{"product_id":"challenging-cases-in-clinical-research-ethics-9781032370958","title":"Challenging Cases in Clinical Research Ethics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eClinical research ethics consultation has emerged in the last 15 years as a service to those involved in the conduct of clinical research who face challenging issues for which more than one course of action may be justified. To respond to a growing field and need for opportunities to share knowledge and experience, the Clinical Research Ethics Consultation Collaborative, established in 2014, holds monthly webinars for its 90 members to present their most challenging cases to each other and engage in substantive discussion. Every year, the group selects the four most interesting cases with accompanying commentaries for publication in the \u003ci\u003eAmerican Journal of Bioethics\u003c\/i\u003e. \u003c\/p\u003e\u003cp\u003eThis timely book brings together these cases and commentaries under a range of common themes for the first time, creating a permanent collection in book format that encourages and supports readers to gain a better understanding of the ethical challenges that they may face, and providing them with a conveni\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cem\u003eForeword\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003eIntroduction\u003ci\u003e \u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eA Framework for Research Ethics. Principles of Research Ethics. Topics in Research Ethics . Values of Research Ethics. \u003c\/p\u003e\u003cp\u003eSection 1. Collaborative Partnership\u003c\/p\u003e\u003cp\u003eIntroduction\u003c\/p\u003e\u003cp\u003eCase 1.1 Supporting Community-Academic Research Partnerships: Reflections from the Ground\u003c\/p\u003e\u003cp\u003eCommentary 1.1.1: Community Partnered Participatory Research in Southeast Louisiana Communities Threatened by Climate Change: The C-LEARN EXPERIENCE. \u003cb\u003eCommentary 1.1.2:\u003c\/b\u003e Leveraging Academic Institutional Structures to Support Asian American Community Organizations’ Engagement in Research: The Korean Community Service Center. \u003cb\u003eCommentary 1.1.3:\u003c\/b\u003e Engaging the Sickle Cell Community in Participatory Research. \u003cb\u003eCommentary 1.1.4:\u003c\/b\u003e Being in Good Community: Engagement in Support of Indigenous Sovereignty.\u003c\/p\u003e\u003cp\u003eCase 1.2 Protecting Research Subject Welfare in Preventative Trials for Autosomal Dominant Alzheimer's Disease\u003c\/p\u003e\u003cp\u003eCommentary 1.2.1: When There Are Only Two Who Can Tango: Ethical Concerns at the Juncture of Highly Novel Interventions and Precisely Targeted Research Populations\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 1.2.2:\u003c\/b\u003e Conceptualization and Assessment of Vulnerability in a Complex International Alzheimer’s Research Study\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 1.2.3:\u003c\/b\u003e Barriers and Facilitators to the Consent Process in a Study of Complex\u003ci\u003e \u003c\/i\u003eGenetic Factors\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 1.3 Studying the Role of Financial Incentives to Promote Hepatitis B Vaccination in a Community Clinic\u003c\/p\u003e\u003cp\u003eCommentary 1.3.1: Treatment Incentives and the Nature of the Doctor-Patient Relationship\u003ci\u003e.\u003c\/i\u003e\u003cb\u003e Commentary 1.3.2:\u003c\/b\u003e The Ethics of Studying Financial Incentives in Public Health Implementation: Study Design Challenges\u003ci\u003e.\u003c\/i\u003e\u003cb\u003e Commentary 1.3.3:\u003c\/b\u003e You Can Lead a Horse to Water, But Can You Pay to Make Him Drink? An Ethical Analysis of Research on Using Incentives to Promote Patient Health\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 1.4 A Cluster Randomized Trial to Screen for Abusive Head Trauma in the Paediatric Intensive Care Unit--How to Manage Site-Specific Evidence of Racial\/Ethnic Disparity\u003c\/p\u003e\u003cp\u003eCommentary 1.4.1: Issues of Justice and Risk: Setting Stopping Criteria in Cluster-Randomized Trials\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 1.4.2:\u003c\/b\u003e Clinical Trials Not Causing Harm with Potential for Realizing Benefit Should Continue. \u003cb\u003eCommentary 1.4.3:\u003c\/b\u003e Responding to Implicit Bias in Abusive Head Trauma Evaluations and Reporting in the PICU: Ethical Consideration During a Clinical Trial.