{"product_id":"linker-strategies-in-solidphase-organic-synthesis-9780470511169","title":"Linker Strategies in SolidPhase Organic Synthesis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eLinker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis.  \u003cp\u003e\u003ci\u003eLinker Strategies in Solid-Phase Organic Synthesis\u003c\/i\u003e guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis. Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003ethe principles of solid phase organic synthesis\u0026lt;\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"It is without a doubt an invaluable addition to any university or corporate library serving organic and biochemical researchers.\" (\u003ci\u003eCHOICE,\u003c\/i\u003e September 2010)\u003cbr\u003e \u003cbr\u003e  \"This book is a useful complement to literature reviews as well as other SPOS books. It will be a valuable resource for university libraries and an excellent first source for practitioners of solid-phase organic synthesis.\" (\u003ci\u003eJACS\u003c\/i\u003e, 2010)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eForeword.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003ePreface.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eList of Contributors.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAbout the Editor.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAbbreviations.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eI: INTRODUCTION.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1: General Introduction\u003c\/b\u003e \u003ci\u003e(Scott L. Dax).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction, Background and Pivotal Discoveries.\u003c\/p\u003e \u003cp\u003e1.2 Fundamentals of Conducting Solid-Phase Organic Chemistry.\u003c\/p\u003e \u003cp\u003e1.3 Concluding Comments.\u003c\/p\u003e \u003cp\u003e1.4 Personal Perspective and Testimony: Solid-phase Mannich Chemistry.\u003c\/p\u003e \u003cp\u003e1.5 References.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eII: TRADITIONAL LINKER UNITS FOR SOLID-PHASE ORGANIC SYNTHESIS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2: Electrophile Cleavable Linker Units\u003c\/b\u003e \u003ci\u003e(Michio Kuruso).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction.\u003c\/p\u003e \u003cp\u003e2.2 Resins for use with Electrophilic Linkers.\u003c\/p\u003e \u003cp\u003e2.3 Electrophile Cleavable Linkers.\u003c\/p\u003e \u003cp\u003e2.4 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3: Nucleophile Cleavable Linker Units\u003c\/b\u003e \u003ci\u003e(Andrea Porcheddu and Giampaolo\u003c\/i\u003e \u003ci\u003eGiacomelli).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction.\u003c\/p\u003e \u003cp\u003e3.2 Linker Units.\u003c\/p\u003e \u003cp\u003e3.3 Nucleophilic Labile Linker Units.\u003c\/p\u003e \u003cp\u003e3.4 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4: Cyclative Cleavage as a Solid-Phase Strategy\u003c\/b\u003e \u003ci\u003e(A. Ganesan).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction.\u003c\/p\u003e \u003cp\u003e4.2 C-N bond formation.\u003c\/p\u003e \u003cp\u003e4.3 C-O bond formation.\u003c\/p\u003e \u003cp\u003e4.4 C-C bond formation.\u003c\/p\u003e \u003cp\u003e4.5 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5: Photolabile Linker Units\u003c\/b\u003e \u003ci\u003e(Christian Bochet and Sébastien Mercier).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction.\u003c\/p\u003e \u003cp\u003e5.2 Linkers Based on the Ortho-Nitrobenzyloxy Function.\u003c\/p\u003e \u003cp\u003e5.3 Linkers Based on the Ortho-Nitrobenzylamino Function.