{"product_id":"medicinal-natural-products-9780470741689","title":"Medicinal Natural Products","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eMedicinal Natural Products: A Biosynthetic Approach, Third Edition , provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"Students should be empowered for a deductive analysis of the presented substances.\" (\u003ci\u003eArzneimittelforschung\u003c\/i\u003e, December 2009)  \u003cp\u003e \"This new edition is an excellent text that is unrivaled in both its scope and overall coverage of natural products biosynthesis.\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, August 2009)\u003c\/p\u003e  \u003cp\u003e \"There is no question that this is the best book available on the biosynthesis and bio-organic chemistry of medicinally important natural products.\" (\u003ci\u003eEducation in Chemistry\u003c\/i\u003e, September 2009)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003e1 About this book, and how to use it 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe subject 1\u003c\/p\u003e \u003cp\u003eThe aim 1\u003c\/p\u003e \u003cp\u003eThe approach 2\u003c\/p\u003e \u003cp\u003eThe topics 2\u003c\/p\u003e \u003cp\u003eThe figures 2\u003c\/p\u003e \u003cp\u003eFurther reading 3\u003c\/p\u003e \u003cp\u003eWhat to study 3\u003c\/p\u003e \u003cp\u003eWhat to learn 3\u003c\/p\u003e \u003cp\u003eNomenclature 3\u003c\/p\u003e \u003cp\u003eConventions regarding acids, bases, and ions 4\u003c\/p\u003e \u003cp\u003eSome common abbreviations 4\u003c\/p\u003e \u003cp\u003eFurther reading 5\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Secondary metabolism: the building blocks and construction mechanisms 7\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePrimary and secondary metabolism 7\u003c\/p\u003e \u003cp\u003eThe building blocks 8\u003c\/p\u003e \u003cp\u003eThe construction mechanisms 11\u003c\/p\u003e \u003cp\u003eAlkylation reactions: nucleophilic substitution 12\u003c\/p\u003e \u003cp\u003eAlkylation reactions: electrophilic addition 12\u003c\/p\u003e \u003cp\u003eWagner–Meerwein rearrangements 15\u003c\/p\u003e \u003cp\u003eAldol and Claisen reactions 15\u003c\/p\u003e \u003cp\u003eImine formation and the Mannich reaction 18\u003c\/p\u003e \u003cp\u003eAmino acids and transamination 20\u003c\/p\u003e \u003cp\u003eDecarboxylation reactions 22\u003c\/p\u003e \u003cp\u003eOxidation and reduction reactions 24\u003c\/p\u003e \u003cp\u003eDehydrogenases 24\u003c\/p\u003e \u003cp\u003eOxidases 26\u003c\/p\u003e \u003cp\u003eMonooxygenases 26\u003c\/p\u003e \u003cp\u003eDioxygenases 26\u003c\/p\u003e \u003cp\u003eAmine oxidases 27\u003c\/p\u003e \u003cp\u003eBaeyer–Villiger monooxygenases 27\u003c\/p\u003e \u003cp\u003ePhenolic oxidative coupling 28\u003c\/p\u003e \u003cp\u003eHalogenation reactions 28\u003c\/p\u003e \u003cp\u003eGlycosylation reactions 31\u003c\/p\u003e \u003cp\u003eElucidating biosynthetic pathways 34\u003c\/p\u003e \u003cp\u003eFurther reading 38\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The acetate pathway: fatty acids and polyketides 39\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eFatty acid synthase: saturated fatty acids 39\u003c\/p\u003e \u003cp\u003eUnsaturated fatty acids 44\u003c\/p\u003e \u003cp\u003eUncommon fatty acids 53\u003c\/p\u003e \u003cp\u003eProstaglandins 58\u003c\/p\u003e \u003cp\u003eThromboxanes 64\u003c\/p\u003e \u003cp\u003eLeukotrienes 64\u003c\/p\u003e \u003cp\u003ePolyketide synthases: generalities 66\u003c\/p\u003e \u003cp\u003ePolyketide synthases: macrolides 68\u003c\/p\u003e \u003cp\u003ePolyketide