{"product_id":"extremophiles-9781118103005","title":"Extremophiles","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eExplores the utility and potential of extremophiles in sustainability and biotechnology\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMany extremophilic bio-products are already used as life-saving drugs. Until recently, however, the difficulty of working with these microbes has discouraged efforts to develop extremophilic microbes as potential drug reservoirs of the future. Recent technological advances have opened the door to exploring these organisms anew as sources of products that might prove useful in clinical and environmental biotechnology and drug development.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eExtremophiles\u003c\/i\u003e features outstanding articles by expert scientists who shed light on broad-ranging areas of progress in the development of smart therapeutics for multiple disease types and products for industrial use. It bridges technological gaps, focusing on critical aspects of extremolytes and the mechanisms regulating their biosynthesis that are relevant to human health and bioenergy, including value-added products of commercial sign\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eContributors xv\u003c\/p\u003e \u003cp\u003eIntroduction xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 MOLECULAR EVOLUTION OF EXTREMOPHILES 1\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDebamitra Chakravorty, Ashwinee Kumar Shreshtha, V. R. Sarath Babu, and Sanjukta Patra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Molecular Evolution of Thermophiles 2\u003c\/p\u003e \u003cp\u003e1.3 Molecular Evolution of Psychrophiles 4\u003c\/p\u003e \u003cp\u003e1.4 Molecular Evolution of Halophiles 6\u003c\/p\u003e \u003cp\u003e1.5 Molecular Evolution of Alkaliphiles 7\u003c\/p\u003e \u003cp\u003e1.6 Molecular Evolution of Acidophiles 8\u003c\/p\u003e \u003cp\u003e1.7 Molecular Evolution of Barophiles 10\u003c\/p\u003e \u003cp\u003e1.8 Engineering Extremophiles 12\u003c\/p\u003e \u003cp\u003e1.9 Case Studies 17\u003c\/p\u003e \u003cp\u003e1.10 Implications of Engineered Extremophiles on Ecology, Environment, and Health 20\u003c\/p\u003e \u003cp\u003e1.11 Conclusions and Recommendations 20\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 ATTAINING EXTREMOPHILES AND EXTREMOLYTES: METHODOLOGIES AND LIMITATIONS 29\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDebamitra Chakravorty and Sanjukta Patra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 29\u003c\/p\u003e \u003cp\u003e2.2 Extremophiles: Types and Diversity 30\u003c\/p\u003e \u003cp\u003e2.3 Extremolytes 54\u003c\/p\u003e \u003cp\u003e2.4 Conclusions 64\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 STRATEGIES FOR THE ISOLATION AND CULTIVATION OF HALOPHILIC MICROORGANISMS 75\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAharon Oren\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 75\u003c\/p\u003e \u003cp\u003e3.2 Thalassohaline and Athalassohaline Hypersaline Environments 76\u003c\/p\u003e \u003cp\u003e3.3 Case Studies 79\u003c\/p\u003e \u003cp\u003e3.4 The Upper Salinity Limits of Different Types of Energy Generation 85\u003c\/p\u003e \u003cp\u003e3.5 Final Comments 88\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 HALOPHILIC PROPERTIES AND THEIR MANIPULATION AND APPLICATION 95\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eTsutomu Arakawa, Hiroko Tokunaga, Matsujiro Ishibashi, and Masao Tokunaga\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 95\u003c\/p\u003e \u003cp\u003e4.2 Industrial Applications of Halophilic Organisms and Their Proteins 96\u003c\/p\u003e \u003cp\u003e4.3 Extreme and Moderate Halophiles and Their Proteins 98\u003c\/p\u003e \u003cp\u003e4.4 Generation of Low-Salt Stable Extreme-Halophilic Proteins 99\u003c\/p\u003e \u003cp\u003e4.5 Interconversion of Halophilic and Nonhalophilic Proteins 105\u003c\/p\u003e \u003cp\u003e4.6 Soluble Expression of Recombinant Proteins 110\u003c\/p\u003e \u003cp\u003e4.7 Natively Unfolded Proteins 113\u003c\/p\u003e \u003cp\u003e4.8 Organic Solvent Tolerance 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 FEATURES AND APPLICATIONS OF HALOPHILIC ARCHAEA 123\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eXimena C. Abrevaya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 123\u003c\/p\u003e \u003cp\u003e5.2 General Features 124\u003c\/p\u003e \u003cp\u003e5.3 Applications of Halophilic Archaea 130\u003c\/p\u003e \u003cp\u003e5.4 Concluding Remarks 143\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 BIOTECHNOLOGICAL APPLICATIONS OF COLD-ADAPTED BACTERIA 159\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eLaura Garcia-Descalzo, Alberto Alcazar, Fernando Baquero, and Cristina Cid\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 159\u003c\/p\u003e \u003cp\u003e6.2 Molecular Mechanisms of Adaptation to Cold Environments 162\u003c\/p\u003e \u003cp\u003e6.3 Exopolysaccharides 163\u003c\/p\u003e \u003cp\u003e6.4 Lipids 164\u003c\/p\u003e \u003cp\u003e6.5 Proteins 164\u003c\/p\u003e \u003cp\u003e6.6 Biotechnological Applications of Cold-Adapted Enzymes 168\u003c\/p\u003e \u003cp\u003e6.7 Biodegradation and Bioremediation in Cold Environments 169\u003c\/p\u003e \u003cp\u003e6.8 Conclusions 172\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 ECOLOGY AND BIOTECHNOLOGY OF EXTREMOPHILIC MICROORGANISMS, PARTICULARLY ANAEROBIC HERMOPHILES 175\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eFrancesco Canganella\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 175\u003c\/p\u003e \u003cp\u003e7.2 Thermophiles 176\u003c\/p\u003e \u003cp\u003e7.3 Acidophiles 187\u003c\/p\u003e \u003cp\u003e7.4 Alkaliphiles 191\u003c\/p\u003e \u003cp\u003e7.5 Halophiles 193\u003c\/p\u003e \u003cp\u003e7.6 Piezophiles 194\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 THE ROLE OF EXTREMOPHILIC MICROORGANISMS AND THEIR BIOPRODUCTS IN FOOD PROCESSING AND PRODUCTION 205\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJane A. Irwin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 205\u003c\/p\u003e \u003cp\u003e8.2 Enzymes from Extremophiles in Food Processing 206\u003c\/p\u003e \u003cp\u003e8.3 Alkaliphiles, Acidophiles, and Piezophiles 217\u003c\/p\u003e \u003cp\u003e8.4 Extremophiles in Food Spoilage and Contamination 218\u003c\/p\u003e \u003cp\u003e8.5 Extremophiles as Pathogens of Food Species 221\u003c\/p\u003e \u003cp\u003e8.6 Conclusions 222\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 EXTREMOPHILES AND THEIR APPLICATION TO BIOFUEL RESEARCH 233\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eM.P. Taylor, R. Bauer, S. Mackay, M. Tuffin, and D.A. Cowan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 233\u003c\/p\u003e \u003cp\u003e9.2 Extremophiles and Fuels 235\u003c\/p\u003e \u003cp\u003e9.3 Exploiting Extremophilic Enzymes in Biomass Conversion to Biofuel 241\u003c\/p\u003e \u003cp\u003e9.4 Conclusions and Future Prospects 249\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 SUSTAINABLE ROLE OF THERMOPHILES IN THE SECOND GENERATION OF ETHANOL PRODUCTION 267\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAnuj K. Chandel, Ellen C. Giese, Om V. Singh, and Silvio Silverio da Silva\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 267\u003c\/p\u003e \u003cp\u003e10.2 Thermophilic Cellulases for Deconstruction of the Plant Cell Wall 269\u003c\/p\u003e \u003cp\u003e10.3 Ethanol Production at Elevated Temperatures 274\u003c\/p\u003e \u003cp\u003e10.4 Future Perspectives and Challenges 281\u003c\/p\u003e \u003cp\u003e10.5 Conclusions 283\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 ECOFRIENDLY ASPECTS OF THE USE OF EXTREMOPHILIC ENZYMES IN TEXTILE SUBSTRATES 291\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eBipin J. Agrawal and Sandhya Mishra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 291\u003c\/p\u003e \u003cp\u003e11.2 Biopolymeric Fibers 292\u003c\/p\u003e \u003cp\u003e11.3 Extremophilic Enzymes and Their Use in the Textile Industry 293\u003c\/p\u003e \u003cp\u003e11.4 Utilization of Extremophilic Enzymes in Textile Wet Processing 297\u003c\/p\u003e \u003cp\u003e11.5 Finishing with Extremophilic Enzymes 306\u003c\/p\u003e \u003cp\u003e11.6 Role of Enzymes in Textile After-Care 311\u003c\/p\u003e \u003cp\u003e11.7 Role of Enzymes in Effluent Treatment of Textiles 314\u003c\/p\u003e \u003cp\u003e11.8 Conclusions 315\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 THE USE OF EXTREMOPHILIC MICROORGANISMS IN THE INDUSTRIAL RECOVERY OF METALS 319\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eCarlos A. Jerez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 319\u003c\/p\u003e \u003cp\u003e12.2 Biomining Extremophiles and Their Industrial Applications 320\u003c\/p\u003e \u003cp\u003e12.3 Molecular Studies in Acidophilic Biomining Microorganisms 322\u003c\/p\u003e \u003cp\u003e12.4 Microbial Resistance to Acid and Metals 324\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 BACTERIAL POLYMERS PRODUCED BY EXTREMOPHILES: BIOSYNTHESIS, CHARACTERIZATION, AND APPLICATIONS OF EXOPOLYSACCHARIDES 335\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNicolaus Barbara, Anzelmo Gianluca, and Poli Annarita\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 335\u003c\/p\u003e \u003cp\u003e13.2 EPS Produced by Extremophilic Bacteria 336\u003c\/p\u003e \u003cp\u003e13.3 Examples of Proposed EPS Biosynthesis from Extremophiles 345\u003c\/p\u003e \u003cp\u003e13.4 Physicochemical Investigations for Potential Applications 349\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 BIOMEDICAL APPLICATIONS OF EXOPOLYSACCHARIDES PRODUCED BY MICROORGANISMS ISOLATED FROM EXTREME ENVIRONMENTS 357\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eIgnacio J. Molina, Carmen Ruiz-Ruiz, Emilia Quesada, and Victoria B´ejar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 357\u003c\/p\u003e \u003cp\u003e14.2 Chemical Composition and Structure of EPSs 358\u003c\/p\u003e \u003cp\u003e14.3 Physical Properties of EPSs 358\u003c\/p\u003e \u003cp\u003e14.4 Biological Functions of EPSs 359\u003c\/p\u003e \u003cp\u003e14.5 Exopolysaccharides Deriving from Extremophilic Organisms 359\u003c\/p\u003e \u003cp\u003e14.6 Clinical Applications of EPSs 359\u003c\/p\u003e \u003cp\u003e14.7 Exopolysaccharides of Halophilic Microorganisms 361\u003c\/p\u003e \u003cp\u003e14.8 Concluding Remarks 362\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 BIOSYNTHESIS OF EXTREMOLYTES: RADIATION RESISTANCE AND BIOTECHNOLOGICAL IMPLICATIONS 367\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eErin Copeland, Nicholas Choy, Prashant Gabani, and Om V. Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 367\u003c\/p\u003e \u003cp\u003e15.2 Biotechnological Implications of Extremolytes 369\u003c\/p\u003e \u003cp\u003e15.3 Fermentative Production of Extremolytes 371\u003c\/p\u003e \u003cp\u003e15.4 Commercialization of Extremolytes and Extremozymes 380\u003c\/p\u003e \u003cp\u003e15.5 Product Recovery 382\u003c\/p\u003e \u003cp\u003e15.6 Conclusions 383\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 SMART THERAPEUTICS FROM EXTREMOPHILES: UNEXPLORED APPLICATIONS AND TECHNOLOGICAL CHALLENGES 389\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRaj Kumar and Ajeet Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 389\u003c\/p\u003e \u003cp\u003e16.2 Extremolytes as Protein Protectants 391\u003c\/p\u003e \u003cp\u003e16.3 Extremolytes as Cell Protectants 391\u003c\/p\u003e \u003cp\u003e16.4 Novel Therapeutics in the Developmental Stage 393\u003c\/p\u003e \u003cp\u003e16.5 Homeland Security and Military Medicine 394\u003c\/p\u003e \u003cp\u003e16.6 Technological Gaps in Therapeutic Product Development Using Extremophiles 396\u003c\/p\u003e \u003cp\u003e16.7 Conclusions 397\u003c\/p\u003e \u003cp\u003eAcknowledgment 398\u003c\/p\u003e \u003cp\u003eReferences 398\u003c\/p\u003e \u003cp\u003eIndex 403\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49406830018903,"sku":"9781118103005","price":128.66,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118103005.jpg?v=1730497261","url":"https:\/\/bookcurl.com\/products\/extremophiles-9781118103005","provider":"Book Curl","version":"1.0","type":"link"}