{"product_id":"classics-in-stereoselective-synthesis-9783527324521","title":"Classics in Stereoselective Synthesis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book provides a noteworthy compilation of the groundbreaking methods of stereoselective synthesis, belonging to the repertoire of every modern practitioner of synthetic organic chemistry. The general principles underlying these processes are highlighted as they form the basis for the rapid and continuing developments in the field. The work also features illustrative examples of drug and natural product syntheses, resulting in a rich source of stimulating ideas for the efficient use of asymmetric reactions in the construction of stereochemically complex structures. \u003cbr\u003e \u003cbr\u003e \u003cbr\u003e From the contents:\u003cbr\u003e \u003cbr\u003e \"Macrocyclic stereocontrol\u003cbr\u003e \"Carbonyl addition reactions\u003cbr\u003e \"alpha-Functionalization of enolates\u003cbr\u003e \"Aldol and allylation reactions\u003cbr\u003e \"Chiral acetals\u003cbr\u003e \"Alkene hydroboration, reduction, and oxidation\u003cbr\u003e \"Additions to C=N bonds and synthesis of amino acids \u003cbr\u003e \"Conjugate additions\u003cbr\u003e \"Chiral carbanions\u003cbr\u003e \"Metal-catalyzed allylations\u003cbr\u003e \"Cyclopropanations and CH-insertion reactions\u003cbr\u003e \"Sigmatropic rearrangements\u003cbr\u003e \"Diels-Alder and hetero-Diels-Alder reactions\u003cbr\u003e \"[3+2]- and [2+2]-cycloaddition reactions\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"The book provides a collection of classic methods for stereoselective synthesis that have been developed over the past two decades - methods that should be at the command of every modern practitioner of synthetic organic chemistry.\" (Booknews, 1 April 2011)  \u003cp\u003e \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eMACROCYCLIC STEREOCONTROL\u003cbr\u003e Introduction\u003cbr\u003e Background\u003cbr\u003e Conformational Control in Medium-Sized Rings\u003cbr\u003e Asymmetric Synthesis with Medium-Sized Rings\u003cbr\u003e Case Studies in Natural Products Total Synthesis\u003cbr\u003e Macrocyclic Stereocontrol in Cyclic Peptides\u003cbr\u003e Appendix: Macrocycle Formation\u003cbr\u003e CARBONYL ADITION REACTIONS\u003cbr\u003e Introduction\u003cbr\u003e Non-Chelated 1,2-Asymmetric Induction and the Operation of Steric and Electronic Effects\u003cbr\u003e 1,2-Asymmetric Induction Predicated on Chelation Control\u003cbr\u003e 1,3-Asymmetric Induction from CBeta Stereogenic Centers\u003cbr\u003e Asymmetric Induction by Remote Stereocenters (Beyond 1,3-Induction)\u003cbr\u003e Catalytic Enantioselective Carbonyl Additions of Arganozinc Species\u003cbr\u003e Enantioselective Ketone Reduction\u003cbr\u003e Enzymatic Reduction of Ketones\u003cbr\u003e Enantioselective Formation of Cyanohydrins\u003cbr\u003e Enantioselective Alkyne Additions\u003cbr\u003e Asymmetric Carbonyl-Ene Reactions\u003cbr\u003e ALPHA-FUNCTIONALIZATIONS OF ENOLATES\u003cbr\u003e Introduction\u003cbr\u003e Diastereoselective Alpha-Alkylations of Chiral Enolates\u003cbr\u003e Heteroatom-Substituted Enolates\u003cbr\u003e Asymmetric Enolate Alkylations Using Chiral Auxiliaries\u003cbr\u003e Enantioselective Enolate Alkylations\u003cbr\u003e Alpha-Hydroxylations of Enolates\u003cbr\u003e Alpha-Halogenations of