{"product_id":"building-brains-9781119293880","title":"Building Brains","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eProvides a highly visual, readily accessible introduction to the main events that occur during neural development and their mechanisms Building Brains: An Introduction to Neural Development, 2ndEditiondescribes how brains construct themselves, from simple beginnings in the early embryo to become the most complex living structures on the planet. It explains how cells first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity, and why some neurons normally die. This student-friendly guide stresses and justifies the generally-held belief that a greater knowledge of how nervous systems construct themselves will help us find new ways of treating diseases of the nervous system that are thought to originate from faulty development, such as autism spectrum disorders, epilepsy, and schizophrenia.    A concise, illustrated guide focusing on core elements and emphasizing common principles of developmental mechanisms, supplemented by suggestions for further readingText boxes provide detail on major advances, issues of particular uncertainty or controversy, and examples of human diseases that result from abnormal developmentIntroduces the methods for studying neural development, allowing the reader to understand the main evidence underlying research advancesOffers a balanced mammalian\/non-mammalian perspective (and emphasizes mechanisms that are conserved across species), drawing on examples from model organisms like the fruit fly, nematode worm, frog, zebrafish, chick, mouse and humanAssociated Website includes all the figures from the textbook and explanatory movies Filled with full-colorartwork that reinforces important concepts; an extensive glossary and definitions that help readers from different backgrounds; and chapter summaries that stress important points and aid revision,Building Brains: An Introduction to Neural Development, 2ndEditionis perfect for undergraduate students and postgraduates who may not have a background in neuroscience and\/or molecular genetics.    This elegant book ranges with ease and authority over the vast field of developmental neuroscience. This excellent textbook should be on the shelf of every neuroscientist, as well as on the reading list of every neuroscience student.Sir Colin Blakemore, Oxford University With an extensive use of clear and colorful illustrations, this book makes accessible to undergraduates the beauty and complexity of neural development. The book fills a void in undergraduate neuroscience curricula.Professor Mark Bear, Picower Institute, MIT.    Highly Commended, British Medical Association Medical Book Awards 2012 Published with the New York Academy of Sciences\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface to Second Edition xi\u003c\/p\u003e \u003cp\u003ePreface to First Edition xiii\u003c\/p\u003e \u003cp\u003eConventions and Commonly used Abbreviations xv\u003c\/p\u003e \u003cp\u003eIntroduction xix\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xxiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Models and Methods for Studying Neural Development 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 What is neural development? 1\u003c\/p\u003e \u003cp\u003e1.2 Why research neural development? 