{"product_id":"essentials-of-inorganic-chemistry-9780470665589","title":"Essentials of Inorganic Chemistry","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eA comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, \u003ci\u003eEssentials of Inorganic Chemistry\u003c\/i\u003e describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e“It would be a useful adjunct to more general chemistry texts for students in first and second years of study in pharmacy, pharmaceutical sciences, and medicinal chemistry, providing a framework to structure the more detailed but less contextualised information on inorganic pharmaceuticals they will doubtless be looking up on the internet.”  (\u003ci\u003eChemistry in Australia\u003c\/i\u003e, 1 October 2015)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Medicinal inorganic chemistry 1\u003c\/p\u003e \u003cp\u003e1.1.1 Why use metal-based drugs? 2\u003c\/p\u003e \u003cp\u003e1.2 Basic inorganic principles 3\u003c\/p\u003e \u003cp\u003e1.2.1 Electronic structures of atoms 3\u003c\/p\u003e \u003cp\u003e1.2.2 Bonds 9\u003c\/p\u003e \u003cp\u003e1.3 Exercises 17\u003c\/p\u003e \u003cp\u003eReferences 18\u003c\/p\u003e \u003cp\u003eFurther Reading 18\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Alkali Metals 19\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Alkali metal ions 19\u003c\/p\u003e \u003cp\u003e2.1.1 Extraction of alkali metals: an introduction to redox chemistry 20\u003c\/p\u003e \u003cp\u003e2.1.2 Excursus: reduction – oxidation reactions 21\u003c\/p\u003e \u003cp\u003e2.1.3 Chemical behaviour of alkali metals 27\u003c\/p\u003e \u003cp\u003e2.2 Advantages and disadvantages using lithium-based drugs 29\u003c\/p\u003e \u003cp\u003e2.2.1 Isotopes of lithium and their medicinal application 29\u003c\/p\u003e \u003cp\u003e2.2.2 Historical developments in lithium-based drugs 29\u003c\/p\u003e \u003cp\u003e2.2.3 The biology of lithium and its medicinal application 30\u003c\/p\u003e \u003cp\u003e2.2.4 Excursus: diagonal relationship and periodicity 31\u003c\/p\u003e \u003cp\u003e2.2.5 What are the pharmacological targets of lithium? 33\u003c\/p\u003e \u003cp\u003e2.2.6 Adverse effects and toxicity 34\u003c\/p\u003e \u003cp\u003e2.3 Sodium: an essential ion in the human body 34\u003c\/p\u003e \u003cp\u003e2.3.1 Osmosis 35\u003c\/p\u003e \u003cp\u003e2.3.2 Active transport of sodium ions 37\u003c\/p\u003e \u003cp\u003e2.3.3 Drugs, diet and toxicity 38\u003c\/p\u003e \u003cp\u003e2.4 Potassium and its clinical application 40\u003c\/p\u003e \u003cp\u003e2.4.1 Biological importance of potassium ions in the human body – action potential 40\u003c\/p\u003e \u003cp\u003e2.4.2 Excursus: the Nernst equation 40\u003c\/p\u003e \u003cp\u003e2.4.3 Potassium salts and their clinical application: hypokalaemia 42\u003c\/p\u003e \u003cp\u003e2.4.4 Adverse effects and toxicity: hyperkalaemia 43\u003c\/p\u003e \u003cp\u003e2.5 Exercises 45\u003c\/p\u003e \u003cp\u003e2.6 Case studies 47\u003c\/p\u003e \u003cp\u003e2.6.1 Lithium carbonate (Li\u003csub\u003e2\u003c\/sub\u003eCO\u003csub\u003e3\u003c\/sub\u003e) tablets 47\u003c\/p\u003e \u003cp\u003e2.6.2 Sodium chloride eye drops 