{"product_id":"hydrogen-sulfide-9781119799870","title":"Hydrogen Sulfide","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eHYDROGEN SULFIDE\u003c\/b\u003e \u003cp\u003e\u003cb\u003eCovers H\u003csub\u003e2\u003c\/sub\u003eS interactions, methods of detection and delivery in biological environments, and a wide range of applications\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eResearch on hydrogen sulfide (H\u003csub\u003e2\u003c\/sub\u003eS) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H\u003csub\u003e2\u003c\/sub\u003eS and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H\u003csub\u003e2\u003c\/sub\u003eS are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eHydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies\u003c\/i\u003e provides the foundation required for understanding the fundamental chemical biology of H\u003csub\u003e2\u003c\/sub\u003eS while highlighting the compound's therapeutic potential and medicinal applications. This book covers key aspects of H\u003csub\u003e2\u003c\/sub\u003eS chemical biology, in\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003eList of Contributors xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Fundamental and Biologically Relevant Chemistry of H\u003csub\u003e2\u003c\/sub\u003eS and Related Species \u003c\/b\u003e\u003cb\u003e1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJon M. Fukuto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 1\u003c\/p\u003e \u003cp\u003e1.1 Introduction 2\u003c\/p\u003e \u003cp\u003e1.2 The Chemical Biology of H\u003csub\u003e2\u003c\/sub\u003eS 2\u003c\/p\u003e \u003cp\u003e1.2.1 Basic Chemical Properties of H\u003csub\u003e2\u003c\/sub\u003eS 3\u003c\/p\u003e \u003cp\u003e1.2.2 H\u003csub\u003e2\u003c\/sub\u003eS Redox Chemistry 4\u003c\/p\u003e \u003cp\u003e1.2.3 Reactions of H\u003csub\u003e2\u003c\/sub\u003eS with Metals\/Metalloproteins 5\u003c\/p\u003e \u003cp\u003e1.2.4 H\u003csub\u003e2\u003c\/sub\u003eS and Sulfheme Formation 6\u003c\/p\u003e \u003cp\u003e1.2.5 H\u003csub\u003e2\u003c\/sub\u003eS and Heavy Metals 7\u003c\/p\u003e \u003cp\u003e1.3 H\u003csub\u003e2\u003c\/sub\u003eS Reactions with Other Sulfur Species 8\u003c\/p\u003e \u003cp\u003e1.3.1 Sulfane Sulfur 8\u003c\/p\u003e \u003cp\u003e1.3.2 Generation of RSSH 8\u003c\/p\u003e \u003cp\u003e1.3.3 RSH Versus RSSH Comparison 9\u003c\/p\u003e \u003cp\u003e1.3.4 RSSH Interactions with Metals\/Metalloproteins 14\u003c\/p\u003e \u003cp\u003e1.3.5 The Electrophilicity of RSSH 14\u003c\/p\u003e \u003cp\u003e1.3.6 Higher-Order Polysulfides 15\u003c\/p\u003e \u003cp\u003e1.3.7 RSSH Instability 16\u003c\/p\u003e \u003cp\u003e1.4 The Biochemical Utility of RSSH 17\u003c\/p\u003e \u003cp\u003e1.5 Summary\/Conclusion 18\u003c\/p\u003e \u003cp\u003eReferences 18\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Signaling by Hydrogen Sulfide (H\u003csub\u003e2\u003c\/sub\u003eS) and Polysulfides (H\u003csub\u003e2\u003c\/sub\u003eS\u003ci\u003e\u003csub\u003en\u003c\/sub\u003e\u003c\/i\u003e) and the Interaction with Other Signaling Pathways \u003c\/b\u003e\u003cb\u003e27\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eHideo Kimura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 27\u003c\/p\u003e \u003cp\u003e2.1 Introduction 28\u003c\/p\u003e \u003cp\u003e2.2 Determination of the Endogenous Concentrations of H\u003csub\u003e2\u003c\/sub\u003eS 29\u003c\/p\u003e \u003cp\u003e2.3 H\u003csub\u003e2\u003c\/sub\u003eS and H\u003csub\u003e2\u003c\/sub\u003eS\u003ci\u003e\u003csub\u003en\u003c\/sub\u003e \u003c\/i\u003eas Signaling Molecules 31\u003c\/p\u003e \u003cp\u003e2.4 Crosstalk Between