{"product_id":"highthroughput-screening-methods-in-toxicity-testing-9781118065631","title":"HighThroughput Screening Methods in Toxicity","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eExplores the benefits and limitations of the latest high-throughput screening methods\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWith its expert coverage of high-throughput \u003ci\u003ein vitro\u003c\/i\u003e screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council''s Toxicity Testing in the 21st Century: A Vision and Strategy and the E.U.''s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testing.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eHigh-Throughput Screening Methods in Toxicity Testing\u003c\/i\u003e is divided into five parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eGeneral aspects, including predicting the toxicity potential of chemicals and drugs via high-throughput bioactivity profiling\u003c\/li\u003e \u003cli\u003eAssessing different cytotoxic\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePREFACE ix\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I GENERAL ASPECTS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling 3\u003cbr\u003e \u003ci\u003eKeith A. Houck, Ann M. Richard, Richard S. Judson, Matthew T. Martin, David M. Reif, and Imran Shah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 High-Throughput Toxicity Testing in Drug Development: Aims, Strategies, and Novel Trends 33\u003cbr\u003e \u003ci\u003eWillem G.E.J. Schoonen, Walter M.A. Westerink, Femke M. van de Water, and Horbach G. Jean\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Incorporating Human Dosimetry and Exposure Information with High-Throughput Screening Data in Chemical Toxicity Assessment 77\u003cbr\u003e \u003ci\u003eBarbara A. Wetmore and Russell S. Thomas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 The Use of Human Embryonic Stem Cells in High-Throughput Toxicity Assays 97\u003cbr\u003e \u003ci\u003eXin Huang, Dan-yan Zhu, and Yi-jia Lou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II HIGH-THROUGHPUT ASSAYS TO ASSESS DIFFERENT CYTOTOXICITY ENDPOINTS\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003e 5 High-Throughput Screening Assays for the Assessment of Cytotoxicity 109\u003cbr\u003e \u003ci\u003eAndrew L. Niles, Richard A. Moravec, Tracy J. Worzella, Nathan J. Evans, and Terry L. Riss\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 High-Throughput Flow Cytometry Analysis of Apoptosis 129\u003cbr\u003e Francesca de Giorgi and Franc¸ois Ichas\u003c\/p\u003e \u003cp\u003e7 High Content Imaging-Based Screening for Cellular Toxicity Pathways 143\u003cbr\u003e \u003ci\u003eBram Herpers and Bob van de Water\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 The Keratinosens Assay: A High-Throughput Screening Assay to Assess Chemical Skin Sensitization 159\u003cbr\u003e \u003ci\u003eAndreas Natsch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 High-Throughput Screening Assays to Assess Chemical Phototoxicity 177\u003cbr\u003e \u003ci\u003eSatomi Onoue, Yoshiki Seto, and Shizuo Yamada\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III HIGH-THROUGHPUT ASSAYS TO ASSESS DNA DAMAGE AND CARCINOGENESIS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10 Ames IITM and Ames Liquid Format Mutagenicity Screening Assays 193\u003cbr\u003e \u003ci\u003eKamala Pant\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 High-Throughput Bacterial Mutagenicity Testing: VitotoxTM Assay 213\u003cbr\u003e \u003ci\u003eLuc Verschaeve\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Genotoxicity and Carcinogenicity: Regulatory and Novel Test Methods 233\u003cbr\u003e \u003ci\u003eWalter M.A. Westerink, Joe C.R. Stevenson, G. Jean Horbach, Femke M. van de Water, Beppy van de Waart, and Willem G.E.J. Schoonen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 High-Throughput Genotoxicity Testing: The Greenscreen Assay 271\u003cbr\u003e \u003ci\u003eJorg Blumel and Nadine Krause\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 High-Throughput Assays to Quantify the Formation of DNA Strand Breaks 285\u003cbr\u003e \u003ci\u003eMarýa Moreno-Villanueva and