{"product_id":"in-silico-dreams-9781119745570","title":"In Silico Dreams","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eLearn how AI and data science are upending the worlds of biology and medicine In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future delivers an illuminating and fresh perspective on the convergence of two powerful technologies: AI and biotech. Accomplished genomics expert, executive, and author Brian Hilbush offers readers a brilliant exploration of the most current work of pioneering tech giants and biotechnology startups who have already started disrupting healthcare. The book provides an in-depth understanding of the sources of innovation that are driving the shift in the pharmaceutical industry away from serendipitous therapeutic discovery and toward engineered medicines and curative therapies.    In this fascinating book, you'll discover: An overview of the rise of data science methods and the paradigm shift in biology that led to the in silico revolutionAn outline of the fundamental breakthroughs in AI and deep learning and their applications across medicineA compelling argument for the notion that AI and biotechnology tools will rapidly accelerate the development of therapeuticsA summary of innovative breakthroughs in biotechnology with a focus on gene editing and cell reprogramming technologies for therapeutic developmentA guide to the startup landscape in AI in medicine, revealing where investments are poised to shape the innovation base for the pharmaceutical industry Perfect for anyone with an interest in scientific topics and technology, In Silico Dreams also belongs on the bookshelves of decision-makers in a wide range of industries, including healthcare, technology, venture capital, and government.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eIntroduction xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1 The Information Revolution’s Impact on Biology 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA Biological Data Avalanche at Warp Speed 5\u003c\/p\u003e \u003cp\u003eTracking SARS-CoV-2 with Genomic Epidemiology 11\u003c\/p\u003e \u003cp\u003eBiology’s Paradigm Shift Enables \u003ci\u003eIn Silico \u003c\/i\u003eBiology 17\u003c\/p\u003e \u003cp\u003eTransitions and Computation in Cancer Research 18\u003c\/p\u003e \u003cp\u003eStructural Biology and Genomics 24\u003c\/p\u003e \u003cp\u003eSequencing the Human Genome 27\u003c\/p\u003e \u003cp\u003eComputational Biology in the Twenty-First Century 33\u003c\/p\u003e \u003cp\u003eApplications of Human Genome Sequencing 35\u003c\/p\u003e \u003cp\u003eAnalyzing Human Genome Sequence Information 37\u003c\/p\u003e \u003cp\u003eOmics Technologies and Systems Biology 40\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 A New Era of Artificial Intelligence 53\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAI Steps Out of the Bronx 55\u003c\/p\u003e \u003cp\u003eFrom Neurons and Cats Brains to Neural Networks 58\u003c\/p\u003e \u003cp\u003eMachine Learning and the Deep Learning Breakthrough 66\u003c\/p\u003e \u003cp\u003eDeep Learning Arrives for AI 73\u003c\/p\u003e \u003cp\u003eDeep Neural Network Architectures 75\u003c\/p\u003e \u003cp\u003eDeep Learning’s Beachhead on Medicine: Medical Imaging 78\u003c\/p\u003e \u003cp\u003eLimitations on Artificial Intelligence 83\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3 The Long Road to New Medicines 91\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMedicine’s Origins: The Role of Opium Since the Stone Age 96\u003c\/p\u003e \u003cp\u003eIndustrial Manufacturing of Medicines 102\u003c\/p\u003e \u003cp\u003ePaul Ehrlich and the Birth of Chemotherapeutic Drug Discovery 108\u003c\/p\u003e \u003cp\u003eThe Pharmaceutical Industry: Drugs and War—New Medicines in the Twentieth Century 112\u003c\/p\u003e \u003cp\u003eFrom Synthetic Antibiotics to the Search for New Drugs from the Microbial World 116\u003c\/p\u003e \u003cp\u003eDeveloping Therapeutics for Cancer 119\u003c\/p\u003e \u003cp\u003eAntifolates and the Emergence of DNA Synthesis Inhibitors 120\u003c\/p\u003e \u003cp\u003eAntibiotics as Cancer Chemotherapeutic Drugs 123\u003c\/p\u003e \u003cp\u003eImmunotherapy 125\u003c\/p\u003e \u003cp\u003eThe