{"product_id":"glycochemical-synthesis-9781118299845","title":"Glycochemical Synthesis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars.\u003cbr\u003e\u003cbr\u003e Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design\u003cbr\u003e Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field\u003cbr\u003e Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eContributors xv\u003c\/p\u003e \u003cp\u003eForeword xix\u003c\/p\u003e \u003cp\u003ePreface xxiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Glycochemistry: Overview and Progress 1\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMatthew Schombs and Jacquelyn Gervay-Hague\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction, 1\u003c\/p\u003e \u003cp\u003e1.2 Nomenclature, Structures, and Properties of Sugars, 2\u003c\/p\u003e \u003cp\u003e1.3 Historical Overview of Carbohydrate Research, 12\u003c\/p\u003e \u003cp\u003e1.4 Onward to the Twenty-First Century, 22\u003c\/p\u003e \u003cp\u003e1.5 Conclusion and Outlook, 28\u003c\/p\u003e \u003cp\u003eReferences, 29\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Protecting Group Strategies in Carbohydrate Synthesis 35\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eShang-Cheng Hung and Cheng-Chung Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction, 35\u003c\/p\u003e \u003cp\u003e2.2 General Considerations for Protecting Group Selection, 36\u003c\/p\u003e \u003cp\u003e2.3 Common Protecting Groups in Carbohydrate Synthesis, 38\u003c\/p\u003e \u003cp\u003e2.4 Regioselective Protection of Monosaccharides, 46\u003c\/p\u003e \u003cp\u003e2.5 One-Pot Protection Methods, 57\u003c\/p\u003e \u003cp\u003e2.6 Conclusion, 61\u003c\/p\u003e \u003cp\u003eReferences, 62\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 General Aspects in O-Glycosidic Bond Formation 69\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eXin-Shan Ye and Weigang Lu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction, 69\u003c\/p\u003e \u003cp\u003e3.2 Some Basic Concepts, 69\u003c\/p\u003e \u003cp\u003e3.3 Methods for Glycosidic Bond Formation, 74\u003c\/p\u003e \u003cp\u003e3.4 Glycosylation Strategies, 86\u003c\/p\u003e \u003cp\u003e3.5 Conclusion, 91\u003c\/p\u003e \u003cp\u003eReferences, 91\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Controlling Anomeric Selectivity, Reactivity, and Regioselectivity in Glycosylations Using Protecting Groups 97\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eThomas Jan Boltje, Lin Liu, and Geert-Jan Boons\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction, 97\u003c\/p\u003e \u003cp\u003e4.2 Protecting Group and Control of Anomeric Selectivity of Glycosylations, 98\u003c\/p\u003e \u003cp\u003e4.3 Use of Protecting Groups for Chemoselective Glycosylations, 115\u003c\/p\u003e \u003cp\u003e4.4 Protecting Groups in Regioselective Glycosylations, 118\u003c\/p\u003e \u003cp\u003e4.5 Conclusion, 125\u003c\/p\u003e \u003cp\u003eReferences, 125\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Stereocontrolled Synthesis of Sialosides 131\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eChandrasekhar Navuluri and David Crich\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction, 131\u003c\/p\u003e \u003cp\u003e5.2 Conformational Analysis of Sialyl Oxocarbenium Ions, 132\u003c\/p\u003e \u003cp\u003e5.3 Additives in Sialylations, 133\u003c\/p\u003e \u003cp\u003e5.4 Leaving Groups in Sialylations, 134\u003c\/p\u003e \u003cp\u003e5.5 Influence of the N5 Protecting Group on Reactivity and Selectivity, 134\u003c\/p\u003e \u003cp\u003e5.6 4-O,5-N-Oxazolidinone Group and its Stereodirecting Influence on Sialylations, 139\u003c\/p\u003e \u003cp\u003e5.7 4,5-O-Carbonate Protecting Group in α-Selective KDN Donors, 144\u003c\/p\u003e \u003cp\u003e5.8 Other Cyclic and Bicyclic Protecting Systems for Sialyl Donors, 145\u003c\/p\u003e \u003cp\u003e5.9 Mechanistic Aspects of Sialylation with Cyclically Protected Sialyl Donors, 146\u003c\/p\u003e \u003cp\u003e5.10 Influence of Hydroxy Protecting Groups on Sialyl Donor Reactivity and Selectivity, 147\u003c\/p\u003e \u003cp\u003e5.11 Stereoselective C-Sialoside Formation, 148\u003c\/p\u003e \u003cp\u003e5.12 Stereoselective S-Sialoside Formation, 149\u003c\/p\u003e \u003cp\u003e5.13 Conclusion, 151\u003c\/p\u003e \u003cp\u003eReferences, 151\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Strategies for One-Pot Synthesis of Oligosaccharides 155\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eBo Yang, Keisuke Yoshida, and Xuefei Huang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction, 155\u003c\/p\u003e \u003cp\u003e6.2 One-Pot Glycosylation from the Nonreducing End to the Reducing End, 156\u003c\/p\u003e \u003cp\u003e6.3 Regioselective One-Pot Glycosylation: Construction of Oligosaccharides from the Reducing End to the Nonreducing End, 175\u003c\/p\u003e \u003cp\u003e6.4 Hybrid One-Pot Glycosylation, 179\u003c\/p\u003e \u003cp\u003e6.5 Conclusion, 183\u003c\/p\u003e \u003cp\u003eAcknowledgments, 183\u003c\/p\u003e \u003cp\u003eReferences, 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Automated Oligosaccharide Synthesis: Techniques and Applications 189\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMattan Hurevich, Jeyakumar Kandasamy, and Peter H. Seeberger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction, 189\u003c\/p\u003e \u003cp\u003e7.2 Challenges and Limitations in Solution-Phase Oligosaccharide Synthesis, 190\u003c\/p\u003e \u003cp\u003e7.3 Solid-Phase Oligosaccharide Synthesis, 191\u003c\/p\u003e \u003cp\u003e7.4 Automated Oligosaccharide Synthesis, 193\u003c\/p\u003e \u003cp\u003e7.5 Microfluidic Techniques for Oligosaccharide Synthesis, 199\u003c\/p\u003e \u003cp\u003e7.6 Conclusion and Outlook, 202\u003c\/p\u003e \u003cp\u003eAcknowledgments, 202\u003c\/p\u003e \u003cp\u003eReferences, 202\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Sugar Synthesis by Microfluidic Techniques 205\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eKoichi Fukase, Katsunori Tanaka, Yukari Fujimoto, Atsushi Shimoyama, and Yoshiyuki Manabe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction, 205\u003c\/p\u003e \u003cp\u003e8.2 Microfluidic Glycosylation, 206\u003c\/p\u003e \u003cp\u003e8.3 Conclusion, 216\u003c\/p\u003e \u003cp\u003eReferences, 217\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Chemoenzymatic Synthesis of Carbohydrates 221\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eKasemsiri Chandarajoti and Jian Liu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction, 221\u003c\/p\u003e \u003cp\u003e9.2 Oligosaccharides and Polysaccharides Produced by GTases, 222\u003c\/p\u003e \u003cp\u003e9.3 Chemoenzymatic Synthesis of HS, 223\u003c\/p\u003e \u003cp\u003e9.4 Conclusion, 231\u003c\/p\u003e \u003cp\u003eReferences, 231\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Synthesis of Glycosaminoglycans 235\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMedel Manuel L. Zulueta, Shu-Yi Lin, Yu-Peng Hu, and Shang-Cheng Hung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction, 235\u003c\/p\u003e \u003cp\u003e10.2 General Strategies, 238\u003c\/p\u003e \u003cp\u003e10.3 Synthesis of Derivatives of l-Idose and IdoA, 240\u003c\/p\u003e \u003cp\u003e10.4 Synthesis via Stepwise Solution-Phase Assembly and Compound Diversification, 242\u003c\/p\u003e \u003cp\u003e10.5 Synthesis via Solution-Phase One-Pot Assembly, 250\u003c\/p\u003e \u003cp\u003e10.6 Polymer-Supported Synthesis and Automation, 253\u003c\/p\u003e \u003cp\u003e10.7 GAG