Alexander Burkle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 High-Throughput Versions of the Comet Assay 295\u003cbr\u003e \u003ci\u003eIrene Witte and Andre Stang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Automated Soft Agar Colony Formation Assay for the High-Throughput Screening of Malignant Cell Transformation 309\u003cbr\u003e \u003ci\u003ePablo Steinberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 High-Throughput Quantification of Morphologically Transformed Foci in Bhas 42 Cells (v-Ha-ras Transfected BALB\/c 3T3) Using Spectrophotometry 317\u003cbr\u003e \u003ci\u003eKiyoshi Sasaki, Ayako Sakai, and Noriho Tanaka\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV HIGH-THROUGHPUT ASSAYS TO ASSESS REPRODUCTIVE TOXICITY, CARDIOTOXICITY,\u003c\/b\u003e\u003cbr\u003e \u003cb\u003eAND HAEMATOTOXICITY\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18 ReProGlo: A New Stem-Cell-Based High-Throughput Assay to Predict the Embryotoxic Potential of Chemicals 343\u003cbr\u003e \u003ci\u003eFrederik Uibel and Michael Schwarz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Embryonic Stem Cell Test (EST): Molecular Endpoints Toward High-Throughput Analysis of Chemical Embryotoxic Potential 357\u003cbr\u003e \u003ci\u003ePeter T. Theunissen, Esther de Jong, Joshua F. Robinson, and Aldert H. Piersma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Zebrafish Development: High-Throughput Test Systems to Assess Developmental Toxicity 371\u003cbr\u003e \u003ci\u003eStephanie Padilla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Single Cell Imaging Cytometry-Based High-Throughput Analysis of Drug-Induced Cardiotoxicity 385\u003cbr\u003e \u003ci\u003eMin Jung Kim and Joon Myong Song\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 High-Throughput Screening Assays to Evaluate the Cardiotoxic Potential of Drugs 403\u003cbr\u003e \u003ci\u003eCarl-Fredrik Mandenius and Thomas Meyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 High-Throughput Screening Assays to Evaluate the Hematotoxic Potential of Drugs 421\u003cbr\u003e \u003ci\u003eCaroline Haglund, Rolf Larsson, and Martin Hoglund\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V HIGH-THROUGHPUT ASSAYS TO ASSESS DRUG METABOLISM AND RECEPTOR-RELATED TOXICITY\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e24 High-Throughput Enzyme Biocolloid Systems for Drug Metabolism and Genotoxicity Profiling Using LC–MS\/MS 433\u003cbr\u003e \u003ci\u003eJames F. Rusling and John Schenkman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Higher-Throughput Screening Methods to Identify Cytochrome P450 Inhibitors and Inducers: Current Applications and Practice 453\u003cbr\u003e \u003ci\u003eDavid M. Stresser and George Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 High-Throughput Yeast-Based Assays to Study Receptor-Mediated Toxicity 479\u003cbr\u003e Johanna Rajasarkka and Marko Virta\u003c\/p\u003e \u003cp\u003e27 Evaluating the Peroxisomal Phenotype in High Content Toxicity Profiling 501\u003cbr\u003e \u003ci\u003eJonathan Z. Sexton and Kevin P. Williams\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 A Panel of Quantitative Calux R  Reporter Gene Assays for Reliable High-Throughput Toxicity Screening of Chemicals and Complex Mixtures 519\u003cbr\u003e \u003ci\u003eBart van der Burg, Sander van der Linden, Hai-yen Man, Roos Winter, Lydia\u003c\/i\u003e \u003ci\u003eJonker, Barbara van Vugt-Lussenburg, and Abraham Brouwer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 DR-Calux R  : A High-Throughput Screening Assay for the Detection of Dioxin and Dioxin-Like Compounds in Food and Feed 533\u003cbr\u003e \u003ci\u003eBarbara van Vugt-Lussenburg, Harrie T. Besselink, Bart van der Burg, and\u003c\/i\u003e \u003ci\u003eAbraham Brouwer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 547\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406825562455,"sku":"9781118065631","price":128.66,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118065631.jpg?v=1730497244","url":"https:\/\/bookcurl.com\/products\/highthroughput-screening-methods-in-toxicity-testing-9781118065631","provider":"Book Curl","version":"1.0","type":"link"}