{"product_id":"blood-science-9781118351383","title":"Blood Science","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e* Integrated textbook combining three subjects, haematology, clinical biochemistry and immunology to provide a one-stop text on blood science, in line with the new IBMS and NHS training structure          * Suitable for blood science courses opening in many universities at senior Undergraduate level (units) and Masters level.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003ci\u003ePreface, xiii\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eAcknowledgements, xv\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eList of Abbreviations, xvii\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eAbout the Companion Website, xxi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction to Blood Science, 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 What is blood science?, 1\u003c\/p\u003e \u003cp\u003e1.2 Biochemistry, 6\u003c\/p\u003e \u003cp\u003e1.3 Blood transfusion, 8\u003c\/p\u003e \u003cp\u003e1.4 Genetics, 10\u003c\/p\u003e \u003cp\u003e1.5 Haematology, 14\u003c\/p\u003e \u003cp\u003e1.6 Immunology, 17\u003c\/p\u003e \u003cp\u003e1.7 The role of blood science in modern healthcare, 19\u003c\/p\u003e \u003cp\u003e1.8 What this book will achieve, 22\u003c\/p\u003e \u003cp\u003eSummary, 23\u003c\/p\u003e \u003cp\u003eReferences, 23\u003c\/p\u003e \u003cp\u003eFurther reading, 23\u003c\/p\u003e \u003cp\u003eWeb sites, 23\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Analytical Techniques in Blood Science, 25\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Venepuncture, 25\u003c\/p\u003e \u003cp\u003e2.2 Anticoagulants, 26\u003c\/p\u003e \u003cp\u003e2.3 Sample identification and tracking, 27\u003c\/p\u003e \u003cp\u003e2.4 Technical and analytical confidence, 27\u003c\/p\u003e \u003cp\u003e2.5 Major techniques, 32\u003c\/p\u003e \u003cp\u003e2.6 Molecular genetics, 43\u003c\/p\u003e \u003cp\u003e2.7 Point of care testing, 47\u003c\/p\u003e \u003cp\u003e2.8 Health and safety in the laboratory, 48\u003c\/p\u003e \u003cp\u003eSummary, 49\u003c\/p\u003e \u003cp\u003eFurther reading, 50\u003c\/p\u003e \u003cp\u003eWeb sites, 50\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The Physiology of the Red Blood Cell, 51\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction, 51\u003c\/p\u003e \u003cp\u003e3.2 The development of blood cells, 52\u003c\/p\u003e \u003cp\u003e3.3 Erythropoiesis, 56\u003c\/p\u003e \u003cp\u003e3.4 The red cell membrane, 58\u003c\/p\u003e \u003cp\u003e3.5 The cytoplasm of the red cell, 60\u003c\/p\u003e \u003cp\u003e3.6 Oxygen transport, 66\u003c\/p\u003e \u003cp\u003e3.7 Recycling the red cell, 68\u003c\/p\u003e \u003cp\u003e3.8 Red cell indices in the full blood count, 69\u003c\/p\u003e \u003cp\u003e3.9 Morphology of the red cell, 72\u003c\/p\u003e \u003cp\u003eSummary, 74\u003c\/p\u003e \u003cp\u003eFurther reading, 74\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The Pathology of the Red Blood Cell, 75\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction: diseases of red cells, 75\u003c\/p\u003e \u003cp\u003e4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78\u003c\/p\u003e \u003cp\u003e4.3 Anaemia due to deficiency, 80\u003c\/p\u003e \u003cp\u003e4.4 Intrinsic defects in the red cell, 85\u003c\/p\u003e \u003cp\u003e4.5 External factors acting on healthy cells, 100\u003c\/p\u003e \u003cp\u003e4.6 Erythrocytosis and polycythaemia, 103\u003c\/p\u003e \u003cp\u003e4.7 Molecular genetics and red cell disease, 105\u003c\/p\u003e \u003cp\u003e4.8 Inclusion bodies, 105\u003c\/p\u003e \u003cp\u003e4.9 Case studies, 105\u003c\/p\u003e \u003cp\u003eSummary, 107\u003c\/p\u003e \u003cp\u003eReferences, 107\u003c\/p\u003e \u003cp\u003eFurther reading, 107\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 White Blood Cells in Health and Disease, 109\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction, 109\u003c\/p\u003e \u003cp\u003e5.2 Leukopoiesis, 111\u003c\/p\u003e \u003cp\u003e5.3 Neutrophils, 115\u003c\/p\u003e \u003cp\u003e5.4 Lymphocytes, 116\u003c\/p\u003e \u003cp\u003e5.5 Monocytes, 117\u003c\/p\u003e \u003cp\u003e5.6 Eosinophils, 118\u003c\/p\u003e \u003cp\u003e5.7 Basophils, 119\u003c\/p\u003e \u003cp\u003e5.8 Leukocytes in action, 120\u003c\/p\u003e \u003cp\u003e5.9 White cells in clinical medicine, 127\u003c\/p\u003e \u003cp\u003e5.10 Case studies, 132\u003c\/p\u003e \u003cp\u003eSummary, 132\u003c\/p\u003e \u003cp\u003eFurther reading, 133\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 White Blood Cell Malignancy 135\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 The genetic basis of leukocyte malignancy, 135\u003c\/p\u003e \u003cp\u003e6.2 Tissue techniques in haemato-oncology, 139\u003c\/p\u003e \u003cp\u003e6.3 Leukaemia, 141\u003c\/p\u003e \u003cp\u003e6.4 Lymphoma, 149\u003c\/p\u003e \u003cp\u003e6.5 Myeloma and related conditions, 152\u003c\/p\u003e \u003cp\u003e6.6 Myelofibrosis and myelodysplasia, 157\u003c\/p\u003e \u003cp\u003e6.7 Case studies, 157\u003c\/p\u003e \u003cp\u003eSummary, 158\u003c\/p\u003e \u003cp\u003eFurther reading, 159\u003c\/p\u003e \u003cp\u003eGuidelines, 159\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 The Physiology and Pathology of Haemostasis, 161\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 The blood vessel wall, 162\u003c\/p\u003e \u003cp\u003e7.2 Platelets, 163\u003c\/p\u003e \u003cp\u003e7.3 The coagulation pathway, 165\u003c\/p\u003e \u003cp\u003e7.4 Haemostasis as the balance between thrombus formation and removal, 168\u003c\/p\u003e \u003cp\u003e7.5 The haemostasis laboratory, 171\u003c\/p\u003e \u003cp\u003e7.6 The pathology of thrombosis, 173\u003c\/p\u003e \u003cp\u003eSummary, 175\u003c\/p\u003e \u003cp\u003eFurther reading, 175\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 The Diagnosis and Management of Disorders of Haemostasis, 177\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177\u003c\/p\u003e \u003cp\u003e8.2 Thrombosis 2: overactive coagulation, 181\u003c\/p\u003e \u003cp\u003e8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193\u003c\/p\u003e \u003cp\u003e8.4 Haemorrhage 2: coagulation underactivity, 199\u003c\/p\u003e \u003cp\u003e8.5 Disseminated intravascular coagulation, 203\u003c\/p\u003e \u003cp\u003e8.6 Molecular genetics in haemostasis, 204\u003c\/p\u003e \u003cp\u003e8.7 Case studies, 205\u003c\/p\u003e \u003cp\u003eSummary, 206\u003c\/p\u003e \u003cp\u003eReferences, 206\u003c\/p\u003e \u003cp\u003eFurther reading, 207\u003c\/p\u003e \u003cp\u003eGuidelines, 207\u003c\/p\u003e \u003cp\u003eWeb sites, 207\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Immunopathology, 209\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction, 209\u003c\/p\u003e \u003cp\u003e9.2 Basics of the immune system, 210\u003c\/p\u003e \u003cp\u003e9.3 Humoral immunity, 212\u003c\/p\u003e \u003cp\u003e9.4 Immunopathology 1: immunodeficiency, 215\u003c\/p\u003e \u003cp\u003e9.5 Immunopathology 2: hypersensitivity, 221\u003c\/p\u003e \u003cp\u003e9.6 Immunopathology 3: autoimmune disease, 226\u003c\/p\u003e \u003cp\u003e9.7 Immunotherapy, 232\u003c\/p\u003e \u003cp\u003e9.8 The immunology laboratory, 234\u003c\/p\u003e \u003cp\u003e9.9 Case studies, 238\u003c\/p\u003e \u003cp\u003eSummary, 239\u003c\/p\u003e \u003cp\u003eReferences, 240\u003c\/p\u003e \u003cp\u003eFurther reading, 240\u003c\/p\u003e \u003cp\u003eGuidelines, 240\u003c\/p\u003e \u003cp\u003eWeb sites, 240\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Immunogenetics and Histocompatibility, 241\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 The genetics of antigen recognition, 241\u003c\/p\u003e \u003cp\u003e10.2 Human leukocyte antigens, 245\u003c\/p\u003e \u003cp\u003e10.3 Transplantation, 251\u003c\/p\u003e \u003cp\u003e10.4 Autoimmunity and human leukocyte antigens, 257\u003c\/p\u003e \u003cp\u003eSummary, 260\u003c\/p\u003e \u003cp\u003eFurther reading, 260\u003c\/p\u003e \u003cp\u003eGuidelines, 260\u003c\/p\u003e \u003cp\u003eWeb sites, 260\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Blood Transfusion, 261\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Blood