{"product_id":"heart-failure-molecules-mechanisms-and-therapeutic-targets-274-novartis-foundation-symposia-9780470015971","title":"Heart Failure Molecules Mechanisms and","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eOver the past five years, there has been dramatic progress in unravelling the cellular circuitry involved in cardiac failure, as well as in normal cardiac growth, development and apoptosis. These studies have revealed new and unanticipated therapeutic targets in the heart.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"…most up-to-date analysis on ways that science might look to reduce the harsh impact of heart disease.\" (\u003ci\u003eElectric Review\u003c\/i\u003e, February\/March 2007)  \u003cp\u003e\"This book offers an update in the basic mechanism of heart failure from the premier investigators in the field.\" (\u003ci\u003eDoody's Health Services\u003c\/i\u003e)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eIntroduction \u003ci\u003e(Eric N. Olson)\u003c\/i\u003e.  \u003cp\u003eControl of cardiac hypertrophy and heart failure by histone acetylation\/deacetylation \u003ci\u003e(Eric N. Olson, Johannes Backs and Timothy A. McKinsey)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eA novel mechanism of mechanical stress-induced hypertrophy \u003ci\u003e(Hiroshi Akazawa, Yunzeng Zou and Issei Komuro)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eControlling cardiomyocyte survival \u003ci\u003e(N. de Jonge, M. J. Goumans, Daan Lips, Rutger Hassink, Eva J. Vlug, Roy van der Meel, Christopher Donald Emmerson, Joppe Nijman, Leon de Windt and Pieter A. Doevendans)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMechanisms of angiotensin II-dependent progression to heart failure \u003ci\u003e(Mona Nemer, Nassim Dali-Youcef, Hao Wang, Anne Aries and Pierre Paradis)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eAlterations in myocardial gene expression as a basis for cardiomyopathies and heart failure \u003ci\u003e(Matthew R. Taylor and Michael R. Bristow)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eRole of the insulin-like growth factor 1 (IGF1)\/phosphoinositide-3-kinase (PI3K) pathway mediating physiological cardiac hypertrophy \u003ci\u003e(Julie R. McMullen and Seigo Izumo)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003eRole of Akt in cardiac growth and metabolism\u003ci\u003e(Anthony J. Muslin and Brian DeBosch)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eNovel therapy for heart failure and exercise-induced ventricular tachycardia based on ‘fixing’ the leak in ryanodine receptors \u003ci\u003e(Andrew R. Marks)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGeneral discussion I.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePhospholamban as a therapeutic modality in heart failure \u003ci\u003e(Guoxiang Chu and Evangelia G. Kranias)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSarcomere protein gene mutations and inherited heart disease: a b-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure \u003ci\u003e(Mitsuhiro Kamisago, Joachim P. Schmitt, Dennis McNamara, Christine Seidman and Jonathan G. Seidman)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe cardiomyocyte cell cycle \u003ci\u003e(Pascal J. E. Lafontant and Loren J. Field)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eRestoration of cardiac function with progenitor cells \u003ci\u003e(Carmen Urbich, Lothar Rössig and Stefanie Dimmeler)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSignalling pathways in cardiac regeneration \u003ci\u003e(Maria Paola Santini, Nadine Winn and Nadia Rosenthal)\u003c\/i\u003e\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBeyond small molecule drugs for heart failure: prospects for gene therapy \u003ci\u003e(Kenneth R. Chien)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDual roles of telomerase in cardiac protection and repair \u003ci\u003e(Michael D. Schneider).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFinal general discussion.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eClosing remarks: historical perspective \u003ci\u003e(Arnold M. Katz)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003eIndex of contributors.\u003c\/p\u003e \u003cp\u003eSubject index.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49525360918871,"sku":"9780470015971","price":146.75,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470015971.jpg?v=1731860224","url":"https:\/\/bookcurl.com\/products\/heart-failure-molecules-mechanisms-and-therapeutic-targets-274-novartis-foundation-symposia-9780470015971","provider":"Book Curl","version":"1.0","type":"link"}