\u003c\/p\u003e\u003cp\u003eCase 1.5 When a Clinical Trial Is the Only Option\u003c\/p\u003e\u003cp\u003eCommentary 1.5.1: \"Respect for Persons,\" Not \"Respect for Citizens\". \u003cb\u003eCommentary 1.5.2:\u003c\/b\u003e The Potentially High Cost of a Free Clinical Trial\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 1.5.3:\u003c\/b\u003e Contextualizing \"Choice\" for Undocumented Immigrants in U.S. Clinical Trials Research\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 1.6 A Randomized Trial of Rapamycin to Increase Longevity and Healthspan in Companion Animals: Navigating the Boundary Between Protections for Animal Research and Human Subjects Research\u003c\/p\u003e\u003cp\u003eCommentary 1.6.1: Rapamycin: Risking Harm for Canine Longevity\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 1.6.2:\u003c\/b\u003e Companion Animal Studies: Slipping Through a Research Oversight Gap. \u003cb\u003eCommentary 1.6.3:\u003c\/b\u003e Research to Promote Longevity and Health Span in Companion Dogs: A Paediatric Perspective\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eSection 2. Respect for Participants\u003c\/p\u003e\u003cp\u003eIntroduction\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 2.1 Ethical Considerations for Unblinding a Participant’s Assignment to Interpret a Resolved Adverse Event\u003c\/p\u003e\u003cp\u003eCommentary 2.1.1: Considerations for Unblinding in Biopharmaceutical Industry\u003c\/p\u003e\u003cp\u003eSponsored Trials. \u003cb\u003eCommentary 2.1.2:\u003c\/b\u003e Blinds and Research Risks\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 2.1.3:\u003c\/b\u003e The Scientific and Social Implications of Unblinding a Study Subject\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 2.2 Should Research Participants Be Notified About Results of Currently Unknown by Potential Significance?\u003c\/p\u003e\u003cp\u003eCommentary 2.2.1: The Need for National Guidance Around Informed Consent About GBCA Safety\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 2.2.2:\u003c\/b\u003e Returning Individual Research Results Regarding Gadolinium Deposition in the Brain Is the Preferable Choice\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 2.2.3:\u003c\/b\u003e Research Participants Should Have the Option to Be Notified of Results of Unknown but Potential Significance\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 2.3 The Ethics of Contacting Family Members of a Subject in a Genetic Research Study to Return Results for an Autosomal Dominant Syndrome\u003c\/p\u003e\u003cp\u003eCommentary 2.3.1: What Does the Duty to Warn Require?\u003ci\u003e \u003c\/i\u003e\u003cb\u003eCommentary 2.3.2:\u003c\/b\u003e Should Researchers Disclose Results to Descendants?\u003ci\u003e \u003c\/i\u003e\u003cb\u003eCommentary 2.3.3:\u003c\/b\u003e Relationships Matter: Ethical Considerations for Returning Results to Family Members of Deceased Subjects.\u003c\/p\u003e\u003cp\u003eCase 2.4 Ethics of Continuing to Provide a Drug on an Open-Label Extension Study for an \"Unapproved Indication\"\u003c\/p\u003e\u003cp\u003eCommentary 2.4.1: When Should Open-Label Extension Studies Be Stopped? \u003cb\u003eCommentary 2.4.2:\u003c\/b\u003e The Role of Clinical Equipoise and Practical Considerations in Deciding Whether to Continue to Provide a Drug on an Open-Label Extension Study for an \"Unapproved Indication\". \u003cb\u003eCommentary 2.4.3:\u003c\/b\u003e Open-Label Extension Studies: Are They Really Research?\u003c\/p\u003e\u003cp\u003eCase 2.5 Supporting Investigators in Challenging Cases: Unease in the Face of an Ethically Appropriate Action\u003c\/p\u003e\u003cp\u003eCommentary 2.5.1: Researchers Experience Moral Distress Too!\u003ci\u003e \u003c\/i\u003e\u003cb\u003eCommentary 2.5.2:\u003c\/b\u003e Relieving Investigator Angst After an Appropriate but Concerning Ethics Consultation\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 2.5.3:\u003c\/b\u003e Acknowledging Angst: Research Ethics Consultation in Disclosing Experimental Research Results of Uncertain Benefit\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 2.6 Recontact and Recruitment of Young Adults Previously Enrolled in Neonatal Herpes Simplex Virus Research\u003c\/p\u003e\u003cp\u003eCommentary 2.6.1: Research Recruitment of Adult Survivors of Neonatal Infections: Is There a Role for Parental Consent?