2\u003c\/p\u003e \u003cp\u003eThe uncertainty of current understanding 2\u003c\/p\u003e \u003cp\u003eImplications for human health 3\u003c\/p\u003e \u003cp\u003eImplications for future technologies 4\u003c\/p\u003e \u003cp\u003e1.3 Major breakthroughs that have contributed to understanding developmental mechanisms 4\u003c\/p\u003e \u003cp\u003e1.4 Invertebrate model organisms 5\u003c\/p\u003e \u003cp\u003eFly 5\u003c\/p\u003e \u003cp\u003eWorm 7\u003c\/p\u003e \u003cp\u003eOther invertebrates 11\u003c\/p\u003e \u003cp\u003e1.5 Vertebrate model organisms 11\u003c\/p\u003e \u003cp\u003eFrog 11\u003c\/p\u003e \u003cp\u003eChick 12\u003c\/p\u003e \u003cp\u003eZebrafish 12\u003c\/p\u003e \u003cp\u003eMouse 12\u003c\/p\u003e \u003cp\u003eHumans 19\u003c\/p\u003e \u003cp\u003eOther vertebrates 20\u003c\/p\u003e \u003cp\u003e1.6 Observation and experiment: methods for studying neural development 23\u003c\/p\u003e \u003cp\u003e1.7 Summary 24\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 The Anatomy of Developing Nervous Systems 25\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 The nervous system develops from the embryonic neuroectoderm 25\u003c\/p\u003e \u003cp\u003e2.2 Anatomical terms used to describe locations in embryos 26\u003c\/p\u003e \u003cp\u003e2.3 Development of the neuroectoderm of invertebrates 27\u003c\/p\u003e \u003cp\u003eC. elegans 27\u003c\/p\u003e \u003cp\u003eDrosophila 27\u003c\/p\u003e \u003cp\u003e2.4 Development of the neuroectoderm of vertebrates and the process of neurulation 30\u003c\/p\u003e \u003cp\u003eFrog 31\u003c\/p\u003e \u003cp\u003eChick 33\u003c\/p\u003e \u003cp\u003eZebrafish 35\u003c\/p\u003e \u003cp\u003eMouse 36\u003c\/p\u003e \u003cp\u003eHuman 43\u003c\/p\u003e \u003cp\u003e2.5 Secondary neurulation in vertebrates 47\u003c\/p\u003e \u003cp\u003e2.6 Formation of invertebrate and vertebrate peripheral nervous systems 47\u003c\/p\u003e \u003cp\u003eInvertebrates 49\u003c\/p\u003e \u003cp\u003eVertebrates: the neural crest and the placodes 49\u003c\/p\u003e \u003cp\u003eVertebrates: development of sense organs 50\u003c\/p\u003e \u003cp\u003e2.7 Summary 52\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Neural Induction: An Example of How Intercellular Signalling Determines Cell Fates 53\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 What is neural induction? 53\u003c\/p\u003e \u003cp\u003e3.2 Specification and commitment 54\u003c\/p\u003e \u003cp\u003e3.3 The discovery of neural induction 54\u003c\/p\u003e \u003cp\u003e3.4 A more recent breakthrough: identifying molecules that mediate neural induction 56\u003c\/p\u003e \u003cp\u003e3.5 Conservation of neural induction mechanisms in Drosophila 58\u003c\/p\u003e \u003cp\u003e3.6 Beyond the default model – other signalling pathways involved in neural induction 59\u003c\/p\u003e \u003cp\u003e3.7 Signal transduction: how cells respond to intercellular signals 64\u003c\/p\u003e \u003cp\u003e3.8 Intercellular signalling regulates gene expression 65\u003c\/p\u003e \u003cp\u003eGeneral mechanisms of transcriptional regulation 65\u003c\/p\u003e \u003cp\u003eTranscription factors involved in neural induction 67\u003c\/p\u003e \u003cp\u003eWhat genes do transcription factors control? 69\u003c\/p\u003e \u003cp\u003eGene function can also be controlled by other mechanisms 71\u003c\/p\u003e \u003cp\u003e3.9 The essence of development: a complex interplay of intercellular and intracellular signalling 75\u003c\/p\u003e \u003cp\u003e3.10 Summary 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Patterning the Neuroectoderm 77\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Regional patterning of the nervous system 77\u003c\/p\u003e \u003cp\u003ePatterns of gene expression are set up by morphogens 78\u003c\/p\u003e \u003cp\u003ePatterning happens progressively 