{"product_id":"human-drug-targets-9781118849859","title":"Human Drug Targets","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface vii \u003cp\u003e\u003cb\u003eChapter 1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Magic bullets 1\u003c\/p\u003e \u003cp\u003e1.2 Background to modern pharmacology 2\u003c\/p\u003e \u003cp\u003e1.2.1 The receptor theory 3\u003c\/p\u003e \u003cp\u003e1.2.2 Molecular pharmacology 4\u003c\/p\u003e \u003cp\u003e1.2.3 Receptors, signals and enzymes 4\u003c\/p\u003e \u003cp\u003e1.2.4 Recombinant DNA technology and target discovery 5\u003c\/p\u003e \u003cp\u003e1.3 Drug and therapeutic targets in the biomedical literature 5\u003c\/p\u003e \u003cp\u003e1.4 How many drug targets are there? 5\u003c\/p\u003e \u003cp\u003e1.4.1 Systematic target discovery 6\u003c\/p\u003e \u003cp\u003e1.5 Screening for active molecules 7\u003c\/p\u003e \u003cp\u003eReferences 9\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 Overview of the drug target compendium 11\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introductory comments 11\u003c\/p\u003e \u003cp\u003e2.2 Selection of entries 12\u003c\/p\u003e \u003cp\u003e2.2.1 Gene name and symbol 12\u003c\/p\u003e \u003cp\u003e2.2.2 Drug\/investigational compound name 12\u003c\/p\u003e \u003cp\u003e2.2.3 Literature reference 13\u003c\/p\u003e \u003cp\u003e2.2.4 Involvement in disease 14\u003c\/p\u003e \u003cp\u003e2.3 Organization of entries 15\u003c\/p\u003e \u003cp\u003e2.3.1 Cell surface and secreted proteins 16\u003c\/p\u003e \u003cp\u003e2.3.2 Enzymes 16\u003c\/p\u003e \u003cp\u003e2.3.3 Entries classified by subcellular location 17\u003c\/p\u003e \u003cp\u003e2.3.4 Non]coding RNAs 18\u003c\/p\u003e \u003cp\u003e2.4 Summary of data entries 18\u003c\/p\u003e \u003cp\u003e2.5 How to use this book 19\u003c\/p\u003e \u003cp\u003e2.6 Final comments 21\u003c\/p\u003e \u003cp\u003eReferences 21\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3 Cell surface and secreted proteins 23\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 G]protein]coupled receptors (GPCRs) 24\u003c\/p\u003e \u003cp\u003e3.1.1 G]protein]coupled receptor (GPCR) ligands 39\u003c\/p\u003e \u003cp\u003e3.2 Nuclear hormone receptors (NHRs) 43\u003c\/p\u003e \u003cp\u003e3.3 Cytokines and receptors 45\u003c\/p\u003e \u003cp\u003e3.4 Adhesion molecules 64\u003c\/p\u003e \u003cp\u003e3.5 Host defence molecules 75\u003c\/p\u003e \u003cp\u003e3.6 Transporters and channels 90\u003c\/p\u003e \u003cp\u003e3.6.1 ATP]binding cassette families and transporting ATPases 90\u003c\/p\u003e \u003cp\u003e3.6.2 Solute carrier (SLC) families 96\u003c\/p\u003e \u003cp\u003e3.6.3 Ligand]gated ion channels 112\u003c\/p\u003e \u003cp\u003e3.6.4 Voltage]gated ion channels 116\u003c\/p\u003e \u003cp\u003e3.6.5 Assorted transport and carrier proteins 128\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 Enzymes: Part 1 135\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Signalling enzymes 136\u003c\/p\u003e \u003cp\u003e4.1.1 Protein kinases 136\u003c\/p\u003e \u003cp\u003e4.1.2 Protein phosphatases 160\u003c\/p\u003e \u003cp\u003e4.1.3 Cyclic nucleotides and phosphodiesterases 168\u003c\/p\u003e \u003cp\u003e4.1.4 GTPase signalling proteins 170\u003c\/p\u003e \u003cp\u003e4.1.5 Other signalling enzymes 176\u003c\/p\u003e \u003cp\u003e4.2 Protein modification 179\u003c\/p\u003e \u003cp\u003e4.2.1 Peptidases 179\u003c\/p\u003e \u003cp\u003e4.2.1.1 Peptidase inhibitors 202\u003c\/p\u003e \u003cp\u003e4.2.2 Glycosylation 208\u003c\/p\u003e \u003cp\u003e4.2.3 Ubiquitylation and related modifications 218\u003c\/p\u003e \u003cp\u003e4.2.4 Chromatin modification 230\u003c\/p\u003e \u003cp\u003e4.2.5 Protein synthesis and folding 236\u003c\/p\u003e \u003cp\u003e4.2.6 Other protein modifications 241\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5 Enzymes: Part 2 247\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Lipids and related 248\u003c\/p\u003e \u003cp\u003e5.2 Amino acids and related 267\u003c\/p\u003e \u003cp\u003e5.3 Nucleotides and related 276\u003c\/p\u003e \u003cp\u003e5.4 Carbohydrates and related 282\u003c\/p\u003e \u003cp\u003e5.5 Vitamins, cofactors and related 293\u003c\/p\u003e \u003cp\u003e5.6 DNA]processing enzymes 296\u003c\/p\u003e \u003cp\u003e5.7 RNA]processing enzymes 304\u003c\/p\u003e \u003cp\u003e5.8 Stress response and homeostasis 316\u003c\/p\u003e \u003cp\u003e5.9 Miscellaneous enzymes 330\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6 Remaining annotated entries grouped by subcellular location 335\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Cell surface and secreted proteins 335\u003c\/p\u003e \u003cp\u003e6.2 Cytoskeleton 356\u003c\/p\u003e \u003cp\u003e6.3 Cytoplasm to nucleus 364\u003c\/p\u003e \u003cp\u003e6.4 Nucleus 375\u003c\/p\u003e \u003cp\u003e6.5 Internal membranes and organelles 400\u003c\/p\u003e \u003cp\u003e6.6 Cytoplasmic proteins 417\u003c\/p\u003e \u003cp\u003e6.7 Subcellular location not annotated 424\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7 Non-Coding RNAs 437\u003c\/b\u003e\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49406934384983,"sku":"9781118849859","price":96.26,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118849859.jpg?v=1730497608","url":"https:\/\/bookcurl.com\/products\/human-drug-targets-9781118849859","provider":"Book Curl","version":"1.0","type":"link"}