{"product_id":"evolutionary-biology-9780470647202","title":"Evolutionary Biology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAn integrative view of the evolution of genetics and the natural world  \u003cp\u003eEven in this advanced age of genomics, the evolutionary process of unicellular and multicellular organisms is continually in debate. Evolutionary Biology, CellCell Communication, and Complex Disease challenges current wisdom by using physiology to present an integrative view of the nature, origins, and evolution of fundamental biological systems.\u003c\/p\u003e \u003cp\u003eProviding a deeper understanding of the way genes relate to the traits of living organisms, this book offers useful information applying evolutionary biology, functional genomics, and cell communication studies to complex disease. Examining the 4.5 billion-year evolution process from environment adaptations to cell-cell communication to communication of genetic information for reproduction, Evolutionary Biology hones in on the why and how of evolution by uniquely focusing on the cell as the smallest unit of biologic structure and function.\u003c\/p\u003e \u003cp\u003eBased on empiric\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\"…the book offers the biology-savvy reader with interesting insights into the contribution of cell-cell interactions to the development and evolution of phenotypes.  Given the technical nature of the subject, this book will have particular appeal among researchers and students of cellular and molecular biology and among evolutionary biologists interested in the pathways linking genes to phenotypes.  In keeping with the complexity of the topic, there is much to digest here, and readers knowledgeable in these fields will find interesting food for thought.”  (\u003ci\u003eQuarterly Reviews in Biology\u003c\/i\u003e, 1  July 2013)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cb\u003ePreface xi\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eAbout the Authors xiii\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 THE CELLULAR ORIGIN OF VERTEBRATES 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe Origins of Unicellular Life on Earth 1\u003c\/p\u003e \u003cp\u003eProkaryotes versus Eukaryotes 4\u003c\/p\u003e \u003cp\u003eCoevolution of traits 5\u003c\/p\u003e \u003cp\u003eCholesterol Facilitates Lipid Rafts for Cell–Cell Communication 7\u003c\/p\u003e \u003cp\u003eThe Endomembrane System 9\u003c\/p\u003e \u003cp\u003eThe Cellular Mechanism of Evolution 10\u003c\/p\u003e \u003cp\u003eWhy Evolve? 11\u003c\/p\u003e \u003cp\u003eCell–Cell Communication and Aging 12\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 REDUCING LUNG PHYSIOLOGY TO ITS MOLECULAR PHENOTYPES 17\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eHormonal Acceleration of Lung Development 17\u003c\/p\u003e \u003cp\u003eNeutral Lipid Traffi cking and Lung Evolution 19\u003c\/p\u003e \u003cp\u003eOther Examples of Cellular Cooperativity 23\u003c\/p\u003e \u003cp\u003eSummary 24\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 A CELL–MOLECULAR STRATEGY FOR SOLVING THE EVOLUTIONARY PUZZLE 25\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRationale for Cell–Molecular Evolution 25\u003c\/p\u003e \u003cp\u003eMechanism of Mammalian Lung Development 28\u003c\/p\u003e \u003cp\u003eAvian Lung Structure–Function Relationship: The Exception that Proves the Rule 32\u003c\/p\u003e \u003cp\u003eDoes Ontogeny Recapitulate Phylogeny? The Role of PTHrP in Lung Development 32\u003c\/p\u003e \u003cp\u003eInterrelationship between PTHrP, Development, Physiology, and Repair: Is Repair a Recapitulation of Ontogeny and Phylogeny? 