{"product_id":"genome-editing-in-drug-discovery-9781119671343","title":"Genome Editing in Drug Discovery","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eGENOME EDITING IN DRUG DISCOVERY  A practical guide for researchers and professionals applying genome editing techniques to drug discovery In Genome Editing in Drug Discovery, a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology's history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues. The safety and efficacy of drugs and new target discovery, as well as next-generation therapeutics are also presented. Offering practical suggestions for practitioners and academicians involved in drug discovery, Genome Editing in Drug Discovery is a fulsome treatment of a technology that has become part of nearly every early step in the drug discovery pipeline. Selected contributions also include:  A thorough introduc\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eList of Abbreviations viii\u003c\/p\u003e \u003cp\u003eList of Contributors ix\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Introduction to Drug Discovery and Genome Editing Methods 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Genome Editing in Drug Discovery 3\u003cbr\u003e\u003ci\u003eSteve Rees\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Historical Overview of Genome Editing from Bacteria to Higher Eukaryotes 9\u003cbr\u003e\u003ci\u003eMarcello Maresca\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 CRISPR Cas: From Bacterial Adaptive Immunity to the Swiss Army Knife of Drug Discovery 19\u003cbr\u003e\u003ci\u003eSaša Šviković\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Commercially Available Reagents and Contract Research Services for CRISPR-Based Studies 47\u003cbr\u003e\u003ci\u003eKlio Maratou, Aaron T. Cheng, Fiona M. Behan, Ning Sun, and Quinn Lu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Computational Tools for Target Design and Analysis 61\u003cbr\u003e\u003ci\u003eGue-Ho Hwang and Sangsu Bae\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Genome Editing in Disease Modeling 73\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6 Genome Editing in Cellular Disease Models 75\u003cbr\u003e\u003ci\u003ePierre Theurey, Kader Thiam, Yacine Chérifi, Alexandre Fraichard, and Amélie Rezza\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Utilizing CRISPR\/Cas9 Technologies for in vivo Disease Modeling and Therapy 93\u003cbr\u003e\u003ci\u003eLukas Badertscher and Michelle J. Porritt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Genome Editing in Target Identification and Validation 111\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Pooled CRISPR KO Screens for Target Identification 113\u003cbr\u003e\u003ci\u003eAntje Grotz and Sumit Deswal\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Functional Genomics: Arrayed CRISPR KO Screens 127\u003cbr\u003e\u003ci\u003eDavide Gianni and Leire Escudero-Ibarz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Applications of CRISPRi and CRISPRa in Drug Discovery 139\u003cbr\u003e\u003ci\u003eLuke A. Gilbert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Sequence Diversification Screens with CRISPR-Cas9-Guided Base Editors 151\u003cbr\u003e\u003ci\u003eJenna Persson and Bernhard Schmierer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Single-Cell Transcriptomics and Epigenomics for CRISPR-Mediated Perturbation Studies 165\u003cbr\u003e\u003ci\u003eSaumyaa Saumyaa, Ramy Elgendy, and Alessandro Bonetti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 4 Therapeutic Genome Editing 175\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 DNA Repair Pathways in the Context of Therapeutic Genome Editing 177\u003cbr\u003e\u003ci\u003eSandra Wimberger, Nina Akrap, and Amir Taheri-Ghahfarokhi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 DNA Base Editing Strategies for Genome Editing 193\u003cbr\u003e\u003ci\u003eMatthew Coelho, Songyuan Li, and Benjamin JM Taylor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 RNA Base Editing Technologies for Gene Therapy 203\u003cbr\u003e\u003ci\u003eSumit Deswal\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Genome Editing Applications in Cancer T Cell Therapy 213\u003cbr\u003e\u003ci\u003eWilliam A. Nyberg and Justin Eyquem\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Genome-Editing Applications in Stem Cell Engineering and Regenerative Medicine 231\u003cbr\u003e\u003ci\u003ePragya Gupta, Shashank Jaitly, Priya Thakur, Sangam Giri Goswami, Nupur Bhargava, and Sivaprakash Ramalingam\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Delivery and Formulation Methods for Therapeutic Genome Editing 261\u003cbr\u003e\u003ci\u003eErik Oude Blenke and Venkata R. Krishnamurthy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Safety Aspects of Genome Editing: Immunogenicity 281\u003cbr\u003e\u003ci\u003eRakesh Kantilal Chandode and Roberto Nitsch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Specificity of CRISPR-Cas9 Gene Editing 289\u003cbr\u003e\u003ci\u003eNiklas Selfjord, Alexandra Madsen, and Pinar Akcakaya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 5 Intellectual Property Aspects and Future Prospects 313\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e21 Key Socio-Economic and (Bio)Ethical Challenges in the CRISPR-Cas9 Patent Landscape 315\u003cbr\u003e\u003ci\u003eFranc Mali\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Emerging Technologies for Genome Editing 329\u003cbr\u003e\u003ci\u003eMartin Peterka\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 337\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49407115329879,"sku":"9781119671343","price":999.99,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/genome-editing-in-drug-discovery-9781119671343","provider":"Book Curl","version":"1.0","type":"link"}