{"product_id":"evaluation-of-drug-candidates-for-preclinical-development-9780470044919","title":"Evaluation of Drug Candidates for Preclinical Development","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eEmphasizes the integration of major areas of drug discovery and their importance in candidate evaluation\u003c\/p\u003e \u003cp\u003eIt is believed that selecting the right drug candidate for development is the key to success. In the last decade, pharmaceutical R\u0026amp;D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.\u003c\/p\u003e \u003cp\u003eEncompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical?pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment?this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eCover drug tra\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"This is a useful reference source for those new to, or aspiring to join the pharmaceutical industry, for academics, and for students of pharmacy and pharmaceutical sciences.\" (Chromatographia, 1 December 2010)\u003cbr\u003e\u003cbr\u003e\"In conclusion, the book brings the areas of ADME, toxicology and pharmaceutical science together to describe the approaches used to select safe compounds with the required pharmacokinetic and physiochemical properties for progressing into clinical development\". (British Toxicology Society, Winter 2010)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePREFACE.  \u003c\/p\u003e\n\u003cp\u003eCONTRIBUTORS.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. INTRODUCTION\u003c\/b\u003e \u003ci\u003e(Charles B. Davis).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. PHARMACOKINETICS IN PRECLINICAL DRUG DEVELOPMENT: AN OVERVIEW\u003c\/b\u003e \u003ci\u003e(Dion Brocks).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. THE ROLE OF MEMBRANE TRANSPORTERS IN DRUG DISPOSITION\u003c\/b\u003e \u003ci\u003e(Fanfan Zhou, Peng Duan, and Guofeng You).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. CYTOCHROME P450: STRUCTURE, FUNCTION, AND APPLICATION IN DRUG DISCOVERY AND DEVELOPMENT\u003c\/b\u003e \u003ci\u003e(Ramesh B. Bambal and Stephen E. Clarke).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. THE ROLE OF DRUG METABOLISM AND METABOLITE IDENTIFICATION IN DRUG DISCOVERY\u003c\/b\u003e \u003ci\u003e(Xiangming Guan).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. PROTEIN BINDING IN DRUG DISCOVERY AND DEVELOPMENT\u003c\/b\u003e \u003ci\u003e(Vikram Ramanathan and Nimish Vachharajani).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. PREDICTION OF THE PHARMACOKINETICS IN HUMANS\u003c\/b\u003e \u003ci\u003e(Chao Han and Ramesh Bambal).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. PHARMACEUTICS DEVELOPABILITY ASSESSMENT\u003c\/b\u003e \u003ci\u003e(Lian Huang, Jinquan Dong, and Shyam Karki).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. SAFETY ASSESSMENT IN DRUG DISCOVERY\u003c\/b\u003e \u003ci\u003e(Vito G. Sasseville, William R. Foster, and Bruce D. Car).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. ASSESSMENT OF STRATEGIES UTILIZED TO MINIMIZE THE POTENTIAL FOR INDUCTION OF ACQUIRED LONG QT SYNDROME AND TORSADE DE POINTES\u003c\/b\u003e \u003ci\u003e(Khuram W. Chaudhary and Barry S. Brown).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":53515413487959,"sku":"9780470044919","price":99.86,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/bookcurl.com\/products\/evaluation-of-drug-candidates-for-preclinical-development-9780470044919","provider":"Book Curl","version":"1.0","type":"link"}