{"product_id":"evidencebased-evolutionary-medicine-9781118838372","title":"EvidenceBased Evolutionary Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eA groundbreaking, evidence-based text to the growing field of evolutionary medicine\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eEvidence-Based Evolutionary Medicine\u003c\/i\u003e offers a comprehensive review of the burgeoning field of evolutionary medicine and explores vital topics such as evolution, ecology, and aging as they relate to mainstream medicine. The text integrates Darwinian principles and evidence-based medicine in order to offer a clear picture of the underlying principles that reflect how and why organisms have evolved on a cellular level.\u003c\/p\u003e \u003cp\u003eThe authorsnoted authorities in their respective fieldsaddress evolutionary medicine from a developmental cell-molecular perspective. They explore the first principles of physiology that explain the generation of existing tissues, organs, and organ systems. The text offers an understanding of the overall biology as a vertically integrated whole, from unicellular to multicellular organisms. In addition, it addresses clinical diagnostic and therapeutic approaches\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 A Brief History of Evolutionary Thinking 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 1\u003c\/p\u003e \u003cp\u003eIntroduction 2\u003c\/p\u003e \u003cp\u003eDarwin 3\u003c\/p\u003e \u003cp\u003eDarwin’s Theory 6\u003c\/p\u003e \u003cp\u003eThe Modern Synthesis 7\u003c\/p\u003e \u003cp\u003eThe Darkest Chapter 9\u003c\/p\u003e \u003cp\u003eConclusions 14\u003c\/p\u003e \u003cp\u003eReferences 14\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Outlining the Major Transitions in the History of Life 17\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 17\u003c\/p\u003e \u003cp\u003eIntroduction 18\u003c\/p\u003e \u003cp\u003eThe Major Transitions 20\u003c\/p\u003e \u003cp\u003eConclusions 29\u003c\/p\u003e \u003cp\u003eReferences 30\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 One Central Mystery: Why Did Eukaryotes Only Evolve Once? 31\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 31\u003c\/p\u003e \u003cp\u003eIntroduction 32\u003c\/p\u003e \u003cp\u003eConclusions 45\u003c\/p\u003e \u003cp\u003eReferences 45\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 A Levels‐of‐Selection View of Evolutionary Physiology 49\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 49\u003c\/p\u003e \u003cp\u003eConclusions 59\u003c\/p\u003e \u003cp\u003eReferences 59\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The Cell as the Smallest Functional Unit of Biology\/Physiology 63\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 63\u003c\/p\u003e \u003cp\u003eIn the Beginning 64\u003c\/p\u003e \u003cp\u003eThe Advent of Multicellularity 65\u003c\/p\u003e \u003cp\u003eEvolution: Cellular Style 69\u003c\/p\u003e \u003cp\u003eThe Water–Land Transition and Vertebrate Evolution 70\u003c\/p\u003e \u003cp\u003eThe Cellular Approach to Evolution Is Predictive 74\u003c\/p\u003e \u003cp\u003eWe Are Not Just in This Environment, We Are of It 77\u003c\/p\u003e \u003cp\u003eBioethics Based on Evolutionary Ontology and Epistemology, Not Descriptive Phenotypes, and Genes 78\u003c\/p\u003e \u003cp\u003eThe Theory of Everything (TOE) 79\u003c\/p\u003e \u003cp\u003eCoda 81\u003c\/p\u003e \u003cp\u003eReferences 81\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Development of Tissues and