33\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 THE EVOLUTION OF CELL–CELL COMMUNICATION 35\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCell–Cell Communication as the Mechanistic Basis for Evolutionary Biology 36\u003c\/p\u003e \u003cp\u003eThe Darwinian Biologic Spacetime Continuum and Einstein’s Vision of the Universe 37\u003c\/p\u003e \u003cp\u003eReverse Engineering of Physiologic Traits as a Portal for Viewing Evolution 38\u003c\/p\u003e \u003cp\u003eCell–Cell Communication as the Basis for the Evolution of Metazoans 41\u003c\/p\u003e \u003cp\u003eUnderstanding Lung Evolution from the Middle Out 42\u003c\/p\u003e \u003cp\u003eThe Cell–Cell Communication Model of Lung Evolution Traces Contemporary Phenotypes Back to Ancestral Phenotypes 43\u003c\/p\u003e \u003cp\u003ePredictive Value of the Lung Cell–Cell Communication Model for Understanding the Evolution of Physiologic Systems 44\u003c\/p\u003e \u003cp\u003eSexual Dimorphism of Lung Development: A Case Study in Cell–Cell Communication and Evolutionary Plasticity 46\u003c\/p\u003e \u003cp\u003eAndrogen Affects the Expression of Growth Factors Involved in Lung Development 48\u003c\/p\u003e \u003cp\u003eEvidence for an Association between Steroid-Resistant\/Responsive Phenotypes and Human Lymphocyte Antigen (HLA) Haplotypes 49\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 HOW TO INTEGRATE CELL-MOLECULAR DEVELOPMENT, HOMEOSTASIS, ECOLOGY, AND EVOLUTIONARY BIOLOGY: THE MISSING LINKS 53\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNeutral Theory versus Intelligent Design 54\u003c\/p\u003e \u003cp\u003eInternal Selection Theory 54\u003c\/p\u003e \u003cp\u003eThe Counterintuitive Nature of Physiology and Solution to the Dead Sea Scrolls Puzzle 57\u003c\/p\u003e \u003cp\u003eThe Continuum from Microevolution to Macroevolution 58\u003c\/p\u003e \u003cp\u003e\u003ci\u003ecis\u003c\/i\u003e Regulation and Adaptive Evolution 69\u003c\/p\u003e \u003cp\u003eEvolution of \u003ci\u003ecis\u003c\/i\u003e Regulatory Mechanisms 70\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 FROM CELL–CELL COMMUNICATION TO THE EVOLUTION OF INTEGRATED PHYSIOLOGY 75\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCell–cell Signaling and Alveolar Development: A Reductionist Approach to the Evolution of Physiologic Traits 77\u003c\/p\u003e \u003cp\u003eAn Integrated, Empiric, Middle–Out Approach to Physiology 79\u003c\/p\u003e \u003cp\u003eA Molecular Evolutionary Link between the Lung and the Kidney? 82\u003c\/p\u003e \u003cp\u003eThe Berner Hypothesis and Emergence of the Adipocyte: The Evolutionary Origins of the Lipofi broblast 83\u003c\/p\u003e \u003cp\u003eLung Biology as a Cipher for Evolution 85\u003c\/p\u003e \u003cp\u003eDo Stretch Effects on PTHrP Expression Reflect Its Role in Adapting to Gravity? 85\u003c\/p\u003e \u003cp\u003eWolff’s Law Works for Both Bone and Lung 88\u003c\/p\u003e \u003cp\u003eFunctional Relationship between the External and Internal Environments 89\u003c\/p\u003e \u003cp\u003eAn Evolutionary Vertical Integration of the Phylogeny and Ontogeny of the Thyroid 91\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 EXPLOITING CELL–CELL COMMUNICATION ACROSS SPACETIME TO DECONSTRUCT EVOLUTION 95\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSomewhere between the Gene and the Phenotype Lies the Process of Evolution 98\u003c\/p\u003e \u003cp\u003eA Functional Genomic Approach to Evolution as an Example of Terminal Addition 100\u003c\/p\u003e \u003cp\u003eSeeking Deep Homologies