80\u003c\/p\u003e \u003cp\u003e4.2 Patterning the anteroposterior (AP) axis of the Drosophila CNS 81\u003c\/p\u003e \u003cp\u003eFrom gradients of signals to domains of transcription factor expression 81\u003c\/p\u003e \u003cp\u003eDividing the ectoderm into segmental units 83\u003c\/p\u003e \u003cp\u003eAssigning segmental identity – the Hox code 83\u003c\/p\u003e \u003cp\u003e4.3 Patterning the AP axis of the vertebrate CNS 86\u003c\/p\u003e \u003cp\u003eHox genes are highly conserved 87\u003c\/p\u003e \u003cp\u003eInitial AP information is imparted by the mesoderm 88\u003c\/p\u003e \u003cp\u003eGenes that pattern the anterior brain 90\u003c\/p\u003e \u003cp\u003e4.4 Local patterning in Drosophila: refining neural patterning within segments 91\u003c\/p\u003e \u003cp\u003eIn Drosophila a signalling boundary within each segment provides local AP positional information 92\u003c\/p\u003e \u003cp\u003ePatterning in the Drosophila dorsoventral(DV) axis 94\u003c\/p\u003e \u003cp\u003eUnique neuroblast identities from the integration of AP and DV patterning information 96\u003c\/p\u003e \u003cp\u003e4.5 Local patterning in the vertebrate nervous system 97\u003c\/p\u003e \u003cp\u003eIn the vertebrate brain, AP boundaries organize local patterning 97\u003c\/p\u003e \u003cp\u003ePatterning in the DV axis of the vertebrate CNS 99\u003c\/p\u003e \u003cp\u003eSignal gradients that drive DV patterning 100\u003c\/p\u003e \u003cp\u003eSHH and BMP are morphogens for DV progenitor domains in the neural tube 101\u003c\/p\u003e \u003cp\u003eIntegration of AP and DV patterning information 103\u003c\/p\u003e \u003cp\u003e4.6 Summary 103\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Neurogenesis: Generating Neural Cells 105\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Generating neural cells 105\u003c\/p\u003e \u003cp\u003e5.2 Neurogenesis in Drosophila 106\u003c\/p\u003e \u003cp\u003eProneural genes promote neural commitment 106\u003c\/p\u003e \u003cp\u003eLateral inhibition: Notch signalling inhibits commitment 106\u003c\/p\u003e \u003cp\u003e5.3 Neurogenesis in vertebrates 107\u003c\/p\u003e \u003cp\u003eProneural genes are conserved 107\u003c\/p\u003e \u003cp\u003eIn the vertebrate CNS, neurogenesis involves radial glial cells 111\u003c\/p\u003e \u003cp\u003eProneural factors and Notch signaling in the vertebrate CNS 111\u003c\/p\u003e \u003cp\u003e5.4 The regulation of neuronal subtype identity 114\u003c\/p\u003e \u003cp\u003eDifferent proneural genes – different programmes of neurogenesis 114\u003c\/p\u003e \u003cp\u003eCombinatorial control by transcription factors creates neuronal diversity 114\u003c\/p\u003e \u003cp\u003e5.5 The regulation of cell proliferation during neurogenesis 117\u003c\/p\u003e \u003cp\u003eSignals that promote proliferation 117\u003c\/p\u003e \u003cp\u003eCell division patterns during neurogenesis 118\u003c\/p\u003e \u003cp\u003eAsymmetric cell division in Drosophila requires Numb 118\u003c\/p\u003e \u003cp\u003eControl of asymmetric cell division in vertebrate neurogenesis 121\u003c\/p\u003e \u003cp\u003eIn vertebrates, division patterns are regulated to generate vast numbers of neurons 122\u003c\/p\u003e \u003cp\u003e5.6 Temporal regulation of neural identity 124\u003c\/p\u003e \u003cp\u003eA neural cell’s time of birth is important for neural identity 124\u003c\/p\u003e \u003cp\u003eTime of birth can generate spatial patterns of neurons 126\u003c\/p\u003e \u003cp\u003eHow does birth date influence a neurons fate? 128\u003c\/p\u003e \u003cp\u003eIntrinsic mechanism of temporal control in Drosophila neuroblasts 128\u003c\/p\u003e \u003cp\u003eBirth date, lamination and competence in the mammalian cortex 129\u003c\/p\u003e \u003cp\u003e5.7 Why do we need to know about neurogenesis? 