Organs 83\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 83\u003c\/p\u003e \u003cp\u003eIntroduction 83\u003c\/p\u003e \u003cp\u003eLung Alveolar Morphogenesis 85\u003c\/p\u003e \u003cp\u003eParathyroid Hormone‐Related Protein 86\u003c\/p\u003e \u003cp\u003eStretch‐Induced Cell–Cell Interactions 88\u003c\/p\u003e \u003cp\u003eReferences 89\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 When Homeostasis Fails 91\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 91\u003c\/p\u003e \u003cp\u003eIntroduction 91\u003c\/p\u003e \u003cp\u003ePeroxisome Proliferator Activated Receptor Gamma as a Connection to the Evolution of the LIF 93\u003c\/p\u003e \u003cp\u003ePPARγ, Statins, and TOR as Mechanisms for Homeostasis 93\u003c\/p\u003e \u003cp\u003eHomeostatic Control of What? 93\u003c\/p\u003e \u003cp\u003ePleiotropy: The Deus ex Machina (Ghost in the Machine) 95\u003c\/p\u003e \u003cp\u003eRubik’s Cube as a Metaphor for Pleiotropic Evolution 96\u003c\/p\u003e \u003cp\u003eThe Lung as the Prototypical Pleiotropic Mechanism 99\u003c\/p\u003e \u003cp\u003eThe Lung as an Interactive Barrier: Homolog of the Plasma Membrane, Skin, and Brain 102\u003c\/p\u003e \u003cp\u003eNKX2.1, Thyroid, Pituitary, and Lung Pleiotropy 104\u003c\/p\u003e \u003cp\u003eThe Phylogeny of the Thyroid 105\u003c\/p\u003e \u003cp\u003eAn Evolutionary Vertical Integration of the Phylogeny and Ontogeny of the Thyroid 105\u003c\/p\u003e \u003cp\u003eA Retrospective Understanding of Evolution 107\u003c\/p\u003e \u003cp\u003eDenouement 109\u003c\/p\u003e \u003cp\u003eConclusions 111\u003c\/p\u003e \u003cp\u003eReferences 112\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Wnt Signaling During Development 113\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 113\u003c\/p\u003e \u003cp\u003eIntroduction 113\u003c\/p\u003e \u003cp\u003eRole of Growth Factors in Alveolar Homeostasis 114\u003c\/p\u003e \u003cp\u003eThe Kidney Glomerulus as a Homolog of the Lung Alveolus 116\u003c\/p\u003e \u003cp\u003ePathologic Consequences of Failed Paracrine Signaling 117\u003c\/p\u003e \u003cp\u003eReference 117\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Integrated Regulation of Homeostasis – Vascular, Nervous, Endocrine, Neuroendocrine, Autonomic 119\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 119\u003c\/p\u003e \u003cp\u003eIntroduction 119\u003c\/p\u003e \u003cp\u003eWater–Land Transition as the Catalyst for Vertebrate Evolution 121\u003c\/p\u003e \u003cp\u003eParathyroid Hormone‐Related Protein Signaling Is Key to Understanding the Evolution of the Lung 121\u003c\/p\u003e \u003cp\u003eThe Physics of Lung Evolution 122\u003c\/p\u003e \u003cp\u003eFunctional Homology between Membrane Lipids and Oxygenation 124\u003c\/p\u003e \u003cp\u003eAtmospheric Oxygen, Physiologic Stress, Gene Duplication, and Lung Evolution 125\u003c\/p\u003e \u003cp\u003eDuplication of the β Adrenergic Receptor and the Glucocorticoid Receptor Genes 127\u003c\/p\u003e \u003cp\u003eEvolution of Endothermy\/Homeothermy as Evidence for the Effect of Stress on Vertebrate Physiologic Evolution 127\u003c\/p\u003e \u003cp\u003eHibernation as Reverse Evolution 129\u003c\/p\u003e \u003cp\u003ePredictive Power of the Cellular–Molecular Approach to Evolution 131\u003c\/p\u003e \u003cp\u003eConclusions 133\u003c\/p\u003e \u003cp\u003eReferences 136\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Endogenous and Exogenous Mechanisms for Healing 137\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 137\u003c\/p\u003e \u003cp\u003eIntroduction 138\u003c\/p\u003e \u003cp\u003eEndogenous Mechanisms for Healing 138\u003c\/p\u003e \u003cp\u003eA Fine Homeostatic Balance between the Differentiated Interstitial Fibroblast and the Myofibroblast 138\u003c\/p\u003e \u003cp\u003eUniversality of Wnt\/β‐catenin in Myofibroblast Proliferation and Scarring: DKK, Shh, Alphabet Soup 140\u003c\/p\u003e \u003cp\u003eProstanoids, Homeostasis, and Regeneration 140\u003c\/p\u003e \u003cp\u003ePGJ2 141\u003c\/p\u003e \u003cp\u003eApoE4 143\u003c\/p\u003e \u003cp\u003eEvolutionary versus Traditional Medicine 144\u003c\/p\u003e \u003cp\u003eExogenous Mechanisms for Healing Using Evolutionary Principles 145\u003c\/p\u003e \u003cp\u003eSummary 145\u003c\/p\u003e \u003cp\u003eCholesterol and Homeostasis 145\u003c\/p\u003e \u003cp\u003ePathophysiology of Hypercholesterolemia 145\u003c\/p\u003e \u003cp\u003eStatins as Anti‐Inflammatory Agents 146\u003c\/p\u003e \u003cp\u003ePPARγ and Homeostasis 146\u003c\/p\u003e \u003cp\u003eTOR and Homeostasis 148\u003c\/p\u003e \u003cp\u003eReferences 148\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Systems Biology as Recapitulation of Ontogeny and Phylogeny 151\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 151\u003c\/p\u003e \u003cp\u003eIntroduction 151\u003c\/p\u003e \u003cp\u003eA Paradigm Shift in Evolution 152\u003c\/p\u003e \u003cp\u003eEndothermy as “Proof of Principle” for the Evolution of Serial Exaptations 154\u003c\/p\u003e \u003cp\u003eEndothermy Defies Physics, Fostering Migration 155\u003c\/p\u003e \u003cp\u003eConclusions 157\u003c\/p\u003e \u003cp\u003eReferences 158\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Terminal Addition as Physiologic Homeostasis and Regeneration, or Evolutionary Medicine 159\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 159\u003c\/p\u003e \u003cp\u003eIntroduction 160\u003c\/p\u003e \u003cp\u003eConflicting Viewpoints 161\u003c\/p\u003e \u003cp\u003eTerminal Addition as a Perpetual Cellular Link with the Environment 163\u003c\/p\u003e \u003cp\u003eTerminal Addition as Layered Cell–Cell Signaling 164\u003c\/p\u003e \u003cp\u003eEpigenetic Impacts and Terminal Addition 167\u003c\/p\u003e \u003cp\u003ePhysiologic Stress, Vascular Shear Stress, Radical Oxygen Species, and Mutation within Constraints = The Mechanism of Terminal Addition 168\u003c\/p\u003e \u003cp\u003eHomeobox Genes, Colinearity, and Terminal Addition 169\u003c\/p\u003e \u003cp\u003eThe Alveolar Lipofibroblast as Terminal Addition 170\u003c\/p\u003e \u003cp\u003eThe Participation of Glomerular Mesangial Cells 170\u003c\/p\u003e \u003cp\u003ePTHrP Effects on the Anterior Pituitary, Adrenal Cortex, and Adrenal Medulla 171\u003c\/p\u003e \u003cp\u003eCatecholamines, Lung, and Heart Biology 171\u003c\/p\u003e \u003cp\u003eOxytocin, Endothermy, and the Retina 171\u003c\/p\u003e \u003cp\u003eCentral Nervous System 172\u003c\/p\u003e \u003cp\u003eTerminal Addition, “Reverse Evolution,” and Evolutionary Medicine 172\u003c\/p\u003e \u003cp\u003eDiscussion 173\u003c\/p\u003e \u003cp\u003eTerminal Addition: The Fundament of Haeckel’s Biogenetic Law 173\u003c\/p\u003e \u003cp\u003eSomewhere between Gene and Phenotype Lies the Process of Evolution 174\u003c\/p\u003e \u003cp\u003eConclusions 178\u003c\/p\u003e \u003cp\u003eReferences 179\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Phantom Limbs: Imagination and Epigenetics 181\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 181\u003c\/p\u003e \u003cp\u003eIntroduction 