{"product_id":"glycogen-synthase-kinase-3-gsk3-and-its-inhibitors-9780471770015","title":"Glycogen Synthase Kinase 3 GSK3 and Its","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eMany researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It's a great reference for researchers in drug design and development.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eForeword: The Origins of GSK-3.  \u003cp\u003e Preface.  \u003c\/p\u003e\u003cp\u003e Acknowledgments.  \u003c\/p\u003e\u003cp\u003e Contributors.  \u003c\/p\u003e\u003cp\u003e Abbreviations.   \u003c\/p\u003e\u003cp\u003e \u003cb\u003ePART I: CELLULAR FUNCTIONS OF GSK-3.\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e 1. Glycogen Synthase Kinase-3 - an Introductory Synopsis  .  \u003c\/p\u003e\u003cp\u003e 2. Glycogen-Synthase-Kinase-β (GSK-3β) a Key Signaling Enzyme: A Developmental Neurobiological Perspective.  \u003c\/p\u003e\u003cp\u003e 3. Role of GSK3\/Shaggy in neuronal cell biology.  \u003c\/p\u003e\u003cp\u003e 4. The Crystal Structures of Glycogen Synthase Kinase 3.  \u003c\/p\u003e\u003cp\u003e 5. Kinase-Kinase and Site-Site Interactions in the Phosphorylation of Tau by GSK-3.  \u003c\/p\u003e\u003cp\u003e \u003cb\u003ePART II: GSK3 AS A THERAPEUTIC TARGET IN HUMAN PATHOLOGY.\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e 6. GSK-3, a Key Player in Alzheimer’s Disease.  \u003c\/p\u003e\u003cp\u003e 7. Glycogen Synthase Kinase-3: A Target for Novel Mood Disorder Treatments.  \u003c\/p\u003e\u003cp\u003e 8. GSK3 and Stem Cells.  \u003c\/p\u003e\u003cp\u003e 9. Glycogen Synthase Kinase-3: role in Neurodegeneration and Neuroprotection.  \u003c\/p\u003e\u003cp\u003e 10. Protein Kinase Inhibitors. Assay Development.  \u003c\/p\u003e\u003cp\u003e 11. Animal Models with Modified Expression of GSK-3 for the Study of Its Physiology and of Its Implications in Human Pathologies.  \u003c\/p\u003e\u003cp\u003e \u003cb\u003ePART III: GSK-3 INHIBITORS: DEVELOPMENT AND THERAPEUTIC POTENTIAL.\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e 12. Lithium, the Seminal GSK3 Inhibitor.  \u003c\/p\u003e\u003cp\u003e 13. Inhibition of GSK3 as Therapeutic Strategy in Disease: Efficacy of AR-A014418.  \u003c\/p\u003e\u003cp\u003e 14. TDZD’s: Selective And ATP Non Competitive Glycogen Synthase Kinase-3 Inhibitors.  \u003c\/p\u003e\u003cp\u003e 15. 3-Amino Pyrazoles as Potent and Selective Glycogen Synthase (GSK-3) Inhibitors.  \u003c\/p\u003e\u003cp\u003e 16. Marine compounds as a new source for Glycogen Synthase Kinase-3 Inhibitors.  \u003c\/p\u003e\u003cp\u003e Index.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402671202647,"sku":"9780471770015","price":140.35,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471770015.jpg?v=1730481180","url":"https:\/\/bookcurl.com\/products\/glycogen-synthase-kinase-3-gsk3-and-its-inhibitors-9780471770015","provider":"Book Curl","version":"1.0","type":"link"}