{"product_id":"essentials-of-chemical-biology-9781119437970","title":"Essentials of Chemical Biology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eEssentials of Chemical Biology\u003c\/b\u003e \u003cp\u003e\u003cb\u003eDiscover a detailed knowledge of concepts and techniques that shape this unique multi-discipline\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003eChemical Biology is devoted to understanding the way that Biology works at the molecular level. This is a problem-driven multi-discipline, incorporating as it does Organic, Physical, Inorganic, and Analytical Chemistry alongside newer emerging molecular disciplines. In recent years, Chemical Biology has emerged as a vibrant and growing multi-discipline distinct from Biochemistry that is focused on the quantitative analyses of the structures and functions of biological macromolecules and macromolecular lipid assemblies,  at first in isolation, then \u003ci\u003ein vitro\u003c\/i\u003e and \u003ci\u003ein vivo\u003c\/i\u003e. \u003c\/p\u003e\u003cp\u003eThe second edition of the \u003ci\u003eEssentials of Chemical Biology\u003c\/i\u003e begins with a thorough introduction to the structure of biological macromolecules and macromolecular lipid assemblies, before moving on to the principles of chemical and biological synthesis, fo\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003ePreface x\u003c\/p\u003e \u003cp\u003eGlossary of Physical and Chemical Terms xii\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xviii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The Structures of Biological Macromolecules and Lipid Assemblies 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 General introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Protein structures 3\u003c\/p\u003e \u003cp\u003e1.3 Carbohydrate structures 20\u003c\/p\u003e \u003cp\u003e1.4 Nucleic acid structures 31\u003c\/p\u003e \u003cp\u003e1.5 Macromolecular lipid assemblies 53\u003c\/p\u003e \u003cp\u003e1.6 Structural forces in biological macromolecules 60\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Chemical and Biological Synthesis 68\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction to synthesis in chemical biology 68\u003c\/p\u003e \u003cp\u003e2.2 Chemical synthesis of peptides and proteins 68\u003c\/p\u003e \u003cp\u003e2.3 Chemical synthesis of nucleic acids 75\u003c\/p\u003e \u003cp\u003e2.4 Chemical synthesis of oligosaccharides 84\u003c\/p\u003e \u003cp\u003e2.5 Chemical synthesis of lipids 87\u003c\/p\u003e \u003cp\u003e2.6 Biological synthesis of biological macromolecules 89\u003c\/p\u003e \u003cp\u003e2.7 Directed biological synthesis of proteins 97\u003c\/p\u003e \u003cp\u003e2.8 Biological syntheses of nucleic acids, oligosaccharides and lipids 102\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Molecular Biology as a Toolset for Chemical Biology 104\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Key concepts in molecular biology 104\u003c\/p\u003e \u003cp\u003e3.2 Tools and techniques in molecular biology 108\u003c\/p\u003e \u003cp\u003e3.3 Cloning and identification of genes in DNA 117\u003c\/p\u003e \u003cp\u003e3.4 Integrating cloning and expression 123\u003c\/p\u003e \u003cp\u003e3.5 Site-directed mutagenesis 125\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Electronic and Vibrational Spectroscopy 128\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Electronic and vibrational spectroscopy in chemical biology 128\u003c\/p\u003e \u003cp\u003e4.2 Ultraviolet-visible spectroscopy 128\u003c\/p\u003e \u003cp\u003e4.3 Circular dichroism spectroscopy 134\u003c\/p\u003e \u003cp\u003e4.4 Vibrational spectroscopy 138\u003c\/p\u003e \u003cp\u003e4.5 Fluorescence spectroscopy 141\u003c\/p\u003e \u003cp\u003e4.6 Probing metal centres by absorption spectroscopy 163\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Magnetic Resonance 164\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Magnetic resonance in chemical biology 164\u003c\/p\u003e \u003cp\u003e5.2 Key principles of NMR 164\u003c\/p\u003e \u003cp\u003e5.3 Two-dimensional NMR 176\u003c\/p\u003e \u003cp\u003e5.4 Multidimensional NMR 180\u003c\/p\u003e \u003cp\u003e5.5 Biological macromolecule structural information 183\u003c\/p\u003e \u003cp\u003e5.6 Electron paramagnetic resonance spectroscopy: key principles 193\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Diffraction and Microscopy 199\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Diffraction and microscopy in chemical biology 199\u003c\/p\u003e \u003cp\u003e6.2 Key principles of X-ray diffraction 199\u003c\/p\u003e \u003cp\u003e6.3 Structural information from X-ray diffraction 206\u003c\/p\u003e \u003cp\u003e6.4 Neutron diffraction 216\u003c\/p\u003e \u003cp\u003e6.5 Key principles of electron microscopy 217\u003c\/p\u003e \u003cp\u003e6.6 Key principles of scanning probe microscopy 224\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Molecular Recognition and Binding 232\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Molecular recognition and binding in chemical biology 232\u003c\/p\u003e \u003cp\u003e7.2 Theoretical models of binding 245\u003c\/p\u003e \u003cp\u003e7.3 Analysing molecular recognition and binding 251\u003c\/p\u003e \u003cp\u003e7.4 Biological molecular recognition studies 263\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Kinetics and Catalysis 278\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Catalysis in chemical biology 278\u003c\/p\u003e \u003cp\u003e8.2 Steady state kinetic schemes 300\u003c\/p\u003e \u003cp\u003e8.3 Pre-steady-state kinetics 323\u003c\/p\u003e \u003cp\u003e8.4 Theories of biocatalysis 328\u003c\/p\u003e \u003cp\u003e8.5 Electron transfer 346\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Mass Spectrometry and Proteomics 348\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Mass spectrometry in chemical biology 348\u003c\/p\u003e \u003cp\u003e9.2 Key principles in mass spectrometry 349\u003c\/p\u003e \u003cp\u003e9.3 Structural analysis of biological macromolecules and lipids by mass spectrometry 359\u003c\/p\u003e \u003cp\u003e9.4 The challenge of proteomics 368\u003c\/p\u003e \u003cp\u003e9.5 Genomics: assigning function to genes and proteins 375\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Molecular Selection and Evolution 378\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Chemical biology and the origins of life 378\u003c\/p\u003e \u003cp\u003e10.2 Molecular breeding: natural selection acting on self-organisation 383\u003c\/p\u003e \u003cp\u003e10.3 Directed evolution of protein function 385\u003c\/p\u003e \u003cp\u003e10.4 Directed evolution of nucleic acids 390\u003c\/p\u003e \u003cp\u003e10.5 Catalytic antibodies 398\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Chemical Biology of Cells 401\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 General introduction 401\u003c\/p\u003e \u003cp\u003e11.2 Array technologies, microfluidics and miniaturisation 401\u003c\/p\u003e \u003cp\u003e11.3 Chemical genetics and potential new therapeutics 403\u003c\/p\u003e \u003cp\u003e11.4 Chemical cellular dynamics 412\u003c\/p\u003e \u003cp\u003e11.5 Chemical biology and \u003ci\u003ein vivo\u003c\/i\u003e cell connectomics 415\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Chemical Biology of Stem Cells to Tissue Engineering 421\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 General introduction 421\u003c\/p\u003e \u003cp\u003e12.2 Chemical stem cell biology 421\u003c\/p\u003e \u003cp\u003e12.3 The road to cell therapies 437\u003c\/p\u003e \u003cp\u003e12.4 Tissue engineering 439\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Chemical Biology, Nanomedicine and Advanced Therapeutics 441\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 General introduction 441\u003c\/p\u003e \u003cp\u003e13.2 The chemical biology approach to gene therapy 441\u003c\/p\u003e \u003cp\u003e13.3 Biophysical characterisation of LNPs 467\u003c\/p\u003e \u003cp\u003e13.4 Applications of LNPs with small molecule drugs 471\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Chemical Biology and Advanced Diagnostics Leading to Precision Therapeutic Approaches 472\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 General introduction 472\u003c\/p\u003e \u003cp\u003e14.2 MRI basic principles leading to diagnostic applications 472\u003c\/p\u003e \u003cp\u003e14.3 PET\/CT and SPECT fundamentals 477\u003c\/p\u003e \u003cp\u003e14.4 Understanding how to control nanoparticle biodistribution behaviour \u003ci\u003ein vivo\u003c\/i\u003e 478\u003c\/p\u003e \u003cp\u003e14.5 Theranostics 479\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 DNA Nanotechnology 489\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Background 489\u003c\/p\u003e \u003cp\u003e15.2 Three-dimensional DNA nanostructures 491\u003c\/p\u003e \u003cp\u003e15.3 Dynamic DNA nanostructures 496\u003c\/p\u003e \u003cp\u003e15.4 Biomedical applications of DNA nanostructures 500\u003c\/p\u003e \u003cp\u003eBibliography 502\u003c\/p\u003e \u003cp\u003eIndex 519\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49407056838999,"sku":"9781119437970","price":89.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119437970.jpg?v=1730498021","url":"https:\/\/bookcurl.com\/products\/essentials-of-chemical-biology-9781119437970","provider":"Book Curl","version":"1.0","type":"link"}