{"product_id":"introduction-to-veterinary-genetics-9781405168328","title":"Introduction to Veterinary Genetics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe concepts of veterinary genetics are crucial to understanding and controlling many diseases and disorders in animals. They are also crucial to enhancing animal production. Accessible and clearly presented, \u003ci\u003eIntroduction to Veterinary Genetics\u003c\/i\u003e provides a succinct introduction to the aspects of genetics relevant to animal diseases and production. Now in its third edition, this is the only introductory level textbook on genetics that has been written specifically for veterinary and animal science students.  \u003cp\u003eCoverage includes: basic genetics, molecular biology, genomics, cytogenetics, immunogenetics, population genetics, quantitative genetics, biotechnology, and the use of molecular tools in the control of inherited disorders.\u003c\/p\u003e \u003cp\u003eThis book describes in detail how genetics is being applied to artificial selection in animal production.  It also covers the conservation of genetic diversity in both domesticated and wild animals.\u003c\/p\u003e \u003cp\u003eNew for the Third Edition:\u003c\/p\u003e \u003cul type=\"di\u0026lt;br\"\u003e\n\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cb\u003ePreface\u003c\/b\u003e  \u003cp\u003e\u003cb\u003e1 Basic genetics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChromosomes\u003c\/p\u003e \u003cp\u003eMeiosis and mitosis\u003c\/p\u003e \u003cp\u003eThe biochemistry of inheritance\u003c\/p\u003e \u003cp\u003eWhat is a gene?\u003c\/p\u003e \u003cp\u003eGene regulation\u003c\/p\u003e \u003cp\u003eMutation\u003c\/p\u003e \u003cp\u003eGenes, alleles, and loci\u003c\/p\u003e \u003cp\u003eSimple or Mendelian inheritance\u003c\/p\u003e \u003cp\u003eLinkage\u003c\/p\u003e \u003cp\u003eInactivation\u003c\/p\u003e \u003cp\u003eTypes of DNA\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003eAppendix 1.1 Banded karyotypes of domestic species\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Molecular biology\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRestriction enzymes\u003c\/p\u003e \u003cp\u003eRecombinant DNA and DNA cloning\u003c\/p\u003e \u003cp\u003eComplementary DNA\u003c\/p\u003e \u003cp\u003eDNA sequencing\u003c\/p\u003e \u003cp\u003ePolymerase chain reaction\u003c\/p\u003e \u003cp\u003eSouthern analysis and related technologies\u003c\/p\u003e \u003cp\u003eDNA expression microarrays\u003c\/p\u003e \u003cp\u003eThe detection of variation in base sequence\u003c\/p\u003e \u003cp\u003eVeterinary diagnosis\u003c\/p\u003e \u003cp\u003eVariable number of tandem repeats (VNTR), DNA fingerprints, and microsatellites\u003c\/p\u003e \u003cp\u003eSingle nucleotide polymorphisms (SNPs)\u003c\/p\u003e \u003cp\u003eCopy number variation (CNV)\u003c\/p\u003e \u003cp\u003eGene mapping\u003c\/p\u003e \u003cp\u003eWhole-genome sequence assembly\u003c\/p\u003e \u003cp\u003eProduction of polypeptide from cloned DNA\u003c\/p\u003e \u003cp\u003eTransgenesis\u003c\/p\u003e \u003cp\u003eAntisense technology\u003c\/p\u003e \u003cp\u003eRNA interference\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Single-gene disorders\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eInborn errors of metabolism\u003c\/p\u003e \u003cp\u003eSex-limited inheritance\u003c\/p\u003e \u003cp\u003eGenetic heterogeneity of disease\u003c\/p\u003e \u003cp\u003eType of gene action and type of disease\u003c\/p\u003e \u003cp\u003ePhenocopies\u003c\/p\u003e \u003cp\u003eA sample of single-gene disorders\u003c\/p\u003e \u003cp\u003eA revolution in mapping and identifying the causal mutation of single-gene disorders\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003eAppendix 3.1 A sample of single-gene traits that have been characterized at the molecular level\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Chromosomal aberrations\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAbnormal chromosome number\u003c\/p\u003e \u003cp\u003eAbnormal chromosome structure\u003c\/p\u003e \u003cp\u003eChromosomal aberrations in cancer\u003c\/p\u003e \u003cp\u003eEvolution of karyotypes\u003c\/p\u003e \u003cp\u003eInterspecific hybridization\u003c\/p\u003e \u003cp\u003eFreemartins\u003c\/p\u003e \u003cp\u003eBiological basis of sex\u003c\/p\u003e \u003cp\u003eClassification of intersex 116\u003c\/p\u003e \u003cp\u003eA sample of chromosomal aberrations\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003eAppendix 4.1 A sample of chromosomal aberrations in animals\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Single genes in populations\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGene and genotype frequencies\u003c\/p\u003e \u003cp\u003eRandom mating\u003c\/p\u003e \u003cp\u003eThe Hardy–Weinberg law\u003c\/p\u003e \u003cp\u003eExtensions to the Hardy–Weinberg law\u003c\/p\u003e \u003cp\u003eSelection and mutation\u003c\/p\u003e \u003cp\u003eGenetic drift and the founder effect\u003c\/p\u003e \u003cp\u003eExtending population genetics to more than one locus\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Familial disorders not due to a single gene\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eLiability and threshold\u003c\/p\u003e \u003cp\u003eThe multifactorial model\u003c\/p\u003e \u003cp\u003eMore than one threshold\u003c\/p\u003e \u003cp\u003eSome final points\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Is it inherited?