigma-Complex Formation\u003cbr\u003e \u003cbr\u003e THE SUPERELECTROPHILIC DIMENSION IN SNAr AND RELATED SIGMA-COMPLEXATION PROCESSES\u003cbr\u003e Introduction\u003cbr\u003e The Classical Domain of SNAr and Anionic sigma-Complexation Reactivity\u003cbr\u003e Reaching the Superelectrophilic Dimension\u003cbr\u003e The Synthetic Potential of sigma-Complexation and SNAr Reactivity in the Superelectrophilic Dimension\u003cbr\u003e Origin of the Superelectrophilicity of Neutral 10pi Heteroaromatics\u003cbr\u003e \u003cbr\u003e SYNTHETIC ASPECTS OF INTERMOLECULAR SNAr REACTIONS\u003cbr\u003e Introduction\u003cbr\u003e Intermolecular Displacements of a Nitro Group\u003cbr\u003e Intermolecular Displacements of Halogen and Other Leaving Groups\u003cbr\u003e Conclusion\u003cbr\u003e \u003cbr\u003e INTRAMOLECULAR SNAr REACTIONS\u003cbr\u003e Introduction\u003cbr\u003e SNAr Cyclizations\u003cbr\u003e Smiles Rearrangements\u003cbr\u003e Conclusion\u003cbr\u003e \u003cbr\u003e NUCLEOPHILIC AROMATIC SUBSTITUTIONS OF HYDROGEN\u003cbr\u003e Introduction\u003cbr\u003e Reactions Involving Oxidation of sigma-Complex-Type Intermediates\u003cbr\u003e Vicarious Nucleophilic Aromatic Substitutions of Hydrogen (VNS)\u003cbr\u003e Deoxygenative SNArH Substitutions\u003cbr\u003e Cine and Tele Substitutions\u003cbr\u003e Conclusion\u003cbr\u003e \u003cbr\u003e OTHER SNAr SUBSTITUTION PATHWAYS\u003cbr\u003e SN(ANRORC) Substitutions\u003cbr\u003e Radical Nucleophilic Aromatic Substitutions\u003cbr\u003e Nucleophilic Aromatic Photosubstitutions\u003cbr\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":53196945883479,"sku":"9783527318612","price":139.45,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/modern-nucleophilic-aromatic-substitution-9783527318612","provider":"Book Curl","version":"1.0","type":"link"}