133\u003c\/p\u003e \u003cp\u003e5.8 Summary 133\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 How Neurons Develop Their Shapes 135\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Neurons form two specialized types\u003c\/p\u003e \u003cp\u003eof outgrowth 135\u003c\/p\u003e \u003cp\u003eAxons and dendrites 135\u003c\/p\u003e \u003cp\u003eThe cytoskeleton in mature axons and dendrites 137\u003c\/p\u003e \u003cp\u003e6.2 The growing neurite 138\u003c\/p\u003e \u003cp\u003eA neurite extends by growth at its tip 138\u003c\/p\u003e \u003cp\u003eMechanisms of growth cone dynamics 139\u003c\/p\u003e \u003cp\u003e6.3 Stages of neurite outgrowth 141\u003c\/p\u003e \u003cp\u003eNeurite outgrowth in cultured hippocampal neuron 141\u003c\/p\u003e \u003cp\u003eNeurite outgrowth in vivo 142\u003c\/p\u003e \u003cp\u003e6.4 Neurite outgrowth is influenced by a neuron’s surroundings 143\u003c\/p\u003e \u003cp\u003eThe importance of extracellular cues 143\u003c\/p\u003e \u003cp\u003eExtracellular signals that promote or inhibit neurite outgrowth 143\u003c\/p\u003e \u003cp\u003e6.5 Molecular responses in the growth cone 145\u003c\/p\u003e \u003cp\u003eKey intracellular signal transduction events 145\u003c\/p\u003e \u003cp\u003eSmall G proteins are critical regulators of neurite growth 145\u003c\/p\u003e \u003cp\u003eEffector molecules directly influence actin filament dynamics 147\u003c\/p\u003e \u003cp\u003eRegulation of other processes in the extending neurite 148\u003c\/p\u003e \u003cp\u003e6.6 Active transport along the axon is\u003c\/p\u003e \u003cp\u003eimportant for outgrowth 149\u003c\/p\u003e \u003cp\u003e6.7 The developmental regulation\u003c\/p\u003e \u003cp\u003eof neuronal polarity 149\u003c\/p\u003e \u003cp\u003eSignalling during axon specification 149\u003c\/p\u003e \u003cp\u003eEnsuring there is just one axon 151\u003c\/p\u003e \u003cp\u003eWhich neurite becomes the axon? 152\u003c\/p\u003e \u003cp\u003e6.8 Dendrites 153\u003c\/p\u003e \u003cp\u003eRegulation of dendrite branching 153\u003c\/p\u003e \u003cp\u003eDendrite branches undergo\u003c\/p\u003e \u003cp\u003eself]avoidance 154\u003c\/p\u003e \u003cp\u003eDendritic fields exhibit tiling 155\u003c\/p\u003e \u003cp\u003e6.9 Summary 156\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Neuronal Migration 157\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Many neurons migrate long distances during formation of the nervous system 157\u003c\/p\u003e \u003cp\u003e7.2 How can neuronal migration be observed? 157\u003c\/p\u003e \u003cp\u003eWatching neurons move in living embryos 158\u003c\/p\u003e \u003cp\u003eObserving migrating neurons in cultured tissues 158\u003c\/p\u003e \u003cp\u003eTracking cell migration by indirect methods 158\u003c\/p\u003e \u003cp\u003e7.3 Major modes of migration 164\u003c\/p\u003e \u003cp\u003eSome migrating neurons are guided by a scaffold 164\u003c\/p\u003e \u003cp\u003eSome neurons migrate in groups 165\u003c\/p\u003e \u003cp\u003eSome neurons migrate individually 168\u003c\/p\u003e \u003cp\u003e7.4 Initiation of migration 169\u003c\/p\u003e \u003cp\u003eInitiation of neural crest cell migration 170\u003c\/p\u003e \u003cp\u003eInitiation of neuronal migration 170\u003c\/p\u003e \u003cp\u003e7.5 How are migrating cells guided to their destinations? 