{"product_id":"fluorine-in-medicinal-chemistry-and-chemical-biology-9781405167208","title":"Fluorine in Medicinal Chemistry and Chemical","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe extraordinary potential of fluorine-containing biologically relevant molecules in biology, medicinal chemistry, and medical applications has been recognized by researchers who are not in the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is expanding its biomedical frontiers.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cb\u003e\u003ci\u003eIntroduction\u003c\/i\u003e\u003c\/b\u003e  \u003cp\u003e Chapter 1 “Unique Properties of Fluorine and Their Relevance to Medicinal Chemistry and Chemical Biology” by Takashi Yamazaki, Takeo Taguchi and Iwao Ojima  \u003c\/p\u003e\u003cp\u003e \u003cb\u003e\u003ci\u003eMedicinal Chemistry\u003c\/i\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e Chapter 2 “Fluorinated Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent” by Yasushi Matsumura  \u003c\/p\u003e\u003cp\u003e Chapter 3 “Fluorinated conformationally restricted glutamate analogs for CNS drug discovery and development” by Atsuro Nakazato  \u003c\/p\u003e\u003cp\u003e Chapter 4 “Fluorinated Inhibitors of Matrix Metalloproteinases” by Roberta Sinisi, Monika Jagodzinska, Gabriele Candiani, Florent Huguenot, Monica Sani, Alessandro Volonterio, Raffaella Maffezzoni and Matteo Zanda  \u003c\/p\u003e\u003cp\u003e Chapter 5 “Fluoro-Taxoid Anticancer Agents” by Antonella Pepe, Larisa Kuznetsova, Liang Sun and Iwao Ojima  \u003c\/p\u003e\u003cp\u003e Chapter 6 “Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stability”by Jean-Pierre Bégué, Danièle Bonnet-Delpon  \u003c\/p\u003e\u003cp\u003e Chapter 7 “Synthesis and Biological Activity of Fluorinated Nucleosides” by Tokumi Maruyama, Masahiro Ikejiri, Kunisuke Izawa and Tomoyuki Onishi  \u003c\/p\u003e\u003cp\u003e   \u003c\/p\u003e\u003cp\u003e \u003cb\u003e\u003ci\u003eSynthetic methods for medicinal chemistry and chemical biology\u003c\/i\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e Chapter 8 “Synthesis of \u003ci\u003egem\u003c\/i\u003e-Difluoromethylenated Nucleosides \u003ci\u003evia\u003c\/i\u003e \u003ci\u003egem\u003c\/i\u003e-Difluoromethylene-Containing Building Blocks” by Wei-Dong Meng and Feng-Ling Qing  \u003c\/p\u003e\u003cp\u003e Chapter 9 “Recent Advances in the Syntheses of Fluorinated Amino Acids” by Kenji Uneyama  \u003c\/p\u003e\u003cp\u003e Chapter 10 “Fluorinated Moieties for Replacement of Amide and Peptide Bonds” by Takeo Taguchi and Hikaru Yanai  \u003c\/p\u003e\u003cp\u003e Chapter 11 “Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery” by David Armstrong, Matthew W. Cartwright, Emma L. Parks, Graham Pattison, Graham Sandford, Rachel Slater, John A. Christopher, David D. Miller, Paul W. Smith and Antonio Vong  \u003c\/p\u003e\u003cp\u003e Chapter 12 “\u003ci\u003egem\u003c\/i\u003e-Difluorocyclopropanes as key building blocks for novel biologically active molecules” by Toshiyuki Itoh  \u003c\/p\u003e\u003cp\u003e Chapter 13 “Fluorous Mixture Synthesis (FMS) of Drug-Like Molecules and Enantiomers, Stereoisomers, and Analogs of Natural Products” by Wei Zhang  \u003c\/p\u003e\u003cp\u003e Chapter 14 “Fluorine-18 Radiopharmaceuticals” by Michael R. Kilbourn and Xia Shao  \u003c\/p\u003e\u003cp\u003e \u003cb\u003e\u003ci\u003e\u003cbr\u003e \u003c\/i\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e \u003cb\u003e\u003ci\u003eApplications of fluorinated amino acids and peptides to chemical biology and pharmacology\u003c\/i\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e Chapter 15 “Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins” by Mario Salwiczek, Toni Vagt and Beate Koksch  \u003c\/p\u003e\u003cp\u003e Chapter 16 “Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology” by He Meng, Ginevra A. Clark\u003csup\u003e,\u003c\/sup\u003e and Krishna Kumar  \u003c\/p\u003e\u003cp\u003e Chapter 17 “Effects of Fluorination on the Bioorganic Properties of Methionine” by John F. Honek  \u003c\/p\u003e\u003cp\u003e Chapter 18 “Structure analysis of membrane-active peptides using \u003csup\u003e19\u003c\/sup\u003eF-labeled amino acids and solid state NMR” by Parvesh Wadhwani and Erik Strandberg  \u003c\/p\u003e\u003cp\u003e Chapter 19 “Metabolism of Fluorine-containing Drugs using \u003ci\u003ein vivo\u003c\/i\u003e Magnetic Resonance Spectroscopy” by Erika Schneider  \u003c\/p\u003e\u003cp\u003e   \u003c\/p\u003e\u003cp\u003e \u003cb\u003e\u003ci\u003eAppendix\u003c\/i\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e “FDA-Approved Active Pharmaceutical Ingredients Containing Fluorine” by Elizabeth Pollina-Cormier, Manisha Das, and Iwao Ojima    \u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49407899533655,"sku":"9781405167208","price":167.36,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781405167208.jpg?v=1730500896","url":"https:\/\/bookcurl.com\/products\/fluorine-in-medicinal-chemistry-and-chemical-biology-9781405167208","provider":"Book Curl","version":"1.0","type":"link"}