{"product_id":"microdialysis-9780470409282","title":"Microdialysis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eApplications of Microdialysis in Pharmaceutical Science focuses on the use of microdialysis in drug evaluation for different organs and tissues and pharmacokinetics.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"This book will serve as a valuable reference for pharmaceutical researchers and it will be a logical companion to the Handbook of Behavioral Neuroscience series volume.\" (Doody's, 9 March 2012)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eContributors xi  \u003cp\u003e\u003cb\u003e1. Introduction to Applications of Microdialysis in Pharmaceutical Science 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eTung-Hu Tsai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Microdialysis in Drug Discovery 7\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eChristian Höcht\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 7\u003c\/p\u003e \u003cp\u003e2. Phases of Drug Development 8\u003c\/p\u003e \u003cp\u003e3. Role of Biomarkers in Drug Development 11\u003c\/p\u003e \u003cp\u003e4. Role of Pharmacokinetic-Pharmacodynamic Modeling in Drug Development 12\u003c\/p\u003e \u003cp\u003e5. Role of Microdialysis in Drug Development 15\u003c\/p\u003e \u003cp\u003e6. Microdialysis Sampling in the Drug Development of Specific Therapeutic Groups 20\u003c\/p\u003e \u003cp\u003e7. Regulatory Aspects of Microdialysis Sampling in Drug Development 29\u003c\/p\u003e \u003cp\u003e8. Conclusions 30\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. Analytical Considerations for Microdialysis Sampling 39\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePradyot Nandi, Courtney D. Kuhnline, and Susan M. Lunte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 39\u003c\/p\u003e \u003cp\u003e2. Analytical Methodologies 49\u003c\/p\u003e \u003cp\u003e3. Conclusions 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Monitoring Dopamine in the Mesocorticolimbic and Nigrostriatal Systems by Microdialysis: Relevance for Mood Disorders and Parkinson’s Disease 93\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGiuseppe Di Giovanni, Massimo Peirucci, and Vincenzo Di Matteo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 93\u003c\/p\u003e \u003cp\u003e2. Pathophysiology of Serotonin-Dopamine Interaction: Implication for Mood Disorders 94\u003c\/p\u003e \u003cp\u003e3. Dopamine Depletion in the Nigrostratal System: Parkinson’s Disease 109\u003c\/p\u003e \u003cp\u003e4. Conclusions 120\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Monitoring Neutrotransmitter Amino Acids by Microdialysis: Pharmacodynamic Applications 151\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSandrine Parrot, Bernard Renaud, Luc Zimmer, and Luc Denoroy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 151\u003c\/p\u003e \u003cp\u003e2. Monitoring Neurotransmitter Amino Acids by Microdialysis 152\u003c\/p\u003e \u003cp\u003e3. Basic Research on Receptors 162\u003c\/p\u003e \u003cp\u003e4. Psychostimulants and Addictive Drugs 168\u003c\/p\u003e \u003cp\u003e5. Analgesia 177\u003c\/p\u003e \u003cp\u003e6. Ischemia-Anoxia 182\u003c\/p\u003e \u003cp\u003e7. Conclusions and Perspectives 188\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Microdialysis as a Tool to Unravel Neurobiological Mechanisms of Seizures and Antiepileptic Drug Action 207\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eIlse Smolders, Ralph Clickers, and Yvette Michotte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 207\u003c\/p\u003e \u003cp\u003e2. Microdialysis to Characterize Seizure-Related Neurobiological and Metabolic Changes in Animal Models and in Humans 209\u003c\/p\u003e \u003cp\u003e3. Microdialysis as a Chemoconvulsant Delivery Tool in Animal Seizure Models 217\u003c\/p\u003e \u003cp\u003e4. Microdialysis Used to Elucidate Mechanisms