{"product_id":"dna-in-supramolecular-chemistry-and-nanotechnology-9781118696866","title":"DNA in Supramolecular Chemistry and Nanotechnology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eList of Contributors xv \u003cp\u003ePreface xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I (Non-) Covalently Modified DNA with Novel Functions 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 DNA-Based Construction of Molecular Photonic Devices 3\u003c\/p\u003e \u003cp\u003e1.1.1 Introduction 3\u003c\/p\u003e \u003cp\u003e1.1.2 Using DNA as a template to construct discrete optoelectronic nanostructures 5\u003c\/p\u003e \u003cp\u003e1.1.3 Assembly of photonic arrays based on the molecular recognition of single-stranded DNA templates 7\u003c\/p\u003e \u003cp\u003e1.1.4 Assembly of photonic arrays based on the molecular recognition of double-stranded DNA templates 10\u003c\/p\u003e \u003cp\u003e1.1.5 Towards the construction of photonic devices 13\u003c\/p\u003e \u003cp\u003e1.1.6 Outlook 13\u003c\/p\u003e \u003cp\u003eReferences 15\u003c\/p\u003e \u003cp\u003e1.2 π-Conjugated DNA Binders: Optoelectronics, Molecular Diagnostics and Therapeutics 22\u003c\/p\u003e \u003cp\u003e1.2.1 π-Conjugated compounds 22\u003c\/p\u003e \u003cp\u003e1.2.2 DNA binders for different applications 23\u003c\/p\u003e \u003cp\u003e1.2.3 Targeting duplex DNA 27\u003c\/p\u003e \u003cp\u003e1.2.4 Examples of π-conjugated compounds interacting with hybrid duplexes and higher order nucleic acid structures 32\u003c\/p\u003e \u003cp\u003e1.2.5 Conclusions 33\u003c\/p\u003e \u003cp\u003eReferences 34\u003c\/p\u003e \u003cp\u003e1.3 Metal Ion- and Perylene Diimide-Mediated DNA Architectures 38\u003c\/p\u003e \u003cp\u003e1.3.1 Introduction 38\u003c\/p\u003e \u003cp\u003e1.3.2 Metal ion complexes as DNA modifications: hydroquinoline and terpyridine 39\u003c\/p\u003e \u003cp\u003e1.3.3 Perylene diimide-based DNA architectures 42\u003c\/p\u003e \u003cp\u003e1.3.4 Conclusions 49\u003c\/p\u003e \u003cp\u003eReferences 49\u003c\/p\u003e \u003cp\u003e1.4 DNA with Metal-Mediated Base Pairs 52\u003c\/p\u003e \u003cp\u003e1.4.1 Introduction 52\u003c\/p\u003e \u003cp\u003e1.4.2 Metal-mediated base pairs with natural nucleobases 53\u003c\/p\u003e \u003cp\u003e1.4.3 Metal-mediated base pairs with artificial nucleobases 54\u003c\/p\u003e \u003cp\u003e1.4.4 Outlook 61\u003c\/p\u003e \u003cp\u003eReferences 61\u003c\/p\u003e \u003cp\u003e1.5 Metal-Aided Construction of Unusual DNA Structural Motifs 65\u003c\/p\u003e \u003cp\u003e1.5.1 Introduction 65\u003c\/p\u003e \u003cp\u003e1.5.2 DNA duplexes containing metal-mediated base pairs 66\u003c\/p\u003e \u003cp\u003e1.5.3 Metal-aided formation of triple-stranded structures 69\u003c\/p\u003e \u003cp\u003e1.5.4 Metal-aided formation of four-stranded structures 71\u003c\/p\u003e \u003cp\u003e1.5.5 Metal-aided