{"product_id":"drug-metabolism-basic-concepts-and-practice-9780471733133","title":"Drug Metabolism Basic Concepts and Practice","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDrug Metabolism in Drug Design and Development  provides a practical description of what happens during the drug design and development process and focuses on issues such as: what data are needed; what experiments and analytical methods are typically employed; and how to interpret and apply data.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"I highly recommend this book to anyone interested in drug metabolism.\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, 2008)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface.  \u003cp\u003eContributors.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I: Basic Concepts of Drug Metabolism.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1. Overview: Drug Metabolism in the Modern Pharmaceutical Industry (Scott J. Grossman)\u003c\/p\u003e \u003cp\u003e2. Oxidative, Reductive, and Hydrolytic Metabolism of Drugs (F. Peter Guengerich)\u003c\/p\u003e \u003cp\u003e3. Conjugative Metabolism of Drugs (Rory Remmel, Swati Nagar and Upendra Argikar)\u003c\/p\u003e \u003cp\u003e4. Enzyme Kinetics (Timothy S. Tracy)\u003c\/p\u003e \u003cp\u003e5. Metabolism-Mediated Drug-Drug Interactions (Hongjian Zhang, Michael W. Sinz, and A. David Rodrigues)\u003c\/p\u003e \u003cp\u003e6. Drug Transporters in Drug Disposition, Drug Interactions, and Drug Resistance (Cindy Q. Xia, Johnny J. Yang, and Suresh K. balani)\u003c\/p\u003e \u003cp\u003e7. Regulatory Considerations of Drug Metabolism and Drug Interaction Studies (Xiaoxiong Wei and Mingshe Zhu)\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Role of Drug Metabolism in the Pharmaceutical Industry.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8. Drug Metabolism Research as an Integral Part of the Drug Discovery Process (W. Griffith Humphreys)\u003c\/p\u003e \u003cp\u003e9. Role of Drug Metabosim in Drug Development (Ramaswamy Iyer and Donglu Zhang)\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: Analytical techniques in Drug Metabolism.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10. Applications of Liquid Radiochromatography Techniques in Drug Metabolism Studies (Mingshe Zhu, Weiping Zhao, and W. Griffith Humphreys)\u003c\/p\u003e \u003cp\u003e11. Application of Liquid Chromatogrpahy\/Mass Spectrometry for Metabolite Identification (Shuguang Ma and Swapan K. Chowdhury)\u003c\/p\u003e \u003cp\u003e12. Introductin to NMR and Its Application in Metabolite Structure Determination (Xiaohua Huang, Robert Powers, Adrienne Tymiak, Robert Espina, and Vikram Roongta)\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV: Common Experimental Approaches and Protocols.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13. Determination of Metabolic Rats and Enzyme Kinetics (Zhi-Yi Zhang and Laurence S. Kaminsky)\u003c\/p\u003e \u003cp\u003e14. Protocols for Assessment of In vitro and In vivo Bioactivation Potential of Drug Candidates (Zhoupeng Zhang and Jinping Gan)\u003c\/p\u003e \u003cp\u003e15. Reaction Phenotyping (Susan Hurst, J. Andrew Williams, and Steven Hansel)\u003c\/p\u003e \u003cp\u003e16. Analysis of In vitro Cytochrome P450 Inhibition in Drug Discovery and Development (Magang Shou and Renke Dai)\u003c\/p\u003e \u003cp\u003e17. Testing Drug Candidates for CYP3A4 Induction (Gang Luo, Liang-Shang Gan, and Thomas M. Guenthner)\u003c\/p\u003e \u003cp\u003e18. ADME Studies in Animals and Humans: Experimental Design, Metabolite Profoling and Identification, and Data Presentation (Donglu Zhang and S. Nilgun Comezoglu)\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402663895383,"sku":"9780471733133","price":128.66,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471733133.jpg?v=1730481161","url":"https:\/\/bookcurl.com\/products\/drug-metabolism-basic-concepts-and-practice-9780471733133","provider":"Book Curl","version":"1.0","type":"link"}