synthases: linear polyketides and polyethers 90\u003c\/p\u003e \u003cp\u003eDiels–Alder cyclizations 96\u003c\/p\u003e \u003cp\u003ePolyketide synthases: aromatics 96\u003c\/p\u003e \u003cp\u003eCyclizations 99\u003c\/p\u003e \u003cp\u003ePost-polyketide synthase modifications 103\u003c\/p\u003e \u003cp\u003eStarter groups 116\u003c\/p\u003e \u003cp\u003eFurther reading 131\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The shikimate pathway: aromatic amino acids and phenylpropanoids 137\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAromatic amino acids and simple benzoic acids 137\u003c\/p\u003e \u003cp\u003ePhenylpropanoids 148\u003c\/p\u003e \u003cp\u003eCinnamic acids and esters 148\u003c\/p\u003e \u003cp\u003eLignans and lignin 152\u003c\/p\u003e \u003cp\u003ePhenylpropenes 156\u003c\/p\u003e \u003cp\u003eBenzoic acids from C\u003csub\u003e6\u003c\/sub\u003e C\u003csub\u003e3\u003c\/sub\u003e compounds 157\u003c\/p\u003e \u003cp\u003eCoumarins 161\u003c\/p\u003e \u003cp\u003eAromatic polyketides 166\u003c\/p\u003e \u003cp\u003eStyrylpyrones, diarylheptanoids 166\u003c\/p\u003e \u003cp\u003eFlavonoids and stilbenes 167\u003c\/p\u003e \u003cp\u003eFlavonolignans 173\u003c\/p\u003e \u003cp\u003eIsoflavonoids 174\u003c\/p\u003e \u003cp\u003eTerpenoid quinones 178\u003c\/p\u003e \u003cp\u003eFurther reading 184\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The mevalonate and methylerythritol phosphate pathways: terpenoids and steroids 187\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMevalonic acid and methylerythritol phosphate 188\u003c\/p\u003e \u003cp\u003eHemiterpenes (C\u003csub\u003e5\u003c\/sub\u003e) 192\u003c\/p\u003e \u003cp\u003eMonoterpenes (C\u003csub\u003e10\u003c\/sub\u003e) 193\u003c\/p\u003e \u003cp\u003eIrregular monoterpenes 204\u003c\/p\u003e \u003cp\u003eIridoids (C\u003csub\u003e10\u003c\/sub\u003e) 206\u003c\/p\u003e \u003cp\u003eSesquiterpenes (C\u003csub\u003e15\u003c\/sub\u003e) 210\u003c\/p\u003e \u003cp\u003eDiterpenes (C\u003csub\u003e20\u003c\/sub\u003e) 223\u003c\/p\u003e \u003cp\u003eSesterterpenes (C\u003csub\u003e25\u003c\/sub\u003e) 234\u003c\/p\u003e \u003cp\u003eTriterpenes (C\u003csub\u003e30\u003c\/sub\u003e) 234\u003c\/p\u003e \u003cp\u003eTriterpenoid saponins 242\u003c\/p\u003e \u003cp\u003eSteroids 247\u003c\/p\u003e \u003cp\u003eStereochemistry and nomenclature 247\u003c\/p\u003e \u003cp\u003eCholesterol 248\u003c\/p\u003e \u003cp\u003ePhytosterols 251\u003c\/p\u003e \u003cp\u003eVitamin d 256\u003c\/p\u003e \u003cp\u003eSteroidal saponins 259\u003c\/p\u003e \u003cp\u003eCardioactive glycosides 265\u003c\/p\u003e \u003cp\u003eBile acids 275\u003c\/p\u003e \u003cp\u003eAdrenocortical hormones\/corticosteroids 277\u003c\/p\u003e \u003cp\u003eSemi-synthesis of corticosteroids 277\u003c\/p\u003e \u003cp\u003eProgestogens 287\u003c\/p\u003e \u003cp\u003eOestrogens 290\u003c\/p\u003e \u003cp\u003eAndrogens 296\u003c\/p\u003e \u003cp\u003eTetraterpenes (C\u003csub\u003e40\u003c\/sub\u003e) 298\u003c\/p\u003e \u003cp\u003eHigher terpenoids 306\u003c\/p\u003e \u003cp\u003eFurther reading 306\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Alkaloids 311\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAlkaloids derived from ornithine 311\u003c\/p\u003e \u003cp\u003ePolyamines 311\u003c\/p\u003e \u003cp\u003ePyrrolidine and tropane alkaloids 312\u003c\/p\u003e \u003cp\u003ePyrrolizidine alkaloids 324\u003c\/p\u003e \u003cp\u003eAlkaloids derived from lysine 326\u003c\/p\u003e \u003cp\u003ePiperidine alkaloids 326\u003c\/p\u003e \u003cp\u003eQuinolizidine