H\u003csub\u003e2\u003c\/sub\u003eS and NO 32\u003c\/p\u003e \u003cp\u003e2.4.1 The Chemical Interaction of H\u003csub\u003e2\u003c\/sub\u003eS and NO Produces H\u003csub\u003e2\u003c\/sub\u003eS\u003ci\u003e\u003csub\u003en\u003c\/sub\u003e \u003c\/i\u003e32\u003c\/p\u003e \u003cp\u003e2.4.2 Regulation of NO-Producing Enzymes by H\u003csub\u003e2\u003c\/sub\u003eS and Vice Versa 33\u003c\/p\u003e \u003cp\u003e2.5 Cytoprotective Effect of H\u003csub\u003e2\u003c\/sub\u003eS, H\u003csub\u003e2\u003c\/sub\u003eS\u003ci\u003e\u003csub\u003en\u003c\/sub\u003e\u003c\/i\u003e, and H\u003csub\u003e2\u003c\/sub\u003eSO\u003csub\u003e3\u003c\/sub\u003e 34\u003c\/p\u003e \u003cp\u003e2.6 Energy Formation in Mitochondria with H\u003csub\u003e2\u003c\/sub\u003eS 34\u003c\/p\u003e \u003cp\u003e2.7 \u003ci\u003eS\u003c\/i\u003e-Sulfurated Proteins and Bound Sulfane Sulfur in Cells 35\u003c\/p\u003e \u003cp\u003e2.8 Regulating the Activity of Target Proteins by H\u003csub\u003e2\u003c\/sub\u003eS and H\u003csub\u003e2\u003c\/sub\u003eS\u003ci\u003e\u003csub\u003en\u003c\/sub\u003e \u003c\/i\u003e36\u003c\/p\u003e \u003cp\u003e2.8.1 S-Sulfuration by H\u003csub\u003e2\u003c\/sub\u003eS 37\u003c\/p\u003e \u003cp\u003e2.8.2 S-Sulfuration by H\u003csub\u003e2\u003c\/sub\u003eS\u003ci\u003e\u003csub\u003en\u003c\/sub\u003e \u003c\/i\u003e38\u003c\/p\u003e \u003cp\u003e2.9 Perspectives 38\u003c\/p\u003e \u003cp\u003eAcknowledgments 40\u003c\/p\u003e \u003cp\u003eAuthor Disclosure Statement 41\u003c\/p\u003e \u003cp\u003eReferences 41\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Persulfides and Their Reactions in Biological Contexts \u003c\/b\u003e\u003cb\u003e49\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDayana Benchoam, Ernesto Cuevasanta, Matías N. Möller, and Beatriz Alvarez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 49\u003c\/p\u003e \u003cp\u003e3.1 Persulfides Are Key Intermediates in Sulfur Metabolism and Signaling 49\u003c\/p\u003e \u003cp\u003e3.2 Persulfides Are Formed in Biological Systems through Different Pathways 51\u003c\/p\u003e \u003cp\u003e3.2.1 Disulfides Form Persulfides in the Presence of H\u003csub\u003e2\u003c\/sub\u003eS 51\u003c\/p\u003e \u003cp\u003e3.2.2 Sulfenic Acids Can Also Form Persulfides by Reaction with H\u003csub\u003e2\u003c\/sub\u003eS 53\u003c\/p\u003e \u003cp\u003e3.2.3 Other Persulfide Formation Pathways Involve Oxidation Products of H\u003csub\u003e2\u003c\/sub\u003eS 53\u003c\/p\u003e \u003cp\u003e3.2.4 Some Sulfur Atoms for Persulfides Are Donated by Free Cysteine 54\u003c\/p\u003e \u003cp\u003e3.2.5 Trisulfides Are Also a Source of Persulfides 55\u003c\/p\u003e \u003cp\u003e3.2.6 Persulfides Can Be Prepared in the Lab 56\u003c\/p\u003e \u003cp\u003e3.3 Persulfides Are More Acidic Than Thiols 56\u003c\/p\u003e \u003cp\u003e3.4 Persulfides Are Stronger Nucleophiles Than Thiols 58\u003c\/p\u003e \u003cp\u003e3.5 Persulfidation Protects Against Irreversible Oxidation 60\u003c\/p\u003e \u003cp\u003e3.6 Persulfides Interact with Metals and Metalloproteins 61\u003c\/p\u003e \u003cp\u003e3.7 Persulfides Have Electrophilic Character in Both Sulfur Atoms 62\u003c\/p\u003e \u003cp\u003e3.8 Persulfides Are Efficient One-Electron Reductants 63\u003c\/p\u003e \u003cp\u003e3.9 Concluding Remarks 64\u003c\/p\u003e \u003cp\u003eReferences 64\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Hydrogen Sulfide, Reactive Nitrogen Species, and “The Joy of the Experimental Play” \u003c\/b\u003e\u003cb\u003e77\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMiriam M. Cortese-Krott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 77\u003c\/p\u003e \u003cp\u003e4.2 Basic Physicochemical Properties of Nitric Oxide and Its Biological Relevant Metabolites 79\u003c\/p\u003e \u003cp\u003e4.2.1 Nitric Oxide 79\u003c\/p\u003e \u003cp\u003e4.2.2 Nitrite 80\u003c\/p\u003e \u003cp\u003e4.2.3 Nitrosothiols (RSNOs) 81\u003c\/p\u003e \u003cp\u003e4.3 Basic Physicochemical Properties of H\u003csub\u003e2\u003c\/sub\u003eS and Its Biological Relevant Metabolites 82\u003c\/p\u003e \u003cp\u003e4.3.1 H\u003csub\u003e2\u003c\/sub\u003eS\/HS− 83\u003c\/p\u003e \u003cp\u003e4.3.2 Polysulfides and Persulfide 85\u003c\/p\u003e \u003cp\u003e4.4 Inorganic Sulfur–Nitrogen Compounds 86\u003c\/p\u003e \u003cp\u003e4.4.1 HSNO\/SNO− 87\u003c\/p\u003e \u003cp\u003e4.4.2 SSNO− 89\u003c\/p\u003e \u003cp\u003e4.4.3 SULFI\/NO 90\u003c\/p\u003e \u003cp\u003e4.5 Putative Biological Relevance of the NO\/H\u003csub\u003e2\u003c\/sub\u003eS Chemical Interaction 90\u003c\/p\u003e \u003cp\u003e4.5.1 Pharmacological Activity 90\u003c\/p\u003e \u003cp\u003e4.5.2 Putative Sources of SSNO− and SULFI\/NO \u003ci\u003eIn Vivo \u003c\/i\u003e91\u003c\/p\u003e \u003cp\u003e4.5.3 Methods of Detection \u003ci\u003eIn Vivo \u003c\/i\u003e92\u003c\/p\u003e \u003cp\u003e4.6 Summary and Conclusions 93\u003c\/p\u003e \u003cp\u003eAcknowledgment 93\u003c\/p\u003e \u003cp\u003eReferences 93\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 H\u003csub\u003e2\u003c\/sub\u003eS and Bioinorganic Metal Complexes \u003c\/b\u003e\u003cb\u003e103\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eZachary J. Tonzetich\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 103\u003c\/p\u003e \u003cp\u003e5.1 Introduction 104\u003c\/p\u003e \u003cp\u003e5.2 Basic Ligative Properties of H\u003csub\u003e2\u003c\/sub\u003eS\/HS− 105\u003c\/p\u003e \u003cp\u003e5.3 H\u003csub\u003e2\u003c\/sub\u003eS and Heme Iron 106\u003c\/p\u003e \u003cp\u003e5.4 H\u003csub\u003e2\u003c\/sub\u003eS and Nonheme Iron 112\u003c\/p\u003e \u003cp\u003e5.5 H\u003csub\u003e2\u003c\/sub\u003eS Chemistry with Other Metals 122\u003c\/p\u003e \u003cp\u003e5.6 H\u003csub\u003e2\u003c\/sub\u003eS Sensing with Transition Metal Complexes 126\u003c\/p\u003e \u003cp\u003e5.7 Summary 131\u003c\/p\u003e \u003cp\u003eAcknowledgments 134\u003c\/p\u003e \u003cp\u003eReferences 134\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Measurement of Hydrogen Sulfide Metabolites Using the Monobromobimane Method \u003c\/b\u003e\u003cb\u003e143\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eXinggui Shen, Ellen H. Speers, and Christopher G. Kevil\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 143\u003c\/p\u003e \u003cp\u003e6.1 Introduction 143\u003c\/p\u003e \u003cp\u003e6.1.1 Hydrogen Sulfide: Biological Significance 143\u003c\/p\u003e \u003cp\u003e6.1.2 Hydrogen Sulfide Chemistry 144\u003c\/p\u003e \u003cp\u003e6.1.3 Bioavailable Sulfide 144\u003c\/p\u003e \u003cp\u003e6.2 Monobromobimane: An Optimal Method of Bioavailable Sulfur Detection 145\u003c\/p\u003e \u003cp\u003e6.2.1 Monobromobimane Derivatization of Hydrogen Sulfide 146\u003c\/p\u003e \u003cp\u003e6.2.2 History of the Monobromobimane Method 147\u003c\/p\u003e \u003cp\u003e6.3 Procedures 148\u003c\/p\u003e \u003cp\u003e6.3.1 Sulfide-Dibimane Standard Synthesis 148\u003c\/p\u003e \u003cp\u003e6.3.2 Bioavailable Sulfide Preparation 149\u003c\/p\u003e \u003cp\u003e6.3.3 Monobromobimane Derivatization 149\u003c\/p\u003e \u003cp\u003e6.3.4 HPLC with Fluorescence Detection 150\u003c\/p\u003e \u003cp\u003e6.3.5 Mass Spectrometry Detection 150\u003c\/p\u003e \u003cp\u003e6.4 Caveats and Considerations 151\u003c\/p\u003e \u003cp\u003eAcknowledgment 152\u003c\/p\u003e \u003cp\u003eDisclosures 152\u003c\/p\u003e \u003cp\u003eReferences 152\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Fluorescent Probes for H\u003csub\u003e2\u003c\/sub\u003eS Detection: Cyclization-Based Approaches \u003c\/b\u003e\u003cb\u003e157\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eYingying Wang, Yannie Lam, Caitlin McCartney, Brock Brummett, Geat Ramush, and Ming Xian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 157\u003c\/p\u003e \u003cp\u003e7.1 Introduction 157\u003c\/p\u003e \u003cp\u003e7.2 General Design of Nucleophilic Reaction-Cyclization Based Fluorescent Probes 159\u003c\/p\u003e \u003cp\u003e7.2.1 WSP Probes 159\u003c\/p\u003e \u003cp\u003e7.2.2 2,2′-Dithiosalicylic Ester-Based Probes 164\u003c\/p\u003e \u003cp\u003e7.2.3 Alkyl Halide-Based Probes 166\u003c\/p\u003e \u003cp\u003e7.2.4 Diselenide-Based Probes 167\u003c\/p\u003e \u003cp\u003e7.2.5 Selenenyl Sulfide-Based Probes 167\u003c\/p\u003e \u003cp\u003e7.2.6 Aldehyde Addition-Based Probes 169\u003c\/p\u003e \u003cp\u003e7.2.7 Michael Addition-Cyclization Based Probes 175\u003c\/p\u003e \u003cp\u003e7.3 Conclusions and Perspectives 177\u003c\/p\u003e \u003cp\u003eAcknowledgments 177\u003c\/p\u003e \u003cp\u003eReferences 177\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Fluorescent Probes for H\u003csub\u003e2\u003c\/sub\u003eS Detection: Electrophile-Based Approaches \u003c\/b\u003e\u003cb\u003e183\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eLong Yi and Zhen Xi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 183\u003c\/p\u003e \u003cp\u003e8.2 Selected Probes Based on Different Reaction Types 185\u003c\/p\u003e \u003cp\u003e8.2.1 Cleavage of C—O Bond 185\u003c\/p\u003e \u003cp\u003e8.2.2 Cleavage of C—S Bond 188\u003c\/p\u003e \u003cp\u003e8.2.3 Cleavage of C—Cl Bond 190\u003c\/p\u003e \u003cp\u003e8.2.4 Michael Addition 191\u003c\/p\u003e \u003cp\u003e8.2.5 Cleavage of C—N Bond 193\u003c\/p\u003e \u003cp\u003e8.2.6 Reduction of Aryl Azide 193\u003c\/p\u003e \u003cp\u003e8.3 Conclusion and Future Prospects 197\u003c\/p\u003e \u003cp\u003eReferences 199\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Fluorescent Probes for H\u003csub\u003e2\u003c\/sub\u003eS Detection: Metal-Based Approaches \u003c\/b\u003e\u003cb\u003e203\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMaria Strianese and Claudio Pellecchia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 203\u003c\/p\u003e \u003cp\u003e9.2 Metal Displacement Approach 205\u003c\/p\u003e \u003cp\u003e9.2.1 Copper-Based Systems 205\u003c\/p\u003e \u003cp\u003e9.2.2 Zinc-Based Systems 214\u003c\/p\u003e \u003cp\u003e9.2.3 Different Metal-Based Systems 216\u003c\/p\u003e \u003cp\u003e9.3 Coordinative-Based Approach 218\u003c\/p\u003e \u003cp\u003e9.3.1 Metalloporphyrin-Based Systems 218\u003c\/p\u003e \u003cp\u003e9.3.1.1 Synthetic Systems 219\u003c\/p\u003e \u003cp\u003e9.3.1.2 Natural Systems 220\u003c\/p\u003e \u003cp\u003e9.3.2 Salen-Based Systems 220\u003c\/p\u003e \u003cp\u003e9.3.3 Systems with Different Organic Ligands 221\u003c\/p\u003e \u003cp\u003e9.4 H\u003csub\u003e2\u003c\/sub\u003eS-Mediated Reduction of the Metal Center 223\u003c\/p\u003e \u003cp\u003e9.5 Conclusions and Future Outlooks 224\u003c\/p\u003e \u003cp\u003eReferences 225\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 H\u003csub\u003e2\u003c\/sub\u003eS Release from P=S and Se—S Motifs \u003c\/b\u003e\u003cb\u003e235\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRynne A. Hankins and John C. Lukesh III\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 235\u003c\/p\u003e \u003cp\u003e10.1 Introduction 