47\u003c\/p\u003e \u003cp\u003eReferences 48\u003c\/p\u003e \u003cp\u003eFurther Reading 48\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Alkaline Earth Metals 49\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Earth alkaline metal ions 49\u003c\/p\u003e \u003cp\u003e3.1.1 Major uses and extraction 50\u003c\/p\u003e \u003cp\u003e3.1.2 Chemical properties 51\u003c\/p\u003e \u003cp\u003e3.2 Beryllium and chronic beryllium disease 52\u003c\/p\u003e \u003cp\u003e3.3 Magnesium: competition to lithium? 53\u003c\/p\u003e \u003cp\u003e3.3.1 Biological importance 53\u003c\/p\u003e \u003cp\u003e3.3.2 Clinical applications and preparations 54\u003c\/p\u003e \u003cp\u003e3.4 Calcium: the key to many human functions 55\u003c\/p\u003e \u003cp\u003e3.4.1 Biological importance 56\u003c\/p\u003e \u003cp\u003e3.4.2 How does dietary calcium intake influence our lives? 57\u003c\/p\u003e \u003cp\u003e3.4.3 Calcium deficiency: osteoporosis, hypertension and weight management 57\u003c\/p\u003e \u003cp\u003e3.4.4 Renal osteodystrophy 58\u003c\/p\u003e \u003cp\u003e3.4.5 Kidney stones 59\u003c\/p\u003e \u003cp\u003e3.4.6 Clinical application 59\u003c\/p\u003e \u003cp\u003e3.4.7 Side effects 61\u003c\/p\u003e \u003cp\u003e3.5 Barium: rat poison or radio-contrast agent? 61\u003c\/p\u003e \u003cp\u003e3.6 Exercises 63\u003c\/p\u003e \u003cp\u003e3.7 Case studies 65\u003c\/p\u003e \u003cp\u003e3.7.1 Magnesium hydroxide suspension 65\u003c\/p\u003e \u003cp\u003e3.7.2 Calcium carbonate tablets 65\u003c\/p\u003e \u003cp\u003eReferences 66\u003c\/p\u003e \u003cp\u003eFurther Reading 66\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The Boron Group – Group 13 67\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 General chemistry of group 13 elements 67\u003c\/p\u003e \u003cp\u003e4.1.1 Extraction 68\u003c\/p\u003e \u003cp\u003e4.1.2 Chemical properties 69\u003c\/p\u003e \u003cp\u003e4.2 Boron 70\u003c\/p\u003e \u003cp\u003e4.2.1 Introduction 70\u003c\/p\u003e \u003cp\u003e4.2.2 Pharmaceutical applications of boric acid 71\u003c\/p\u003e \u003cp\u003e4.2.3 Bortezomib 71\u003c\/p\u003e \u003cp\u003e4.3 Aluminium 71\u003c\/p\u003e \u003cp\u003e4.3.1 Introduction 71\u003c\/p\u003e \u003cp\u003e4.3.2 Biological importance 72\u003c\/p\u003e \u003cp\u003e4.3.3 Al3+ and its use in water purification 73\u003c\/p\u003e \u003cp\u003e4.3.4 Aluminium-based adjuvants 73\u003c\/p\u003e \u003cp\u003e4.3.5 Antacids 74\u003c\/p\u003e \u003cp\u003e4.3.6 Aluminium-based therapeutics – alginate raft formulations 75\u003c\/p\u003e \u003cp\u003e4.3.7 Phosphate binders 76\u003c\/p\u003e \u003cp\u003e4.3.8 Antiperspirant 76\u003c\/p\u003e \u003cp\u003e4.3.9 Potential aluminium toxicity 77\u003c\/p\u003e \u003cp\u003e4.4 Gallium 77\u003c\/p\u003e \u003cp\u003e4.4.1 Introduction 77\u003c\/p\u003e \u003cp\u003e4.4.2 Chemistry 77\u003c\/p\u003e \u003cp\u003e4.4.3 Pharmacology of gallium-based drugs 78\u003c\/p\u003e \u003cp\u003e4.4.4 Gallium nitrate – multivalent use 78\u003c\/p\u003e \u003cp\u003e4.4.5 Gallium 8-quinolinolate 79\u003c\/p\u003e \u003cp\u003e4.4.6 Gallium maltolate 79\u003c\/p\u003e \u003cp\u003e4.4.7 Toxicity and administration 80\u003c\/p\u003e \u003cp\u003e4.5 Exercises 81\u003c\/p\u003e \u003cp\u003e4.6 Case studies 83\u003c\/p\u003e \u003cp\u003e4.6.1 Boric acid – API analysis 83\u003c\/p\u003e \u003cp\u003e4.6.2 Aluminium hydroxide tablets 83\u003c\/p\u003e \u003cp\u003eReferences 84\u003c\/p\u003e \u003cp\u003eFurther Reading 84\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The Carbon Group 85\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 General chemistry of group 14 elements 85\u003c\/p\u003e \u003cp\u003e5.1.1 Occurrence, extraction and use of group 14 elements 85\u003c\/p\u003e \u003cp\u003e5.1.2 Oxidation states and ionisation energies 87\u003c\/p\u003e \u003cp\u003e5.1.3 Typical compounds of group 14 elements 87\u003c\/p\u003e \u003cp\u003e5.2 Silicon-based drugs versus carbon-based analogues 89\u003c\/p\u003e \u003cp\u003e5.2.1 Introduction of silicon groups 90\u003c\/p\u003e \u003cp\u003e5.2.2 Silicon isosters 91\u003c\/p\u003e \u003cp\u003e5.2.3 Organosilicon drugs 93\u003c\/p\u003e \u003cp\u003e5.3 Organogermanium compounds: balancing act between an anticancer drug and a herbal\u003cbr\u003e supplement 94\u003c\/p\u003e \u003cp\u003e5.3.1 Germanium sesquioxide 95\u003c\/p\u003e \u003cp\u003e5.3.2 Spirogermanium 97\u003c\/p\u003e \u003cp\u003e5.4 Exercises 99\u003c\/p\u003e \u003cp\u003e5.5 Cases studies 101\u003c\/p\u003e \u003cp\u003e5.5.1 Simethicone 101\u003c\/p\u003e \u003cp\u003e5.5.2 Germanium supplements 101\u003c\/p\u003e \u003cp\u003eReferences 102\u003c\/p\u003e \u003cp\u003eFurther Reading 102\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Group 15 Elements 103\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Chemistry of group 15 elements 103\u003c\/p\u003e \u003cp\u003e6.1.1 Occurrence and extraction 103\u003c\/p\u003e \u003cp\u003e6.1.2 Physical properties 104\u003c\/p\u003e \u003cp\u003e6.1.3 Oxidation states and ionisation energy 105\u003c\/p\u003e \u003cp\u003e6.1.4 Chemical properties 106\u003c\/p\u003e \u003cp\u003e6.2 Phosphorus 106\u003c\/p\u003e \u003cp\u003e6.2.1 Adenosine phosphates: ATP, ADP and AMP 107\u003c\/p\u003e \u003cp\u003e6.2.2 Phosphate in DNA 107\u003c\/p\u003e \u003cp\u003e6.2.3 Clinical use of phosphate 108\u003c\/p\u003e \u003cp\u003e6.2.4 Drug interactions and toxicity 112\u003c\/p\u003e \u003cp\u003e6.3 Arsenic 112\u003c\/p\u003e \u003cp\u003e6.3.1 Salvarsan: the magic bullet – the start of chemotherapy 113\u003c\/p\u003e \u003cp\u003e6.3.2 Arsenic trioxide: a modern anticancer drug? 116\u003c\/p\u003e \u003cp\u003e6.4 Exercises 119\u003c\/p\u003e \u003cp\u003e6.5 Case studies 121\u003c\/p\u003e \u003cp\u003e6.5.1 Phosphate solution for rectal use 121\u003c\/p\u003e \u003cp\u003e6.5.2 Forensic test for arsenic 121\u003c\/p\u003e \u003cp\u003eReferences 122\u003c\/p\u003e \u003cp\u003eFurther Reading 122\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Transition Metals and d-Block Metal Chemistry 123\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 What are d-block metals? 