{"product_id":"medicinal-chemistry-of-bioactive-9780471660071","title":"Medicinal Chemistry of Bioactive","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eCurrent discoveries and research into bioactive natural products    Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"…an in-depth resource for anyone concerned about natural products and their application in medicine...it provides concise information that is difficult to find in a compact format elsewhere.\" (\u003ci\u003eClinical Chemistry\u003c\/i\u003e, January 2007)  \u003cp\u003e\"…I can imagine this book being used in an interdisciplinary graduate course…[or] as a reference text.\" (\u003ci\u003eJournal of the American Chemical Society\u003c\/i\u003e, September 13, 2006)\u003c\/p\u003e \u003cp\u003e\"The authors are to be commended on the excellent blending of chemical, biological, and pharmacologic data…highly recommended to all with an interest in medicinal natural products chemistry.\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, June 1, 2006)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cb\u003ePreface.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eContributors.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The Chemistry and Biology of Epothilones—Lead Structures for the Discovery of Improved Microtubule Inhibitors\u003c\/b\u003e (\u003ci\u003eKarl-Heinz Altmann\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e1.1. Introduction.\u003c\/p\u003e \u003cp\u003e1.2. Biological Effects of Epo B.\u003c\/p\u003e \u003cp\u003e1.3. Epothilone Analogs and SAR Studies.\u003c\/p\u003e \u003cp\u003e1.4. Pharmacophore Modeling and Conformational Studies.\u003c\/p\u003e \u003cp\u003e1.5. Epothilone Analogs in Clinical Development.\u003c\/p\u003e \u003cp\u003e1.6. Conclusions.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives\u003c\/b\u003e (\u003ci\u003eRoderich D. Su¨ssmuth\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2.1. Introduction.\u003c\/p\u003e \u003cp\u003e2.2. Classification of Glycopeptide Antibiotics.\u003c\/p\u003e \u003cp\u003e2.3. Mode of Action.\u003c\/p\u003e \u003cp\u003e2.4. Glycopeptide Resistance.\u003c\/p\u003e \u003cp\u003e2.5. Biosynthesis.\u003c\/p\u003e \u003cp\u003e2.6. Total Synthesis.\u003c\/p\u003e \u003cp\u003e2.7. Glycopeptides as Chiral Selectors in Chromatography and Capillary Electrophoresis.\u003c\/p\u003e \u003cp\u003e2.8. Structural Modifications of Glycopeptide Antibiotics and Structure Activity Relationship (SAR) Studies.\u003c\/p\u003e \u003cp\u003eAcknowledgment.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs\u003c\/b\u003e (\u003ci\u003eWei-Shuo Fang, Qi-Cheng Fang, and Xiao-Tian Liang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3.1. Discovery and Research and Development of Taxol.\u003c\/p\u003e \u003cp\u003e3.2. Paclitaxel Analogs Active Against Normal Tumor Cells.\u003c\/p\u003e \u003cp\u003e3.3. Exploration on Mechanism of Paclitaxel Related to Tubulin Binding and Quest for Its Pharmacophore.\u003c\/p\u003e \u003cp\u003e3.4. Natural and Semisynthetic Taxoids Overcoming Multidrug Resistance (MDR).\u003c\/p\u003e \u003cp\u003e3.5 Design, Synthesis and Pharmacological Activity of Prodrugs of Paclitaxel.\u003c\/p\u003e \u003cp\u003e3.6 Other Biological Actions of Paclitaxel.\u003c\/p\u003e \u003cp\u003e3.7 New Antimicrotubule Molecules Mimicking Action of Paclitaxel.\u003c\/p\u003e \u003cp\u003e3.8 Conclusion.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer\u003c\/b\u003e\u003cb\u003e’\u003c\/b\u003e\u003cb\u003es Disease\u003c\/b\u003e (\u003ci\u003eDa-Yuan Zhu, Chang-Heng Tan, and Yi-Ming Li\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4.1 Introduction.\u003c\/p\u003e \u003cp\u003e4.2. Profiles of HA.\u003c\/p\u003e \u003cp\u003e4.3. Plant Resources.\u003c\/p\u003e \u003cp\u003e4.4. Pharmacology.\u003c\/p\u003e \u003cp\u003e4.5. Clinical Trials.\u003c\/p\u003e \u003cp\u003e4.6. Synthesis of HA and Its Analogs.\u003c\/p\u003e \u003cp\u003e4.7. Structural Biology.\u003c\/p\u003e \u003cp\u003e4.8. ZT-1: New Generation of HA AChE.\u003c\/p\u003e \u003cp\u003eAbbreviations.