Mimetics, 256\u003c\/p\u003e \u003cp\u003e10.8 Conclusion, 257\u003c\/p\u003e \u003cp\u003eReferences, 258\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Chemical Glycoprotein Synthesis 263\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eYasuhiro Kajihara, Masumi Murakami, and Carlo Unverzagt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction, 263\u003c\/p\u003e \u003cp\u003e11.2 Oligosaccharide Structures, 264\u003c\/p\u003e \u003cp\u003e11.3 Biosynthesis of Glycoproteins, 265\u003c\/p\u003e \u003cp\u003e11.4 Chemical Protein Synthesis, 267\u003c\/p\u003e \u003cp\u003e11.5 Synthesis of Glycopeptides, 269\u003c\/p\u003e \u003cp\u003e11.6 Synthesis of Glycopeptide-αthioesters, 270\u003c\/p\u003e \u003cp\u003e11.7 Chemical Synthesis of Glycoproteins, 275\u003c\/p\u003e \u003cp\u003e11.8 Conclusion, 288\u003c\/p\u003e \u003cp\u003eReferences, 288\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Synthesis of Glycosphingolipids 293\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSuvarn S. Kulkarni\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction, 293\u003c\/p\u003e \u003cp\u003e12.2 Classification and Nomenclature of GSLs, 294\u003c\/p\u003e \u003cp\u003e12.3 Biological Significance of GSLs, 296\u003c\/p\u003e \u003cp\u003e12.4 Synthesis of GSLs, 297\u003c\/p\u003e \u003cp\u003e12.5 Conclusion, 320\u003c\/p\u003e \u003cp\u003eReferences, 320\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Synthesis of Glycosylphosphatidylinositol Anchors 327\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eCharles Johnson and Zhongwu Guo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction, 327\u003c\/p\u003e \u003cp\u003e13.2 Synthesis of the Tryp. brucei GPI Anchor, 328\u003c\/p\u003e \u003cp\u003e13.3 Synthesis of the Yeast GPI Anchor, 333\u003c\/p\u003e \u003cp\u003e13.4 Synthesis of the Rat Brain Thy-1 GPI Anchor, 335\u003c\/p\u003e \u003cp\u003e13.5 Synthesis of Plasmodium falciparum GPI Anchor, 340\u003c\/p\u003e \u003cp\u003e13.6 Synthesis of Trypanosoma cruzi GPI Anchor, 344\u003c\/p\u003e \u003cp\u003e13.7 Synthesis of a Human Sperm CD52 Antigen GPI Anchor, 349\u003c\/p\u003e \u003cp\u003e13.8 Synthesis of a Human Lymphocyte CD52 Antigen GPI Anchor, 351\u003c\/p\u003e \u003cp\u003e13.9 Synthesis of the Branched GPI Anchor of Toxoplasma gondii, 354\u003c\/p\u003e \u003cp\u003e13.10 Conclusion, 355\u003c\/p\u003e \u003cp\u003eAcknowledgment, 356\u003c\/p\u003e \u003cp\u003eReferences, 357\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Synthesis of Bacterial Cell Envelope Components 361\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAkihiro Ishiwata and Yukishige Ito\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction, 361\u003c\/p\u003e \u003cp\u003e14.2 Peptidoglycan and Related Glycoconjugates, 362\u003c\/p\u003e \u003cp\u003e14.3 LPS and Related Glycoconjugates, 371\u003c\/p\u003e \u003cp\u003e14.4 Lipoteichoic Acid, 380\u003c\/p\u003e \u003cp\u003e14.5 Mycolyl Arabinogalactan, LAM, and Related Glycoconjugates, 382\u003c\/p\u003e \u003cp\u003e14.6 Oligosaccharides of Bacterial Glycoprotein and Related Glycoconjugates, 390\u003c\/p\u003e \u003cp\u003e14.7 Conclusion, 394\u003c\/p\u003e \u003cp\u003eReferences, 395\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Discoveries and Applications of Glycan Arrays 407\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eChung-Yi Wu and Shih-Huang Chang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction, 407\u003c\/p\u003e \u003cp\u003e15.2 Discoveries of Glycan Arrays, 407\u003c\/p\u003e \u003cp\u003e15.3 Applications of Glycan Array, 412\u003c\/p\u003e \u003cp\u003e15.4 Conclusion, 418\u003c\/p\u003e \u003cp\u003eReferences, 418\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Synthesis and