235\u003c\/p\u003e \u003cp\u003e10.2 H\u003csub\u003e2\u003c\/sub\u003eS Release from P=S Motifs 236\u003c\/p\u003e \u003cp\u003e10.2.1 GYY4137: Synthesis and Characterization of H\u003csub\u003e2\u003c\/sub\u003eS Release 237\u003c\/p\u003e \u003cp\u003e10.2.2 GYY4137: Biological Studies 238\u003c\/p\u003e \u003cp\u003e10.2.3 GYY4137: Mechanistic Studies 240\u003c\/p\u003e \u003cp\u003e10.2.4 GYY4137: Structural Modifications and Activity of Analogs 242\u003c\/p\u003e \u003cp\u003e10.2.5 JK Donors: Cyclization-Assisted H\u003csub\u003e2\u003c\/sub\u003eS Release from P=S Motifs 248\u003c\/p\u003e \u003cp\u003e10.3 H2S Release from Se—S Motifs 249\u003c\/p\u003e \u003cp\u003e10.3.1 Acyl Selenylsulfides: Synthesis and Characterization of H\u003csub\u003e2\u003c\/sub\u003eS Release 251\u003c\/p\u003e \u003cp\u003e10.3.2 Acyl Selenylsulfides: Mechanistic Studies 251\u003c\/p\u003e \u003cp\u003e10.4 Acyl Selenylsulfides: Structural Modifications and Activity of Analogs 253\u003c\/p\u003e \u003cp\u003e10.5 Conclusions 253\u003c\/p\u003e \u003cp\u003eReferences 254\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Hydrogen Sulfide: The Hidden Player of Isothiocyanates Pharmacology \u003c\/b\u003e\u003cb\u003e261\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eValentina Citi, Eugenia Piragine, Vincenzo Calderone, and Alma Martelli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Organic Isothiocyanates as H\u003csub\u003e2\u003c\/sub\u003eS-Donors 261\u003c\/p\u003e \u003cp\u003e11.2 Organic ITCs and Cardiovascular System 266\u003c\/p\u003e \u003cp\u003e11.2.1 Effect of ITCs as H\u003csub\u003e2\u003c\/sub\u003eS Donors in Vascular Inflammation 266\u003c\/p\u003e \u003cp\u003e11.2.2 Vasorelaxing Effect of ITCs as H\u003csub\u003e2\u003c\/sub\u003eS Donors 269\u003c\/p\u003e \u003cp\u003e11.2.3 Organic ITCs and Heart 270\u003c\/p\u003e \u003cp\u003e11.3 Chemopreventive Properties of ITCs 272\u003c\/p\u003e \u003cp\u003e11.4 Anti-nociceptive Effects of ITCs 274\u003c\/p\u003e \u003cp\u003e11.5 Anti-inflammatory and Antiviral Effects of ITCs 277\u003c\/p\u003e \u003cp\u003e11.6 Conclusion 280\u003c\/p\u003e \u003cp\u003eAcknowledgment 281\u003c\/p\u003e \u003cp\u003eReferences 281\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Persulfide Prodrugs \u003c\/b\u003e\u003cb\u003e293\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBingchen Yu, Zhengnan Yuan, and Binghe Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 293\u003c\/p\u003e \u003cp\u003e12.1 Introduction 293\u003c\/p\u003e \u003cp\u003e12.2 Persulfide Prodrugs 295\u003c\/p\u003e \u003cp\u003e12.2.1 Structural Moieties That Have Been Studied for Their Ability to Cage and Release Persulfide Species 296\u003c\/p\u003e \u003cp\u003e12.2.2 Enzyme-Sensitive Prodrugs 298\u003c\/p\u003e \u003cp\u003e12.2.3 ROS-Sensitive Persulfide Prodrugs 303\u003c\/p\u003e \u003cp\u003e12.2.4 pH-Sensitive Persulfide Prodrugs 306\u003c\/p\u003e \u003cp\u003e12.2.5 Photo-Sensitive Persulfide Prodrugs 308\u003c\/p\u003e \u003cp\u003e12.2.6 H\u003csub\u003e2\u003c\/sub\u003eS Prodrugs That Release H\u003csub\u003e2\u003c\/sub\u003eS Via Persulfide Intermediate 309\u003c\/p\u003e \u003cp\u003e12.3 Challenges in Persulfide Prodrug Design and Potential Therapeutic Applications 310\u003c\/p\u003e \u003cp\u003eReferences 313\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 COS-Based H\u003csub\u003e2\u003c\/sub\u003eS Donors \u003c\/b\u003e\u003cb\u003e321\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAnnie K. Gilbert and Michael D. Pluth\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 321\u003c\/p\u003e \u003cp\u003e13.2 