181\u003c\/p\u003e \u003cp\u003eBackground to Phantom Limb Sensation 182\u003c\/p\u003e \u003cp\u003eRelevance of Phantom Limb Sensation to Terminal Addition 183\u003c\/p\u003e \u003cp\u003ePhantom Limb Sensation as Non‐Localization 183\u003c\/p\u003e \u003cp\u003eLimbs and Hearts 184\u003c\/p\u003e \u003cp\u003eRelationship of Limbs to Bipedalism and the Evolution of Birds and Mammals 185\u003c\/p\u003e \u003cp\u003eOf Limbs and Consciousness 186\u003c\/p\u003e \u003cp\u003eLife as Fractals 186\u003c\/p\u003e \u003cp\u003eConsciousness, the Epitome of the Continuum from Inanimate to Animate 188\u003c\/p\u003e \u003cp\u003eReferences 188\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Man’s Place in the Universe 191\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 191\u003c\/p\u003e \u003cp\u003eIntroduction 192\u003c\/p\u003e \u003cp\u003eAnthropomorphisms Subvert the Biologic Imperative to Cooperate 193\u003c\/p\u003e \u003cp\u003eEuphysiology 193\u003c\/p\u003e \u003cp\u003eReferences 200\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Evolution, Deception, and Public Health 203\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSummary 203\u003c\/p\u003e \u003cp\u003ePart I. Deception Is Deceiving: The Exception that Proves the Rule 203\u003c\/p\u003e \u003cp\u003eIntroduction 204\u003c\/p\u003e \u003cp\u003eIn the Beginning 204\u003c\/p\u003e \u003cp\u003eEpigenetics and Niche Construction 205\u003c\/p\u003e \u003cp\u003eThe Deception Proves the Rule 205\u003c\/p\u003e \u003cp\u003eOur Own Personal Heliocentrism 206\u003c\/p\u003e \u003cp\u003eDeception and Social Pathology 207\u003c\/p\u003e \u003cp\u003ePhysiologic Stress 208\u003c\/p\u003e \u003cp\u003eAmbiguities in Biology 211\u003c\/p\u003e \u003cp\u003ePart II. Resolution of the Ambiguities by Assimilating the Deception 214\u003c\/p\u003e \u003cp\u003eIntroduction 214\u003c\/p\u003e \u003cp\u003eThe Cell as the First Niche Construction – Self‐Organization Overcomes the Ambiguity 214\u003c\/p\u003e \u003cp\u003eThe Evolution of Endothermy as Internal Niche Construction; or, Self‐Organization Overcomes Biologic Ambiguities 215\u003c\/p\u003e \u003cp\u003eStress‐Induced Evolution of Endothermy by Stepwise Changes in Physiology Predicts Bipedalism, Evolution of the Avian and Hominid Forelimbs, and Higher Consciousness 217\u003c\/p\u003e \u003cp\u003eCold Stress and DRD4–7: Did Risk‐Taking Drive Us Out of Africa? 218\u003c\/p\u003e \u003cp\u003eHow Androgens Act to Reduce Ambiguities of Life 220\u003c\/p\u003e \u003cp\u003eHow Art Seemingly Resolves the Deception of Life 221\u003c\/p\u003e \u003cp\u003eHow Music Resolves the Deception of Life 221\u003c\/p\u003e \u003cp\u003eLiterature (Deceptively) Resolves the Ambiguities of Life 222\u003c\/p\u003e \u003cp\u003eLiturgy Resolves the Ambiguities of Life: Back to the Garden? 222\u003c\/p\u003e \u003cp\u003ePart III. Deception and Public Health 222\u003c\/p\u003e \u003cp\u003eCognitive Dissonance: Scientific Principles, Disease, and Health 223\u003c\/p\u003e \u003cp\u003ePart IV. Prediction: Bioethics Based on First Principles of Physiology 224\u003c\/p\u003e \u003cp\u003eReferences 226\u003c\/p\u003e \u003cp\u003eIndex 227 \u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49406932123991,"sku":"9781118838372","price":99.86,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118838372.jpg?v=1730497600","url":"https:\/\/bookcurl.com\/products\/evidencebased-evolutionary-medicine-9781118838372","provider":"Book Curl","version":"1.0","type":"link"}