\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGeneral evidence for a genetic aetiology\u003c\/p\u003e \u003cp\u003eThe four types of simple, Mendelian inheritance\u003c\/p\u003e \u003cp\u003eStudying and analysing the data\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Immunogenetics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAntibodies\u003c\/p\u003e \u003cp\u003eRed-cell antigens\u003c\/p\u003e \u003cp\u003eThe major histocompatibility complex (MHC)\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Pharmacogenetics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenetic polymorphisms affecting drug metabolism\u003c\/p\u003e \u003cp\u003eGenetics and anaesthesia\u003c\/p\u003e \u003cp\u003eWarfarin resistance\u003c\/p\u003e \u003cp\u003eMultifactorial pharmacogenetics\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Hosts, parasites, and pathogens\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eHost–pathogen interactions\u003c\/p\u003e \u003cp\u003eResistance in hosts\u003c\/p\u003e \u003cp\u003eResistance in parasites and pathogens\u003c\/p\u003e \u003cp\u003eControl of parasites and pathogens\u003c\/p\u003e \u003cp\u003eIncreasing the level of resistance in hosts\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Single genes in animal breeding\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCoat colour\u003c\/p\u003e \u003cp\u003eExamples of coat-colour genes\u003c\/p\u003e \u003cp\u003eCarpet wool\u003c\/p\u003e \u003cp\u003eProlificacy in sheep\u003c\/p\u003e \u003cp\u003ePolledness\u003c\/p\u003e \u003cp\u003eMuscular hypertrophy in cattle and sheep\u003c\/p\u003e \u003cp\u003eDwarf poultry\u003c\/p\u003e \u003cp\u003eGenes for sexing chickens\u003c\/p\u003e \u003cp\u003ePedigree checking\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Relationship and inbreeding\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe inbreeding coefficient\u003c\/p\u003e \u003cp\u003eRelationship\u003c\/p\u003e \u003cp\u003eThe inbreeding coefficient revisited\u003c\/p\u003e \u003cp\u003eA general expression for relationship and inbreeding\u003c\/p\u003e \u003cp\u003eThe base population\u003c\/p\u003e \u003cp\u003eInbreeding in populations\u003c\/p\u003e \u003cp\u003eInbreeding depression\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Quantitative variation\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eQuantitative traits\u003c\/p\u003e \u003cp\u003eThe performance of an individual animal\u003c\/p\u003e \u003cp\u003eThe differences between animals\u003c\/p\u003e \u003cp\u003eHeritability\u003c\/p\u003e \u003cp\u003eCorrelations between traits\u003c\/p\u003e \u003cp\u003eQuantitative trait loci (QTL)\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Selection between populations\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eComparison between populations\u003c\/p\u003e \u003cp\u003eGenotype–environment interaction\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Selection within populations\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEstimated breeding values and accuracy of selection\u003c\/p\u003e \u003cp\u003eClues to a candidate’s breeding value for a trait\u003c\/p\u003e \u003cp\u003eCombining clues from more than one source\u003c\/p\u003e \u003cp\u003eBest linear unbiased prediction (BLUP)\u003c\/p\u003e \u003cp\u003eCorrelated traits\u003c\/p\u003e \u003cp\u003eSelection for more than one trait\u003c\/p\u003e \u003cp\u003eThe importance of inbreeding and genetic drift\u003c\/p\u003e \u003cp\u003eSire-reference schemes\u003c\/p\u003e \u003cp\u003eMarker-assisted selection (MAS) and genome-wide selection (GWS)\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Breed structure\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe traditional pyramid\u003c\/p\u003e \u003cp\u003eClosed-nucleus breeding schemes\u003c\/p\u003e \u003cp\u003eOpen-nucleus breeding schemes\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Crossing\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRegular crossing\u003c\/p\u003e \u003cp\u003eCrossing to produce a synthetic\u003c\/p\u003e \u003cp\u003eGrading-up\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Selection and regular crossing\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSelection\u003c\/p\u003e \u003cp\u003eSelection and regular crossing\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Biotechnology and the future\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eArtificial insemination (AI)\u003c\/p\u003e \u003cp\u003eMultiple ovulation and embryo transfer (MOET)\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIn vitro\u003c\/i\u003e maturation (IVM) and \u003ci\u003ein vitro\u003c\/i\u003e fertilization (IVF) of ova\u003c\/p\u003e \u003cp\u003eControl of sex ratio\u003c\/p\u003e \u003cp\u003eRecombinant proteins\u003c\/p\u003e \u003cp\u003eTransgenesis\u003c\/p\u003e \u003cp\u003eAnimal cloning\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Conservation genetics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMeasurement of genetic diversity within populations\u003c\/p\u003e \u003cp\u003eMeasurement of genetic diversity among populations\u003c\/p\u003e \u003cp\u003eImportance of genetic diversity\u003c\/p\u003e \u003cp\u003eLoss of genetic diversity\u003c\/p\u003e \u003cp\u003eConservation of genetic diversity\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Genetic and environmental control of inherited disorders\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEnvironmental control of inherited disorders\u003c\/p\u003e \u003cp\u003eGenetic control of single-gene disorders\u003c\/p\u003e \u003cp\u003eGene therapy\u003c\/p\u003e \u003cp\u003eGenetic control of multifactorial disorders\u003c\/p\u003e \u003cp\u003eGenetic control – some final points\u003c\/p\u003e \u003cp\u003eCrossing: thinking outside the square\u003c\/p\u003e \u003cp\u003eFurther reading\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGlossary\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/ul\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49407901008215,"sku":"9781405168328","price":53.15,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781405168328.jpg?v=1730500900","url":"https:\/\/bookcurl.com\/products\/introduction-to-veterinary-genetics-9781405168328","provider":"Book Curl","version":"1.0","type":"link"}