{"product_id":"control-of-biological-and-drugdelivery-systems-for-chemical-biomedical-and-pharmaceutical-engineering-9780470903230","title":"Control of Biological and DrugDelivery Systems","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book presents ways to analyze complex bioprocesses and drug delivery systems using control theory. Filled with detailed examples, case studies, computer projects, and step-by-step solutions to numerical problems using computational software, it addresses issues and solves problems that dominate both fields.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"This text — featuring examples from the biological sciences, including novel drug-delivery systems — will help students and pharmaceutical researchers to develop a better understanding of process dynamics and control theory, so that they can analyze and solve a variety of problems in bioprocess and drug-delivery systems.\" (\u003ci\u003eChemical Engineering Progress\u003c\/i\u003e, 21 May 2013)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eAcknowledgments xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 The Role of Process Dynamics and Control in Branches of Biology 1\u003c\/p\u003e \u003cp\u003e1.2 The Role of Process Dynamics and Control in Drug-Delivery Systems 10\u003c\/p\u003e \u003cp\u003e1.3 Instrumentation 12\u003c\/p\u003e \u003cp\u003e1.4 Summary 18\u003c\/p\u003e \u003cp\u003eProblems 18\u003c\/p\u003e \u003cp\u003eReferences 19\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Mathematical Models 21\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Background 22\u003c\/p\u003e \u003cp\u003e2.2 Dynamics of Bioreactors 27\u003c\/p\u003e \u003cp\u003e2.3 One- and Two-Compartment Models 34\u003c\/p\u003e \u003cp\u003e2.4 Enzyme Kinetics 37\u003c\/p\u003e \u003cp\u003e2.5 Summary 39\u003c\/p\u003e \u003cp\u003eProblems 39\u003c\/p\u003e \u003cp\u003eReferences 41\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Linearization and Deviation Variables 43\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Computer Simulations 43\u003c\/p\u003e \u003cp\u003e3.2 Linearization of Systems 44\u003c\/p\u003e \u003cp\u003e3.3 Glycolytic Oscillation 55\u003c\/p\u003e \u003cp\u003e3.4 Hodgkin–Huxley Model 57\u003c\/p\u003e \u003cp\u003e3.5 Summary 60\u003c\/p\u003e \u003cp\u003eProblems 61\u003c\/p\u003e \u003cp\u003eReferences 63\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Stability Considerations 65\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Definition of Stability 65\u003c\/p\u003e \u003cp\u003e4.2 Steady-State Conditions and Equilibrium Points 79\u003c\/p\u003e \u003cp\u003e4.3 Phase-Plane Diagrams 80\u003c\/p\u003e \u003cp\u003e4.4 Population Kinetics 80\u003c\/p\u003e \u003cp\u003e4.5 Dynamics of Bioreactors 83\u003c\/p\u003e \u003cp\u003e4.6 Glycolytic Oscillation 85\u003c\/p\u003e \u003cp\u003e4.7 Hodgkin–Huxley Model 87\u003c\/p\u003e \u003cp\u003e4.8 Summary 88\u003c\/p\u003e \u003cp\u003eProblems 88\u003c\/p\u003e \u003cp\u003eReferences 91\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Laplace Transforms 93\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Definition of Laplace Transforms 93\u003c\/p\u003e \u003cp\u003e5.2 Properties of Laplace Transforms 95\u003c\/p\u003e \u003cp\u003e5.3 Laplace Transforms of Functions, Derivatives, and Integrals 96\u003c\/p\u003e \u003cp\u003e5.4 Laplace Transforms