\u003c\/p\u003e \u003cp\u003e5.4 Linkers Based on the α–Substituted Ortho-Nitrobenzyl Group.\u003c\/p\u003e \u003cp\u003e5.5 Linkers Based on the Ortho-Nitroveratryl Group.\u003c\/p\u003e \u003cp\u003e5.6 Linkers Based on the Phenacyl Group.\u003c\/p\u003e \u003cp\u003e5.7 Linkers Based on the Para-Methoxyphenacyl Group.\u003c\/p\u003e \u003cp\u003e5.8 Linkers Based on the Benzoin Group.\u003c\/p\u003e \u003cp\u003e5.9 Linkers Based on the Pivaloyl Group.\u003c\/p\u003e \u003cp\u003e5.10 Traceless Linkers.\u003c\/p\u003e \u003cp\u003e5.11 Other Types of Photolabile Linker Units.\u003c\/p\u003e \u003cp\u003e5.12 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6: Safety-Catch Linker Units\u003c\/b\u003e \u003ci\u003e(Sylvain Lebreton and Marcel Pátek).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction.\u003c\/p\u003e \u003cp\u003e6.2 Activation of a carbonyl group by the inductive effect (I-) of an adjacent substituent.\u003c\/p\u003e \u003cp\u003e6.3 Activation by the mesomeric effect (M-) of the X–Y=Z moiety adjacent to a carbonyl group.\u003c\/p\u003e \u003cp\u003e6.4 Activation by the positive mesomeric effect (M+) of the -X-Y=Z moiety adjacent to a \u003ci\u003eN\u003c\/i\u003e-acyl or \u003ci\u003eO\u003c\/i\u003e-alkyl group.\u003c\/p\u003e \u003cp\u003e6.5 Aromatic S\u003csub\u003eN\u003c\/sub\u003eAr substitution.\u003c\/p\u003e \u003cp\u003e6.6 Fragmentation by β-elimination.\u003c\/p\u003e \u003cp\u003e6.7 Safety-catch linker for release in aqueous buffers.\u003c\/p\u003e \u003cp\u003e6.8 Photochemical activation.\u003c\/p\u003e \u003cp\u003e6.9 Miscellaneous safety-catch linkers.\u003c\/p\u003e \u003cp\u003e6.10 Conclusion.\u003c\/p\u003e \u003cp\u003e6.11 References.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7: Enzyme Cleavable Linker Units\u003c\/b\u003e \u003ci\u003e(Mallesham Bejugam and Sabine L. Flitsch).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction.\u003c\/p\u003e \u003cp\u003e7.2 Enzyme Cleavable Linker Units.\u003c\/p\u003e \u003cp\u003e7.3 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIII: MULTIFUNCTIONAL LINKER UNITS FOR DIVERSITY-ORIENTED SYNTHESIS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8: An Introduction to Diversity-Oriented Synthesis\u003c\/b\u003e \u003ci\u003e(Richard J. Spandl, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction.\u003c\/p\u003e \u003cp\u003e8.2 Exploring Chemical Space.\u003c\/p\u003e \u003cp\u003e8.3 Sources of Skeletally Diverse Small Molecules.\u003c\/p\u003e \u003cp\u003e8.4 Enriching Chemical Space Using DOS.\u003c\/p\u003e \u003cp\u003e8.5 The Subjective Nature of ‘Diversity’.\u003c\/p\u003e \u003cp\u003e8.6 Differing Strategies Towards Similar Goals.\u003c\/p\u003e \u003cp\u003e8.7 Generating Skeletal Diversity.\u003c\/p\u003e \u003cp\u003e8.8 DOS and Solid-Phase Organic Synthesis.\u003c\/p\u003e \u003cp\u003e8.9 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 9:\u003c\/b\u003e \u003cb\u003eT1 and T2 – Versatile Triazene Linker Groups\u003c\/b\u003e \u003ci\u003e(Kerstin Knepper and Robert E. Ziegert).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction.\u003c\/p\u003e \u003cp\u003e9.2 The T1 Linker.\u003c\/p\u003e \u003cp\u003e9.3 The T2 Linker Units.\u003c\/p\u003e \u003cp\u003e9.4 Miscellaneous Triazene Linkers.\u003c\/p\u003e \u003cp\u003e9.5 Conclusion.\u003c\/p\u003e \u003cp\u003e9.6 References.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 10: Hydrazone Linker Units\u003c\/b\u003e \u003ci\u003e(Ryszard Lazny).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction.