{"product_id":"engineering-the-genetic-code-expanding-the-amino-acid-repertoire-for-the-design-of-novel-proteins-9783527312436","title":"Engineering the Genetic Code: Expanding the Amino Acid Repertoire for the Design of Novel Proteins","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe ability to introduce non-canonical amino acids in vivo has greatly expanded the repertoire of accessible proteins for basic research and biotechnological application.\u003cbr\u003e Here, the different methods and strategies to incorporate new or modified amino acids are explained in detail, including a lot of practical advice for first-time users of this powerful technique.\u003cbr\u003e Novel applications in protein biochemistry, genomics, biotechnology and biomedicine made possible by the expansion of the genetic code are discussed and numerous examples are given.\u003cbr\u003e Essential reading for all molecular life scientists who want to stay ahead in their research.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"In his book, Nediljko Budisa covers this highly interdisciplinary field and allows people not directly involved in protein engineering to get acquainted and up-to-date with the most recent and exciting developments. The book, which is the first of its kind dedicated entirely to this area of research, provides a comprehensive overview of the field. The book comprises seven chapters and has a clear structure supported by a multitude of fine illustrations, thus making the book a good read for those interested in protein engineering. ... Moreover, an excellent update on protein translation in general is given, which is useful for students and newcomers in the field. (...) The book provides an excellent introduction for first-time readers to the field of genetic-code engineering and, as stated on the back of the book, this is 'essential reading to all molecular life scientists who want to stay ahead in their research'.\" ChemBioChem \u003cbr\u003e \u003cbr\u003e \"The numerous examples illustrate the new prospects that are opened up by genetic code engineering. We can expect novel proteins with properties that cannot be foreseen in detail, when one considers that, even for polypeptides based on the 20 proteinogenic amino acids, the rules of folding are still not known.\"\u003cbr\u003e Angewandte Chemie International Edition\u003cbr\u003e \u003cbr\u003e \u003cbr\u003e\u003cbr\u003e\"...besticht das Buch durch seine terminologische Klarheit und transdisziplinäre Kompetenz. Es dürfte ein Gewinn sein sowohl für Interessierte an aktuellen Methoden der Molekularbiologie als auch für jene, die von der Wandelbarkeit des \"universellen\" genetischen Codes einfach fasziniert sind.\"\u003cbr\u003e Nachrichten aus der Chemie\u003cbr\u003e \u003cbr\u003e \"Die umfangreiche Zahl der Beispiele belegt die neue Dimension, die das Code-Engineering erschließt. Wir können neuartige Proteine mit nicht vorhersehbaren Eigenschaften erwarten, zumal schon für Polypeptide mit den 20 proteinogenen Aminosäuren der Faltungscode ungelöst ist. Aber auch Fragen zu neuen Einsatzfeldern in Technik und Pharmakologie, zur Evolution des genetischen Codes und zur Ethik der tiefgreifenden Veränderungen, die das Code-Engineering ermöglicht, werden behandelt.\"\u003cbr\u003e Angewandte Chemie\u003cbr\u003e \u003cbr\u003e \"Wer sich über diese brisante Materie informieren möchte, ist mit dem konkurrenzlosen Standardwerk von Budisa exzellent beraten.\"\u003cbr\u003e Das Science Fiction Jahr - Wissenschaftsbücher 2005\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eINTRODUCTION\u003cbr\u003e Classical Approaches for Protein Modification\u003cbr\u003e Protein Total Synthesis\u003cbr\u003e Basic Definitions and Taxonomy\u003cbr\u003e HISTORY OF AN EXPANDED AMINO ACID REPERTOIRE\u003cbr\u003e Cell-free Synthesis of Proteins\u003cbr\u003e Noncanonical Amino Acids as Tools for Studying Metabolism\u003cbr\u003e Genetic Code Engineering\u003cbr\u003e BASIC FEATURES OF THE CELLULAR TRANSLATION APPARATUS\u003cbr\u003e Ribosome-mediated Protein Synthesis\u003cbr\u003e tRNAs and tRNA Synthetases\u003cbr\u003e Translational Proofreading\u003cbr\u003e Ribosomal Decoding, Codon Bias and Translational Fidelity\u003cbr\u003e Context-dependent Recoding\u003cbr\u003e Post-translational Modifications\u003cbr\u003e GENETIC CODE ORGANISATION AND PROTEIN STRUCTURE\u003cbr\u003e The Universal Genetic Code\u003cbr\u003e Natural Variations in Codon Assignment\u003cbr\u003e Codon Reassignment and Codon Ambiguity\u003cbr\u003e REPROGRAMMING THE CELLULAR TRANSLATION MACHINERY\u003cbr\u003e Enzyme Specificity and Code Interpretation\u003cbr\u003e Reassigning Coding and Non-Coding Units\u003cbr\u003e In vitro Chemical and Enzymatic tRNA Aminoacylation\u003cbr\u003e Novel Codon-Anticodon Base Pairs\u003cbr\u003e Stop Codon Takover\u003cbr\u003e Suppression-Based Methods\u003cbr\u003e Future Approaches\u003cbr\u003e IMPLICATIONS AND INSIGHTS\u003cbr\u003e Evolution of the Amino Acid Repertoire\u003cbr\u003e Artificial Genetic Systems\u003cbr\u003e De novo Design of Organisms\u003cbr\u003e Chances and Risks\u003cbr\u003e APPLICATIONS FOR REPROGRAMMED CELLULAR TRANSLATION\u003cbr\u003e Genetically Encoded Protein Surface Diversity\u003cbr\u003e Applications in Structural Biology\u003cbr\u003e Atomic Mutations\u003cbr\u003e Protein Folding, Stability and Design\u003cbr\u003e Tailoring Protein Spectroscopy\u003cbr\u003e Protein-based Sensors\u003cbr\u003e Applications in Biomedicine\u003cbr\u003e Noncanonical Amino Acids with Neurological Activity","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":53196945817943,"sku":"9783527312436","price":179.96,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/bookcurl.com\/products\/engineering-the-genetic-code-expanding-the-amino-acid-repertoire-for-the-design-of-novel-proteins-9783527312436","provider":"Book Curl","version":"1.0","type":"link"}