of Linear Ordinary Differential Equation (ODE) and Partial Differential Equation (PDE) 104\u003c\/p\u003e \u003cp\u003e5.5 Continuous Fermentation 108\u003c\/p\u003e \u003cp\u003e5.6 Two-Compartment Models 110\u003c\/p\u003e \u003cp\u003e5.7 Gene Regulation 111\u003c\/p\u003e \u003cp\u003e5.8 Summary 113\u003c\/p\u003e \u003cp\u003eProblems 113\u003c\/p\u003e \u003cp\u003eReference 115\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Inverse Laplace Transforms 117\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Heaviside Expansions 117\u003c\/p\u003e \u003cp\u003e6.2 Residue Theorem 126\u003c\/p\u003e \u003cp\u003e6.3 Continuous Fermentation 134\u003c\/p\u003e \u003cp\u003e6.4 Degradation of Plasmid DNA 136\u003c\/p\u003e \u003cp\u003e6.5 Constant-Rate Intravenous Infusion 138\u003c\/p\u003e \u003cp\u003e6.6 Transdermal Drug-Delivery Systems 139\u003c\/p\u003e \u003cp\u003e6.7 Summary 146\u003c\/p\u003e \u003cp\u003eProblems 146\u003c\/p\u003e \u003cp\u003eReferences 148\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Transfer Functions 149\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Input–Output Models 149\u003c\/p\u003e \u003cp\u003e7.2 Derivation of Transfer Functions 150\u003c\/p\u003e \u003cp\u003e7.3 One- and Two-Compartment Models: Michaelis–Menten Kinetics 154\u003c\/p\u003e \u003cp\u003e7.4 Controlled-Release Systems 157\u003c\/p\u003e \u003cp\u003e7.5 Summary 158\u003c\/p\u003e \u003cp\u003eProblems 158\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Dynamic Behaviors of Typical Plants 163\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 First-, Second- and Higher-Order Systems 163\u003c\/p\u003e \u003cp\u003e8.2 Reduced-Order Models 167\u003c\/p\u003e \u003cp\u003e8.3 Transcendental Transfer Functions 169\u003c\/p\u003e \u003cp\u003e8.4 Time Responses of Systems with Rational Transfer Functions 171\u003c\/p\u003e \u003cp\u003e8.5 Time Responses of Systems with Transcendental Transfer Functions 190\u003c\/p\u003e \u003cp\u003e8.6 Bone Regeneration 192\u003c\/p\u003e \u003cp\u003e8.7 Nitric Oxide Transport to Pulmonary Arterioles 193\u003c\/p\u003e \u003cp\u003e8.8 Transdermal Drug Delivery 194\u003c\/p\u003e \u003cp\u003e8.9 Summary 194\u003c\/p\u003e \u003cp\u003eProblems 195\u003c\/p\u003e \u003cp\u003eReferences 197\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Closed-loop Responses with P, Pi, and Pid Controllers 199\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Block Diagram of Closed-Loop Systems 200\u003c\/p\u003e \u003cp\u003e9.2 Proportional Control 203\u003c\/p\u003e \u003cp\u003e9.3 PI Control 204\u003c\/p\u003e \u003cp\u003e9.4 PID Control 206\u003c\/p\u003e \u003cp\u003e9.5 Total Sugar Concentration in a Glutamic Acid Production 207\u003c\/p\u003e \u003cp\u003e9.6 Temperature Control of Fermentations 209\u003c\/p\u003e \u003cp\u003e9.7 DO Concentration 213\u003c\/p\u003e \u003cp\u003e9.8 Summary 214\u003c\/p\u003e \u003cp\u003eProblems 215\u003c\/p\u003e \u003cp\u003eReferences 217\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Frequency Response Analysis 219\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Frequency Response for Linear Systems 219\u003c\/p\u003e \u003cp\u003e10.2 Bode Diagrams 227\u003c\/p\u003e \u003cp\u003e10.3 Nyquist Plots 229\u003c\/p\u003e \u003cp\u003e10.4 Transdermal Drug Delivery 232\u003c\/p\u003e \u003cp\u003e10.5 Compartmental Models 236\u003c\/p\u003e \u003cp\u003e10.6 Summary 239\u003c\/p\u003e \u003cp\u003eProblems 239\u003c\/p\u003e \u003cp\u003eReferences 240\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Stability Analysis of Feedback Systems 243\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Routh–Hurwitz Stability Criterion 243\u003c\/p\u003e \u003cp\u003e11.2 Root Locus Analysis 248\u003c\/p\u003e \u003cp\u003e11.3 Bode Stability Criterion 249\u003c\/p\u003e \u003cp\u003e11.4 Nyquist Stability Criterion 254\u003c\/p\u003e \u003cp\u003e11.5 Cheyne–Stokes Respiration 257\u003c\/p\u003e \u003cp\u003e11.6 Regulation of Biological Pathways 262\u003c\/p\u003e \u003cp\u003e11.7 Pupillary Light Reflex 264\u003c\/p\u003e \u003cp\u003e11.8 Summary 265\u003c\/p\u003e \u003cp\u003eProblems 265\u003c\/p\u003e \u003cp\u003eReferences 267\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Design of Feedback Controllers 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Tuning Methods for Feedback Controllers 269\u003c\/p\u003e \u003cp\u003e12.2 Regulation of Glycemia 279\u003c\/p\u003e \u003cp\u003e12.3 Dissolved Oxygen Concentration 282\u003c\/p\u003e \u003cp\u003e12.4 Control of Biomass in a Chemostat 284\u003c\/p\u003e \u003cp\u003e12.5 Controlled Infusion of Vasoactive Drugs 285\u003c\/p\u003e \u003cp\u003e12.6 Bone Regeneration 286\u003c\/p\u003e \u003cp\u003e12.7 Fed-Batch Biochemical Processes 288\u003c\/p\u003e \u003cp\u003e12.8 Summary 289\u003c\/p\u003e \u003cp\u003eProblems 289\u003c\/p\u003e \u003cp\u003eReferences 291\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Feedback Control of Dead-time Systems 293\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Smith Predictor-Based Methods 294\u003c\/p\u003e \u003cp\u003e13.2 Control of Biomass 300\u003c\/p\u003e \u003cp\u003e13.3 Zymomonas mobilis Fermentation for Ethanol Production 302\u003c\/p\u003e \u003cp\u003e13.4 Fed-Batch Cultivation of Acinetobacter calcoaceticus Rag-1 304\u003c\/p\u003e \u003cp\u003e13.5 Regulation of Glycemia 304\u003c\/p\u003e \u003cp\u003e13.6 Summary 306\u003c\/p\u003e \u003cp\u003eProblems 306\u003c\/p\u003e \u003cp\u003eReferences 309\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Cascade and Feedforward Control Strategies 311\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Cascade Control 311\u003c\/p\u003e \u003cp\u003e14.2 Feedforward Control 317\u003c\/p\u003e \u003cp\u003e14.3 Insulin Infusion 321\u003c\/p\u003e \u003cp\u003e14.4 A Gaze Control System 323\u003c\/p\u003e \u003cp\u003e14.5 Control of pH 326\u003c\/p\u003e \u003cp\u003e14.6 Summary 330\u003c\/p\u003e \u003cp\u003eProblems 331\u003c\/p\u003e \u003cp\u003eReferences 333\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Effective Time Constant 335\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Linear Second-Order ODEs 335\u003c\/p\u003e \u003cp\u003e15.2 Sturm–Liouville (SL) Eigenvalue Problems 337\u003c\/p\u003e \u003cp\u003e15.3 Relaxation Time Constant 340\u003c\/p\u003e \u003cp\u003e15.4 Implementation in Mathematica ® 342\u003c\/p\u003e \u003cp\u003e15.5 Controlled-Release Devices 342\u003c\/p\u003e \u003cp\u003e15.6 Summary 343\u003c\/p\u003e \u003cp\u003eProblems 344\u003c\/p\u003e \u003cp\u003eReferences 345\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Optimum Control and Design 347\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16.1 Orthogonal Collocation Techniques 348\u003c\/p\u003e \u003cp\u003e16.2 Dynamic Programming 350\u003c\/p\u003e \u003cp\u003e16.3 Optimal Control of Drug-Delivery Rates 350\u003c\/p\u003e \u003cp\u003e16.4 Optimal Design of Controlled-Release Devices 351\u003c\/p\u003e \u003cp\u003e16.5 Implementation in Mathematica ® 352\u003c\/p\u003e \u003cp\u003e16.6 Summary 358\u003c\/p\u003e \u003cp\u003eProblems 359\u003c\/p\u003e \u003cp\u003eReferences 360\u003c\/p\u003e \u003cp\u003eIndex 361\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eAcknowledgments xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 The Role of Process Dynamics and Control in Branches of Biology 1\u003c\/p\u003e \u003cp\u003e1.2 The Role of Process Dynamics and Control in Drug-Delivery Systems 10\u003c\/p\u003e \u003cp\u003e1.3 Instrumentation 12\u003c\/p\u003e \u003cp\u003e1.4 Summary 18\u003c\/p\u003e \u003cp\u003eProblems 18\u003c\/p\u003e \u003cp\u003eReferences 19\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Mathematical Models 21\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Background 22\u003c\/p\u003e \u003cp\u003e2.2 Dynamics of Bioreactors 27\u003c\/p\u003e \u003cp\u003e2.3 One- and Two-Compartment Models 34\u003c\/p\u003e \u003cp\u003e2.4 Enzyme Kinetics 37\u003c\/p\u003e \u003cp\u003e2.5 Summary 39\u003c\/p\u003e \u003cp\u003eProblems 39\u003c\/p\u003e \u003cp\u003eReferences 41\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Linearization and Deviation Variables 43\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Computer Simulations 43\u003c\/p\u003e \u003cp\u003e3.2 Linearization of Systems 44\u003c\/p\u003e \u003cp\u003e3.3 Glycolytic Oscillation 55\u003c\/p\u003e \u003cp\u003e3.4 Hodgkin–Huxley Model 57\u003c\/p\u003e \u003cp\u003e3.5 Summary 60\u003c\/p\u003e \u003cp\u003eProblems 61\u003c\/p\u003e \u003cp\u003eReferences 63\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Stability Considerations 65\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Definition of Stability 65\u003c\/p\u003e \u003cp\u003e4.2 Steady-State Conditions and Equilibrium Points 79\u003c\/p\u003e \u003cp\u003e4.3 Phase-Plane Diagrams 80\u003c\/p\u003e \u003cp\u003e4.4 Population Kinetics 80\u003c\/p\u003e \u003cp\u003e4.5 Dynamics of Bioreactors 83\u003c\/p\u003e \u003cp\u003e4.6 Glycolytic Oscillation 85\u003c\/p\u003e \u003cp\u003e4.7 Hodgkin–Huxley Model 87\u003c\/p\u003e \u003cp\u003e4.8 Summary 88\u003c\/p\u003e \u003cp\u003eProblems 88\u003c\/p\u003e \u003cp\u003eReferences 91\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Laplace Transforms 93\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Definition of Laplace Transforms 93\u003c\/p\u003e \u003cp\u003e5.2 Properties of Laplace Transforms 95\u003c\/p\u003e \u003cp\u003e5.3 Laplace Transforms of Functions, Derivatives, and Integrals 96\u003c\/p\u003e \u003cp\u003e5.4 Laplace Transforms of Linear Ordinary Differential Equation (ODE) and Partial Differential Equation (PDE) 104\u003c\/p\u003e \u003cp\u003e5.5 Continuous Fermentation 108\u003c\/p\u003e \u003cp\u003e5.6 Two-Compartment Models 110\u003c\/p\u003e \u003cp\u003e5.7 Gene Regulation 111\u003c\/p\u003e \u003cp\u003e5.8 Summary 113\u003c\/p\u003e \u003cp\u003eProblems 113\u003c\/p\u003e \u003cp\u003eReference 115\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Inverse Laplace Transforms 117\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Heaviside Expansions 117\u003c\/p\u003e \u003cp\u003e6.2 Residue Theorem 126\u003c\/p\u003e \u003cp\u003e6.3 Continuous Fermentation 134\u003c\/p\u003e \u003cp\u003e6.4 Degradation of Plasmid DNA 136\u003c\/p\u003e \u003cp\u003e6.5 Constant-Rate Intravenous Infusion 138\u003c\/p\u003e \u003cp\u003e6.6 Transdermal Drug-Delivery Systems 139\u003c\/p\u003e \u003cp\u003e6.7 Summary 146\u003c\/p\u003e \u003cp\u003eProblems 146\u003c\/p\u003e \u003cp\u003eReferences 148\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Transfer Functions 149\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Input–Output Models 149\u003c\/p\u003e \u003cp\u003e7.2 Derivation of Transfer Functions 150\u003c\/p\u003e \u003cp\u003e7.3 One- and Two-Compartment Models: Michaelis–Menten Kinetics 154\u003c\/p\u003e \u003cp\u003e7.4 Controlled-Release Systems 157\u003c\/p\u003e \u003cp\u003e7.5 Summary 158\u003c\/p\u003e \u003cp\u003eProblems 158\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Dynamic Behaviors of Typical Plants 163\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 First-, Second- and Higher-Order Systems 163\u003c\/p\u003e \u003cp\u003e8.2 Reduced-Order Models 167\u003c\/p\u003e \u003cp\u003e8.3 Transcendental Transfer Functions 169\u003c\/p\u003e \u003cp\u003e8.4 Time Responses of Systems with Rational Transfer Functions 171\u003c\/p\u003e \u003cp\u003e8.5 Time Responses of Systems with Transcendental Transfer Functions 190\u003c\/p\u003e \u003cp\u003e8.6 Bone Regeneration 192\u003c\/p\u003e \u003cp\u003e8.7 Nitric Oxide Transport to Pulmonary Arterioles 193\u003c\/p\u003e \u003cp\u003e8.8 Transdermal Drug Delivery 194\u003c\/p\u003e \u003cp\u003e8.9 Summary 194\u003c\/p\u003e \u003cp\u003eProblems 195\u003c\/p\u003e \u003cp\u003eReferences 197\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Closed-loop Responses with P, Pi, and Pid Controllers 199\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Block Diagram of Closed-Loop Systems 200\u003c\/p\u003e \u003cp\u003e9.2 Proportional Control 203\u003c\/p\u003e \u003cp\u003e9.3 PI Control 204\u003c\/p\u003e \u003cp\u003e9.4 PID Control 206\u003c\/p\u003e \u003cp\u003e9.5 Total Sugar Concentration in a Glutamic Acid Production 207\u003c\/p\u003e \u003cp\u003e9.6 Temperature Control of Fermentations 209\u003c\/p\u003e \u003cp\u003e9.7 DO Concentration 213\u003c\/p\u003e \u003cp\u003e9.8 Summary 214\u003c\/p\u003e \u003cp\u003eProblems 215\u003c\/p\u003e \u003cp\u003eReferences 217\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Frequency Response Analysis 219\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Frequency Response for Linear Systems 219\u003c\/p\u003e \u003cp\u003e10.2 Bode Diagrams 227\u003c\/p\u003e \u003cp\u003e10.3 Nyquist Plots 229\u003c\/p\u003e \u003cp\u003e10.4 Transdermal Drug Delivery 232\u003c\/p\u003e \u003cp\u003e10.5 Compartmental Models 236\u003c\/p\u003e \u003cp\u003e10.6 Summary 239\u003c\/p\u003e \u003cp\u003eProblems 239\u003c\/p\u003e \u003cp\u003eReferences 240\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Stability Analysis of Feedback Systems 243\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Routh–Hurwitz Stability Criterion 243\u003c\/p\u003e \u003cp\u003e11.2 Root Locus Analysis 248\u003c\/p\u003e \u003cp\u003e11.3 Bode Stability Criterion 249\u003c\/p\u003e \u003cp\u003e11.4 Nyquist Stability Criterion 254\u003c\/p\u003e \u003cp\u003e11.5 Cheyne–Stokes Respiration 