Pharmaceutical Business Model in the Twenty-First Century 126\u003c\/p\u003e \u003cp\u003eR\u0026amp;D Productivity Challenges Within the Pharmaceutical Industry 131\u003c\/p\u003e \u003cp\u003eSources of Pharmaceutical Innovation: Biotechnology and New Therapeutic Modalities 135\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 Gene Editing and the New Tools of Biotechnology 145\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMolecular Biology and Biological Information Flow 150\u003c\/p\u003e \u003cp\u003eManipulating Gene Information with Recombinant DNA Technology 154\u003c\/p\u003e \u003cp\u003eGenetics, Gene Discovery, and Drugs for Rare Human Diseases 160\u003c\/p\u003e \u003cp\u003eSecond-Generation Biotechnology Tools: CRISPR- Cas9 and Genome Editing Technologies 167\u003c\/p\u003e \u003cp\u003eHuman Genome Editing and Clinical Trials 171\u003c\/p\u003e \u003cp\u003eBiotechnology to the Rescue: Vaccine Development Platforms Based on Messenger RNA 179\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5 Healthcare and the Entrance of the Technology Titans 189\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDigital Health and the New Healthcare Investment Arena 191\u003c\/p\u003e \u003cp\u003eAssessing the Tech Titans as Disruptors in Healthcare 195\u003c\/p\u003e \u003cp\u003eAlphabet: Extending Its Tentacles Into Healthcare with Google and Other Bets 196\u003c\/p\u003e \u003cp\u003eApple Inc: Consumer Technology Meets Healthcare 200\u003c\/p\u003e \u003cp\u003eAmazon: Taking Logistics to the Next Level for Delivering Healthcare 204\u003c\/p\u003e \u003cp\u003eEchoes of the Final Frontier 207\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6 AI-Based Algorithms in Biology and Medicine 211\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRecognizing the Faces of Cancer 217\u003c\/p\u003e \u003cp\u003eTumor Classification Using Deep Learning with Genomic Features 222\u003c\/p\u003e \u003cp\u003eAI for Diseases of the Nervous System: Seeing and Changing the Brain 229\u003c\/p\u003e \u003cp\u003eRegulatory Approval and Clinical Implementation: Twin Challenges for AI-Based Algorithms in Medicine 234\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7 AI in Drug Discovery and Development 245\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA Brief Survey of \u003ci\u003eIn Silico \u003c\/i\u003eMethods in Drug Discovery 247\u003c\/p\u003e \u003cp\u003eVirtual Screening with Cheminformatics and HTS Technologies 250\u003c\/p\u003e \u003cp\u003eAI Brings a New Toolset for Computational Drug Design 252\u003c\/p\u003e \u003cp\u003eAI-Based Virtual Screening Tools 257\u003c\/p\u003e \u003cp\u003eGenerative Models for De Novo Drug Design 257\u003c\/p\u003e \u003cp\u003eA New Base of Innovation for the Pharmaceutical Industry 259\u003c\/p\u003e \u003cp\u003eAtomwise 261\u003c\/p\u003e \u003cp\u003eRecursion Pharmaceuticals 262\u003c\/p\u003e \u003cp\u003eDeep Genomics 262\u003c\/p\u003e \u003cp\u003eRelay Therapeutics 263\u003c\/p\u003e \u003cp\u003eSummary 265\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8 Biotechnology, AI, and Medicine’s Future 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBuilding Tools to Decipher Molecular Structures and Biological Systems 272\u003c\/p\u003e \u003cp\u003eAlphaFold: Going Deep in Protein Structure Prediction 274\u003c\/p\u003e \u003cp\u003ePredicting Genome 3D Organization and Regulatory Elements 276\u003c\/p\u003e \u003cp\u003eAI Approaches to Link Genetics-Based Targets to Disease 277\u003c\/p\u003e \u003cp\u003eQuantum Computing for In Silico Chemistry and Biology 278\u003c\/p\u003e \u003cp\u003eNeuroscience and AI: Modeling Brain and Behavior 280\u003c\/p\u003e \u003cp\u003eBrain Information Processing and Modularity: Climbing a Granite Wall 283\u003c\/p\u003e \u003cp\u003eEngineering Medicines with Biotechnology and AI 289\u003c\/p\u003e \u003cp\u003eGlossary 295\u003c\/p\u003e \u003cp\u003eIndex 303\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49407135711575,"sku":"9781119745570","price":27.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119745570.jpg?v=1730498305","url":"https:\/\/bookcurl.com\/products\/in-silico-dreams-9781119745570","provider":"Book Curl","version":"1.0","type":"link"}