{"product_id":"ectoparasites-drug-discovery-against-moving-targets-9783527341689","title":"Ectoparasites: Drug Discovery Against Moving Targets","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities.\u003cbr\u003e Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance,  screening and drug evaluation, and the new isoxazoline class of ectoparasiticides.  The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eList of Contributors VII\u003c\/p\u003e \u003cp\u003eForeword XIII\u003c\/p\u003e \u003cp\u003ePreface XV\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart One Strategies \u0026amp; Resistance 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Comparison of Anti‐ectoparasite and Anti‐endoparasite Therapies and Control Strategies 3\u003ci\u003e\u003cbr\u003eDebra J. Woods*, Tom L. McTier, and Andrew A. DeRosa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 vaccination Against Ticks 25\u003cbr\u003e\u003ci\u003eTheo P.M. Schetters*\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Blocking Transmission of vector‐borne Diseases  43\u003cbr\u003e\u003ci\u003eSandra Schorderet‐Weber, Sandra Noack, Paul M. Selzer, and Ronald Kaminsky*\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 The Threat and Reality of Drug Resistance in the Cattle Tick Rhipicephalus (Boophilus) microplus  95\u003cbr\u003e\u003ci\u003eHeinz Sager*, Léonore Lovis, Christian Epe, and Ronald Kaminsky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Monitoring Drug Sensitivity in Cattle Ticks 109\u003cbr\u003e\u003ci\u003eLeonore Lovis, Christian Epe, Ronald Kaminsky, and Heinz Sager*\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 New Developments in the Control of Human Lice 119\u003cbr\u003e\u003ci\u003eJohn M. Clark*\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Two Screens \u0026amp; Models 139\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7 Molecular Targets to Impair Blood Meal Processing in Ticks 141\u003cbr\u003e\u003ci\u003ePetr Kopáček*, Jan Perner, Daniel Sojka, Radek Šíma, and Ondřej Hajdušek\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Whole‐organism Screens for Ectoparasites 167\u003cbr\u003e\u003ci\u003eJeffrey N. Clark* and Cedric J. Pearce\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 In vitro Feeding Methods for Hematophagous Arthropods and Their Application in Drug Discovery 187\u003cbr\u003e\u003ci\u003eArd M. Nijhof* and Katharine R. Tyson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Testing in Laboratory Animal Models for Ectoparasiticide Discovery and Development 205\u003cbr\u003e\u003ci\u003eSandra Schorderet‐Weber* and Ronald Kaminsky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Testing in Target Hosts for Ectoparasiticide Discovery and Development 223\u003cbr\u003e\u003ci\u003eJeffrey N. Clark*\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Three Isoxazolines 243\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12 Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites 245\u003cbr\u003e\u003ci\u003eTina Weber and Paul M. Selzer*\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 The Discovery of Afoxolaner: A New Ectoparasiticide for Dogs  259\u003cbr\u003e\u003ci\u003eMing Xu, Jeffrey K. Long, George P. Lahm*, Wesley L. Shoop, Daniel Cordova, Ty Wagerle, Ben K. Smith, Thomas F. Pahutski, Rafael Shapiro, Michael Mahaffey, Eric J. Hartline, Brandon R. Gould, Molly E. Waddell, Richard G. McDowell, John B. Kinney, Gail S. Jones, Robert F. Dietrich, Mark E. Schroeder, Daniel F. Rhoades, Eric A. Benner, and Pat N. Confalone\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Development of Afoxolaner as a New Ectoparasiticide for Dogs 273\u003cbr\u003e\u003ci\u003eLaura Letendre*, Diane Larsen, and Mark Soll\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Discovery, Development, and Commercialization of Sarolaner (Simparica\u003csup\u003e®\u003c\/sup\u003e), A Novel Oral Isoxazoline Ectoparasiticide for Dogs 295\u003cbr\u003e\u003ci\u003eDebra J. Woods* and Tom L. McTier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Isoxazolines: Preeminent Ectoparasiticides of the Early Twenty‐first Century 319\u003cbr\u003e\u003ci\u003eAlan Long*\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 353\u003c\/p\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":53196949553495,"sku":"9783527341689","price":125.35,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/ectoparasites-drug-discovery-against-moving-targets-9783527341689","provider":"Book Curl","version":"1.0","type":"link"}