257\u003c\/p\u003e \u003cp\u003e11.6 Regulation of Biological Pathways 262\u003c\/p\u003e \u003cp\u003e11.7 Pupillary Light Reflex 264\u003c\/p\u003e \u003cp\u003e11.8 Summary 265\u003c\/p\u003e \u003cp\u003eProblems 265\u003c\/p\u003e \u003cp\u003eReferences 267\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Design of Feedback Controllers 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Tuning Methods for Feedback Controllers 269\u003c\/p\u003e \u003cp\u003e12.2 Regulation of Glycemia 279\u003c\/p\u003e \u003cp\u003e12.3 Dissolved Oxygen Concentration 282\u003c\/p\u003e \u003cp\u003e12.4 Control of Biomass in a Chemostat 284\u003c\/p\u003e \u003cp\u003e12.5 Controlled Infusion of Vasoactive Drugs 285\u003c\/p\u003e \u003cp\u003e12.6 Bone Regeneration 286\u003c\/p\u003e \u003cp\u003e12.7 Fed-Batch Biochemical Processes 288\u003c\/p\u003e \u003cp\u003e12.8 Summary 289\u003c\/p\u003e \u003cp\u003eProblems 289\u003c\/p\u003e \u003cp\u003eReferences 291\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Feedback Control of Dead-time Systems 293\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Smith Predictor-Based Methods 294\u003c\/p\u003e \u003cp\u003e13.2 Control of Biomass 300\u003c\/p\u003e \u003cp\u003e13.3 Zymomonas mobilis Fermentation for Ethanol Production 302\u003c\/p\u003e \u003cp\u003e13.4 Fed-Batch Cultivation of Acinetobacter calcoaceticus Rag-1 304\u003c\/p\u003e \u003cp\u003e13.5 Regulation of Glycemia 304\u003c\/p\u003e \u003cp\u003e13.6 Summary 306\u003c\/p\u003e \u003cp\u003eProblems 306\u003c\/p\u003e \u003cp\u003eReferences 309\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Cascade and Feedforward Control Strategies 311\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Cascade Control 311\u003c\/p\u003e \u003cp\u003e14.2 Feedforward Control 317\u003c\/p\u003e \u003cp\u003e14.3 Insulin Infusion 321\u003c\/p\u003e \u003cp\u003e14.4 A Gaze Control System 323\u003c\/p\u003e \u003cp\u003e14.5 Control of pH 326\u003c\/p\u003e \u003cp\u003e14.6 Summary 330\u003c\/p\u003e \u003cp\u003eProblems 331\u003c\/p\u003e \u003cp\u003eReferences 333\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Effective Time Constant 335\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Linear Second-Order ODEs 335\u003c\/p\u003e \u003cp\u003e15.2 Sturm–Liouville (SL) Eigenvalue Problems 337\u003c\/p\u003e \u003cp\u003e15.3 Relaxation Time Constant 340\u003c\/p\u003e \u003cp\u003e15.4 Implementation in Mathematica ® 342\u003c\/p\u003e \u003cp\u003e15.5 Controlled-Release Devices 342\u003c\/p\u003e \u003cp\u003e15.6 Summary 343\u003c\/p\u003e \u003cp\u003eProblems 344\u003c\/p\u003e \u003cp\u003eReferences 345\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Optimum Control and Design 347\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16.1 Orthogonal Collocation Techniques 348\u003c\/p\u003e \u003cp\u003e16.2 Dynamic Programming 350\u003c\/p\u003e \u003cp\u003e16.3 Optimal Control of Drug-Delivery Rates 350\u003c\/p\u003e \u003cp\u003e16.4 Optimal Design of Controlled-Release Devices 351\u003c\/p\u003e \u003cp\u003e16.5 Implementation in Mathematica ® 352\u003c\/p\u003e \u003cp\u003e16.6 Summary 358\u003c\/p\u003e \u003cp\u003eProblems 359\u003c\/p\u003e \u003cp\u003eReferences 360\u003c\/p\u003e \u003cp\u003eIndex 361\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default 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