\u003ci\u003e \u003c\/i\u003e\u003cb\u003eCommentary 2.6.2:\u003c\/b\u003e A Knotty Problem of Intertwined Rights\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 2.6.3:\u003c\/b\u003e Consent Is the Cornerstone of Ethically Valid Research: Ethical Issues in Recontacting Subjects Who Enrolled in Research as a Minor.\u003c\/p\u003e\u003cp\u003eCase 2.7 Genotype-Driven Recruitment in Population-Based Biomedical Research\u003c\/p\u003e\u003cp\u003eCommentary 2.7.1: Genotype-Driven Recruitment Without Deception\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 2.7.2:\u003c\/b\u003e Harms of Deception in FMR1 Premutation Genotype-Driven Recruitment\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 2.7.3:\u003c\/b\u003e Genotype-Driven Recruitment and the Disclosure of Individual Research Results\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eSection 3. Fair Participant Selection\u003c\/p\u003e\u003cp\u003eIntroduction\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 3.1 Is It Ethical to Enrol Cognitively Impaired Adults in Research that is More than Minimal Risk with No Prospect of Benefit?\u003c\/p\u003e\u003cp\u003eCommentary 3.1.1: Inconsistent Approaches to Research Involving Cognitively Impaired Adults: Why the Broad View of Substituted Judgment Is Our Best Guide\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 3.1.2:\u003c\/b\u003e Ethical and Regulatory Considerations Regarding Enrolment of Incompetent Adults in More Than Minimal Risk Research as Compared with Children\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 3.1.3:\u003c\/b\u003e Acceptable Approaches to Enrolling Adults Who Cannot Consent in More Than Minimal Risk Research\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 3.2 Should Patients Be Required to Undergo Standard Chemotherapy Before Being Eligible for Novel Phase I Immunotherapy Clinical Trials?\u003c\/p\u003e\u003cp\u003eCommentary 3.2.1: A Rationale for Relaxing the Requirement to Undergo a Noncurative Chemotherapy for Advanced Cancer in a Phase I Immunotherapy Trial\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 3.2.2:\u003c\/b\u003e Participation of Citizen Scientists in Clinical Research and Access to Research Ethics Consultation\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 3.2.3:\u003c\/b\u003e Forgoing Conventional Therapy in Phase I Oncology Research: Don’t Forget About the Children\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 3.3 Involving Pregnant Women in Research: What Should We Recommend When the Regulations Seem Ethically Problematic?\u003c\/p\u003e\u003cp\u003eCommentary 3.3.1: Conflicts Between Regulations and Ethical Principles: Resolving Ambiguity in Favour of the Ethically Preferable Outcome\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 3.3.2:\u003c\/b\u003e When to Avoid Giving Advice on the Ethical Conduct of Research\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 3.3.3:\u003c\/b\u003e When Research Regulations and Ethics Conflict\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 3.4 Regulatory, Legal, Ethical, and Practical Challenges of Enrolling Wards of the State in Research\u003c\/p\u003e\u003cp\u003eCommentary 3.4.1: Fuzzy Logic: How the Practicalities of State Involvement Shape the Most Ethically Supportable Way Forward\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 3.4.2:\u003c\/b\u003e Enrolling Foster Youth in Clinical Trials: Avoiding the Harm of Exclusion\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 3.4.3:\u003c\/b\u003e No Justification to Exclude State Ward from Paediatric Transplant Research\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 3.4.4:\u003c\/b\u003e Life-Saving Experimental Treatment for a Teenage Ward of the State\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 3.5 Selecting Children for an Autism Spectrum Disorder Study: Justice and Geography\u003c\/p\u003e\u003cp\u003eCommentary 3.5.1: Fair Participant Selection: A Negative Obligation Not to Exclude\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 3.5.2:\u003c\/b\u003e Unequal Individual Risk and Potential Benefit Balanced by Benefits to the Population at Large in Autism Clinical Trials? \u003cb\u003eCommentary 3.5.3:\u003c\/b\u003e Justice in Selecting Participants for a Study in Phelan-McDermid Syndrome\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eSection 4. Favourable