123\u003c\/p\u003e \u003cp\u003e7.1.1 Electronic configurations 123\u003c\/p\u003e \u003cp\u003e7.1.2 Characteristic properties 124\u003c\/p\u003e \u003cp\u003e7.1.3 Coordination numbers and geometries 125\u003c\/p\u003e \u003cp\u003e7.1.4 Crystal field theory 129\u003c\/p\u003e \u003cp\u003e7.2 Group 10: platinum anticancer agents 132\u003c\/p\u003e \u003cp\u003e7.2.1 Cisplatin 134\u003c\/p\u003e \u003cp\u003e7.2.2 Platinum anticancer agents 140\u003c\/p\u003e \u003cp\u003e7.3 Iron and ruthenium 147\u003c\/p\u003e \u003cp\u003e7.3.1 Iron 148\u003c\/p\u003e \u003cp\u003e7.3.2 Ruthenium 155\u003c\/p\u003e \u003cp\u003e7.4 The coinage metals 159\u003c\/p\u003e \u003cp\u003e7.4.1 General chemistry 159\u003c\/p\u003e \u003cp\u003e7.4.2 Copper-containing drugs 160\u003c\/p\u003e \u003cp\u003e7.4.3 Silver: the future of antimicrobial agents? 163\u003c\/p\u003e \u003cp\u003e7.4.4 Gold: the fight against rheumatoid arthritis 165\u003c\/p\u003e \u003cp\u003e7.5 Group 12 elements: zinc and its role in biological systems 168\u003c\/p\u003e \u003cp\u003e7.5.1 General chemistry 169\u003c\/p\u003e \u003cp\u003e7.5.2 The role of zinc in biological systems 170\u003c\/p\u003e \u003cp\u003e7.5.3 Zinc: clinical applications and toxicity 173\u003c\/p\u003e \u003cp\u003e7.6 Exercises 177\u003c\/p\u003e \u003cp\u003e7.7 Case studies 179\u003c\/p\u003e \u003cp\u003e7.7.1 Silver nitrate solution 179\u003c\/p\u003e \u003cp\u003e7.7.2 Ferrous sulfate tablets 179\u003c\/p\u003e \u003cp\u003e7.7.3 Zinc sulfate eye drops 180\u003c\/p\u003e \u003cp\u003eReferences 181\u003c\/p\u003e \u003cp\u003eFurther Reading 181\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Organometallic Chemistry 183\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 What is organometallic chemistry? 183\u003c\/p\u003e \u003cp\u003e8.2 What are metallocenes? 185\u003c\/p\u003e \u003cp\u003e8.3 Ferrocene 187\u003c\/p\u003e \u003cp\u003e8.3.1 Ferrocene and its derivatives as biosensors 188\u003c\/p\u003e \u003cp\u003e8.3.2 Ferrocene derivatives as potential antimalarial agent 189\u003c\/p\u003e \u003cp\u003e8.3.3 Ferrocifen – a new promising agent against breast cancer? 191\u003c\/p\u003e \u003cp\u003e8.4 Titanocenes 194\u003c\/p\u003e \u003cp\u003e8.4.1 History of titanium-based anticancer agents: titanocene dichloride and budotitane 195\u003c\/p\u003e \u003cp\u003e8.4.2 Further developments of titanocenes as potential anticancer agents 197\u003c\/p\u003e \u003cp\u003e8.5 Vanadocenes 200\u003c\/p\u003e \u003cp\u003e8.5.1 Vanadocene dichloride as anticancer agents 202\u003c\/p\u003e \u003cp\u003e8.5.2 Further vanadium-based drugs: insulin mimetics 203\u003c\/p\u003e \u003cp\u003e8.6 Exercises 207\u003c\/p\u003e \u003cp\u003e8.7 Case study – titanium dioxide 209\u003c\/p\u003e \u003cp\u003eReferences 210\u003c\/p\u003e \u003cp\u003eFurther Reading 210\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 The Clinical Use of Lanthanoids 211\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Biology and toxicology of lanthanoids 211\u003c\/p\u003e \u003cp\u003e9.2 The clinical use of lanthanum carbonate 213\u003c\/p\u003e \u003cp\u003e9.3 The clinical application of cerium salts 214\u003c\/p\u003e \u003cp\u003e9.4 The use of gadolinium salts as MRI contrast agents 215\u003c\/p\u003e \u003cp\u003e9.5 Exercises 219\u003c\/p\u003e \u003cp\u003e9.6 Case study: lanthanum carbonate tablets 221\u003c\/p\u003e \u003cp\u003eReferences 222\u003c\/p\u003e \u003cp\u003eFurther Reading 222\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Radioactive Compounds and Their Clinical Application 223\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 What is radioactivity? 