Applications of Glyconanoparticles, Glycodendrimers, and Glycoclusters in Biological Systems 425\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAvijit Kumar Adak, Ching-Ching Yu, and Chun-Cheng Lin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction, 425\u003c\/p\u003e \u003cp\u003e16.2 Significance of Multivalent Binding Interactions in Biological Systems, 426\u003c\/p\u003e \u003cp\u003e16.3 Glyconanoparticles, Glycodendrimers, and Glycoclusters: General Overview, 428\u003c\/p\u003e \u003cp\u003e16.4 Plant Lectins, 431\u003c\/p\u003e \u003cp\u003e16.5 AB5 Toxins, 438\u003c\/p\u003e \u003cp\u003e16.6 Bacterial Adhesion Lectins, 440\u003c\/p\u003e \u003cp\u003e16.7 Influenza Virus, 445\u003c\/p\u003e \u003cp\u003e16.8 Detection of Bacteria, 445\u003c\/p\u003e \u003cp\u003e16.9 Glyco-MNPs as Nanoprobes for Labeling Cells and Magnetic Resonance Imaging Agents, 446\u003c\/p\u003e \u003cp\u003e16.10 Cyclopeptide-Based Glycoclusters as Vaccine Adjuvants, 447\u003c\/p\u003e \u003cp\u003e16.11 Conclusion, 449\u003c\/p\u003e \u003cp\u003eAcknowledgments, 449\u003c\/p\u003e \u003cp\u003eReferences, 450\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Design and Synthesis of Carbohydrates and Carbohydrate Mimetics as Anti-Influenza Agents 455\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMauro Pascolutti and Mark von Itzstein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction, 455\u003c\/p\u003e \u003cp\u003e17.2 Influenza Viruses, 456\u003c\/p\u003e \u003cp\u003e17.3 Development of Anti-Influenza Therapeutics, 459\u003c\/p\u003e \u003cp\u003e17.4 Sialic Acid: The Viral Cell-Surface Receptor Ligand, 460\u003c\/p\u003e \u003cp\u003e17.5 Hemagglutinin, 460\u003c\/p\u003e \u003cp\u003e17.6 Sialidase, 461\u003c\/p\u003e \u003cp\u003e17.7 Influenza Virus Sialidase as a Drug Discovery Target, 464\u003c\/p\u003e \u003cp\u003e17.8 Structural Differences Recently Identified in Influenza a Virus Sialidase Subtypes, 471\u003c\/p\u003e \u003cp\u003e17.9 New Influenza Virus Sialidase Inhibitors Targeting the 150-Cavity, 473\u003c\/p\u003e \u003cp\u003eReferences, 476\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Design and Synthesis of Ligands and Antagonists of Siglecs as Immune Response Modifiers 483\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHajjaj H. M. Abdu-Allah, Hideharu Ishida, and Makoto Kiso\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction, 483\u003c\/p\u003e \u003cp\u003e18.2 Lectins, 484\u003c\/p\u003e \u003cp\u003e18.3 Siglecs, 484\u003c\/p\u003e \u003cp\u003e18.4 Siglecs and Innate Immunity, 489\u003c\/p\u003e \u003cp\u003e18.5 Design and Synthesis of High-Affinity Ligands for Siglecs, 494\u003c\/p\u003e \u003cp\u003e18.6 Conclusion and Future Directions, 501\u003c\/p\u003e \u003cp\u003eReferences, 502\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Sugar–Protein Hybrids for Biomedical Applications 509\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMacarena Sánchez-Navarro and Benjamin G. Davis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction, 509\u003c\/p\u003e \u003cp\u003e19.2 Challenges in the Development of Glycoprotein-Based Therapeutics, 510\u003c\/p\u003e \u003cp\u003e19.3 Why Unnatural? 510\u003c\/p\u003e \u003cp\u003e19.4 Retrosynthetic Analysis, 511\u003c\/p\u003e \u003cp\u003e19.5 Linkages, 512\u003c\/p\u003e \u003cp\u003e19.6 Glycoprotein-Based Therapeutics, 521\u003c\/p\u003e \u003cp\u003e19.7 Conclusion, 527\u003c\/p\u003e \u003cp\u003eReferences, 527\u003c\/p\u003e \u003cp\u003eIndex 535\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406847975767,"sku":"9781118299845","price":152.06,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/glycochemical-synthesis-9781118299845","provider":"Book Curl","version":"1.0","type":"link"}