\u003c\/p\u003e \u003cp\u003e10.2 Hydrazone Linker Units.\u003c\/p\u003e \u003cp\u003e10.3 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 11: Benzotriazole Linker Units\u003c\/b\u003e \u003ci\u003e(Daniel K. Whelligan).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction.\u003c\/p\u003e \u003cp\u003e11.2 Syntheses of Polymer-Supported Benzotriazoles.\u003c\/p\u003e \u003cp\u003e11.3 Polymer-Supported Benzotriazole Linked Reactions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 12:\u003c\/b\u003e \u003cb\u003eDiversity Cleavage Strategies from Phosphorus Linkers\u003c\/b\u003e \u003ci\u003e(Patrick G. Steel and Tom M. Woods).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction.\u003c\/p\u003e \u003cp\u003e12.2 Diversity Cleavage through olefination reactions.\u003c\/p\u003e \u003cp\u003e12.3 Diversity cleavage of enol phosphonates through palladium catalysed cross-coupling reactions.\u003c\/p\u003e \u003cp\u003e12.4 Oxidative diversity cleavage of cyanophosphoranes.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 13: Sulfur Linker Units\u003c\/b\u003e \u003ci\u003e(Peter J. H. Scott).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction.\u003c\/p\u003e \u003cp\u003e13.2 Sulfide Linker Units.\u003c\/p\u003e \u003cp\u003e13.3 Sulfonium Linker Units.\u003c\/p\u003e \u003cp\u003e13.4 Sulfoxide Linker Units.\u003c\/p\u003e \u003cp\u003e13.5 Sulfone Linker Units.\u003c\/p\u003e \u003cp\u003e13.6 Sulfonate Ester Linker Units.\u003c\/p\u003e \u003cp\u003e13.7 Sulfamate Linker Units.\u003c\/p\u003e \u003cp\u003e13.8 Thioester Linker Units.\u003c\/p\u003e \u003cp\u003e13.9 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 14:\u003c\/b\u003e \u003cb\u003eSelenium- and Tellurium-Based Linker Units\u003c\/b\u003e \u003ci\u003e(Tracy Yuen Sze But and Patrick H. Toy).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction.\u003c\/p\u003e \u003cp\u003e14.2 Selenium- and Tellurium-Based Linker Group Reagents and Their Syntheses.\u003c\/p\u003e \u003cp\u003e14.3 Selenium-Based Linker Group Attachment Methods.\u003c\/p\u003e \u003cp\u003e14.4 Selenium-Based Linker Group Cleavage Methods.\u003c\/p\u003e \u003cp\u003e14.5 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 15: Linker Units Cleaved by Radical Processes: Cleavage of Carbon-Sulfur, -Selenium, -Tellurium, -Oxygen, -Nitrogen and -Carbon Linkers\u003c\/b\u003e \u003ci\u003e(Giuditta Guazzelli, Marc Miller and David J. Procter).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction.\u003c\/p\u003e \u003cp\u003e15.2 Linkers cleaved using tin hydride, alkyltin and silicon hydride reagents.\u003c\/p\u003e \u003cp\u003e15.3 Linkers cleaved by oxidative electron-transfer.\u003c\/p\u003e \u003cp\u003e15.4 Linkers cleaved by reductive electron-transfer.\u003c\/p\u003e \u003cp\u003e15.5 Radical processes that indirectly trigger linker cleavage.\u003c\/p\u003e \u003cp\u003e15.6 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 16: Silicon and Germanium Linker Units\u003c\/b\u003e \u003ci\u003e(Alan C. Spivey and Christopher M. Diaper).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1Introduction.\u003c\/p\u003e \u003cp\u003e16.2 Silicon-based Linkers.\u003c\/p\u003e \u003cp\u003e16.3 Germanium-based Linkers.\u003c\/p\u003e \u003cp\u003e16.4 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 17: Boron and Stannane Linker Units\u003c\/b\u003e \u003ci\u003e(Peter J.H. Scott).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction.\u003c\/p\u003e \u003cp\u003e17.2 Organostannane Linker Units.\u003c\/p\u003e \u003cp\u003e17.3 Organoboron Linker Units.