Properties of COS 322\u003c\/p\u003e \u003cp\u003e13.3 COS-Based H\u003csub\u003e2\u003c\/sub\u003eS Delivery 323\u003c\/p\u003e \u003cp\u003e13.3.1 Stimuli Responsive COS\/H\u003csub\u003e2\u003c\/sub\u003eS Donors 325\u003c\/p\u003e \u003cp\u003e13.3.2 Bio-orthogonal Donor Activation 326\u003c\/p\u003e \u003cp\u003e13.3.3 Donors Activated by Nucleophiles 329\u003c\/p\u003e \u003cp\u003e13.3.4 Enzyme-Activated Donors 334\u003c\/p\u003e \u003cp\u003e13.3.5 pH-Activated Donors 337\u003c\/p\u003e \u003cp\u003e13.3.6 Fluorescent Donors 339\u003c\/p\u003e \u003cp\u003e13.4 Conclusions and Outlook 341\u003c\/p\u003e \u003cp\u003eAcknowledgments 342\u003c\/p\u003e \u003cp\u003eReferences 342\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Light-Activatable H\u003csub\u003e2\u003c\/sub\u003eS Donors \u003c\/b\u003e\u003cb\u003e347\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePetr Klán, Tomáš Slanina, and Peter Štacko\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 347\u003c\/p\u003e \u003cp\u003e14.2 Photophysical and Photochemical Concepts 347\u003c\/p\u003e \u003cp\u003e14.3 Phototherapeutic Window 349\u003c\/p\u003e \u003cp\u003e14.4 Light Sources 349\u003c\/p\u003e \u003cp\u003e14.5 (Photo)Physical Properties of H\u003csub\u003e2\u003c\/sub\u003eS 351\u003c\/p\u003e \u003cp\u003e14.6 Mechanisms and Examples of H\u003csub\u003e2\u003c\/sub\u003eS Photorelease 351\u003c\/p\u003e \u003cp\u003e14.6.1 Photorelease of H\u003csub\u003e2\u003c\/sub\u003eS from Excited State 352\u003c\/p\u003e \u003cp\u003e14.6.2 Release of H\u003csub\u003e2\u003c\/sub\u003eS from a Reactive Intermediate 355\u003c\/p\u003e \u003cp\u003e14.6.3 Photorelease of Potential H\u003csub\u003e2\u003c\/sub\u003eS Donors 357\u003c\/p\u003e \u003cp\u003e14.6.4 Photosensitized H\u003csub\u003e2\u003c\/sub\u003eS Release 362\u003c\/p\u003e \u003cp\u003e14.6.5 Photothermal Effect 364\u003c\/p\u003e \u003cp\u003e14.7 Outlook 365\u003c\/p\u003e \u003cp\u003eAcknowledgment 366\u003c\/p\u003e \u003cp\u003eReferences 366\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Macromolecular and Supramolecular Approaches for H\u003csub\u003e2\u003c\/sub\u003eS Delivery \u003c\/b\u003e\u003cb\u003e373\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSarah N. Swilley-Sanchez, Zhao Li, and John B. Matson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 373\u003c\/p\u003e \u003cp\u003e15.1 Introduction 375\u003c\/p\u003e \u003cp\u003e15.2 H\u003csub\u003e2\u003c\/sub\u003eS-Donating Linear Polymers 377\u003c\/p\u003e \u003cp\u003e15.2.1 Pendant H\u003csub\u003e2\u003c\/sub\u003eS Donors 378\u003c\/p\u003e \u003cp\u003e15.2.2 H\u003csub\u003e2\u003c\/sub\u003eS Donors on Chain Ends 379\u003c\/p\u003e \u003cp\u003e15.2.3 Depolymerizable Polymers for the Release of H\u003csub\u003e2\u003c\/sub\u003eS via COS 383\u003c\/p\u003e \u003cp\u003e15.3 H\u003csub\u003e2\u003c\/sub\u003eS Delivery from Branched and Graft Polymer Topologies 384\u003c\/p\u003e \u003cp\u003e15.3.1 Graft Polymers for the Delivery of H\u003csub\u003e2\u003c\/sub\u003eS 386\u003c\/p\u003e \u003cp\u003e15.4 Polymer Micelles for H\u003csub\u003e2\u003c\/sub\u003eS Delivery 388\u003c\/p\u003e \u003cp\u003e15.4.1 H\u003csub\u003e2\u003c\/sub\u003eS Donors Covalently Attached to Polymer Amphiphiles 389\u003c\/p\u003e \u003cp\u003e15.5 Polymer Networks for Localized H\u003csub\u003e2\u003c\/sub\u003eS Delivery 394\u003c\/p\u003e \u003cp\u003e15.5.1 Physical Encapsulation of H\u003csub\u003e2\u003c\/sub\u003eS Donors Within Networks 394\u003c\/p\u003e \u003cp\u003e15.5.2 Covalent Attachment of H\u003csub\u003e2\u003c\/sub\u003eS Donors Within Hydrogels 