Enolates\u003cbr\u003e ALDOL REACTIONS\u003cbr\u003e Introduction\u003cbr\u003e Chiral Enolates Through the Use of Chiral Auxiliaries or Chiral Controller Groups\u003cbr\u003e Substrate Control with Chiral Carbonyl Compounds\u003cbr\u003e Catalytic Enantioselective Aldol Reactions\u003cbr\u003e ALLYLATIONS OF C=O BONDS\u003cbr\u003e Introduction\u003cbr\u003e Reactivity of Allylmetal Reagents\u003cbr\u003e Boronate Additions\u003cbr\u003e Enantioselective Additions of Optically Active Allylic Boron Reagents\u003cbr\u003e Diastereoselecive Allylations with Chiral Boron Reagents\u003cbr\u003e Mechanistic Aspects -\u003cbr\u003e Lewis Acid-Promoted Addition of Allylsilanes and Allylstannanes to Aldehydes\u003cbr\u003e Chelation Control in the Allylation of Alpha- and Beta-Alkoxy Aldehydes\u003cbr\u003e Allylchromium Reagents\u003cbr\u003e Diastereoselective Allylations with Chiral Silanes and Stannanes\u003cbr\u003e Catalytic Asymmetric Allylations\u003cbr\u003e CHIRAL ACETALS\u003cbr\u003e Introduction\u003cbr\u003e Diastereoselective Reactions of Chiral Acetals\u003cbr\u003e Glycosylations\u003cbr\u003e Spiroketals in Natural Product Synthesis\u003cbr\u003e ALKENE HYDROBORATION\u003cbr\u003e Introduction\u003cbr\u003e Hydroborations with Acyclic Stereocontrol\u003cbr\u003e Metal-Catalyzed Hydroborations\u003cbr\u003e Asymmetric Hydroborations with Chiral Boranes\u003cbr\u003e Catalytic Asymmetric Hydroboration, Hydrosilylation, and Hydroalumination\u003cbr\u003e REDUCTIONS OF OLEFINS\u003cbr\u003e Introduction\u003cbr\u003e Diastereoselective Olefin Reductions by Catalytic Hydrogenation\u003cbr\u003e Alternative Methods for Diastereoselective Olefin Reductions\u003cbr\u003e Catalytic Asymmetric Olefin Hydrogenations\u003cbr\u003e OXIDATIONS OF OLEFINS\u003cbr\u003e Introduction\u003cbr\u003e Diastereoselective Epoxidations\u003cbr\u003e Enantioselective Epoxidations\u003cbr\u003e Asymmetric Ring-Opening of Epoxides\u003cbr\u003e Synthesis of Aziridines\u003cbr\u003e Iodolactonizations and Other Olefin Cyclizations Induced by Electrophiles\u003cbr\u003e Diastereoselective Dihydroxylations of Olefins\u003cbr\u003e Enantioselective Dihydroxylations of Olefins\u003cbr\u003e Enantioselective Aminohydroxylation of Olefins\u003cbr\u003e AMINO ACIDS\u003cbr\u003e Introduction\u003cbr\u003e Enantioselective Hydrogenations of Alpha, Beta-Didehydroamino Acids\u003cbr\u003e Enolate Alkylations in the Presence of Chiral Auxiliaries\u003cbr\u003e Alkylation of Glycine Anion Equivalents in the Presence of Chiral Phase-Transfer Catalysts\u003cbr\u003e Enolate Aminations\u003cbr\u003e Enzymatic Syntheses of Alpha-Amino Acids\u003cbr\u003e Catalytic Asymmetric Strecker Reactions\u003cbr\u003e ADDITIONS TO C=N BONDS\u003cbr\u003e Introduction\u003cbr\u003e Substrate-Controlled Diastereoselective Additions to C=N Bonds\u003cbr\u003e Additions to Imine Derivatives Bearing N-Bound Auxiliaries\u003cbr\u003e Formation of Beta-Lactams Through Staudinger Reactions\u003cbr\u003e Intramolecular Diastereoselective Iminium Ion Cyclizations\u003cbr\u003e Pictet-Spengler Reactions\u003cbr\u003e Catalytic Asymmetric Reductions of Imines and Imine Derivatives\u003cbr\u003e Catalytic Enantioselective Mannich and Mannich-Type Reactions\u003cbr\u003e Enantioselective Additions of Carbon Nucleophiles to C=N Bonds\u003cbr\u003e CONJUGATE