\u003c\/p\u003e \u003cp\u003e17.4 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 18: Bismuth Linker Units\u003c\/b\u003e \u003ci\u003e(Peter J.H Scott).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction.\u003c\/p\u003e \u003cp\u003e18.2 Bismuth Linker Units.\u003c\/p\u003e \u003cp\u003e18.3 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 19: Transition Metal Carbonyl Linker Units\u003c\/b\u003e \u003ci\u003e(Susan E. Gibson and Amol A. Walke).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction.\u003c\/p\u003e \u003cp\u003e19.2 Chromium carbonyl linker units.\u003c\/p\u003e \u003cp\u003e19.3 Cobalt carbonyl linker units.\u003c\/p\u003e \u003cp\u003e19.4 Manganese carbonyl linker units.\u003c\/p\u003e \u003cp\u003e19.5 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 20:\u003c\/b\u003e \u003cb\u003eLinkers Releasing Olefins or Cycloolefins by Ring Closing Metathesis\u003c\/b\u003e \u003ci\u003e(Jan H. van Maarseveen).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 Introduction.\u003c\/p\u003e \u003cp\u003e20.2 Cycloolefins via method I.\u003c\/p\u003e \u003cp\u003e20.3 Terminal olefins via route II.\u003c\/p\u003e \u003cp\u003e20.4 Terminal and internal olefins via route III.\u003c\/p\u003e \u003cp\u003e20.5 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 4: ALTERNATIVE LINKER STRATEGIES.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 21: Fluorous Linker Units\u003c\/b\u003e \u003ci\u003e(Wei Zhang).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21.1 Introduction.\u003c\/p\u003e \u003cp\u003e21.2 Fluorous linkers for synthesis of small molecules.\u003c\/p\u003e \u003cp\u003e21.3 Fluorous linkers for synthesis of biomolecules.\u003c\/p\u003e \u003cp\u003e21.4 Other applications of fluorous linkers.\u003c\/p\u003e \u003cp\u003e21.5 Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 22: Solid-Phase Radiochemistry\u003c\/b\u003e \u003ci\u003e(Brian G. Hockley, Peter J. H. Scott and Michael R. Kilbourn).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22.1 Introduction.\u003c\/p\u003e \u003cp\u003e22.2 Solid-Phase Surrogates in Radiochemistry.\u003c\/p\u003e \u003cp\u003e22.3 Solid-Phase Radiochemistry.\u003c\/p\u003e \u003cp\u003e22.4 Conclusions and Perspectives.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 5: LINKER SELECTION TABLES.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 23: Linker Selection Tables\u003c\/b\u003e \u003ci\u003e(Peter J.H. Scott).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23.1 Introduction.\u003c\/p\u003e \u003cp\u003e23.2 Linkers for Alcohols, Phenols and Diols.\u003c\/p\u003e \u003cp\u003e23.3 Linkers for Carboxylic Acids, Esters and Related Compounds.\u003c\/p\u003e \u003cp\u003e23.4 Linkers for Aldehydes, Ketones and Related Carbonyl Compounds.\u003c\/p\u003e \u003cp\u003e23.5 Linkers for Amides, Ureas and Related Compounds.\u003c\/p\u003e \u003cp\u003e23.6 Linkers for Amines.\u003c\/p\u003e \u003cp\u003e23.7 Linkers Thiols, Thioethers and Disulfides.\u003c\/p\u003e \u003cp\u003e23.8 Linkers for Sugars.\u003c\/p\u003e \u003cp\u003e23.9 Linkers Liberating Alkyl Groups.\u003c\/p\u003e \u003cp\u003e23.10 Linkers for Alkenes, Alkynes and Related Compounds.\u003c\/p\u003e \u003cp\u003e23.11 Linkers for Aryl Compounds.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49525376385367,"sku":"9780470511169","price":179.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470511169.jpg?v=1731860281","url":"https:\/\/bookcurl.com\/products\/linker-strategies-in-solidphase-organic-synthesis-9780470511169","provider":"Book Curl","version":"1.0","type":"link"}