{"product_id":"metals-in-medicine-9781119191308","title":"Metals in Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eWorking from basic chemical principles, \u003ci\u003eMetals in Medicine,\u003c\/i\u003e 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition.\u003c\/p\u003e \u003cp\u003eTopics include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eMetallo-Drugs and their action\u003c\/li\u003e \u003cli\u003ePlatinum drugs for treating cancer\u003c\/li\u003e \u003cli\u003eAnticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium\u003c\/li\u003e \u003cli\u003eResponsive Metal Complexes\u003c\/li\u003e \u003cli\u003eTreating arthritis and diabetes with metal complexes\u003c\/li\u003e \u003cli\u003eMetal complexes for killing bacteria, parasites and viruses\u003c\/li\u003e \u003cli\u003eMetal ion imbalance and its links to diseases including Alzheimer''s, Wilson''s and Menkes disease\u003c\/li\u003e \u003cli\u003eMetal complexes for detecting disease\u003c\/li\u003e \u003cli\u003eNanotechnology in medicine\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eNow i\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eFeature Boxes xv\u003c\/p\u003e \u003cp\u003ePreface to the Second Edition xvii\u003c\/p\u003e \u003cp\u003ePreface to the First Edition xix\u003c\/p\u003e \u003cp\u003eAcknowledgments xxi\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xxiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Inorganic Chemistry Basics 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Crystal Field Theory 1\u003c\/p\u003e \u003cp\u003e1.3 Molecular Orbital Theory 12\u003c\/p\u003e \u003cp\u003e1.4 Absorption Spectra of Metal Complexes 22\u003c\/p\u003e \u003cp\u003e1.5 Magnetic Properties of Metal Complexes 33\u003c\/p\u003e \u003cp\u003e1.6 Structure and Reactivity of Metal Complexes 35\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Metallo-Drugs and Their Action 59\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 59\u003c\/p\u003e \u003cp\u003e2.2 Proteins asTargets forMetallo-Drugs 59\u003c\/p\u003e \u003cp\u003e2.3 DNAas aTarget forMetallo-Drugs 71\u003c\/p\u003e \u003cp\u003e2.4 Reaction of Metal Complexes in the Biological Milieu 76\u003c\/p\u003e \u003cp\u003e2.5 Evaluating the Pharmacological Effects of Agents 79\u003c\/p\u003e \u003cp\u003e2.6 FromDiscoverytotheClinic 82\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Platinum Drugs for Treating Cancer 91\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 91\u003c\/p\u003e \u003cp\u003e3.2 Cisplatin 91\u003c\/p\u003e \u003cp\u003e3.3 Carboplatin 115\u003c\/p\u003e \u003cp\u003e3.4 Oxaliplatin 126\u003c\/p\u003e \u003cp\u003e3.5 RegionallyUsedPlatinumDrugs 133\u003c\/p\u003e \u003cp\u003e3.6 Platinum Agents in Preclinical Development 135\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Anticancer Agents Beyond Cisplatin 157\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 157\u003c\/p\u003e \u003cp\u003e4.2 Ruthenium Anticancer Agents 157\u003c\/p\u003e \u003cp\u003e4.3 Gold Anticancer Agents 173\u003c\/p\u003e \u003cp\u003e4.4 Titanium Compounds for Treating Cancer 181\u003c\/p\u003e \u003cp\u003e4.5 Gallium for Treating Cancer 187\u003c\/p\u003e \u003cp\u003e4.6 Other Anticancer Active Metal Complexes 194\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Responsive Metal Complexes 217\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 217\u003c\/p\u003e \u003cp\u003e5.2 Prodrug Activation by Redox 217\u003c\/p\u003e \u003cp\u003e5.3 ProdrugActivationbypH 225\u003c\/p\u003e \u003cp\u003e5.4 Prodrug Activation by Enzymes 227\u003c\/p\u003e \u003cp\u003e5.5 ProdrugActivationbyLight 229\u003c\/p\u003e \u003cp\u003e5.6 Photodynamic Therapy 233\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Metal Complexes for Treating Arthritis and Diabetes 245\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 245\u003c\/p\u003e \u003cp\u003e6.2 ChemistryofGoldinBiologicalMedia 245\u003c\/p\u003e \u003cp\u003e6.3 Gold Compounds for Treating Arthritis 247\u003c\/p\u003e \u003cp\u003e6.4 Vanadium Compounds for Treating Diabetes 263\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Metal Complexes for Killing Parasites, Bacteria and Viruses 285\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 285\u003c\/p\u003e \u003cp\u003e7.2 Malaria 285\u003c\/p\u003e \u003cp\u003e7.3 Leishmaniasis 293\u003c\/p\u003e \u003cp\u003e7.4 American Trypanosomiasis (Chagas Disease) 298\u003c\/p\u003e \u003cp\u003e7.5 Human African Trypanosomiasis 301\u003c\/p\u003e \u003cp\u003e7.6 Tuberculosis 301\u003c\/p\u003e \u003cp\u003e7.7 PepticUlcerDisease 306\u003c\/p\u003e \u003cp\u003e7.8 Syphilis 311\u003c\/p\u003e \u003cp\u003e7.9 Bacterial Infections 312\u003c\/p\u003e \u003cp\u003e7.10 Acquired Immunodeficiency Syndrome (AIDS) 314\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Metal Ion Imbalance in the Body 329\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 329\u003c\/p\u003e \u003cp\u003e8.2 Alzheimer’s Disease 329\u003c\/p\u003e \u003cp\u003e8.3 LithiumandtheBrain 337\u003c\/p\u003e \u003cp\u003e8.4 Wilson’s Disease: Copper Overload 338\u003c\/p\u003e \u003cp\u003e8.5 Menkes Disease: Copper Deficiency 340\u003c\/p\u003e \u003cp\u003e8.6 Beta-Thalassemia: IronOverload 342\u003c\/p\u003e \u003cp\u003e8.7 Iron-Deficiency Anemia 344\u003c\/p\u003e \u003cp\u003e8.8 Calcium Imbalance 344\u003c\/p\u003e \u003cp\u003e8.9 ChelationTherapy 346\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Metal Complexes for Detecting Disease 357\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 357\u003c\/p\u003e \u003cp\u003e9.2 Technetium in Diagnostic Nuclear Medicine 358\u003c\/p\u003e \u003cp\u003e9.3 Metal Compounds as Contrast Agents for MRI 371\u003c\/p\u003e \u003cp\u003e9.4 Radiotherapy 382\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Nanomedicine 395\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 395\u003c\/p\u003e \u003cp\u003e10.2 Circulation, Uptake, and Elimination of Nanoparticles 396\u003c\/p\u003e \u003cp\u003e10.3 Nanoscience for Treating Cancer 407\u003c\/p\u003e \u003cp\u003e10.4 Nanoparticles for Detecting Disease 419\u003c\/p\u003e \u003cp\u003e10.5 Theranostic Nanoparticles 426\u003c\/p\u003e \u003cp\u003e10.6 Cytotoxicity of Nanoparticles 428\u003c\/p\u003e \u003cp\u003eIndex 441\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":51039264964951,"sku":"9781119191308","price":67.4,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119191308.jpg?v=1750943101","url":"https:\/\/bookcurl.com\/products\/metals-in-medicine-9781119191308","provider":"Book Curl","version":"1.0","type":"link"}