alkaloids 328\u003c\/p\u003e \u003cp\u003eIndolizidine alkaloids 330\u003c\/p\u003e \u003cp\u003eAlkaloids derived from nicotinic acid 331\u003c\/p\u003e \u003cp\u003ePyridine alkaloids 331\u003c\/p\u003e \u003cp\u003eAlkaloids derived from tyrosine 336\u003c\/p\u003e \u003cp\u003ePhenylethylamines and simple tetrahydroisoquinoline alkaloids 336\u003c\/p\u003e \u003cp\u003eModified benzyltetrahydroisoquinoline alkaloids 346\u003c\/p\u003e \u003cp\u003ePhenethylisoquinoline alkaloids 359\u003c\/p\u003e \u003cp\u003eTerpenoid tetrahydroisoquinoline alkaloids 363\u003c\/p\u003e \u003cp\u003eAmaryllidaceae alkaloids 365\u003c\/p\u003e \u003cp\u003eAlkaloids derived from tryptophan 366\u003c\/p\u003e \u003cp\u003eSimple indole alkaloids 366\u003c\/p\u003e \u003cp\u003eSimple β-carboline alkaloids 369\u003c\/p\u003e \u003cp\u003eTerpenoid indole alkaloids 369\u003c\/p\u003e \u003cp\u003eQuinoline alkaloids 380\u003c\/p\u003e \u003cp\u003ePyrroloindole alkaloids 385\u003c\/p\u003e \u003cp\u003eErgot alkaloids 387\u003c\/p\u003e \u003cp\u003eAlkaloids derived from anthranilic acid 395\u003c\/p\u003e \u003cp\u003eQuinazoline alkaloids 395\u003c\/p\u003e \u003cp\u003eQuinoline and acridine alkaloids 396\u003c\/p\u003e \u003cp\u003eAlkaloids derived from histidine 398\u003c\/p\u003e \u003cp\u003eImidazole alkaloids 398\u003c\/p\u003e \u003cp\u003eAlkaloids derived by amination reactions 400\u003c\/p\u003e \u003cp\u003eAcetate-derived alkaloids 401\u003c\/p\u003e \u003cp\u003ePhenylalanine-derived alkaloids 401\u003c\/p\u003e \u003cp\u003eTerpenoid alkaloids 406\u003c\/p\u003e \u003cp\u003eSteroidal alkaloids 406\u003c\/p\u003e \u003cp\u003ePurine alkaloids 413\u003c\/p\u003e \u003cp\u003eCaffeine 413\u003c\/p\u003e \u003cp\u003eSaxitoxin and tetrodotoxin 416\u003c\/p\u003e \u003cp\u003eFurther reading 417\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Peptides, proteins, and other amino acid derivatives 421\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePeptides and proteins 421\u003c\/p\u003e \u003cp\u003eRibosomal peptide biosynthesis 422\u003c\/p\u003e \u003cp\u003ePeptide hormones 426\u003c\/p\u003e \u003cp\u003eThyroid hormones 426\u003c\/p\u003e \u003cp\u003eHypothalamic hormones 427\u003c\/p\u003e \u003cp\u003eAnterior pituitary hormones 429\u003c\/p\u003e \u003cp\u003ePosterior pituitary hormones 430\u003c\/p\u003e \u003cp\u003ePancreatic hormones 432\u003c\/p\u003e \u003cp\u003eInterferons 433\u003c\/p\u003e \u003cp\u003eOpioid peptides 434\u003c\/p\u003e \u003cp\u003eRibosomal peptide toxins 434\u003c\/p\u003e \u003cp\u003eEnzymes 438\u003c\/p\u003e \u003cp\u003eNon-ribosomal peptide biosynthesis 438\u003c\/p\u003e \u003cp\u003eModified peptides: penicillins, cephalosporins, and other β-lactams 458\u003c\/p\u003e \u003cp\u003ePenicillins 458\u003c\/p\u003e \u003cp\u003eCephalosporins 465\u003c\/p\u003e \u003cp\u003eOther β-lactams 469\u003c\/p\u003e \u003cp\u003eCyanogenic glycosides 476\u003c\/p\u003e \u003cp\u003eGlucosinolates 477\u003c\/p\u003e \u003cp\u003eCysteine sulfoxides 480\u003c\/p\u003e \u003cp\u003eFurther reading 481\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Carbohydrates 485\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMonosaccharides 485\u003c\/p\u003e \u003cp\u003eOligosaccharides 490\u003c\/p\u003e \u003cp\u003ePolysaccharides 493\u003c\/p\u003e \u003cp\u003eAminosugars and aminoglycosides 498\u003c\/p\u003e \u003cp\u003eFurther reading 507\u003c\/p\u003e \u003cp\u003eIndex 509\u003c\/p\u003e","brand":"John Wiley \u0026 Sons 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