{"product_id":"mechanobiology-9781118966143","title":"Mechanobiology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eAn emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signalsand holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. \u003ci\u003eMechanobiology: Exploitation for Medical Benefit\u003c\/i\u003e presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field.\u003c\/p\u003e \u003cp\u003eFeaturing contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e \u003cp\u003eList of Contributors xiii\u003c\/p\u003e \u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Extracellular Matrix Structure and Stem Cell Mechanosensing 1\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eNicholas D. Evans and Camelia G. Tusan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Mechanobiology 1\u003c\/p\u003e \u003cp\u003e1.2 Stem Cells 3\u003c\/p\u003e \u003cp\u003e1.3 Substrate Stiffness in Cell Behavior 5\u003c\/p\u003e \u003cp\u003e1.3.1 A Historical Perspective on Stiffness Sensing 5\u003c\/p\u003e \u003cp\u003e1.4 Stem Cells and Substrate Stiffness 7\u003c\/p\u003e \u003cp\u003e1.4.1 ESCs and Substrate Stiffness 8\u003c\/p\u003e \u003cp\u003e1.4.2 Collective Cell Behavior in Substrate Stiffness Sensing 11\u003c\/p\u003e \u003cp\u003e1.5 Material Structure and Future Perspectives in Stem Cell Mechanobiology 14\u003c\/p\u003e \u003cp\u003e1.6 Conclusion 15\u003c\/p\u003e \u003cp\u003eReferences 16\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Molecular Pathways of Mechanotransduction: From Extracellular Matrix to Nucleus 23\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHamish T. J. Gilbert and Joe Swift\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction: Mechanically Influenced Cellular Behavior 23\u003c\/p\u003e \u003cp\u003e2.2 Mechanosensitive Molecular Mechanisms 24\u003c\/p\u003e \u003cp\u003e2.3 Methods Enabling the Study of Mechanobiology 29\u003c\/p\u003e \u003cp\u003e2.4 Conclusion 34\u003c\/p\u003e \u003cp\u003eAcknowledgements 34\u003c\/p\u003e \u003cp\u003eReferences 34\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Sugar-Coating the Cell: The Role of the Glycocalyx in Mechanobiology 43\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eStefania Marcotti and Gwendolen C. Reilly\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 What is the Glycocalyx? 43\u003c\/p\u003e \u003cp\u003e3.2 Composition of the Glycocalyx 44\u003c\/p\u003e \u003cp\u003e3.3 Morphology of the Glycocalyx 45\u003c\/p\u003e \u003cp\u003e3.4 Mechanical Properties of the Glycocalyx 46\u003c\/p\u003e \u003cp\u003e3.5 Mechanobiology of the Endothelial Glycocalyx 49\u003c\/p\u003e \u003cp\u003e3.6 Does the Glycocalyx Play a Mechanobiological Role in Bone? 50\u003c\/p\u003e \u003cp\u003e3.7 Glycocalyx in Muscle 52\u003c\/p\u003e \u003cp\u003e3.8 How Can the Glycocalyx be Exploited for Medical Benefit? 53\u003c\/p\u003e \u003cp\u003e3.9 Conclusion 53\u003c\/p\u003e \u003cp\u003eReferences 54\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The Role of the Primary Cilium in Cellular Mechanotransduction: An Emerging Therapeutic Target 61\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eKian F. Eichholz and David A. Hoey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 61\u003c\/p\u003e \u003cp\u003e4.2 The Primary Cilium 63\u003c\/p\u003e \u003cp\u003e4.3 Cilia-Targeted Therapeutic Strategies 68\u003c\/p\u003e \u003cp\u003e4.4 Conclusion 70\u003c\/p\u003e \u003cp\u003eAcknowledgements 70\u003c\/p\u003e \u003cp\u003eReferences 70\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Mechanosensory and Chemosensory Primary Cilia in Ciliopathy and Ciliotherapy 75\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSurya M. Nauli, Rinzhin T. Sherpa, Caretta J. Reese, and Andromeda M. Nauli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 75\u003c\/p\u003e \u003cp\u003e5.2 Mechanobiology and Diseases 76\u003c\/p\u003e \u003cp\u003e5.3 Primary Cilia as Biomechanics 78\u003c\/p\u003e \u003cp\u003e5.4 Modulating Mechanobiology Pathways 83\u003c\/p\u003e \u003cp\u003e5.5 Conclusion 85\u003c\/p\u003e \u003cp\u003eReferences 86\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Mechanobiology