{"product_id":"calcium-entry-channels-in-nonexcitable-cells-9781498752725","title":"Calcium Entry Channels in NonExcitable Cells","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cem\u003eCalcium Entry Channels in Non-Excitable Cells\u003c\/em\u003e focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the \u003ci\u003eMethods in Signal Transduction\u003c\/i\u003e series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eElectrophysiological methods of studying store-operated calcium channels. Genome wide RNAi screens to identify components of calcium entry pathways in insect and mammalian cells. Optical methods to measure store-operated calcium entry through Orai\/STIM channels. Determination of structure and subunit composition of Orai\/STIM channels by crystallography. Non-Orai interacting partners of STIM proteins. Modulation of Orai\/STIM by cellular factors. Function of Orai\/STIM proteins studied in transgenic mouse models. TRPV5 and TRPV6 calcium selective channels. Pharmacology of store-operated calcium channels. Role of calcium entry channels in immune cells. Practical methods for separation of store-dependent and independent calcium entry in vitro. Signaling ER store depletion to plasma membrane Orai channels.\u003c\/p\u003e","brand":"Taylor \u0026 Francis Inc","offers":[{"title":"Default Title","offer_id":49409292075351,"sku":"9781498752725","price":142.5,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/calcium-entry-channels-in-nonexcitable-cells-9781498752725","provider":"Book Curl","version":"1.0","type":"link"}