{"product_id":"enzyme-technologies-9780470286265","title":"Enzyme Technologies","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eHighlighting the critical importance of enzymes in pharmaceutical and biotechnology research,   Enzyme Technologies presents thorough discussions on chemical biology of enzymes, redesigning binding and catalytic specificities of enzymes, and applications of enzymes to biotechnology research in the post-genomic era.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e“The book serves as a valuable desk reference volume and describes well the key concepts of the standard and emerging enzyme technologies that together constitute some of the fundamental principles and knowledge on which drug discovery research is based.”  (\u003ci\u003eChemMedChem\u003c\/i\u003e, 1 August 2015)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eContributors vii\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePreface ix\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart A _Enzymes – essential workhorses in pharmaceutical research 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Assay Technologies for Proteases 3\u003cbr\u003e Anuradha Roy, Gerald H. Lushington, James McGee, and Rathnam Chaguturu\u003c\/p\u003e \u003cp\u003e2 Discovery and Development of Isozyme-Selective Inhibitors Involved in Lipid Metabolism 55\u003cbr\u003e Taichi Ohshiro and Hiroshi Tomoda\u003c\/p\u003e \u003cp\u003e3 Covalent Enzyme Inhibition in Drug Discovery and Development 81\u003cbr\u003e Shujaath Mehdi\u003c\/p\u003e \u003cp\u003e4 Preclinomics: Enzyme Assays and Rodent Models for Metabolic diseases 131\u003cbr\u003e Wu-Kuang Yeh and Richard G. Peterson\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart B _Enzymes – indispensable tools for improving druggability 163\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5 Enzymes and Targeted Activation of Prodrugs 165\u003cbr\u003e Yanhui Yang, Yu Chen, Herve Aloysius, Daigo Inoyama, and Longqin Hu\u003c\/p\u003e \u003cp\u003e6 Evolution of an Orally Active Prodrug of Gemcitabine 237\u003cbr\u003e James R. McCarthy\u003c\/p\u003e \u003cp\u003e7 Enzymatically Activated Phosphate and Phosphonate Prodrugs 253\u003cbr\u003e Ivan S. Krylov and Charles E. McKenna\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart C E nzymes – powerful weapons for correcting Nature’s errors 301\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Treatment Options for Mucopolysaccharidosis Type II (Hunter’s Syndrome) 303\u003cbr\u003e Michael Beck\u003c\/p\u003e \u003cp\u003e9 Enzyme Replacement Therapy for Fabry Disease 321\u003cbr\u003e Ley Nadine Lacbawan, Wei Zheng, and Ozlem Goker-Alpan\u003c\/p\u003e \u003cp\u003e10 Methods and Principles of Pancreatic Function Tests 335\u003cbr\u003e Henrike von Schassen, Jutta Keller, and Peter Layer\u003c\/p\u003e \u003cp\u003eIndex 341\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402313146711,"sku":"9780470286265","price":125.06,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470286265.jpg?v=1730480034","url":"https:\/\/bookcurl.com\/products\/enzyme-technologies-9780470286265","provider":"Book Curl","version":"1.0","type":"link"}