170\u003c\/p\u003e \u003cp\u003eDirectional migration of neurons in C. elegans 171\u003c\/p\u003e \u003cp\u003eGuidance of neural crest cell migration 173\u003c\/p\u003e \u003cp\u003eGuidance of neural precursors in the developing lateral line of zebrafish 174\u003c\/p\u003e \u003cp\u003eGuidance by radial glial fibres 174\u003c\/p\u003e \u003cp\u003e7.6 Locomotion 176\u003c\/p\u003e \u003cp\u003e7.7 Journey’s end – termination of migration 179\u003c\/p\u003e \u003cp\u003e7.8 Embryonic cerebral cortex contains both radially and tangentially migrating cells 182\u003c\/p\u003e \u003cp\u003e7.9 Summary 184\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Axon Guidance 185\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Many axons navigate long and complex routes 185\u003c\/p\u003e \u003cp\u003eHow might axons be guided to their targets? 185\u003c\/p\u003e \u003cp\u003eThe growth cone 187\u003c\/p\u003e \u003cp\u003eBreaking the journey – intermediate targets 188\u003c\/p\u003e \u003cp\u003e8.2 Contact guidance 190\u003c\/p\u003e \u003cp\u003eContact guidance in action: pioneers and followers, fasciculation and defasciculation 191\u003c\/p\u003e \u003cp\u003eEphs and ephrins: versatile cell surface molecules with roles in contact guidance 191\u003c\/p\u003e \u003cp\u003e8.3 Guidance of axons by diffusible cues – chemotropism 194\u003c\/p\u003e \u003cp\u003eNetrin – a chemotropic cue expressed at the ventral midline 195\u003c\/p\u003e \u003cp\u003eSlits 195\u003c\/p\u003e \u003cp\u003eSemaphorins 198\u003c\/p\u003e \u003cp\u003eOther axon guidance molecules 198\u003c\/p\u003e \u003cp\u003e8.4 How do axons change their behavior at choice points? 199\u003c\/p\u003e \u003cp\u003eCommissural axons lose their attraction to netrin once they have crossed the floor plate 199\u003c\/p\u003e \u003cp\u003ePutting it all together – guidance cues and their receptors choreograph commissural axon pathfinding at the ventral midline 202\u003c\/p\u003e \u003cp\u003eAfter crossing the midline, commissural axons project towards the brain 205\u003c\/p\u003e \u003cp\u003e8.5 How can such a small number of cues guide such a large number of axons? 207\u003c\/p\u003e \u003cp\u003eThe same guidance cues are deployed in multiple axon pathways 208\u003c\/p\u003e \u003cp\u003eInteractions between guidance cues and their receptors can be altered by co]factors 208\u003c\/p\u003e \u003cp\u003e8.6 Some axons form specific connections over very short distances, probably using different mechanisms 209\u003c\/p\u003e \u003cp\u003e8.7 The growth cone has autonomy in its ability to respond to guidance cues 209\u003c\/p\u003e \u003cp\u003eGrowth cones can still navigate when severed from their cell bodies 209\u003c\/p\u003e \u003cp\u003eLocal translation in growth cones 210\u003c\/p\u003e \u003cp\u003e8.8 Transcription factors regulate axon guidance decisions 211\u003c\/p\u003e \u003cp\u003e8.9 Summary 212\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Life and Death in the Developing Nervous System 215\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 The frequency and function of cell death during normal development 215\u003c\/p\u003e \u003cp\u003e9.2 Cells die in one of two main ways: apoptosis or necrosis 217\u003c\/p\u003e \u003cp\u003e9.3 Studies in invertebrates have taught us much about how cells kill themselves 219\u003c\/p\u003e \u003cp\u003eThe specification phase 221\u003c\/p\u003e \u003cp\u003eThe killing phase 221\u003c\/p\u003e \u003cp\u003eThe engulfment phase 222\u003c\/p\u003e \u003cp\u003e9.4 Most of the genes that regulate programmed cell death in C. elegans are conserved in vertebrates 222\u003c\/p\u003e \u003cp\u003e9.5 Examples of neurodevelopmental processes in which programmed cell death plays a prominent role 224\u003c\/p\u003e \u003cp\u003eProgrammed cell death in early progenitor cell populations 224\u003c\/p\u003e \u003cp\u003eProgrammed cell death contributes to sexual differences in the nervous system 225\u003c\/p\u003e \u003cp\u003eProgrammed cell death removes cells with transient functions once their task is done 227\u003c\/p\u003e \u003cp\u003eProgrammed cell death matches the numbers of cells in interacting neural tissues 230\u003c\/p\u003e \u003cp\u003e9.6 Neurotrophic factors are important regulators of cell survival and death 232\u003c\/p\u003e \u003cp\u003eGrowth factors 232\u003c\/p\u003e \u003cp\u003eCytokines 235\u003c\/p\u003e \u003cp\u003e9.7 A role for electrical activity in regulating programmed cell death 235\u003c\/p\u003e \u003cp\u003e9.8 Summary 237\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Map Formation 239\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 What are maps? 239\u003c\/p\u003e \u003cp\u003e10.2 Types of maps 239\u003c\/p\u003e \u003cp\u003eCoarse maps 241\u003c\/p\u003e \u003cp\u003eFine maps 242\u003c\/p\u003e \u003cp\u003e10.3 Principles of map formation 243\u003c\/p\u003e \u003cp\u003eAxon order during development 244\u003c\/p\u003e \u003cp\u003eTheories of map formation 245\u003c\/p\u003e \u003cp\u003e10.4 Development of coarse maps: cortical areas 246\u003c\/p\u003e \u003cp\u003eProtomap versus protocortex 246\u003c\/p\u003e \u003cp\u003eSpatial position of cortical areas 247\u003c\/p\u003e \u003cp\u003e10.5 Development of fine maps: topographic 248\u003c\/p\u003e \u003cp\u003eRetinotectal pathways 248\u003c\/p\u003e \u003cp\u003eSperry and the chemoaffinity hypothesis 250\u003c\/p\u003e \u003cp\u003eEphrins act as molecular postcodes in the chick tectum 252\u003c\/p\u003e \u003cp\u003e10.6 Inputs from multiple structures: when maps collide 253\u003c\/p\u003e \u003cp\u003eFrom retina to cortex in mammals 254\u003c\/p\u003e \u003cp\u003eActivity]dependent eye]specific segregation: a role for retinal waves 254\u003c\/p\u003e \u003cp\u003eFormation of ocular dominance bands 257\u003c\/p\u003e \u003cp\u003eOcular dominance bands form by directed In growth of thalamocortical axons 257\u003c\/p\u003e \u003cp\u003eActivity and the formation of ocular dominance bands 259\u003c\/p\u003e \u003cp\u003eIntegration of sensory maps 260\u003c\/p\u003e \u003cp\u003e10.7 Development of feature maps 261\u003c\/p\u003e \u003cp\u003eFeature maps in the visual system 261\u003c\/p\u003e \u003cp\u003eRole of experience in orientation and direction map formation 263\u003c\/p\u003e \u003cp\u003e10.8 Summary 264\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Maturation of Functional\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eProperties 265\u003c\/p\u003e \u003cp\u003e11.1 Neurons are excitable cells 266\u003c\/p\u003e \u003cp\u003eWhat makes a cell excitable? 266\u003c\/p\u003e \u003cp\u003eElectrical properties of neurons 267\u003c\/p\u003e \u003cp\u003eRegulation of intrinsic neuronal\u003c\/p\u003e \u003cp\u003ephysiology 269\u003c\/p\u003e \u003cp\u003e11.2 Neuronal excitability during development 271\u003c\/p\u003e \u003cp\u003eNeuronal excitability changes dramatically during development 271\u003c\/p\u003e \u003cp\u003eEarly action potentials are driven by Ca2+, not Na+ 271\u003c\/p\u003e \u003cp\u003eNeurotransmitter receptors regulate excitability prior to synapse formation 273\u003c\/p\u003e \u003cp\u003eGABAergic receptor activation switches from being