ADDITIONS\u003cbr\u003e Introduction\u003cbr\u003e Diastereoselective Conjugate Additions\u003cbr\u003e \u003cbr\u003e Diastereoselective Conjugate Additions with Use of Chiral Auxiliaries\u003cbr\u003e Enantioselective Conjugate Additions of Enolates and other Stabilized Carbon Nucleophiles\u003cbr\u003e Enantioselective Conjugate Additions of Organometallic Species\u003cbr\u003e Enantioselective Conjugate Additions of Radicals\u003cbr\u003e Enantioselective Conjugate Additions of Heteroatom Nucleophiles\u003cbr\u003e Conjugate Reductions\u003cbr\u003e Catalytic Enantioselective Stetter Reactions\u003cbr\u003e CHIRAL CARBONIONS\u003cbr\u003e Introduction\u003cbr\u003e Organolithium Reagents by Transmetalation of Organostannanes\u003cbr\u003e Carbanions by Reductive Methods\u003cbr\u003e Chiral Carbanions by Deprotonation\u003cbr\u003e Sulfoxide- and Phosphorus-Stabilized Carbanions\u003cbr\u003e Metal-Mediated Enantioselective Olefin Functionalizations\u003cbr\u003e METAL-CATALYZED ALLYLATIONS\u003cbr\u003e Introduction\u003cbr\u003e Diastereoselective Palladium-Catalyzed Allylation Reactions\u003cbr\u003e Enantioselective Palladium-Catalyzed Allylation Reactions\u003cbr\u003e Iridium-Catalyzed Enantioselective Allylation Reactions\u003cbr\u003e Copper-Catalyzed SN2' Allylation Reactions\u003cbr\u003e Enantioselective Allylation Reactions Catalyzed by Other Transition Metals\u003cbr\u003e Asymmetric Ring-Opening Reactions of Unsaturated Heterocycles\u003cbr\u003e CYCLOPROPANATIONS AND C-H INSERTION REACTIONS\u003cbr\u003e Introduction\u003cbr\u003e Diastereoselective Cyclopropanations with Carbenoids Generated from Diazoalkanes\u003cbr\u003e Enantioselective Dyclopropanations with Carbenoids Generated from Diazoalkanes\u003cbr\u003e Diastereoselective Simmons-Smith Cyclopropanations\u003cbr\u003e Enantioselective Simmons-Smith Cyclopropanations\u003cbr\u003e Alternative Classes Cyclopropanations\u003cbr\u003e Diastereoselective C-H Bonds\u003cbr\u003e SIGMATROPIC REARRANGEMENTS\u003cbr\u003e Introduction\u003cbr\u003e Claisen and Claisen-Type [3,3]-Sigmatropic Rearrangements\u003cbr\u003e Cope and Cope-Type [3,3]-Sigmatropic Rearrangements\u003cbr\u003e [2,3]-Sigmatropic Rearrangements\u003cbr\u003e Ene Reactions\u003cbr\u003e Nazarov Cyclizations\u003cbr\u003e DIELS-ALDER AND HETERO-DIELS-ALDER REACTIONS\u003cbr\u003e Introduction\u003cbr\u003e Diastereoselective Intermolecular Diels-Alder Reactions\u003cbr\u003e Diastereoselective Intramolecular Diels-Alder Reactions\u003cbr\u003e Diastereoselective Diels-Alder Reactions Using Chiral Auxiliaries\u003cbr\u003e Catalytic Enantioselective Diels-Alder Reactions\u003cbr\u003e Diastereoselective Hetero-Diels-Alder Reactions\u003cbr\u003e Enantioselective Hetero-Diels-Alder Reactions\u003cbr\u003e [3+2]- AND [2+2]-CYCLOADDITION REACTIONS\u003cbr\u003e Introduction\u003cbr\u003e Substrate-Controlled Diastereoselective [1,3]-Dipolar Cycloadditions\u003cbr\u003e Diastereoselective [1,3]-Dipolar Cycloadditions  Using Chiral Auxiliaries\u003cbr\u003e Catalytic Enantioselective [1,3]-Dipolar Cycloadditions\u003cbr\u003e [3+2]-Cycloadditions with Trimethylenemethane Equivalents\u003cbr\u003e Ketene Cycloadditions\u003cbr\u003e Photochemical [2+2]-Cycloadditions","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default 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