{"product_id":"mechanisms-of-gene-regulation-how-science-works-9783030523206","title":"Mechanisms of Gene Regulation: How Science Works","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cb\u003e1 Genes and chromatin\u003c\/b\u003e1.1\tCentral dogma of molecular biology1.2\tImpact of chromatin structure1.3\tEpigenetics enables gene expression1.4\tGene regulation in the context of nuclear architecture\u003cb\u003e2 Basal transcriptional machinery\u003c\/b\u003e2.1\tCore promoter2.2\tTATA box and other core promoter elements2.3\tGenome-wide core promoter identification2.4\tTFIID and Mediator as paradigms of multi-protein complexes\u003cb\u003e3 Transcription factors and signal transduction\u003c\/b\u003e3.1\tSite-specific transcription factors and their domains3.2\tClassification of transcription factors3.3.\tActivation of transcription factors3.4\tPrograming cellular differentiation by transcription factors3.5\tInflammatory signaling via NF-B3.6\tSensing cellular stress via p53\u003cb\u003e4 A key transcription factor family: Nuclear receptors\u003c\/b\u003e4.1\tThe nuclear receptor superfamily4.2\tMolecular interactions of nuclear receptors4.3\tPhysiological role of nuclear receptors\u003cb\u003e5 Genome-wide principles of gene regulation\u003c\/b\u003e5.1\tNext-generation sequencing5.2\tGene regulation in the context of Big Biology5.3\tExploring genome-wide transcription factor binding5.4\tIntegrating epigenome-wide datasets\u003cb\u003e6 Chromatin modifiers\u003c\/b\u003e6.1\tCytosines and their methylation6.2\tHistone modifications6.3\tGene regulation via chromatin modifiers6.4\tSensing energy metabolism via chromatin modifiers\u003cb\u003e7 Epigenetics\u003c\/b\u003e7.1\tEpigenetics and chromatin7.2\tGenome-wide understanding of epigenetics7.3\tCTCF and genetic imprinting7.4\tEpigenetics in health and disease\u003cb\u003e8 Chromatin remodeling and organization\u003c\/b\u003e8.1\tNucleosome positioning at promoters8.2\tChromatin remodeling8.3\tTranscriptional dynamics in the presence of chromatin8.4\tOrganization of the nucleus\u003cb\u003e9 Regulatory impact of non-coding RNA\u003c\/b\u003e9.1\tNon-coding RNAs9.2\tmiRNAs and their regulatory potential9.3\tLong ncRNAs9.4\tEnhancer RNAs\u003cbr\u003e","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":51043559768407,"sku":"9783030523206","price":56.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783030523206.jpg?v=1750958693","url":"https:\/\/bookcurl.com\/products\/mechanisms-of-gene-regulation-how-science-works-9783030523206","provider":"Book Curl","version":"1.0","type":"link"}