396\u003c\/p\u003e \u003cp\u003e15.6 Other Polymeric Systems for the Encapsulation of H\u003csub\u003e2\u003c\/sub\u003eS Donors 399\u003c\/p\u003e \u003cp\u003e15.6.1 Microfibers as H\u003csub\u003e2\u003c\/sub\u003eS Donors 400\u003c\/p\u003e \u003cp\u003e15.6.2 Membranes as H\u003csub\u003e2\u003c\/sub\u003eS Donors 400\u003c\/p\u003e \u003cp\u003e15.6.3 Microparticles and Nanoparticles as H\u003csub\u003e2\u003c\/sub\u003eS Donors 401\u003c\/p\u003e \u003cp\u003e15.7 H\u003csub\u003e2\u003c\/sub\u003eS Release via Supramolecular Systems 404\u003c\/p\u003e \u003cp\u003e15.7.1 Self-Assembled, Peptide-Based Materials for H\u003csub\u003e2\u003c\/sub\u003eS Delivery 405\u003c\/p\u003e \u003cp\u003e15.7.2 Self-Assembled Nanoparticles and Proteins for H\u003csub\u003e2\u003c\/sub\u003eS Delivery 410\u003c\/p\u003e \u003cp\u003e15.8 Conclusions and Future Perspectives 414\u003c\/p\u003e \u003cp\u003eReferences 416\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 H2S and Hypertension \u003c\/b\u003e\u003cb\u003e427\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eVincenzo Brancaleone, Mariarosaria Bucci, and Giuseppe Cirino\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 427\u003c\/p\u003e \u003cp\u003e16.1 Hypertension, Vascular Homeostasis and Mediators Controlling Blood Pressure 428\u003c\/p\u003e \u003cp\u003e16.2 Generation of H\u003csub\u003e2\u003c\/sub\u003eS in the Cardiovascular System 429\u003c\/p\u003e \u003cp\u003e16.2.1 Biosynthetic Pathways 429\u003c\/p\u003e \u003cp\u003e16.2.2 Catabolic Pathway for H\u003csub\u003e2\u003c\/sub\u003eS 430\u003c\/p\u003e \u003cp\u003e16.3 Relevance of H\u003csub\u003e2\u003c\/sub\u003eS in Hypertension 432\u003c\/p\u003e \u003cp\u003e16.3.1 Preclinical Evidence 432\u003c\/p\u003e \u003cp\u003e16.3.2 Clinical Evidence 436\u003c\/p\u003e \u003cp\u003e16.4 Conclusions 437\u003c\/p\u003e \u003cp\u003eReferences 438\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 H2S Supplementation and Augmentation: Approaches for Healthy Aging \u003c\/b\u003e\u003cb\u003e445\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eChristopher Hine, Jie Yang, Aili Zhang, Natalia Llarena, and Christopher Link\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 445\u003c\/p\u003e \u003cp\u003e17.1 Introduction and Background 445\u003c\/p\u003e \u003cp\u003e17.1.1 Global Aging Populations 445\u003c\/p\u003e \u003cp\u003e17.1.2 Pathophysiological Aspects of Aging 447\u003c\/p\u003e \u003cp\u003e17.1.3 Alterations in Sulfur Amino Acid Metabolism and Hydrogen Sulfide During Aging 448\u003c\/p\u003e \u003cp\u003e17.1.4 Geroscience Approaches to Address Longevity and Improved Healthspan, and Their Connection to Hydrogen Sulfide 451\u003c\/p\u003e \u003cp\u003e17.2 Hydrogen Sulfide Metabolism and Applications in Non-mammalian Aging 454\u003c\/p\u003e \u003cp\u003e17.2.1 Plants 454\u003c\/p\u003e \u003cp\u003e17.2.2 Bacteria 454\u003c\/p\u003e \u003cp\u003e17.2.3 Yeast 455\u003c\/p\u003e \u003cp\u003e17.2.4 Worms 458\u003c\/p\u003e \u003cp\u003e17.2.5 Flies 459\u003c\/p\u003e \u003cp\u003e17.3 Hydrogen Sulfide Metabolism and Applications in Nonhuman Mammalian Aging 460\u003c\/p\u003e \u003cp\u003e17.3.1 Standard Laboratory Rodents (Mice and Rats) 460\u003c\/p\u003e \u003cp\u003e17.3.2 Naked Mole-Rats 464\u003c\/p\u003e \u003cp\u003e17.4 Hydrogen Sulfide Metabolism and Applications in Human Aging and Aging-Related Disorders 464\u003c\/p\u003e \u003cp\u003e17.4.1 Human Exposure to H\u003csub\u003e2\u003c\/sub\u003eS and Advances in Clinical Biomarker and Interventional H\u003csub\u003e2\u003c\/sub\u003eS Approaches 464\u003c\/p\u003e \u003cp\u003e17.4.2 