{"product_id":"disulfiram-and-its-metabolite-diethyldithiocarbamate-pharmacology-and-status-in-the-treatment-of-alcoholism-hiv-infections-aids-and-heavy-metal-toxicity-9789401050289","title":"Disulfiram and its Metabolite,","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book is aimed at those in the biomedical community that are interested in the therapeutic applications, pharmacology, biochemistry, toxicology and pharmacokinetics of the title compounds. Recent findings regarding the ability of diethyldithiocarbamate (ditiocarb, Imuthiol®) to delay the progression of HN infections and AIDS, the discovery of its potential as a rescue agent in cancer chemotherapy, and the identification of disulfiram (Antabuse®) regimens that allow alcoholics to achieve abstinence of many months' duration have made writing this book an exciting experience. At the same time the fact that the two drugs differ substantially in their pharmacological effects in spite of their easy interconvertibility has rendered the writing intellec­ tually challenging. Diethyldithiocarbamate, an agent seemingly less toxic than aspirin, rivals it in the multiplicity and diversity of its pharmacological proper­ ties. Notable among these are the manyfold potent immunostimulant effects, and though most of these involve effects on T -cells, the mechanism of diethyldithiocarbamate's action remains far from clear. The drug is also a potent chelator of heavy metals and this has led to a number of clinical applications. As might be expected, it inhibits several important enzymes. Further, it is one of the most effective radioprotective agents; it also protects organisms against a variety of toxic agents.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e...a well written, detailed publication on literally  everything the reader would wish to know about disulfiram and its  metabolite -  British Journal of Psychiatry; This well written and  carefully edited  volume deserves the interest of toxicologists,  pharmacologists,  immunologists, biochemists and clinicians. Journal  of Applied  Toxicology; It is hoped that clinicians and behavioral  scientists  have read this book for their own education and also to  appreciate  the advances made in the biochemical pharmacology of DSSD  and SSH.  This book should capture the interest of medicinal chemists  and  pharmacologists who are engaged in research in cancer,  immunomodulation, HIV, and heavy metal toxicity. Selected chapters  are must reading for biomedical scientists pursuing alcoholism  research. Journal of Medicinal Chemistry\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eIntroduction and scope of monograph. Relevant chemical and  physical properties. Reactions of disulfiram and  diethyldithiocarbamate with  blood constituents. Assay methods for  disulfiram and metabolites in  biological materials. Metabolism of  disulfiram and  diethyldithiocarbamate. Pharmacokinetic aspects of the  disposition of  disulfiram and metabolites. Heavy metals: effects of  diethyldithiocarbamate and disulfiram administration. Disulfiram and  diethyldithiocarbamate  as enzyme inhibitors. Inhibition of aldehyde  dehydrogenase. The disulfiram-ethanol reaction. Disulfiram therapy of  alcohol abuse. Various biological phenomena. Immunomodulatory actions  of diethyldithiocarbamate. Clinical status of diethyldithiocarbamate  as an immunostimulant. Modulation of various biological phenomena.  Modulation of cancer chemotherapy. Toxicology. Bibliography. Index.","brand":"Springer","offers":[{"title":"Default Title","offer_id":51535943532887,"sku":"9789401050289","price":44.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9789401050289.jpg?v=1755863858","url":"https:\/\/bookcurl.com\/products\/disulfiram-and-its-metabolite-diethyldithiocarbamate-pharmacology-and-status-in-the-treatment-of-alcoholism-hiv-infections-aids-and-heavy-metal-toxicity-9789401050289","provider":"Book Curl","version":"1.0","type":"link"}