{"product_id":"building-breakthroughs-9781421444871","title":"Building Breakthroughs","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eFrom mRNA vaccines to gene therapies, the next frontier of medical innovation is here.   In Building Breakthroughs, Raju Prasad tells the story of important advancements in biotechnology and medical innovation from gene therapies to mRNA vaccines, providing historical context and examining cutting-edge research. Based on in-depth interviews with both the scientists who developed these discoveries and the patients who have benefited from them, Building Breakthroughs reveals the key players behind drug development and the inner workings of this essential business. Through stories of patients and their families, and of the researchers creating new treatments, Prasad reveals how cell therapies are advancing to treat childhood leukemia and a form of lymphoma, how a gene therapy was established to treat the rare disease spinal muscular atrophy type I, and potentially curative therapies that are being developed for sickle cell disease. By examining the clinical trial and regulatory paths each\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eIntroduction\u003cbr\u003e\u003cb\u003ePart I. The Journey from Idea to Approval\u003c\/b\u003e\u003cbr\u003eChapter 1. Leukemia and Lymphoma\u003cbr\u003eChapter 2. Chimeric Antigen Receptor (CAR)-T Cell Therapy\u003cbr\u003eChapter 3. Spinal Muscular Atrophy\u003cbr\u003eChapter 4. \u003ci\u003eIn Vivo\u003c\/i\u003e Gene Therapy\u003cbr\u003eChapter 5. Sickle Cell Anemia\u003cbr\u003eChapter 6. \u003ci\u003eEx Vivo \u003c\/i\u003eGene-Modified Cell Therapy\u003cbr\u003eChapter 7. A Brief History of FDA Regulation\u003cbr\u003eChapter 8. The Path to Approval\u003cbr\u003e\u003cb\u003ePart II. Enabling the Next Wave Of Innovation\u003c\/b\u003e\u003cbr\u003eChapter 9. Building Blocks \u003cbr\u003eChapter 10. Recognizing Value\u003cbr\u003eChapter 11. Financial and Human Capital Investments in Biotechnology\u003cbr\u003eChapter 12. Looking Forward\u003cbr\u003eEpilogue. COVID-19\u003cbr\u003eAcknowledgments\u003cbr\u003eReferences\u003cbr\u003eIndex\u003c\/p\u003e","brand":"Johns Hopkins University Press","offers":[{"title":"Default Title","offer_id":49408147030359,"sku":"9781421444871","price":20.7,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781421444871.jpg?v=1730501760","url":"https:\/\/bookcurl.com\/products\/building-breakthroughs-9781421444871","provider":"Book Curl","version":"1.0","type":"link"}