Cardiovascular Diseases 467\u003c\/p\u003e \u003cp\u003e17.4.3 Oncological Diseases 469\u003c\/p\u003e \u003cp\u003e17.5 Conclusions and Summary 472\u003c\/p\u003e \u003cp\u003eAcknowledgments 472\u003c\/p\u003e \u003cp\u003eReferences 472\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Aberrant Hydrogen Sulfide Signaling in Alzheimer’s Disease \u003c\/b\u003e\u003cb\u003e489\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBindu D. Paul\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 489\u003c\/p\u003e \u003cp\u003e18.1 Introduction 490\u003c\/p\u003e \u003cp\u003e18.1.1 Hydrogen Sulfide 490\u003c\/p\u003e \u003cp\u003e18.1.2 Protein Sulfhydration\/Persulfidation 492\u003c\/p\u003e \u003cp\u003e18.1.3 Reciprocity of Protein Sulfhydration and Nitrosylation 492\u003c\/p\u003e \u003cp\u003e18.2 Alzheimer’s Disease 494\u003c\/p\u003e \u003cp\u003e18.2.1 Neuropathology of AD 494\u003c\/p\u003e \u003cp\u003e18.2.2 H\u003csub\u003e2\u003c\/sub\u003eS Signaling in Alzheimer’s Disease 496\u003c\/p\u003e \u003cp\u003e18.2.3 Sulfhydration in Aging and AD 496\u003c\/p\u003e \u003cp\u003e18.3 Therapeutic Avenues 497\u003c\/p\u003e \u003cp\u003eAcknowledgments 499\u003c\/p\u003e \u003cp\u003eReferences 500\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Multifaceted Actions of Hydrogen Sulfide in the Kidney \u003c\/b\u003e\u003cb\u003e507\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBalakuntalam S. Kasinath and Hak Joo Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eList of Abbreviations 507\u003c\/p\u003e \u003cp\u003e19.1 Introduction 508\u003c\/p\u003e \u003cp\u003e19.2 H\u003csub\u003e2\u003c\/sub\u003eS Synthesis in the Kidney 509\u003c\/p\u003e \u003cp\u003e19.3 H\u003csub\u003e2\u003c\/sub\u003eS and Kidney Physiology 511\u003c\/p\u003e \u003cp\u003e19.4 H\u003csub\u003e2\u003c\/sub\u003eS and the Aging Kidney 513\u003c\/p\u003e \u003cp\u003e19.5 H\u003csub\u003e2\u003c\/sub\u003eS and Acute Kidney Injury (AKI) 517\u003c\/p\u003e \u003cp\u003e19.5.1 H\u003csub\u003e2\u003c\/sub\u003eS in AKI Due to Intrinsic Kidney Injury 517\u003c\/p\u003e \u003cp\u003e19.5.1.1 Ischemia-Induced AKI 517\u003c\/p\u003e \u003cp\u003e19.5.1.2 Rhabdomyolysis-Induced AKI 519\u003c\/p\u003e \u003cp\u003e19.5.1.3 Nephrotoxic AKI 519\u003c\/p\u003e \u003cp\u003e19.5.1.4 Glomerulonephritis-Associated AKI 520\u003c\/p\u003e \u003cp\u003e19.5.2 H\u003csub\u003e2\u003c\/sub\u003eS in AKI Due to Obstruction of the Genitourinary Tract 521\u003c\/p\u003e \u003cp\u003e19.5.3 Injurious Role of H\u003csub\u003e2\u003c\/sub\u003eS in AKI 521\u003c\/p\u003e \u003cp\u003e19.6 H\u003csub\u003e2\u003c\/sub\u003eS in Chronic Kidney Disease (CKD) 521\u003c\/p\u003e \u003cp\u003e19.6.1 H\u003csub\u003e2\u003c\/sub\u003eS in Obesity-Related CKD 524\u003c\/p\u003e \u003cp\u003e19.6.2 H\u003csub\u003e2\u003c\/sub\u003eS in Diabetic Kidney Disease (DKD) 525\u003c\/p\u003e \u003cp\u003e19.6.3 H\u003csub\u003e2\u003c\/sub\u003eS in Congestive Heart Failure (CHF) Associated CKD 530\u003c\/p\u003e \u003cp\u003e19.7 H\u003csub\u003e2\u003c\/sub\u003eS and Preeclampsia 530\u003c\/p\u003e \u003cp\u003e19.8 H\u003csub\u003e2\u003c\/sub\u003eS and Genitourinary Cancers 531\u003c\/p\u003e \u003cp\u003e19.9 Conclusion and Future Directions 531\u003c\/p\u003e \u003cp\u003eAcknowledgments 532\u003c\/p\u003e \u003cp\u003eReferences 532\u003c\/p\u003e \u003cp\u003eIndex 551\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49407156715863,"sku":"9781119799870","price":171.0,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/hydrogen-sulfide-9781119799870","provider":"Book Curl","version":"1.0","type":"link"}