{"product_id":"diversityoriented-synthesis-9781118145654","title":"DiversityOriented Synthesis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eDiscover an enhanced synthetic approach to developing and screening chemical compound libraries\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDiversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiversity-Oriented Synthesis\u003c\/i\u003e begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eOffers\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eCONTRIBUTORS xv\u003c\/p\u003e \u003cp\u003eFOREWORD xix\u003c\/p\u003e \u003cp\u003ePREFACE xxi\u003c\/p\u003e \u003cp\u003eABBREVIATIONS xxv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The Basics of Diversity-Oriented Synthesis 1\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKieron M. G. O'Connell, Warren R. J. D. Galloway, and David R. Spring\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction, 1\u003c\/p\u003e \u003cp\u003e1.2 What Is Diversity-Oriented Synthesis?, 1\u003c\/p\u003e \u003cp\u003e1.3 Small Molecules and Biology, 2\u003c\/p\u003e \u003cp\u003e1.4 Comparing DOS, TOS, and Combinatorial Chemistry: Focused Library Synthesis, 4\u003c\/p\u003e \u003cp\u003e1.5 Molecular Diversity, 5\u003c\/p\u003e \u003cp\u003e1.6 Molecular Diversity and Chemical Space, 8\u003c\/p\u003e \u003cp\u003e1.7 Synthetic Strategies for Creating Molecular Diversity, 8\u003c\/p\u003e \u003cp\u003e1.8 Reagent-Based Approaches to Diversity Generation, 11\u003c\/p\u003e \u003cp\u003e1.9 Substrate-Based Approach to Skeletal Diversity Generation, 19\u003c\/p\u003e \u003cp\u003e1.10 Other Build\/Couple\/Pair Examples, 19\u003c\/p\u003e \u003cp\u003e1.11 Concluding Remarks, 24\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I CHEMICAL METHODOLOGY IN DIVERSITY-ORIENTED SYNTHESIS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Strategic Applications of Multicomponent Reactions in Diversity-Oriented Synthesis 29\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJohn M. Knapp, Mark J. Kurth, Jared T. Shaw, and Ashkaan Younai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction, 29\u003c\/p\u003e \u003cp\u003e2.2 MCR Products for HTS, 31\u003c\/p\u003e \u003cp\u003e2.3 MCRs as Starting Points for DOS, 39\u003c\/p\u003e \u003cp\u003e2.4 Conclusions, 55\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Cycloaddition Reactions in Diversity-Oriented Synthesis 59\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eGiovanni Muncipinto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction, 59\u003c\/p\u003e \u003cp\u003e3.2 [4+2] Cycloaddition Reactions, 60\u003c\/p\u003e \u003cp\u003e3.3 1,3-Dipolar Cycloaddition Reactions, 70\u003c\/p\u003e \u003cp\u003e3.4 Miscellaneous Cycloadditions, 83\u003c\/p\u003e \u003cp\u003e3.5 Conclusions, 91\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Phosphine Organocatalysis as a Platform for Diversity-Oriented Synthesis 97\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eZhiming Wang and Ohyun Kwon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction, 97\u003c\/p\u003e \u003cp\u003e4.2 DOS Using Phosphine Organocatalysis, 100\u003c\/p\u003e \u003cp\u003e4.3 Skeletal Diversity Based on a Phosphine Catalysis\/Combinatorial Scaffolding Strategy, 116\u003c\/p\u003e \u003cp\u003e4.4 A DOS Library Based on Phosphine Organocatalysis: Biological Screening, Analog Synthesis, and Structure–Activity Relationship Analysis, 121\u003c\/p\u003e \u003cp\u003e4.5 Conclusions, 129\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Domino Reactions in Library Synthesis 135\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMatthew G. LaPorte, John R. Goodell, Sammi Tsegay, and Peter Wipf\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction, 135\u003c\/p\u003e \u003cp\u003e5.2 Pericyclic Domino Reactions, 136\u003c\/p\u003e \u003cp\u003e5.3 Anionic Domino Reactions, 150\u003c\/p\u003e \u003cp\u003e5.4 Transition-Metal-Mediated Domino Reactions, 159\u003c\/p\u003e \u003cp\u003e5.5 Radical Domino Reactions, 165\u003c\/p\u003e \u003cp\u003e5.6 Conclusions, 174\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Diversity-Oriented Synthesis of Amino Acid–Derived Scaffolds and Peptidomimetics: A Perspective 177\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAndrea Trabocchi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction, 177\u003c\/p\u003e \u003cp\u003e6.2 Definition and Classification