{"product_id":"hplc-methods-for-clinical-pharmaceutical-analysis-a-users-guide-9783527331291","title":"HPLC Methods for Clinical Pharmaceutical Analysis: A User's Guide","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eFilling a gap in the literature for a hands-on guide focusing on everyday laboratory challenges, this English edition has been expanded and revised using the feedback received on the successful German precursor. Throughout the book, Professor Mascher draws on his 30 years of\u003cbr\u003e experience and provides abundant practical advice, troubleshooting and other hints highlighted in boxes, as well as a broad selection of walkthrough case studies. Based on a course taught by the author, the first part of the book intuitively explains all steps of routine bioanalysis and explains how to set up a robust, inexpensive and effi cient method for a given substance. In the second part he includes 20 worked example cases that highlight common challenges and how to overcome them.\u003cbr\u003e \u003cbr\u003e With its appendix containing tried-and-tested analytical methods for 100 clinically relevant substances from the author`s own laboratory,\u003cbr\u003e complete with spectral and MS data as well as literature references and basic pharmacokinetic information, this is a life-long companion for\u003cbr\u003e everyone working in clinical, pharmaceutical and biochemical analysis.\u003cbr\u003e \u003cbr\u003e Comments to the German book: \u003cbr\u003e \"The book comes to life through its examples, showing not only what did work in the author's laboratory, but also what didn't.\"\u003cbr\u003e ChemieReport\u003cbr\u003e \u003cbr\u003e \"Indispensable for novices, while even old hands will be able to expand their knowledge. A collection of analytical data for ca. 100 substances completes the book's offering, leaving almost nothing to be desired.\"\u003cbr\u003e pharmind\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\"The book is clearly written and comprehensive. A lot of practical advice and tips makes it helpful for any practically oriented clinical laboratory and it can be counted as a valuable source for everyone working with chromatographic techniques in a bioanalytical laboratory.\"  (\u003ci\u003eAnalytical and Bioanalytical Chemistry\u003c\/i\u003e, 13 November 2012)\u003c\/p\u003e \u003cp\u003e“This book is more than a very successful and useful user guide, and is a valuable tool for the laboratorywork, not only for clinical analysts, but also for biochemists, pharmacists, etc. In addition to a compact targeted representation of the most important theoretical foundations for the planning and execution of (clinical) analysis (sample preparation, HPLC separation, usage of different modes, detection capabilities, derivatization techniques to the point of validation), the readers receive valuable information for their work, which are explained on the basis of practical examples [pages 1–64].”  (\u003ci\u003eChemMedChem\u003c\/i\u003e, 1 November 2012)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface\u003cbr\u003e \u003cbr\u003e INTRODUCTION\u003cbr\u003e First Question: Determination of Ibuprofen in Plasma\u003cbr\u003e Second Question: Determination of Tryptophan in Urine\u003cbr\u003e Third Question: Determination of Paclitaxel in Tissue\u003cbr\u003e \u003cbr\u003e PLANNING OF ANALYSES\u003cbr\u003e Introduction\u003cbr\u003e Limit of Detection (LOD) and Determination (LLOQ)\u003cbr\u003e Detectors\u003cbr\u003e Structure of the Analyte\u003cbr\u003e Solubility of an Analyte\u003cbr\u003e Selection of the Detector\u003cbr\u003e \u003cbr\u003e SAMPLE PREPARATION\u003cbr\u003e Dilution\u003cbr\u003e Protein Precipitation, Overview\u003cbr\u003e Extraction\u003cbr\u003e \u003cbr\u003e HPLC SEPARATION\u003cbr\u003e HPLC Pumps\u003cbr\u003e Degassers\u003cbr\u003e Injector\u003cbr\u003e HPLC Columns\u003cbr\u003e \u003cbr\u003e DETECTION\u003cbr\u003e Detection in the Pharmaceutical\/Bioanalytical Area\u003cbr\u003e Detection in the \"Clinical Area\" (Therapy Control\/Compliance)\u003cbr\u003e \u003cbr\u003e CHEMICAL DERIVATISATION FOR DETECTION ENHANCEMENT\u003cbr\u003e \u003cbr\u003e VALIDATION CONCEPTS\u003cbr\u003e Introduction\u003cbr\u003e Realisation of the FDA Guideline\u003cbr\u003e \u003cbr\u003e PRACTICAL HINTS CONCERNING STABILITY, DESTRUCTION AND DEGRADATION PRODUCTS\u003cbr\u003e \u003cbr\u003e METABOLITES\u003cbr\u003e \u003cbr\u003e INTERNAL STANDARDS\u003cbr\u003e \u003cbr\u003e CASE STUDIES WITH INTENSIVE DISCUSSION FOR EACH SUBSTANCE\u003cbr\u003e Acetylcarnitine in Plasma\u003cbr\u003e Acetylcysteine in Plasma\u003cbr\u003e Acyclovir in Plasma and Urine\u003cbr\u003e Caffeine in Plasma\u003cbr\u003e Diazepam in Plasma\u003cbr\u003e Diclofenac in Plasma\u003cbr\u003e Dihydralazine in Plasma\u003cbr\u003e Duramycin (Moli1901) in Plasma\u003cbr\u003e Fluticasone Propionate in Plasma\u003cbr\u003e Hydroxytriamterene Sulfate and Triamterene in Plasma and Urine\u003cbr\u003e Ibuprofen in Plasma (also Enantiomeric Separation)\u003cbr\u003e Minocycline in plasma\u003cbr\u003e Norfloxacine in Plasma and Urine\u003cbr\u003e Paclitaxel in Plasma, Urine, and Tissue\u003cbr\u003e Paracetamol (Acetaminophen) in Plasma\u003cbr\u003e Pimelic Acid in Plasma and Urine\u003cbr\u003e 8-Prenylnaringenin in Plasma and in Different Types of Tissues\u003cbr\u003e Silibinin in Plasma\u003cbr\u003e Valnemulin in Plasma, Different Tissue Types and Animal Feed\u003cbr\u003e Vitamin B1 (Total Thiamine) in Plasma\u003cbr\u003e \u003cbr\u003e APPENDIX\u003cbr\u003e Short Description of Determination for about 100 Substances\u003cbr\u003e Substances listed in the Appendix\u003cbr\u003e A Short Explanation of Tables Presented in the Appendix","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":51742968938839,"sku":"9783527331291","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783527331291.jpg?v=1758387707","url":"https:\/\/bookcurl.com\/products\/hplc-methods-for-clinical-pharmaceutical-analysis-a-users-guide-9783527331291","provider":"Book Curl","version":"1.0","type":"link"}