Risk-Benefit Ratio\u003c\/p\u003e\u003cp\u003eIntroduction\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 4.1 Obligations to Act on Patient Reported Outcomes in Electronic Health Records\u003c\/p\u003e\u003cp\u003eCommentary 4.1.1: Informed Consent for PROs in EHR Research: Are Additional Requirements Necessary? \u003cb\u003eCommentary 4.1.2:\u003c\/b\u003e Patient Reported Outcomes at the Crossroads of Clinical Research and Informatics\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 4.1.3:\u003c\/b\u003e PROs in the Balance: Ethical Implications of Collecting Patient Reported Outcome Measures in the Electronic Health Record\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 4.2 A Trial to Test a Novel Approach to Diabetes Prevention\u003c\/p\u003e\u003cp\u003eCommentary 4.2.1: Is It Ethically Acceptable to Screen Patients for Obstructive Sleep Apnea and Not Offer Them Positive Air Pressure Therapy in a Clinical Trial? \u003cb\u003eCommentary 4.2.2:\u003c\/b\u003e Can We Breathe Easy If PAP Therapy Is Withheld? \u003cb\u003eCommentary 4.2.3:\u003c\/b\u003e Risks of Clinical Research Must Be Reasonable and Necessary\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 4.3 Is It Ethically Appropriate to Refuse to Compensate Participants Who Are Believed to Have Intentionally Concealed Medical Conditions?\u003c\/p\u003e\u003cp\u003eCommentary 4.3.1: Mutual Obligations in Research and Withholding Payment from Deceptive Participants\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 4.3.2:\u003c\/b\u003e Best to Exclude but Pay\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 4.3.3:\u003c\/b\u003e To Pay or Not to Pay? Withholding Payment from Research Participants\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 4.4 Ethical Drug Development for Rare Childhood Diseases: When There are Limited but Promising Data in Adults, How to Choose Between Safety or Efficacy Studies?\u003c\/p\u003e\u003cp\u003eCommentary 4.4.1: The Use of Paediatric Extrapolation to Avoid Unnecessary Paediatric Clinical Trials\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 4.4.2:\u003c\/b\u003e Flexibility Required: Balancing the Interests of Children and Risk in Drug Development for Rare Paediatric Conditions\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 4.4.3:\u003c\/b\u003e When Higher Risk Does Not Equal Greater Harm: Doing the Most Good in a Limited Paediatric Study Population.\u003c\/p\u003e\u003cp\u003eCase 4.5 Greater than Minimal Risk, No Direct Benefit – Bridging Drug Trials and Novel Therapy in Paediatric Populations\u003c\/p\u003e\u003cp\u003eCommentary 4.5.1: Balancing Risk and Reward: Greater Research Oversight Is Appropriate for Novel Therapies for Children with Life-Limiting Illness\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 4.5.2:\u003c\/b\u003e Bringing Known Drugs to Paediatric Research: Safety, Efficacy, and the Ambiguous Minor Increase in Minimal Risk\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 4.5.3:\u003c\/b\u003e Balancing Scientific Progress with Paediatric Protections: No Direct Benefit Now, But Potential Novel Therapy in the Future. \u003c\/p\u003e\u003cp\u003eSection 5. Informed Consent\u003c\/p\u003e\u003cp\u003eIntroduction\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 5.1 The Ethics of Disclosing to Research Subjects the Availability of Off-Label Marketed Drugs\u003c\/p\u003e\u003cp\u003eCommentary 5.1.1: Researchers Have an Ethical Obligation to Disclose the Availability of Off-Label Marketed Drugs\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.1.2:\u003c\/b\u003e The Relevance of Research Study Phase to Disclosure of Off-Label Drug Availability\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.1.3:\u003c\/b\u003e Which Alternatives Should Investigators Disclose to Research Subjects?