of Embryonic Skeletal Development: Lessons for Osteoarthritis 101\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAndrea S. Pollard and Andrew A. Pitsillides\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 101\u003c\/p\u003e \u003cp\u003e6.2 An Overview of Embryonic Skeletal Development 102\u003c\/p\u003e \u003cp\u003e6.3 Regulation of Joint Formation 103\u003c\/p\u003e \u003cp\u003e6.4 Regulation of Endochondral Ossification 105\u003c\/p\u003e \u003cp\u003e6.5 An Overview of Relevant Osteoarthritic Joint Changes 106\u003c\/p\u003e \u003cp\u003e6.6 Lessons for Osteoarthritis from Joint Formation 108\u003c\/p\u003e \u003cp\u003e6.7 Lessons for Osteoarthritis from Endochondral Ossification 109\u003c\/p\u003e \u003cp\u003e6.8 Conclusion 110\u003c\/p\u003e \u003cp\u003eAcknowledgements 111\u003c\/p\u003e \u003cp\u003eReferences 111\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Modulating Skeletal Responses to Mechanical Loading by Targeting Estrogen Receptor Signaling 115\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGabriel L. Galea and Lee B. Meakin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 115\u003c\/p\u003e \u003cp\u003e7.2 Biomechanical Activation of Estrogen Receptor Signaling: In Vitro Studies 116\u003c\/p\u003e \u003cp\u003e7.3 Skeletal Consequences of Altered Estrogen Receptor Signaling: In Vivo Mouse Studies 120\u003c\/p\u003e \u003cp\u003e7.4 Skeletal Consequences of Human Estrogen Receptor Polymorphisms: Human Genetic and Exercise-Intervention Studies 125\u003c\/p\u003e \u003cp\u003e7.5 Conclusion 126\u003c\/p\u003e \u003cp\u003eReferences 126\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Mechanical Responsiveness of Distinct Skeletal Elements: Possible Exploitation of Low Weight-Bearing Bone 131\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSimon C. F. Rawlinson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 131\u003c\/p\u003e \u003cp\u003e8.2 Anatomy and Loading-Related Stimuli 132\u003c\/p\u003e \u003cp\u003e8.3 Preosteogenic Responses In Vitro 135\u003c\/p\u003e \u003cp\u003e8.4 Site-Specific, Animal-Strain Differences 136\u003c\/p\u003e \u003cp\u003e8.5 Exploitation of Regional Information 137\u003c\/p\u003e \u003cp\u003e8.6 Conclusion 138\u003c\/p\u003e \u003cp\u003eReferences 138\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Pulmonary Vascular Mechanics in Pulmonary Hypertension 143\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eZhijie Wang, Lian Tian, and Naomi C. Chesler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 143\u003c\/p\u003e \u003cp\u003e9.2 Pulmonary Vascular Mechanics 143\u003c\/p\u003e \u003cp\u003e9.3 Measurements of Pulmonary Arterial Mechanics 147\u003c\/p\u003e \u003cp\u003e9.4 Mechanobiology in Pulmonary Hypertension 150\u003c\/p\u003e \u003cp\u003e9.5 Computational Modeling in Pulmonary Circulation 151\u003c\/p\u003e \u003cp\u003e9.6 Impact of Pulmonary Arterial Biomechanics on the Right Heart 152\u003c\/p\u003e \u003cp\u003e9.7 Conclusion 153\u003c\/p\u003e \u003cp\u003eReferences 153\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Mechanobiology and the Kidney Glomerulus 161\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eFranziska Lausecker, Christoph Ballestrem, and Rachel Lennon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 161\u003c\/p\u003e \u003cp\u003e10.2 Glomerular Filtration Barrier 161\u003c\/p\u003e \u003cp\u003e10.3 Podocyte Adhesion 163\u003c\/p\u003e \u003cp\u003e10.4 Glomerular Disease 165\u003c\/p\u003e \u003cp\u003e10.5 Forces in the Glomerulus 166\u003c\/p\u003e \u003cp\u003e10.6 Mechanosensitive Components and Prospects for Therapy 167\u003c\/p\u003e \u003cp\u003e10.7 Conclusion 169\u003c\/p\u003e \u003cp\u003eReferences 169\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Dynamic Remodeling of the Heart and Blood Vessels: Implications of Health and Disease 175\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eKen Takahashi, Hulin Piao, and Keiji Naruse\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 175\u003c\/p\u003e \u003cp\u003e11.2 Causes of Remodeling 176\u003c\/p\u003e \u003cp\u003e11.3 Mechanical Transduction