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Qinghaosu (Artemisinin)\u003c\/b\u003e\u003cb\u003e—\u003c\/b\u003e\u003cb\u003eA Fantastic Antimalarial Drug from a Traditional Chinese Medicine\u003c\/b\u003e (\u003ci\u003eYing Li, Hao Huang, and Yu-Lin Wu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5.1. Introduction.\u003c\/p\u003e \u003cp\u003e5.2. Qinghaosu and Qinghao (Artemisia annua L. Composites).\u003c\/p\u003e \u003cp\u003e5.3. Reaction of Qinghaosu.\u003c\/p\u003e \u003cp\u003e5.4. Chemical Synthesis and Biosynthesis of Qinghaosu.\u003c\/p\u003e \u003cp\u003e5.5. Derivatives and Antimalarial Activity.\u003c\/p\u003e \u003cp\u003e5.6. Pharmacology and Chemical Biology of Qinghaosu and Its Derivatives.\u003c\/p\u003e \u003cp\u003e5.7 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Progress of Studies on the Natural Cembranoids from the Soft Coral Species of\u003c\/b\u003e \u003cb\u003eSarcophyton\u003c\/b\u003e \u003cb\u003eGenus\u003c\/b\u003e (\u003ci\u003eYulin Li, Lizeng Peng, and Tao Zhang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6.1. Introduction.\u003c\/p\u003e \u003cp\u003e6.2. Cembrane-Type Constituents from the Sarcophyton Genus.\u003c\/p\u003e \u003cp\u003e6.3. Physiological Action of Sarcophytol A and Sarcophytol B.\u003c\/p\u003e \u003cp\u003e6.4. Total Synthesis of the Natural Cembranoids.\u003c\/p\u003e \u003cp\u003e6.5. Studies on Novel Macrocyclization Methods of Cembrane-Type Diterpenoids.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Medicinal Chemistry of Ginkgolides from\u003c\/b\u003e \u003cb\u003eGinkgo biloba\u003c\/b\u003e (\u003ci\u003eKristian Strø\u003c\/i\u003e\u003ci\u003emgaard\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7.1. Introduction.\u003c\/p\u003e \u003cp\u003e7.2. Ginkgolides and the PAF Receptor.\u003c\/p\u003e \u003cp\u003e7.3. Ginkgolides and Glycine Receptors.\u003c\/p\u003e \u003cp\u003e7.4. Various Effects of Ginkgolides.\u003c\/p\u003e \u003cp\u003e7.5. Conclusions and Outlook.\u003c\/p\u003e \u003cp\u003eAcknowledgment.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Recent Progress in\u003c\/b\u003e \u003cb\u003eCalophyllum\u003c\/b\u003e \u003cb\u003eCoumarins as Potent Anti-HIV Agents\u003c\/b\u003e (\u003ci\u003eLin Wang, Tao Ma, and Gang Liu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8.1. Introduction.\u003c\/p\u003e \u003cp\u003e8.2. Anti-HIV-1 Activity of Calophyllum Coumarins.\u003c\/p\u003e \u003cp\u003e8.3. Pharmacology of Calanolides.\u003c\/p\u003e \u003cp\u003e8.4. Preparation of Calophyllum Coumarins.\u003c\/p\u003e \u003cp\u003e8.5. Structure Modification of Calanolides.\u003c\/p\u003e \u003cp\u003e8.6. Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Recent Progress and Prospects on Plant-Derived Anti-HIV Agents and Analogs\u003c\/b\u003e (\u003ci\u003eDonglei Yu and Kuo-Hsiung Lee\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9.1. Introduction.\u003c\/p\u003e \u003cp\u003e9.2. Khellactone Coumarin Analogs as Anti-HIV Agents.\u003c\/p\u003e \u003cp\u003e9.3. Biphenyl Derivatives as Anti-HIV Agents.\u003c\/p\u003e \u003cp\u003e9.4. Triterpene Betulinic Acid Derivatives as Anti-HIV Agents.\u003c\/p\u003e \u003cp\u003e9.5. Conclusions.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Recent Progress on the Chemical Synthesis of Annonaceous Acetogenins and Their Structurally Modi\u003c\/b\u003e\u003cb\u003efi\u003c\/b\u003e\u003cb\u003eed Mimics\u003c\/b\u003e (\u003ci\u003eTai-Shan Hu, Yu-Lin Wu, and Zhu-Jun Yao\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10.1. Introduction.\u003c\/p\u003e \u003cp\u003e10.2. Total Synthesis of Mono-THF Acetogenins.\u003c\/p\u003e \u003cp\u003e10.3. Total Synthesis of Bis-THF Acetogenins.\u003c\/p\u003e \u003cp\u003e10.4. Total Synthesis of THP-Containing Acetogenins.\u003c\/p\u003e \u003cp\u003e10.5. Design and Synthesis of Mimics of Acetogenins.\u003c\/p\u003e \u003cp\u003e10.6. Summary.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402649936215,"sku":"9780471660071","price":116.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471660071.jpg?v=1730481113","url":"https:\/\/bookcurl.com\/products\/medicinal-chemistry-of-bioactive-9780471660071","provider":"Book Curl","version":"1.0","type":"link"}