of Electrical Brain Stimulation and Neuronal Circuits Involved in Seizures 218\u003c\/p\u003e \u003cp\u003e5. Microdialysis Used to Unravel the Mechanisms of Action of Established Antiepileptic Drugs and New Therapeutic Strategies 219\u003c\/p\u003e \u003cp\u003e6. Microdialysis Studies in the Search for Mechanisms of Adverse Effects of Clinically Used Drugs, Drugs of Abuse, and Toxins 224\u003c\/p\u003e \u003cp\u003e7. Combining Microdialysis with Other Complementary Neurotechniques to Unravel Mechanisms of Seizures and Epilepsy 226\u003c\/p\u003e \u003cp\u003e8. The Advantage of Microdialysis Used to Sample Biophase Antiepileptic Drug Levels and to Monitor Neurotransmitters as Markers for Anticonvulsant Activity 228\u003c\/p\u003e \u003cp\u003e9. Microdialysis Used to Study Relationships Between Epilepsy and Its Comorbidities 236\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Microdialysis in Lung Tissue: Monitoring of Exogenous and Endogenous Compounds 255\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eThomas Feurstein and Markus Zeitlinger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 255\u003c\/p\u003e \u003cp\u003e2. Special Aspects Associated with Lung Microdialysis Compared to Microdialysis in Other Tissues 252\u003c\/p\u003e \u003cp\u003e3. Insertion of Microdialysis Probes into Lung Tissue 256\u003c\/p\u003e \u003cp\u003e4. Insertion of Microdialysis Probes into the Bronchial System 257\u003c\/p\u003e \u003cp\u003e5. Types of Probes 258\u003c\/p\u003e \u003cp\u003e6. Endogenous Compounds 258\u003c\/p\u003e \u003cp\u003e7. Exogenous Drugs 259\u003c\/p\u003e \u003cp\u003e8. Animal Data 260\u003c\/p\u003e \u003cp\u003e9. Clinical Data 262\u003c\/p\u003e \u003cp\u003e10. Comparison of Pharmacokinetic Data in Lung Obtained by Microdialysis and Other Techniques 264\u003c\/p\u003e \u003cp\u003e11. Predictability of Lung Concentrations by Measurements on Other Tissues 265\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Microdialysis in the Hepatobility System: Monitoring Drug Metabolism, Hepatebiliary Excretion, and Enterohepatic Circulation 275\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYu-Tse Wu and Tung-Hu Tsia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 275\u003c\/p\u003e \u003cp\u003e2. Experimental Considerations of Pharmacokinetic Studies 279\u003c\/p\u003e \u003cp\u003e3. Pharmacokinetic and Hepatobiliary Excretion Studies Emproving Microdialysis 284\u003c\/p\u003e \u003cp\u003e4. Conclusions 287\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Microdialysis Used to Measure the Metabolism of Glucose, Lactate, and Glycerol 295\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGreg Nowak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.Introduction 295\u003c\/p\u003e \u003cp\u003e2. Glucose 299\u003c\/p\u003e \u003cp\u003e3. Lactate 301\u003c\/p\u003e \u003cp\u003e4. Lactate\/Pyruvate Ratio 303\u003c\/p\u003e \u003cp\u003e5. Glycerol 303\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Clinical Microdialysis in Skin and Soft Tissues 313\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMartina Sahre, Runa Naik, and Hartmut Derendorf\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 313\u003c\/p\u003e \u003cp\u003e2. Tissue Bioavailability 314\u003c\/p\u003e \u003cp\u003e3. PK-PD Indices 323\u003c\/p\u003e \u003cp\u003e4. Topical Bioequivalence 329\u003c\/p\u003e \u003cp\u003e5. Endogenous Compounds 330\u003c\/p\u003e \u003cp\u003e6. Conclusion 331\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. Microdialysis on Adipose Tissue: Monitoring Tissue Metabolism and Blood Flow in Humans 335\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGijs H. Goossens, Wim H. Saris, and Ellen E. Black\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 335\u003c\/p\u003e \u003cp\u003e2. Principles and Practical Considerations in the Use of Microdialysis on Adipose Tissue 