\u003c\/p\u003e\u003cp\u003eCase 5.2 A Pragmatic Trial of Suicide Risk Assessment and Ambulance Transport Decision Making Among Emergency Medical Services Providers: Implications for Patient Consent\u003c\/p\u003e\u003cp\u003eCommentary 5.2.1: Improving Care for Suicidal Patients While Protecting Human Subjects: Addressing Ethical Challenges in Mental Health Research Involving Emergency Medical Services Providers\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.2.2:\u003c\/b\u003e A Stepwise Approach to Ethically Assess Pragmatic Cluster Randomized Trials: Implications for Informed Consent for Suicide Prevention Implementation Research\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.2.3:\u003c\/b\u003e Informed Consent in a Pragmatic Emergency Suicide Trial: Rejecting the Research-Practice Distinction\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.2.4:\u003c\/b\u003e A Pragmatic Trial for Emergency Medical Service Providers’ Prehospital Response to Suicidality: Consent Is Not Essential, but Limited Patient Engagement May Be Meaningful\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 5.3 The Obligations to Report Statutory Sexual Abuse Disclosed in a Research Study\u003c\/p\u003e\u003cp\u003eCommentary 5.3.1: The Moral and Legal Need to Disclose Despite a Certificate of Confidentiality\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.3.2:\u003c\/b\u003e Informed Consent and the Implications for Statutory Rape Reporting in Research with Adolescents\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.3.3: \u003c\/b\u003eCommunity, Context, and the Contrasting Roles of Clinicians and Researchers: Challenges Raised by Statutory Rape\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 5.4 Conjoined Consent: Informed Consent When Donor and Recipient Are Both Research Participants\u003c\/p\u003e\u003cp\u003eCommentary 5.4.1: Moving Beyond Standard Informed Consent for Interventional Organ Transplant Research\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.4.2:\u003c\/b\u003e Risks to Relationships in Kidney Transplant Research with Living Donors and Recipients\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eCase 5.5 Navigating Parental Permission for Neonatal Research\u003c\/p\u003e\u003cp\u003eCommentary 5.5.1: Informed Consent and Parental Permission for Research: Rules, Roles, and Relationships\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 5.5.2:\u003c\/b\u003e Research Involving Premature Infants: Timing Is Everything\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.5.3:\u003c\/b\u003e Precluding Consent by Clinicians Who Are Both the Attending and the Investigator: An Outdated Shibboleth?\u003c\/p\u003e\u003cp\u003eCase 5.6 Click Here to Complete This Survey: Online Research, Adolescents, and Parental Consent\u003c\/p\u003e\u003cp\u003eCommentary 5.6.1: Digital Negotiations: Navigating Parental Permission and Adolescent Assent for On-Line Survey Participation\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.6.2:\u003c\/b\u003e Constrained Adolescent Autonomy for Healthcare Should Include Participation in Survey Research\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 5.6.3:\u003c\/b\u003e Respecting Parental Permission and Maintaining Flexibility in Online Research Involving Adolescent Participants.\u003c\/p\u003e\u003cp\u003eCase 5.7 When Professional Meets Personal: How Should Research Staff Advertise on social media for Research Opportunities?\u003c\/p\u003e\u003cp\u003eCommentary 5.7.1: Sharing Research Opportunities on Personal Social Media Accounts and Fair Subject Selection\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.7.2:\u003c\/b\u003e How Should Investigators Advertise on social media for Research Opportunities?\u003c\/p\u003e\u003cp\u003eCase 5.8 The Limitation of \"Boilerplate\" Language in Informed Consent: Single IRB Review of Multisite Genetic Research in Military Personnel\u003c\/p\u003e\u003cp\u003eCommentary 5.8.1: The Bane of \"Boilerplate\" Language in Research Consent Forms: Ensuring Consent Forms Promote Autonomous Authorization\u003ci\u003e.\u003c\/i\u003e \u003cb\u003eCommentary 5.8.2:\u003c\/b\u003e Single IRBs Are Responsible to Ensure Consent Language Effectively Conveys the Local Context\u003ci\u003e. \u003c\/i\u003e\u003cb\u003eCommentary 5.8.3:\u003c\/b\u003e Solving the Single IRB\/Boilerplate Bind: Establishing Institutional Guidelines\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eAppendix A. Cases Organized by Principles. Appendix B. Cases Organized by Topics. Appendix C. Cases Organized by Values.\u003c\/p\u003e","brand":"Taylor \u0026 Francis Ltd","offers":[{"title":"Default Title","offer_id":51019010867543,"sku":"9781032370958","price":38.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781032370958.jpg?v=1750779016","url":"https:\/\/bookcurl.com\/products\/challenging-cases-in-clinical-research-ethics-9781032370958","provider":"Book Curl","version":"1.0","type":"link"}