223\u003c\/p\u003e \u003cp\u003e10.1.1 The atomic structure 223\u003c\/p\u003e \u003cp\u003e10.1.2 Radioactive processes 224\u003c\/p\u003e \u003cp\u003e10.1.3 Radioactive decay 224\u003c\/p\u003e \u003cp\u003e10.1.4 Penetration potential 227\u003c\/p\u003e \u003cp\u003e10.1.5 Quantification of radioactivity 227\u003c\/p\u003e \u003cp\u003e10.2 Radiopharmacy: dispensing and protection 232\u003c\/p\u003e \u003cp\u003e10.3 Therapeutic use of radiopharmaceuticals 233\u003c\/p\u003e \u003cp\u003e10.3.1 \u003csup\u003e131\u003c\/sup\u003eIodine: therapy for hyperthyroidism 233\u003c\/p\u003e \u003cp\u003e10.3.2 \u003csup\u003e89\u003c\/sup\u003eStrontium 234\u003c\/p\u003e \u003cp\u003e10.3.3 Boron neutron capture therapy (BNCT) 235\u003c\/p\u003e \u003cp\u003e10.4 Radiopharmaceuticals for imaging 235\u003c\/p\u003e \u003cp\u003e10.4.1 \u003csup\u003e99m\u003c\/sup\u003eTechnetium 237\u003c\/p\u003e \u003cp\u003e10.4.2 \u003csup\u003e18\u003c\/sup\u003eFluoride: PET scan 240\u003c\/p\u003e \u003cp\u003e10.4.3\u003csup\u003e 67\u003c\/sup\u003eGallium: PET 241\u003c\/p\u003e \u003cp\u003e10.4.4 \u003csup\u003e201\u003c\/sup\u003eThallium 242\u003c\/p\u003e \u003cp\u003e10.5 Exercises 245\u003c\/p\u003e \u003cp\u003e10.6 Case studies 247\u003c\/p\u003e \u003cp\u003e10.6.1 A sample containing \u003csup\u003e99m\u003c\/sup\u003eTc was found to have a radioactivity of 15 mCi at 8 a.m. when the sample was tested. 247\u003c\/p\u003e \u003cp\u003e10.6.2 A typical intravenous dose of \u003csup\u003e99m\u003c\/sup\u003eTc-albumin used for lung imaging contains a radioactivity of 4 mCi 247\u003c\/p\u003e \u003cp\u003e10.6.3 Develop a quick-reference radioactive decay chart for \u003csup\u003e131\u003c\/sup\u003eI 247\u003c\/p\u003e \u003cp\u003eReferences 248\u003c\/p\u003e \u003cp\u003eFurther Reading 248\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Chelation Therapy 249\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 What is heavy-metal poisoning? 249\u003c\/p\u003e \u003cp\u003e11.2 What is chelation? 250\u003c\/p\u003e \u003cp\u003e11.3 Chelation therapy 252\u003c\/p\u003e \u003cp\u003e11.3.1 Calcium disodium edetate 252\u003c\/p\u003e \u003cp\u003e11.3.2 Dimercaprol (BAL) 253\u003c\/p\u003e \u003cp\u003e11.3.3 Dimercaptosuccinic acid (DMSA) 254\u003c\/p\u003e \u003cp\u003e11.3.4 2,3-Dimercapto-1-propanesulfonic acid (DMPS) 254\u003c\/p\u003e \u003cp\u003e11.3.5 Lipoic acid (ALA) 254\u003c\/p\u003e \u003cp\u003e11.4 Exercises 257\u003c\/p\u003e \u003cp\u003e11.5 Case studies 259\u003c\/p\u003e \u003cp\u003e11.5.1 Disodium edetate 259\u003c\/p\u003e \u003cp\u003e11.5.2 Dimercaprol 259\u003c\/p\u003e \u003cp\u003eReferences 261\u003c\/p\u003e \u003cp\u003eFurther Reading 261\u003c\/p\u003e \u003cp\u003eIndex 263\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default 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