{"product_id":"human-and-animal-filariases-landscape-challenges-and-control-9783527346592","title":"Human and Animal Filariases: Landscape, Challenges, and Control","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eHuman and Animal Filariases\u003c\/b\u003e \u003cp\u003e\u003cb\u003eThe rational approach to controlling human and animal diseases caused by nematodes\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eFilariae are a family of parasitic worms which infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfiguration resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs.  \u003c\/p\u003e\u003cp\u003e\tConsidering the current and future import of this topic, \u003ci\u003eHuman and Animal Filariases\u003c\/i\u003e takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eHuman and Animal Filariases\u003c\/i\u003e readers will find: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eA comprehensive approach that integrates current chemotherapy with recent advances in antifilarial drug discovery\u003c\/li\u003e\n\u003cli\u003ePractical information on assay development, target validation, and required drug product profiles\u003c\/li\u003e\n\u003cli\u003eInsights from global experts from leading academic institutions as well as from pharma and healthcare companies\u003c\/li\u003e\n\u003c\/ul\u003e  \u003cp\u003e\u003ci\u003eHuman and Animal Filariases\u003c\/i\u003e is a unique reference for parasitologists, veterinarians, as well as professionals in the pharmaceutical industry and in public health agencies.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePART I: Background, Status and Gaps\u003cbr\u003e Filariae as organisms (including life cycles)\u003cbr\u003e Human filariasis - disease and current problems \u003cbr\u003e Canine filariasis (heartworm) - disease and current problems\/gaps \u003cbr\u003e diagnosis of human filarial infections\u003cbr\u003e diagnosis of canine filarial infections\u003cbr\u003e Antifilarial chemotherapy: current options (human section) \u003cbr\u003e Antifilarial chemotherapy: current options (veterinary section)\u003cbr\u003e Current products\u003cbr\u003e Current antifilarial drug - mode of action\u003cbr\u003e Drug resistance in canine filarial chemotherapy\u003cbr\u003e Eradication\/elimination of human filariae\u003cbr\u003e The economic impact of human filariasis\u003cbr\u003e The economic impact of canine filariasis\u003cbr\u003e \u003cbr\u003e PART II: Antifilarial Drug Discovery and Development\u003cbr\u003e Product profiles of new antifilarial drugs - \u003cbr\u003e Discovery and development of new antifilarial drugs (in vitro assays)\u003cbr\u003e Rodent models for the discovery of new antifilarial drugs \u003cbr\u003e Discovery and development of new canine antifilarial drugs (in vivo assays) \u003cbr\u003e Discovery and development of new human antifilarial drugs (in vivo assays)\u003cbr\u003e The drug pipeline, including triple combination therapy, moxidectin, emodepside, TylaMac, auranofin \u003cbr\u003e \u003cbr\u003e PART III: Alternative Approaches\u003cbr\u003e Functional genomics of filariae \u003cbr\u003e Vector control approaches: humans\u003cbr\u003e Vector control approaches: canine\u003cbr\u003e Drug targets at the host-parasite interface\u003cbr\u003e Endosymbionts as targets\u003cbr\u003e Vaccines: progress and prospects","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":51742970085719,"sku":"9783527346592","price":142.5,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/bookcurl.com\/products\/human-and-animal-filariases-landscape-challenges-and-control-9783527346592","provider":"Book Curl","version":"1.0","type":"link"}