formation of DNA junction structures 73\u003c\/p\u003e \u003cp\u003e1.5.6 Summary and outlook 75\u003c\/p\u003e \u003cp\u003eReferences 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II DNA Wires and Electron Transport Through DNA 79\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Gating Electrical Transport Through DNA 81\u003c\/p\u003e \u003cp\u003e2.1.1 Introduction 81\u003c\/p\u003e \u003cp\u003e2.1.2 DNA structure 82\u003c\/p\u003e \u003cp\u003e2.1.3 Direct electrical measurements of DNA 82\u003c\/p\u003e \u003cp\u003e2.1.4 Gate modulation of current flow in DNA 84\u003c\/p\u003e \u003cp\u003e2.1.5 DNA transistors 86\u003c\/p\u003e \u003cp\u003e2.1.6 Summary and outlook 92\u003c\/p\u003e \u003cp\u003eReferences 92\u003c\/p\u003e \u003cp\u003e2.2 Electrical Conductance of DNA Oligomers — A Review of Experimental Results 94\u003c\/p\u003e \u003cp\u003e2.2.1 Introduction 94\u003c\/p\u003e \u003cp\u003e2.2.2 DNA structures 95\u003c\/p\u003e \u003cp\u003e2.2.3 Scanning probe microscopy 95\u003c\/p\u003e \u003cp\u003e2.2.4 Lithographically defined junctions 98\u003c\/p\u003e \u003cp\u003e2.2.5 Conclusions 101\u003c\/p\u003e \u003cp\u003eReferences 102\u003c\/p\u003e \u003cp\u003e2.3 DNA Sensors Using DNA Charge Transport Chemistry 105\u003c\/p\u003e \u003cp\u003e2.3.1 Introduction 105\u003c\/p\u003e \u003cp\u003e2.3.2 DNA-functionalized electrochemical sensors 107\u003c\/p\u003e \u003cp\u003e2.3.3 Detection of DNA-binding proteins 111\u003c\/p\u003e \u003cp\u003e2.3.4 DNA CT within the cell 115\u003c\/p\u003e \u003cp\u003e2.3.5 Conclusions 117\u003c\/p\u003e \u003cp\u003eAcknowledgements 117\u003c\/p\u003e \u003cp\u003eReferences 117\u003c\/p\u003e \u003cp\u003e2.4 Charge Transfer in Non-B DNA with a Tetraplex Structure 121\u003c\/p\u003e \u003cp\u003e2.4.1 Introduction 121\u003c\/p\u003e \u003cp\u003e2.4.2 CT in dsDNA (B-DNA) 122\u003c\/p\u003e \u003cp\u003e2.4.3 CT in non-B DNA with a tetraplex structure 123\u003c\/p\u003e \u003cp\u003e2.4.4 Conclusions 132\u003c\/p\u003e \u003cp\u003eAcknowledgments 132\u003c\/p\u003e \u003cp\u003eReferences 132\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Oligonucleotides in Sensing and Diagnostic Applications 137\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Development of Electrochemical Sensors for DNA Analysis 139\u003c\/p\u003e \u003cp\u003e3.1.1 Introduction 139\u003c\/p\u003e \u003cp\u003e3.1.2 Genosensors based on direct electrocactivity of nucleic bases 140\u003c\/p\u003e \u003cp\u003e3.1.3 Genosensors based on electrochemical mediators 141\u003c\/p\u003e \u003cp\u003e3.1.4 Genosensors based on free diffusional redox markers 142\u003c\/p\u003e \u003cp\u003e3.1.5 Genosensors incorporating DNA probes modified with redox active molecules – ‘signal-off’ and ‘signal-on’ working modes 145\u003c\/p\u003e \u003cp\u003e3.1.6 Genosensors for