336\u003c\/p\u003e \u003cp\u003e3. Use of Microdialysis on Adipose Tissue in Humans 342\u003c\/p\u003e \u003cp\u003e4. Summary and Conclusions 353\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Microdialysis as a Monitoring System for Human Diabetes 359\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAnna Ciechanowska, Jan M. Wojcick, Iwuna Maruniak-Chudek,Piotr Ladyzynski, and Janusz Kraybien\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 359\u003c\/p\u003e \u003cp\u003e2. Monitoring Acute Complications of Diabetes 362\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13. Microdialysis Use in Tumors Drug Disposition and Tumor Response 403\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eQuigyu Zhou and James M. Gallo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 403\u003c\/p\u003e \u003cp\u003e2. Microdialysis as a Sampling Technique in Oncology 404\u003c\/p\u003e \u003cp\u003e3. Experimental Considerations 408\u003c\/p\u003e \u003cp\u003e4. Examples of the Use of Microdualysis to Characterize Drug Disposition in Tumor 414\u003c\/p\u003e \u003cp\u003e5. Use of Microdialysis in the Evaluation of Tumor Response to Therapy 423\u003c\/p\u003e \u003cp\u003e6. Conclusions and Future Perspectives 423\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14. Microdialysis Versus Imaging Techniques for In Vivo Drug Distribution Measurements 431\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMartin Brunner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 431\u003c\/p\u003e \u003cp\u003e2. Microdialysis 432\u003c\/p\u003e \u003cp\u003e3. Imaging Techniques 434\u003c\/p\u003e \u003cp\u003e4. Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy 434\u003c\/p\u003e \u003cp\u003e5. Positron-Emission Tomography 435\u003c\/p\u003e \u003cp\u003e6. Combination of Microdialysis and Imaging Techniques 436\u003c\/p\u003e \u003cp\u003e7. Summary and Conclusions 438\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15. In Vitro Applications of Microdialysis 445\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eWen-Chuan Lee and Tung-Hu Tsai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 445\u003c\/p\u003e \u003cp\u003e2. Microdialysis Used in Culture Systems 446\u003c\/p\u003e \u003cp\u003e3. Microdialysis Used in Enzyme Kinetics 453\u003c\/p\u003e \u003cp\u003e4. Microdialysis Used in Protein Binding 455\u003c\/p\u003e \u003cp\u003e5. Conclusions 456\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16. Microdialysis in Drug-Drug Interaction 465\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMitsuhito Wada, Rie Ikeda, and Kenichiro Nakashima\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 465\u003c\/p\u003e \u003cp\u003e2. Pharmacokinetic Drug-Drug Interaction 472\u003c\/p\u003e \u003cp\u003e3. Pharmacodynamic Drug-Drug Interaction 487\u003c\/p\u003e \u003cp\u003e4. Conclusions 501\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17. Microdialysis in Environmental Monitoring 509\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eManuel Miró and Wolfgang Frenzel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1. Introduction 509\u003c\/p\u003e \u003cp\u003e2. In Vivo and In Situ Sampling: Similarities and Differences 510\u003c\/p\u003e \u003cp\u003e3. Critical Parameters Influencing Relative Recoveries 513\u003c\/p\u003e \u003cp\u003e4. Detection Techniques 516\u003c\/p\u003e \u003cp\u003e5. Calibration Methods 519\u003c\/p\u003e \u003cp\u003e6. Environmental Applications of Microdialysis 520\u003c\/p\u003e \u003cp\u003e7. Conclusions and Future Trends 524\u003c\/p\u003e \u003cp\u003eIndex 531\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":51767549100375,"sku":"9780470409282","price":134.06,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470409282.jpg?v=1758713740","url":"https:\/\/bookcurl.com\/products\/microdialysis-9780470409282","provider":"Book Curl","version":"1.0","type":"link"}