of Peptidomimetics, 179\u003c\/p\u003e \u003cp\u003e6.3 Early Combinatorial Approaches to Peptidomimetic Scaffolds, 180\u003c\/p\u003e \u003cp\u003e6.4 Amino Acid–Derived Scaffolds, 183\u003c\/p\u003e \u003cp\u003e6.5 Macrocyclic Peptidomimetic Scaffolds, 194\u003c\/p\u003e \u003cp\u003e6.6 Conclusions, 197\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Solid-Phase Synthesis Enabling Chemical Diversity 201\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNadezda Canka¡rova and Viktor Krch¡nak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction, 201\u003c\/p\u003e \u003cp\u003e7.2 Skeletal Diversity, 203\u003c\/p\u003e \u003cp\u003e7.3 Stereochemical Diversity, 234\u003c\/p\u003e \u003cp\u003e7.4 Appendage Diversity, 238\u003c\/p\u003e \u003cp\u003e7.5 Build\/Couple\/Pair Strategy, 239\u003c\/p\u003e \u003cp\u003e7.6 Scaffold Hopping, 243\u003c\/p\u003e \u003cp\u003e7.7 Conclusions, 249\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Macrocycles as Templates for Diversity Generation in Drug Discovery 253\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eEric Marsault\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction, 253\u003c\/p\u003e \u003cp\u003e8.2 Challenges Associated with Macrocycles, 254\u003c\/p\u003e \u003cp\u003e8.3 Macrocyclic Peptides, 259\u003c\/p\u003e \u003cp\u003e8.4 Peptidomimetic Macrocycles, 265\u003c\/p\u003e \u003cp\u003e8.5 Diversity-Oriented Strategies Based on Nonpeptidic Natural Product Scaffolds, 273\u003c\/p\u003e \u003cp\u003e8.6 Conclusions, 281\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II CHEMICAL LIBRARIES AND DIVERSITY-ORIENTED SYNTHESIS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Diversity-Oriented Synthesis of Natural Product–Like Libraries 291\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMark Dow, Francesco Marchetti, and Adam Nelson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction, 291\u003c\/p\u003e \u003cp\u003e9.2 Libraries Inspired by Natural Product Scaffolds, 292\u003c\/p\u003e \u003cp\u003e9.3 Folding Pathways in the Synthesis of Natural Product–Like Libraries, 297\u003c\/p\u003e \u003cp\u003e9.4 Branching Pathways in the Synthesis of Natural Product–Like Libraries, 305\u003c\/p\u003e \u003cp\u003e9.5 Oligomer-Based Approaches to Natural Product–Like Libraries, 312\u003c\/p\u003e \u003cp\u003e9.6 Summary, 320\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Chemoinformatic Characterization of the Chemical Space and Molecular Diversity of Compound Libraries 325\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJose Luis Medina-Franco\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction, 325\u003c\/p\u003e \u003cp\u003e10.2 Concept of Chemical Space, 326\u003c\/p\u003e \u003cp\u003e10.3 General Aspects of Chemoinformatic Methods to Analyze the Chemical Space, 327\u003c\/p\u003e \u003cp\u003e10.4 Chemoinformatic-Based Analysis of Libraries using Different Representations, 328\u003c\/p\u003e \u003cp\u003e10.5 Recent Trends in Computational Approaches to Characterize Compound Libraries, 344\u003c\/p\u003e \u003cp\u003e10.6 Concluding Remarks, 345\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 DNA-Encoded Chemical Libraries 353\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eLuca Mannocci\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction, 353\u003c\/p\u003e \u003cp\u003e11.2 DNA-Encoded Chemical Libraries, 357\u003c\/p\u003e \u003cp\u003e11.3 Selection and Decoding, 386\u003c\/p\u003e \u003cp\u003e11.4 Drug Discovery by DNA-Encoded Chemical Libraries, 388\u003c\/p\u003e \u003cp\u003e11.5 DNA-Encoded Chemical Libraries: Prospects and Outlook, 391\u003c\/p\u003e \u003cp\u003e11.6 Conclusions, 393\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III SCREENING METHODS AND LEAD IDENTIFICATION\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Experimental Approaches to Rapid Identification, Profiling, and Characterization of Specific Biological Effects of DOS Compounds 403\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eEduard A. Sergienko and Susanne Heynen-Genel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction, 403\u003c\/p\u003e \u003cp\u003e12.2 Basic Principles of HTS, 405\u003c\/p\u003e \u003cp\u003e12.3 Common Assay Methods and Techniques, 415\u003c\/p\u003e \u003cp\u003e12.4 Future Perspectives, 428\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Small-Molecule Microarrays 