simultaneous detection of two different DNA targets 151\u003c\/p\u003e \u003cp\u003e3.1.7 Conclusions 154\u003c\/p\u003e \u003cp\u003eAcknowledgements 154\u003c\/p\u003e \u003cp\u003eReferences 154\u003c\/p\u003e \u003cp\u003e3.2 Oligonucleotide Based Artificial Ribonucleases (OBANs) 158\u003c\/p\u003e \u003cp\u003e3.2.1 Introduction 158\u003c\/p\u003e \u003cp\u003e3.2.2 Early development of OBANs 159\u003c\/p\u003e \u003cp\u003e3.2.3 Metal ion based artificial nucleases 159\u003c\/p\u003e \u003cp\u003e3.2.4 Non-metal ion based systems 161\u003c\/p\u003e \u003cp\u003e3.2.5 Creating bulges in the RNA substrate 162\u003c\/p\u003e \u003cp\u003e3.2.6 PNAzymes and creation of artificial RNA restriction enzymes 164\u003c\/p\u003e \u003cp\u003e3.2.7 Conclusions 167\u003c\/p\u003e \u003cp\u003eReferences 168\u003c\/p\u003e \u003cp\u003e3.3 Exploring Nucleic Acid Conformations by Employment of Porphyrin Non-covalent and Covalent Probes and Chiroptical Analysis 172\u003c\/p\u003e \u003cp\u003e3.3.1 Introduction 172\u003c\/p\u003e \u003cp\u003e3.3.2 Non-covalent interaction of porphyrin–DNA complexes 174\u003c\/p\u003e \u003cp\u003e3.3.3 Porphyrins covalently linked to DNA 187\u003c\/p\u003e \u003cp\u003e3.3.4 Conclusions 203\u003c\/p\u003e \u003cp\u003eReferences 203\u003c\/p\u003e \u003cp\u003e3.4 Chemical Reactions Controlled by Nucleic Acids and their Applications for Detection of Nucleic Acids in Live Cells 209\u003c\/p\u003e \u003cp\u003e3.4.1 Introduction 209\u003c\/p\u003e \u003cp\u003e3.4.2 Intracellular nucleic acid targets 211\u003c\/p\u003e \u003cp\u003e3.4.3 Methods for monitoring ribonucleic acids in live cells 211\u003c\/p\u003e \u003cp\u003e3.4.4 Perspectives 225\u003c\/p\u003e \u003cp\u003eReferences 226\u003c\/p\u003e \u003cp\u003e3.5 The Biotechnological Applications of G-Quartets 229\u003c\/p\u003e \u003cp\u003e3.5.1 Introduction 229\u003c\/p\u003e \u003cp\u003e3.5.2 Nucleobases and H-bonds 229\u003c\/p\u003e \u003cp\u003e3.5.3 Duplex-DNA mimics 231\u003c\/p\u003e \u003cp\u003e3.5.4 Guanine and G-quartets 232\u003c\/p\u003e \u003cp\u003e3.5.5 G-Quartets and G-quadruplexes 232\u003c\/p\u003e \u003cp\u003e3.5.6 Quadruplex-DNA mimics 236\u003c\/p\u003e \u003cp\u003e3.5.7 Conclusions 244\u003c\/p\u003e \u003cp\u003eReferences 244\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Conjugation of DNA with Biomolecules and Nanoparticles 247\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Nucleic Acid Controlled Reactions on Large Nucleic Acid Templates 249\u003c\/p\u003e \u003cp\u003e4.1.1 Introduction 249\u003c\/p\u003e \u003cp\u003e4.1.2 Nucleic acid controlled chemical reactions 250\u003c\/p\u003e \u003cp\u003e4.1.3 Applications 257\u003c\/p\u003e \u003cp\u003e4.1.4 Conclusions 268\u003c\/p\u003e \u003cp\u003eReferences 270\u003c\/p\u003e \u003cp\u003e4.2 Lipid Oligonucleotide Bioconjugates: Applications in Medicinal Chemistry 276\u003c\/p\u003e \u003cp\u003e4.2.1 Introduction 276\u003c\/p\u003e \u003cp\u003e4.2.2 Chemical approach to the synthesis of lipid–oligonucleotide conjugates 277\u003c\/p\u003e \u003cp\u003e4.2.3 Biomedical applications 286\u003c\/p\u003e \u003cp\u003e4.2.4 Conclusions 288\u003c\/p\u003e \u003cp\u003eAcknowledgements 289\u003c\/p\u003e \u003cp\u003eReferences 289\u003c\/p\u003e \u003cp\u003e4.3 Amphiphilic Peptidyl–RNA 294\u003c\/p\u003e \u003cp\u003e4.3.1 Introduction 294\u003c\/p\u003e \u003cp\u003e4.3.2 Three souls alas! are dwelling in my breast [2] 295\u003c\/p\u003e \u003cp\u003e4.3.3 Why RNA? Why peptides? 296\u003c\/p\u003e \u003cp\u003e4.3.4 Hydrolysis-resistant amphiphilic 3ʹ-peptidyl–RNA 297\u003c\/p\u003e \u003cp\u003e4.3.5 Synthetic strategy 299\u003c\/p\u003e \u003cp\u003e4.3.6 Pros’n cons 300\u003c\/p\u003e \u003cp\u003e4.3.7 Alternative methods and strategies 302\u003c\/p\u003e \u003cp\u003e4.3.8 Molecular properties 302\u003c\/p\u003e \u003cp\u003e4.3.9 Supramolecular properties 302\u003c\/p\u003e \u003cp\u003e4.3.10 Conclusions and perspectives 304\u003c\/p\u003e \u003cp\u003eAcknowledgements 306\u003c\/p\u003e \u003cp\u003eReferences 306\u003c\/p\u003e \u003cp\u003e4.4 Oligonucleotide-Stabilized Silver Nanoclusters 308\u003c\/p\u003e \u003cp\u003e4.4.1 Introduction 308\u003c\/p\u003e \u003cp\u003e4.4.2 Sensors 311\u003c\/p\u003e \u003cp\u003e4.4.3 DNA computing (logic gates) 321\u003c\/p\u003e \u003cp\u003e4.4.4 Assorted examples 322\u003c\/p\u003e \u003cp\u003e4.4.5 Conclusions 323\u003c\/p\u003e \u003cp\u003eReferences 323\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Alternative DNA Structures, Switches and Nanomachines 329\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Structure and Stabilization of CGC+ Triplex DNA 331\u003c\/p\u003e \u003cp\u003e5.1.1 Introduction 331\u003c\/p\u003e \u003cp\u003e5.1.2 Classification of DNA triplets 332\u003c\/p\u003e \u003cp\u003e5.1.3 Structure of triplexes 332\u003c\/p\u003e \u003cp\u003e5.1.4 Triplex stabilizing factors 334\u003c\/p\u003e \u003cp\u003e5.1.5 Formation of stable CGC+ triplex DNA 337\u003c\/p\u003e \u003cp\u003e5.1.6 Summary 346\u003c\/p\u003e \u003cp\u003eReferences 346\u003c\/p\u003e \u003cp\u003e5.2 Synthetic Molecules as Guides for DNA Nanostructure Formation 353\u003c\/p\u003e \u003cp\u003e5.2.1 Introduction 353\u003c\/p\u003e \u003cp\u003e5.2.2 Covalent insertion of synthetic molecules into DNA 353\u003c\/p\u003e \u003cp\u003e5.2.3 Non-covalently guided DNA assembly 364\u003c\/p\u003e \u003cp\u003e5.2.4 Conclusions 369\u003c\/p\u003e \u003cp\u003eReferences 369\u003c\/p\u003e \u003cp\u003e5.3 DNA-Based Nanostructuring with Branched Oligonucleotide Hybrids 375\u003c\/p\u003e \u003cp\u003e5.3.1 Introduction 375\u003c\/p\u003e \u003cp\u003e5.3.2 Branched oligonucleotides 