{"product_id":"drugreceptor-thermodynamics-introduction-and-applications-life-sciences-9780471720423","title":"Drugreceptor Thermodynamics Introduction and Applications Life Sciences","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDrug-Receptor Thermodynamics is the first book to provide in depth coverage of principles and applications of thermodynamic drug-receptor interactions. The book starts from familiar points, making thermodynamics accessible to anyone interested in how drugs work. The ideas presented cover general principles as well as laying the groundwork for new ways of examining drug action.\u003cbr\u003e * covers an area of increasing interest and relevance in the field of drug design and discovery\u003cbr\u003e * excellent explanation of why thermodynamics is at the heart of drug action\u003cbr\u003e * contributions from many of the worlds leading experts in the field\u003cbr\u003e Anyone interested in drug receptor interaction will find something of use in this book. It will be of particular relevance for pharmacologists, health science researchers and medicinal chemists.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eContributors.\u003cbr\u003e \u003cbr\u003e Foreword (R. Tallarida).\u003cbr\u003e \u003cbr\u003e Preface.\u003cbr\u003e \u003cbr\u003e PRINCIPLES.\u003cbr\u003e \u003cbr\u003e Introduction: On the Relevance of Thermodynamics to Pharmacology (R. Raffa).\u003cbr\u003e \u003cbr\u003e Mathematical Models of the Drug--Receptor Interaction: Theory of Drug Action (R. Tallarida).\u003cbr\u003e Thermodynamic Concepts: Evolution and Applications (I. Klotz).\u003cbr\u003e \u003cbr\u003e A Brief History of Thermodynamics Terminology and Notation (R. Battino).\u003cbr\u003e \u003cbr\u003e General Thermodynamic Definitions and Equations (I. Haq, et al.).\u003cbr\u003e \u003cbr\u003e Thermodynamic Models of Drug--Receptor Interactions: A General Introduction (G. Klebe, et al.).\u003cbr\u003e \u003cbr\u003e Effector--Receptor Interactions: Origin and Development of Energetic Perspectives (I. Klotz).\u003cbr\u003e \u003cbr\u003e Measurement of Drug--Receptor Binding Constants (D. Winzor \u0026amp; W. Sawyer).\u003cbr\u003e \u003cbr\u003e Heat Capacity in Ligand--Receptor Interactions (V. Pliska)\u003cbr\u003e \u003cbr\u003e Early Applications of Thermodynamics to Drug--Receptor Interactions (R. Raffa).\u003cbr\u003e \u003cbr\u003e SPECIFIC APPLICATIONS.\u003cbr\u003e \u003cbr\u003e Thermodynamics of Adenosine (A1 and A2A) Receptor Interactions (P. Borea, et al.).\u003cbr\u003e \u003cbr\u003e Thermodynamics of Benzodiazepine Receptor Interactions (R. Raffa).\u003cbr\u003e Thermodynamics of Catecholamine Receptor Interactions (G. Weiland).\u003cbr\u003e \u003cbr\u003e Thermodynamics of Muscarinic Receptor Interactions (Y. Landry \u0026amp; J.-P. Gies).\u003cbr\u003e \u003cbr\u003e Thermodynamics of Nicotonic Receptor Interactions (H. Arias).\u003cbr\u003e \u003cbr\u003e Thermodynamics of Ionotropic GABA_A, Glycine and 5-HT_3-type Serotonin Receptor Interactions (G. Maksay).\u003cbr\u003e \u003cbr\u003e Thermodynamics of Opioid Receptor Interactions (R. Raffa).\u003cbr\u003e \u003cbr\u003e Thermodynamics of Serotonin Receptor Interactions (A. Dalpiaz, et al.).\u003cbr\u003e \u003cbr\u003e Thermodynamics and Structural Basis of Insulin Receptor Interactions with Phosphotyrosine Binding Domains (A. Farooq \u0026amp; M. Zhou).\u003cbr\u003e \u003cbr\u003e Thermodynamics of the Visual-pigment System (E. Ito \u0026amp; H. Suzuki).\u003cbr\u003e \u003cbr\u003e Thermodynamics of Protein Modules Involved in Tyrosine Kinase Signaling Pathways (J. Bradshaw, et al.).\u003cbr\u003e \u003cbr\u003e Thermodynamics of Antibody-Fc-receptor Interactions: IgE and FcRI, FCII (R. Ghirlando \u0026amp; H. Gould).\u003cbr\u003e \u003cbr\u003e Metal Ion Binding to the Conantokins: Inhibitors of Ion Channel Opening of the NMDA Receptor (M. Prorok \u0026amp; F. Castellino).\u003cbr\u003e \u003cbr\u003e METHODS\/ADVANCED CONCEPTS.\u003cbr\u003e \u003cbr\u003e Direct Method for the Determination of Thermodynamic Quantities (R. O'Brien, et al.).\u003cbr\u003e \u003cbr\u003e Enthalpy--Entropy Compensation and Solvent Reorganization (E. Grunwald).\u003cbr\u003e \u003cbr\u003e Basics of Correlations: Relevance to Enthalpy--Entropy Compensation (R. Raffa \u0026amp; R. Tallarida).\u003cbr\u003e \u003cbr\u003e Thermodynamic Maps of Receptor--Ligand Pairs Reveal How Some Proteins Bind (C. Camacho, et al.).\u003cbr\u003e \u003cbr\u003e Thermodynamic Distributions of Heterogeneous Receptor Populations (M. José \u0026amp; J. José).\u003cbr\u003e \u003cbr\u003e Protein-Ligand Docking as an Energy Optimization Problem (M. Totrov \u0026amp; R. Abagyan).\u003cbr\u003e \u003cbr\u003e Prediction of Ligand--Receptor Binding Thermodynamics by Free Energy Force Field (FEFF) 3D-QSAR Analysis (J. Tokarski).\u003cbr\u003e \u003cbr\u003e Hydrophobic Mode-targeted, Algorithmically Designed Peptide Ligands as Modulators of Protein Thermodynamic Structure and Function (A. Mandell, et al.).\u003cbr\u003e \u003cbr\u003e Non-equilibrium Thermodynamics and Kinetics of the Multidrug Transporter (S. Caplan \u0026amp; R. Johnstone).\u003cbr\u003e \u003cbr\u003e Convergence of Recombinant Mutagenesis and Kinetics Interaction Analysis for Revealing Receptor Recognition Mechanisms and Designing Receptor Ligands (I. Chaiken, et al.).\u003cbr\u003e \u003cbr\u003e Index.","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":53515431936343,"sku":"9780471720423","price":432.86,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/bookcurl.com\/products\/drugreceptor-thermodynamics-introduction-and-applications-life-sciences-9780471720423","provider":"Book Curl","version":"1.0","type":"link"}