in Cardiac Remodeling 177\u003c\/p\u003e \u003cp\u003e11.4 The Remodeling Process 178\u003c\/p\u003e \u003cp\u003e11.5 Conclusion 183\u003c\/p\u003e \u003cp\u003eReferences 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Aortic Valve Mechanobiology: From Organ to Cells 191\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eK. Jane Grande-Allen, Daniel Puperi, Prashanth Ravishankar, and Kartik Balachandran\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 191\u003c\/p\u003e \u003cp\u003e12.2 Mechanobiology at the Organ Level 192\u003c\/p\u003e \u003cp\u003e12.3 Mechanobiology at the Cellular Level 197\u003c\/p\u003e \u003cp\u003e12.4 Conclusion 201\u003c\/p\u003e \u003cp\u003eAcknowledgments 201\u003c\/p\u003e \u003cp\u003eReferences 201\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Testing the Perimenopause Ageprint using Skin Visoelasticity under Progressive Suction 207\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGérald E. Piérard, Claudine Piérard-Franchimont, Ulysse Gaspard, Philippe Humbert, and Sébastien L. Piérard\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 207\u003c\/p\u003e \u003cp\u003e13.2 Gender-Linked Skin Aging 208\u003c\/p\u003e \u003cp\u003e13.3 Dermal Aging, Thinning, and Wrinkling 209\u003c\/p\u003e \u003cp\u003e13.4 Skin Viscoelasticity under Progressive Suction 209\u003c\/p\u003e \u003cp\u003e13.5 Skin Tensile Strength during the Perimenopause 211\u003c\/p\u003e \u003cp\u003e13.6 Conclusion 214\u003c\/p\u003e \u003cp\u003eAcknowledgements 215\u003c\/p\u003e \u003cp\u003eReferences 216\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Mechanobiology and Mechanotherapy for Skin Disorders 221\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eChao-Kai Hsu and Rei Ogawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 221\u003c\/p\u003e \u003cp\u003e14.2 Skin Disorders Associated with Mechanobiological Dysfunction 223\u003c\/p\u003e \u003cp\u003e14.3 Mechanotherapy 231\u003c\/p\u003e \u003cp\u003e14.4 Conclusion 232\u003c\/p\u003e \u003cp\u003eAcknowledgement 232\u003c\/p\u003e \u003cp\u003eReferences 233\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Mechanobiology and Mechanotherapy for Cutaneous Wound-Healing 239\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eChenyu Huang, Yanan Du, and Rei Ogawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 239\u003c\/p\u003e \u003cp\u003e15.2 The Mechanobiology of Cutaneous Wound-Healing 240\u003c\/p\u003e \u003cp\u003e15.3 Mechanotherapy to Improve Cutaneous Wound-Healing 242\u003c\/p\u003e \u003cp\u003e15.4 Future Considerations 246\u003c\/p\u003e \u003cp\u003eReferences 246\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Mechanobiology and Mechanotherapy for Cutaneous Scarring 255\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRei Ogawa and Chenyu Huang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 255\u003c\/p\u003e \u003cp\u003e16.2 Cutaneous Wound-Healing and Mechanobiology 255\u003c\/p\u003e \u003cp\u003e16.3 Cutaneous Scarring and Mechanobiology 256\u003c\/p\u003e \u003cp\u003e16.4 Cellular and Tissue Responses to Mechanical Forces 257\u003c\/p\u003e \u003cp\u003e16.5 Keloids and Hypertrophic Scars and Mechanobiology 258\u003c\/p\u003e \u003cp\u003e16.6 Relationship Between Scar Growth and Tension 260\u003c\/p\u003e \u003cp\u003e16.7 A Hypertrophic Scar Animal Model Based on Mechanotransduction 261\u003c\/p\u003e \u003cp\u003e16.8 Mechanotherapy for Scar Prevention and Treatment 262\u003c\/p\u003e \u003cp\u003e16.9 Conclusion 263\u003c\/p\u003e \u003cp\u003eReferences 264\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Mechanobiology and Mechanotherapy for the Nail 267\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHitomi Sano and Rei Ogawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 267\u003c\/p\u003e \u003cp\u003e17.2 Nail Anatomy 267\u003c\/p\u003e \u003cp\u003e17.3 Role of Mechanobiology in Nail Morphology 268\u003c\/p\u003e \u003cp\u003e17.4 Nail Diseases and Mechanical Forces 269\u003c\/p\u003e \u003cp\u003e17.5 Current Nail Treatment Strategies 270\u003c\/p\u003e \u003cp\u003e17.6 Mechanotherapy for Nail Deformities 270\u003c\/p\u003e \u003cp\u003e17.7 Conclusion 271\u003c\/p\u003e \u003cp\u003eReferences 271\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Bioreactors: Recreating the Biomechanical Environment In Vitro 275\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJames R. Henstock and Alicia J. El Haj\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 The Mechanical Environment: Forces in the Body 275\u003c\/p\u003e \u003cp\u003e18.2 Bioreactors: A Short History 276\u003c\/p\u003e \u003cp\u003e18.3 Bioreactor Types 278\u003c\/p\u003e \u003cp\u003e18.4 Commercial versus Homemade Bioreactors 288\u003c\/p\u003e \u003cp\u003e18.5 Automated Cell-Culture Systems 289\u003c\/p\u003e \u003cp\u003e18.6 The Future of Bioreactors in Research and Translational Medicine 290\u003c\/p\u003e \u003cp\u003eReferences 291\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Cell Sensing of the Physical Properties of the Microenvironment at Multiple Scales 297\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJulien E. Gautrot\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 297\u003c\/p\u003e \u003cp\u003e19.2 Cells Sense their Mechanical Microenvironment at the Nanoscale Level 298\u003c\/p\u003e \u003cp\u003e19.3 Cell Sensing of the Nanoscale Physicochemical Landscape of the Environment 306\u003c\/p\u003e \u003cp\u003e19.4 Cell Sensing of the Microscale Geometry and Topography of the Environment 312\u003c\/p\u003e \u003cp\u003e19.5 Conclusion 319\u003c\/p\u003e \u003cp\u003eReferences 319\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Predictive Modeling in Musculoskeletal Mechanobiology 331\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHanifeh Khayyeri, Hanna Isaksson, and Patrick J. Prendergast\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 What is Mechanobiology? Background and Concepts 331\u003c\/p\u003e \u003cp\u003e20.2 Examples of Mechanobiological Experiments 333\u003c\/p\u003e \u003cp\u003e20.3 Modeling Mechanobiological Tissue Regeneration 337\u003c\/p\u003e \u003cp\u003e20.4 Mechanoregulation Theories for Bone Regeneration 338\u003c\/p\u003e \u003cp\u003e20.5 Use of Computational Modeling Techniques to Corroborate Theories and Predict Experimental Outcomes 340\u003c\/p\u003e \u003cp\u003e20.6 Horizons of Computational Mechanobiology 341\u003c\/p\u003e \u003cp\u003eReferences 343\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Porous Bone Graft Substitutes: When Less is More 347\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eCharlie Campion and Karin A. Hing\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21.1 Introduction 347\u003c\/p\u003e \u003cp\u003e21.2 Bone: The Ultimate Smart Material 350\u003c\/p\u003e \u003cp\u003e21.3 Bone-Grafting Classifications 353\u003c\/p\u003e \u003cp\u003e21.4 Synthetic Bone Graft Structures 356\u003c\/p\u003e \u003cp\u003e21.5 Conclusion 361\u003c\/p\u003e \u003cp\u003eReferences 362\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 Exploitation of Mechanobiology for Cardiovascular Therapy 373\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eWinston Elliott, Amir Keshmiri, and Wei Tan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22.1 Introduction 373\u003c\/p\u003e \u003cp\u003e22.2 Arterial Wall Mechanics and Mechanobiology 374\u003c\/p\u003e \u003cp\u003e22.3 Mechanical Signal and Mechanotransduction on the Arterial Wall 375\u003c\/p\u003e \u003cp\u003e22.4 Physiological and Pathological Responses to Mechanical Signals 377\u003c\/p\u003e \u003cp\u003e22.5 The Role of Vascular Mechanics in Modulating Mechanical Signals 378\u003c\/p\u003e \u003cp\u003e22.6 Therapeutic Strategies Exploiting Mechanobiology 380\u003c\/p\u003e \u003cp\u003e22.7 The Role of Hemodynamics in Mechanobiology 381\u003c\/p\u003e \u003cp\u003e22.8 Conclusion 390\u003c\/p\u003e \u003cp\u003eReferences 391\u003c\/p\u003e \u003cp\u003eIndex 401\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49406957748567,"sku":"9781118966143","price":117.85,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118966143.jpg?v=1730497689","url":"https:\/\/bookcurl.com\/products\/mechanobiology-9781118966143","provider":"Book Curl","version":"1.0","type":"link"}