377\u003c\/p\u003e \u003cp\u003e5.3.3 Hybrids with rigid cores 378\u003c\/p\u003e \u003cp\u003e5.3.4 Second-generation hybrids with a rigid core 382\u003c\/p\u003e \u003cp\u003e5.3.5 Solution-phase syntheses: Synthetic challenges 385\u003c\/p\u003e \u003cp\u003e5.3.6 Hybrid materials 389\u003c\/p\u003e \u003cp\u003e5.3.7 Outlook 392\u003c\/p\u003e \u003cp\u003e5.3.8 Conclusions 394\u003c\/p\u003e \u003cp\u003eAcknowledgements 394\u003c\/p\u003e \u003cp\u003eReferences 394\u003c\/p\u003e \u003cp\u003e5.4 DNA-Controlled Assembly of Soft Nanoparticles 397\u003c\/p\u003e \u003cp\u003e5.4.1 Introduction 397\u003c\/p\u003e \u003cp\u003e5.4.2 Sequence design 399\u003c\/p\u003e \u003cp\u003e5.4.3 Lipid membrane anchors 400\u003c\/p\u003e \u003cp\u003e5.4.4 DNA-controlled assembly studied by UV spectroscopy 402\u003c\/p\u003e \u003cp\u003e5.4.5 Assembly on solid support 406\u003c\/p\u003e \u003cp\u003e5.4.6 Assembly of giant unilamellar liposomes (GUVs) 408\u003c\/p\u003e \u003cp\u003e5.4.7 Conclusions 409\u003c\/p\u003e \u003cp\u003eAcknowledgements 409\u003c\/p\u003e \u003cp\u003eReferences 409\u003c\/p\u003e \u003cp\u003e5.5 Metal Ions in Ribozymes and Riboswitches 412\u003c\/p\u003e \u003cp\u003e5.5.1 Introduction 412\u003c\/p\u003e \u003cp\u003e5.5.2 Coordination chemistry of RNA 413\u003c\/p\u003e \u003cp\u003e5.5.3 Ribozymes 415\u003c\/p\u003e \u003cp\u003e5.5.4 Riboswitches 420\u003c\/p\u003e \u003cp\u003e5.5.5 Summary 425\u003c\/p\u003e \u003cp\u003eAcknowledgement 426\u003c\/p\u003e \u003cp\u003eReferences 426\u003c\/p\u003e \u003cp\u003e5.6 DNA Switches and Machines 434\u003c\/p\u003e \u003cp\u003e5.6.1 Introduction 434\u003c\/p\u003e \u003cp\u003e5.6.2 Ion-stimulated and photonic\/electrical-triggered DNA switches 438\u003c\/p\u003e \u003cp\u003e5.6.3 Switchable DNA machines 447\u003c\/p\u003e \u003cp\u003e5.6.4 Applications of DNA switches and machines 459\u003c\/p\u003e \u003cp\u003e5.6.5 Conclusions and perspectives 466\u003c\/p\u003e \u003cp\u003eReferences 467\u003c\/p\u003e \u003cp\u003e5.7 DNA-Based Asymmetric Catalysis 474\u003c\/p\u003e \u003cp\u003e5.7.1 Introduction 474\u003c\/p\u003e \u003cp\u003e5.7.2 Concept of DNA-based asymmetric catalysis 474\u003c\/p\u003e \u003cp\u003e5.7.3 Design approaches in DNA-based asymmetric catalysis 475\u003c\/p\u003e \u003cp\u003e5.7.4 Covalent anchoring 476\u003c\/p\u003e \u003cp\u003e5.7.5 Supramolecular anchoring 478\u003c\/p\u003e \u003cp\u003e5.7.6 Conclusions and perspectives 488\u003c\/p\u003e \u003cp\u003eReferences 489\u003c\/p\u003e \u003cp\u003eIndex 491\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":53515636670807,"sku":"9781118696866","price":123.26,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/bookcurl.com\/products\/dna-in-supramolecular-chemistry-and-nanotechnology-9781118696866","provider":"Book Curl","version":"1.0","type":"link"}