{"product_id":"hydrophilic-interaction-chromatography-9781118054178","title":"Hydrophilic Interaction Chromatography","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAn increasingly popular analytical method, hydrophilic interaction chromatography (HILIC) has the ability to retain and separate polar compounds that are often difficult to analyze by reversed-phase high-performance liquid chromatography (HPLC) or other analytical methods.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e“The well-balanced mixture with updated HILIC theory and detailed practical descriptions makes it a useful resource for scientists working in analytical chemistry, biochemistry, biotechnology, and bioinformatics, and a valuable resource for people in the analytical column industry.”  (\u003ci\u003eAnalytical and Bioanalytical Chemistry\u003c\/i\u003e, 22 September 2013)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePREFACE xiii\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 1 SEPARATION MECHANISMS IN HYDROPHILIC INTERACTION CHROMATOGRAPHY 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDavid V. McCalley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Historical Background: Recognition of the Contribution of Partition, Ion Exchange, and RP Interactions to the Retention Process 3\u003c\/p\u003e \u003cp\u003e1.3 Recent Studies on the Contributory Mechanisms to HILIC Retention 7\u003c\/p\u003e \u003cp\u003e1.4 Conclusions 38\u003c\/p\u003e \u003cp\u003eReferences 38\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 2 STATIONARY PHASES FOR HILIC 43\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMohammed E.A. Ibrahim and Charles A. Lucy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 43\u003c\/p\u003e \u003cp\u003e2.2 HILIC Stationary Phases 44\u003c\/p\u003e \u003cp\u003e2.3 Commercial HILIC Phases 61\u003c\/p\u003e \u003cp\u003e2.4 Conclusions 77\u003c\/p\u003e \u003cp\u003eAcknowledgments 77\u003c\/p\u003e \u003cp\u003eReferences 77\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 3 HILIC METHOD DEVELOPMENT 87\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYong Guo and Xiande Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 87\u003c\/p\u003e \u003cp\u003e3.2 General Method Development Considerations 88\u003c\/p\u003e \u003cp\u003e3.3 HILIC Method Development 93\u003c\/p\u003e \u003cp\u003e3.4 Detection for HILIC Methods 104\u003c\/p\u003e \u003cp\u003e3.5 Conclusions 107\u003c\/p\u003e \u003cp\u003eReferences 108\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 4 PHARMACEUTICAL APPLICATIONS OF HYDROPHILIC INTERACTION CHROMATOGRAPHY 111\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eBernard A. Olsen, Donald S. Risley, V. Scott Sharp, Brian W. Pack, and Michelle L. Lytle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 112\u003c\/p\u003e \u003cp\u003e4.2 Determination of Counterions 117\u003c\/p\u003e \u003cp\u003e4.3 Main Component Methods 129\u003c\/p\u003e \u003cp\u003e4.4 Determination of Impurities 135\u003c\/p\u003e \u003cp\u003e4.5 Excipients 146\u003c\/p\u003e \u003cp\u003e4.6 Chiral Applications 152\u003c\/p\u003e \u003cp\u003e4.7 Conclusions 161\u003c\/p\u003e \u003cp\u003eReferences 161\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 5 HYDROPHILIC INTERACTION CHROMATOGRAPHY (HILIC) FOR DRUG DISCOVERY 169\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAlfonso Espada and Mark Strege\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Drug Discovery Model 169\u003c\/p\u003e \u003cp\u003e5.2 HILIC Applications for \u003ci\u003eIn Vitro \u003c\/i\u003eBiology 170\u003c\/p\u003e \u003cp\u003e5.4 Practical Considerations 186\u003c\/p\u003e \u003cp\u003e5.5 Conclusions 187\u003c\/p\u003e \u003cp\u003eReferences 188\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 6 ADVANCES IN HYDROPHILIC INTERACTION CHROMATOGRAPHY (HILIC) FOR BIOCHEMICAL APPLICATIONS 195\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eFred Rabel and Bernard A. Olsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 195\u003c\/p\u003e \u003cp\u003e6.2 Carbohydrates 196\u003c\/p\u003e \u003cp\u003e6.2.1 Mono- and Disaccharides 196\u003c\/p\u003e \u003cp\u003e6.3 Nucleobases and Nucleosides 203\u003c\/p\u003e \u003cp\u003e6.4 Oligonucleotides 205\u003c\/p\u003e \u003cp\u003e6.5 Amino Acids and Peptides 206\u003c\/p\u003e \u003cp\u003e6.6 Proteins 209\u003c\/p\u003e \u003cp\u003e6.7 Phospholipids 209\u003c\/p\u003e \u003cp\u003e6.8 Conclusions 211\u003c\/p\u003e \u003cp\u003eReferences 212\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 7 HILIC-MS FOR TARGETED METABOLOMICS AND SMALL MOLECULE BIOANALYSIS 219\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHien P. Nguyen, Heather D. Tippens, and Kevin A. Schug\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 219\u003c\/p\u003e \u003cp\u003e7.2 The Role of HILIC-MS in Targeted Metabolomics versus Other LC Modes 221\u003c\/p\u003e \u003cp\u003e7.3 Strategies for Method Development Based on Retention Behavior of Targeted Metabolites on HILIC Stationary Phases 223\u003c\/p\u003e \u003cp\u003e7.4 Summary 231\u003c\/p\u003e \u003cp\u003eAcknowledgments 232\u003c\/p\u003e \u003cp\u003eReferences 232\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 8 HILIC FOR FOOD, ENVIRONMENTAL, AND OTHER APPLICATIONS 239\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMichael A. Koupparis, Nikolaos C. Megoulas, and Aikaterini M. Gremilogianni\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 239\u003c\/p\u003e \u003cp\u003e8.2 Food Applications for HILIC 240\u003c\/p\u003e \u003cp\u003e8.3 Environmental and Other Applications of HILIC 254\u003c\/p\u003e \u003cp\u003e8.4 Conclusions 257\u003c\/p\u003e \u003cp\u003eReferences 259\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHAPTER 9 THEORY AND PRACTICE OF TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY SEPARATIONS INVOLVING THE HILIC MODE OF SEPARATION 265\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eStephen R. Groskreutz and Dwight R. Stoll\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Fundamentals of Multidimensional Liquid Chromatography 265\u003c\/p\u003e \u003cp\u003e9.2 Complementarity of HILIC Selectivity to Other Separation Modes 278\u003c\/p\u003e \u003cp\u003e9.3 Instrumentation and Experimental Considerations 278\u003c\/p\u003e \u003cp\u003e9.4 Applications 291\u003c\/p\u003e \u003cp\u003e9.5 The Future of HILIC Separations in 2DLC 298\u003c\/p\u003e \u003cp\u003eReferences 298\u003c\/p\u003e \u003cp\u003eINDEX 307\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406824382807,"sku":"9781118054178","price":86.36,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118054178.jpg?v=1730497240","url":"https:\/\/bookcurl.com\/products\/hydrophilic-interaction-chromatography-9781118054178","provider":"Book Curl","version":"1.0","type":"link"}