in Lung Evolution 102\u003c\/p\u003e \u003cp\u003eSystems Biology Based on Cell–Cell Communication 105\u003c\/p\u003e \u003cp\u003eVertical Integration of Leptin Signaling, Human Evolution, and the Trojan Horse Effect 108\u003c\/p\u003e \u003cp\u003eLeptin and Human Evolution: Food for Thought 109\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 THE PERIODIC TABLE OF BIOLOGY 115\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe Prospect of a Periodic Table of Biology 115\u003c\/p\u003e \u003cp\u003eCellular Cooperation Is Key 116\u003c\/p\u003e \u003cp\u003eElemental Biology 118\u003c\/p\u003e \u003cp\u003ePTHrP as an Archetype 118\u003c\/p\u003e \u003cp\u003eEvolution as the Solution 119\u003c\/p\u003e \u003cp\u003eRamping Up a Mathematical Model of Evolution 121\u003c\/p\u003e \u003cp\u003eThe Anthropic Principle Results from the Evolution of Cell–Cell Interactions 124\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 VALUE ADDED BY THINKING IN TERMS OF THE CELL–CELL COMMUNICATION MODEL FOR EVOLUTION 125\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThis is \u003ci\u003eNot\u003c\/i\u003e a Just-So Story 126\u003c\/p\u003e \u003cp\u003eBeyond Genomics 128\u003c\/p\u003e \u003cp\u003eFrom Fat Cells to Integrated Physiology 128\u003c\/p\u003e \u003cp\u003eMolecular Homologies Distinguish between the Evolutionary Forest and Trees 129\u003c\/p\u003e \u003cp\u003eThe Oxygen–Cholesterol–Surfactant–Membrane Connection 130\u003c\/p\u003e \u003cp\u003eCholesterol Metabolism as the Data Operating System for Vertebrate Biology? 131\u003c\/p\u003e \u003cp\u003eTranslation of Genomics into the Periodic Table for Biology 132\u003c\/p\u003e \u003cp\u003eDeep Homologies 134\u003c\/p\u003e \u003cp\u003eSelection Pressure for Cell–Cell Communication: The Key to Understanding Evolution 135\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 CELL–CELL COMMUNICATION AS THE BASIS FOR PRACTICING CLINICAL MEDICINE 139\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCell–Cell Communication Maintenance and Breakdown Represent Heath and Disease, Respectively 140\u003c\/p\u003e \u003cp\u003eCell–Cell Communications as a Framework for Human Evolution 140\u003c\/p\u003e \u003cp\u003eCanalization, Decanalization, and the Holistic Approach to the Practice of Medicine 141\u003c\/p\u003e \u003cp\u003eExploiting Lung Evolution to Prevent and Treat Chronic Lung Disease 141\u003c\/p\u003e \u003cp\u003eLung Evolution Explains the Magic of Continuous Positive Airway Pressure 142\u003c\/p\u003e \u003cp\u003eThe Paradox of Infecting the Lung in Order to Treat Lung Disease Caused by Infection 143\u003c\/p\u003e \u003cp\u003eExploiting Lung Evolution to Prevent and Treat Smoking-Related Lung Damage 144\u003c\/p\u003e \u003cp\u003eThe Trojan Horse Effect of Canalization 145\u003c\/p\u003e \u003cp\u003eImpetus for Evolutionary Science as an Integral Part of the Clinical Curriculum 146\u003c\/p\u003e \u003cp\u003eApplication of Evolutionary Science to Bioethics 147\u003c\/p\u003e \u003cp\u003eEvolutionary Science, a Biologic Periodic Table, and a Unifi ed Theory of Biology 148\u003c\/p\u003e \u003cp\u003eSummary 149\u003c\/p\u003e \u003cp\u003e\u003cb\u003eName Index 151\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSubject Index 153\u003c\/b\u003e\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49525383823703,"sku":"9780470647202","price":77.85,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470647202.jpg?v=1731860308","url":"https:\/\/bookcurl.com\/products\/evolutionary-biology-9780470647202","provider":"Book Curl","version":"1.0","type":"link"}