{"product_id":"mammalian-heme-peroxidases-9781032079646","title":"Mammalian Heme Peroxidases","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eMammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our unde\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eSECTION 1: INTRODUCTION TO MAMMALIAN HEME PEROXIDASES \u003cbr\u003eStructure, function, phylogeny of heme peroxidases \u003cbr\u003eBiosynthesis of MPO and other heme peroxidases \u003cbr\u003ePeroxidasin structure and function \u003cbr\u003eSECTION 2: REACTIVITY OF PEROXIDASE OXIDANTS \u003cbr\u003eReactivity of peroxidase oxidants with proteins and proteoglycans \u003cbr\u003eReactivity of peroxidase with nucleic acids, RNA and DNA \u003cbr\u003eReactivity of peroxidase oxidants with lipids – modification and signaling \u003cbr\u003eRole of MPO in the modification of lipoproteins (LDL and HDL) \u003cbr\u003eRegulation of cellular signaling and survival by peroxidase oxidants \u003cbr\u003eGlobal profiling of cell responses to peroxidase oxidants \u003cbr\u003eSECTION 3: PEROXIDASES IN INNATE IMMUNITY \u003cbr\u003eMPO and immune cell recruitment and activation \u003cbr\u003eRole of MPO in extracellular trap release by neutrophils \u003cbr\u003eImaging HOCl production by neutrophils \u003cbr\u003eHow microbes combat reactive chlorine species \u003cbr\u003ePriming the innate immune system to combat respiratory disease \u003cbr\u003eSECTION 4: PEROXIDASES IN PATHOLOGY \u003cbr\u003eImaging the reactivity of MPO in vivo \u003cbr\u003eRole of MPO in vascular dysfunction and signaling \u003cbr\u003eMPO in ischemic heart disease \u003cbr\u003eRole of MPO in neurodegenerative disease \u003cbr\u003eRole of MPO in kidney disease \u003cbr\u003eRole of peroxidases in respiratory disease \u003cbr\u003eRole of peroxidasins in disease \u003cbr\u003eSECTION 5: PREVENTION OF MPO INDUCED DAMAGE \u003cbr\u003eDesign and functionality of MPO inhibitors \u003cbr\u003eModulation of disease using MPO inhibitors \u003cbr\u003eNovel peroxidase inhibitory protein “SPIN” with broad target specificity \u003cbr\u003eSelenium and resistance to oxidative enzyme inactivation\u003c\/p\u003e","brand":"Taylor \u0026 Francis Ltd","offers":[{"title":"Default Title","offer_id":51018828579159,"sku":"9781032079646","price":43.69,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781032079646.jpg?v=1750778306","url":"https:\/\/bookcurl.com\/products\/mammalian-heme-peroxidases-9781032079646","provider":"Book Curl","version":"1.0","type":"link"}