{"product_id":"inducing-targeted-protein-degradation-from-chemical-biology-to-drug-discovery-and-clinical-applications-9783527350131","title":"Inducing Targeted Protein Degradation: From","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eInducing Targeted Protein Degradation\u003c\/b\u003e \u003cp\u003e\u003cb\u003eEnables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eSince the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. \u003ci\u003eInducing Targeted Protein Degradation\u003c\/i\u003e is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space.  \u003c\/p\u003e\u003cp\u003eIn \u003ci\u003eInducing Targeted Protein Degradation\u003c\/i\u003e, readers will find the most recent information on:  \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eCellular mechanisms of targeted protein degradation and current approaches \tto utilize these mechanisms for drug discovery \u003c\/li\u003e\n\u003cli\u003eA comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs and ATTECs as well as additional post translational modifications\u003c\/li\u003e\n\u003cli\u003eDrug development aspects such as DMPK optimization and criteria for the selection of clinical candidates\u003c\/li\u003e\n\u003cli\u003eA discussion of the potential of targeted degradation for expanding the druggable space\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e  \u003c\/p\u003e\u003cp\u003e\u003ci\u003eInducing Targeted Protein Degradation\u003c\/i\u003e will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eTargeted Protein Degradation - The Story So Far \u003cbr\u003e Cellular Principles of Targeted Protein Degradation \u003cbr\u003e E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug Development\u003cbr\u003e A Structural and Biophysical Perspective of Degrader Activity through Ternary Complex Formation \u003cbr\u003e Computational Modeling of PROTAC Ternary Complexes and Linker Design \u003cbr\u003e Molecular Glue Degraders: From Serendipity to Hunting and Design\u003cbr\u003e Targeted Protein Degradation as a Therapeutic Strategy in Neurodegenerative Diseases \u003cbr\u003e Insights and Future Perspectives of Covalent Protein Degraders \u003cbr\u003e Extending the Degradation Toolkit - mRNA targeting as Alternative Means to Affect Protein Levels\u003cbr\u003e The Future of Heterobifunctional Compounds: PROTACs and Beyond \u003cbr\u003e Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery\u003cbr\u003e Taming the Beast: How to Optimize DMPK-PD Properties of Oral Degraders \u003cbr\u003e PROTAC® Protein Degraders: Bridging the Divide from Chemical Biology Tools to Clinical Candidates","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":49372702277975,"sku":"9783527350131","price":106.25,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783527350131.jpg?v=1730163869","url":"https:\/\/bookcurl.com\/products\/inducing-targeted-protein-degradation-from-chemical-biology-to-drug-discovery-and-clinical-applications-9783527350131","provider":"Book Curl","version":"1.0","type":"link"}