431\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHongyan Sun\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction, 431\u003c\/p\u003e \u003cp\u003e13.2 Chemical Library Design and Synthesis, 432\u003c\/p\u003e \u003cp\u003e13.3 Fabrication of SMMs, 438\u003c\/p\u003e \u003cp\u003e13.4 Applications of SMM, 446\u003c\/p\u003e \u003cp\u003e13.5 Summary and Outlook, 451\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Yeast as a Model in High-Throughput Screening of Small-Molecule Libraries 455\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eIrene Stefanini, Carlotta De Filippo, and Duccio Cavalieri\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction, 455\u003c\/p\u003e \u003cp\u003e14.2 Chemical Genetics and S. cerevisiae, 461\u003c\/p\u003e \u003cp\u003e14.3 Chemical Genomics and S. cerevisiae, 471\u003c\/p\u003e \u003cp\u003e14.4 Conclusions: The Route of Drug Discovery with the Budding Yeast, 477\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Virtual Screening Methods 483\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJurgen Bajorath\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction, 483\u003c\/p\u003e \u003cp\u003e15.2 Basic Virtual Screening Concepts, 484\u003c\/p\u003e \u003cp\u003e15.3 Molecular Similarity in Virtual Screening, 487\u003c\/p\u003e \u003cp\u003e15.4 Spectrum of Virtual Screening Approaches, 489\u003c\/p\u003e \u003cp\u003e15.5 Docking, 490\u003c\/p\u003e \u003cp\u003e15.6 Similarity Searching, 491\u003c\/p\u003e \u003cp\u003e15.7 Compound Classification, 496\u003c\/p\u003e \u003cp\u003e15.8 Machine Learning, 498\u003c\/p\u003e \u003cp\u003e15.9 Conclusions, 501\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Structure–Activity Relationship Data Analysis: Activity Landscapes and Activity Cliffs 507\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJurgen Bajorath\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction, 507\u003c\/p\u003e \u003cp\u003e16.2 Numerical SAR Analysis Functions, 508\u003c\/p\u003e \u003cp\u003e16.3 Principles and Intrinsic Limitations of Activity Landscape Design, 511\u003c\/p\u003e \u003cp\u003e16.4 Activity Landscape Representations, 513\u003c\/p\u003e \u003cp\u003e16.5 Defining and Identifying Activity Cliffs, 520\u003c\/p\u003e \u003cp\u003e16.6 Activity Cliff Survey, 525\u003c\/p\u003e \u003cp\u003e16.7 Activity Cliffs and SAR Information, 526\u003c\/p\u003e \u003cp\u003e16.8 Concluding Remarks, 528\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV APPLICATIONS IN CHEMICAL BIOLOGY AND DRUG DISCOVERY\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Diversity-Oriented Synthesis and\u003c\/b\u003e \u003cb\u003eDrug Development: Facilitating the Discovery of Novel Probes and Therapeutics 535\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJeremy R. Duvall, Eamon Comer, and Sivaraman Dandapani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction, 535\u003c\/p\u003e \u003cp\u003e17.2 Case Study 1: Inhibition of Cytokine-Induced -cell Apoptosis, 540\u003c\/p\u003e \u003cp\u003e17.3 Case Study 2: Identification of Antimalarials, 548\u003c\/p\u003e \u003cp\u003e17.4 Case Study 3: Targeting Protein–Protein and Protein–DNA Interactions, 558\u003c\/p\u003e \u003cp\u003e17.5 Conclusions, 570\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 DOS-Derived Small-Molecule Probes in Chemical Biology 575\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNicholas Hill, Lingyan Du, and Qiu Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction, 575\u003c\/p\u003e \u003cp\u003e18.2 DOS-Derived Small-Molecule Probes, 576\u003c\/p\u003e \u003cp\u003e18.3 Developing Small-Molecule Probes of Complex Biological Pathways, 576\u003c\/p\u003e \u003cp\u003e18.4 Expanding the Collection of Important Biological Probes, 595\u003c\/p\u003e \u003cp\u003e18.5 Developing Probes for Therapeutically Desirable Phenotypes, 603\u003c\/p\u003e \u003cp\u003e18.6 Natural Product–Inspired Small-Molecule Probes Developed from DOS and Biology-Oriented Synthesis, 606\u003c\/p\u003e \u003cp\u003e18.7 Summary and Outlook, 611\u003c\/p\u003e \u003cp\u003eReferences, 611\u003c\/p\u003e \u003cp\u003eINDEX 619\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":53515635720535,"sku":"9781118145654","price":125.96,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/bookcurl.com\/products\/diversityoriented-synthesis-9781118145654","provider":"Book Curl","version":"1.0","type":"link"}