excitatory to inhibitory 273\u003c\/p\u003e \u003cp\u003e11.3 Developmental processes regulated by neuronal excitability 275\u003c\/p\u003e \u003cp\u003eElectrical excitability regulates neuronal proliferation and migration 275\u003c\/p\u003e \u003cp\u003eNeuronal activity and axon guidance 277\u003c\/p\u003e \u003cp\u003e11.4 Synaptogenesis 277\u003c\/p\u003e \u003cp\u003eThe synapse 278\u003c\/p\u003e \u003cp\u003eElectrical properties of dendrites 278\u003c\/p\u003e \u003cp\u003eStages of synaptogenesis 280\u003c\/p\u003e \u003cp\u003eSynaptic specification and induction 281\u003c\/p\u003e \u003cp\u003eSynapse formation 285\u003c\/p\u003e \u003cp\u003eSynapse selection: stabilization and withdrawal 286\u003c\/p\u003e \u003cp\u003e11.5 Spinogenesis 286\u003c\/p\u003e \u003cp\u003eSpine shape and dynamics 287\u003c\/p\u003e \u003cp\u003eTheories of spinogenesis 289\u003c\/p\u003e \u003cp\u003eMouse models of spinogenesis: the weaver mutant 290\u003c\/p\u003e \u003cp\u003eMolecular regulators of spine development 291\u003c\/p\u003e \u003cp\u003e11.6 Summary 293\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Experience]Dependent Development 295\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Effects of experience on visual system development 296\u003c\/p\u003e \u003cp\u003eSeeing one world with two eyes: ocular dominance of cortical cells 296\u003c\/p\u003e \u003cp\u003eVisual experience regulates ocular dominance 297\u003c\/p\u003e \u003cp\u003eCompetition regulates experiencedependent plasticity: the effects of darkrearing and strabismus 299\u003c\/p\u003e \u003cp\u003ePhysiological changes in ocular dominance prior to anatomical changes 301\u003c\/p\u003e \u003cp\u003eCooperative binocular interactions and visual cortex plasticity 304\u003c\/p\u003e \u003cp\u003eThe timing of developmental plasticity: sensitive or critical periods 305\u003c\/p\u003e \u003cp\u003eMultiple sensitive periods in the developing visual system 306\u003c\/p\u003e \u003cp\u003e12.2 How does experience change functional connectivity? 307\u003c\/p\u003e \u003cp\u003eCellular basis of plasticity: synaptic strengthening and weakening 309\u003c\/p\u003e \u003cp\u003eThe time]course of changes in synaptic weight in response to monocular deprivation 310\u003c\/p\u003e \u003cp\u003eCellular and molecular mechanisms of LTP\/LTD induction 312\u003c\/p\u003e \u003cp\u003eSynaptic changes that mediate the expression of LTP\/LTD and experiencedependent plasticity 314 Metaplasticity 318\u003c\/p\u003e \u003cp\u003eSpike]timing dependent plasticity 320\u003c\/p\u003e \u003cp\u003e12.3 Cellular basis of plasticity: development of inhibitory networks 322\u003c\/p\u003e \u003cp\u003eInhibition contributes to the expression of the effects of monocular deprivation 322\u003c\/p\u003e \u003cp\u003eDevelopment of inhibitory circuits regulates the time]course of the sensitive period for monocular deprivation 323\u003c\/p\u003e \u003cp\u003e12.4 Homeostatic plasticity 324\u003c\/p\u003e \u003cp\u003eMechanisms of homeostatic plasticity 325\u003c\/p\u003e \u003cp\u003e12.5 Structural plasticity and the role of the extracellular matrix 327\u003c\/p\u003e \u003cp\u003e12.6 Summary 328\u003c\/p\u003e \u003cp\u003eGlossary 329\u003c\/p\u003e \u003cp\u003eIndex 349\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49407030165847,"sku":"9781119293880","price":59.8,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119293880.jpg?v=1730497932","url":"https:\/\/bookcurl.com\/products\/building-brains-9781119293880","provider":"Book Curl","version":"1.0","type":"link"}