collection and processing, 262\u003c\/p\u003e \u003cp\u003e11.2 Blood groups, 265\u003c\/p\u003e \u003cp\u003e11.3 Laboratory practice of blood transfusion, 273\u003c\/p\u003e \u003cp\u003e11.4 Clinical practice of blood transfusion, 279\u003c\/p\u003e \u003cp\u003e11.5 Hazards of blood transfusion, 281\u003c\/p\u003e \u003cp\u003eSummary, 284\u003c\/p\u003e \u003cp\u003eReferences, 284\u003c\/p\u003e \u003cp\u003eFurther reading, 284\u003c\/p\u003e \u003cp\u003eGuidelines, 284\u003c\/p\u003e \u003cp\u003eWeb sites, 285\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Waste Products, Electrolytes and Renal Disease, 287\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Renal anatomy and physiology, 287\u003c\/p\u003e \u003cp\u003e12.2 Homeostasis, 288\u003c\/p\u003e \u003cp\u003e12.3 Excretion, 295\u003c\/p\u003e \u003cp\u003e12.4 Renal endocrinology, 297\u003c\/p\u003e \u003cp\u003e12.5 Renal disease, 298\u003c\/p\u003e \u003cp\u003e12.6 Case studies, 301\u003c\/p\u003e \u003cp\u003eSummary, 303\u003c\/p\u003e \u003cp\u003eFurther reading, 303\u003c\/p\u003e \u003cp\u003eGuidelines, 303\u003c\/p\u003e \u003cp\u003eWeb sites, 303\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Hydrogen Ions, pH, and Acid–Base Disorders, 305\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Ions and molecules, 305\u003c\/p\u003e \u003cp\u003e13.2 Blood gases, 308\u003c\/p\u003e \u003cp\u003e13.3 Acidosis (pH \u0026lt;7.3), 312\u003c\/p\u003e \u003cp\u003e13.4 Alkalosis (pH \u0026gt;7.5), 313\u003c\/p\u003e \u003cp\u003e13.5 Mixed acid–base conditions, 314\u003c\/p\u003e \u003cp\u003e13.6 Clinical interpretation, 314\u003c\/p\u003e \u003cp\u003e13.7 Case studies, 315\u003c\/p\u003e \u003cp\u003eSummary, 316\u003c\/p\u003e \u003cp\u003eFurther reading, 317\u003c\/p\u003e \u003cp\u003eWeb site, 317\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Glucose, Lipids and Atherosclerosis, 319\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Glucose, 319\u003c\/p\u003e \u003cp\u003e14.2 Dyslipidaemia, 333\u003c\/p\u003e \u003cp\u003e14.3 Atherosclerosis, 343\u003c\/p\u003e \u003cp\u003e14.4 Case studies, 347\u003c\/p\u003e \u003cp\u003eSummary, 348\u003c\/p\u003e \u003cp\u003eFurther reading, 348\u003c\/p\u003e \u003cp\u003eGuidelines, 349\u003c\/p\u003e \u003cp\u003eWeb sites, 349\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Calcium, Phosphate, Magnesium and Bone Disease, 351\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Calcium, 352\u003c\/p\u003e \u003cp\u003e15.2 Phosphates, 355\u003c\/p\u003e \u003cp\u003e15.3 Magnesium, 355\u003c\/p\u003e \u003cp\u003e15.4 The laboratory, 355\u003c\/p\u003e \u003cp\u003e15.5 Disorders of calcium homeostasis, 357\u003c\/p\u003e \u003cp\u003e15.6 Disorders of phosphate homeostasis, 360\u003c\/p\u003e \u003cp\u003e15.7 Disorders of magnesium homeostasis, 362\u003c\/p\u003e \u003cp\u003e15.8 Bone physiology, 363\u003c\/p\u003e \u003cp\u003e15.9 Bone disease, 364\u003c\/p\u003e \u003cp\u003e15.10 Case studies, 368\u003c\/p\u003e \u003cp\u003eSummary, 369\u003c\/p\u003e \u003cp\u003eFurther reading, 370\u003c\/p\u003e \u003cp\u003eGuidelines, 370\u003c\/p\u003e \u003cp\u003eWeb sites, 370\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Nutrients and Gastrointestinal Disorders, 371\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16.1 Nutrients, 371\u003c\/p\u003e \u003cp\u003e16.2 The intestines, 375\u003c\/p\u003e \u003cp\u003e16.3 Case studies, 381\u003c\/p\u003e \u003cp\u003eSummary, 382\u003c\/p\u003e \u003cp\u003eFurther reading, 382\u003c\/p\u003e \u003cp\u003eGuidelines, 382\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Liver Function Tests and Plasma Proteins, 383\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17.1 Anatomy and physiology of the liver, 384\u003c\/p\u003e \u003cp\u003e17.2 Liver function tests, 389\u003c\/p\u003e \u003cp\u003e17.3 Diseases of the liver, 390\u003c\/p\u003e \u003cp\u003e17.4 Plasma proteins, 396\u003c\/p\u003e \u003cp\u003e17.5 Case studies, 405\u003c\/p\u003e \u003cp\u003eSummary, 406\u003c\/p\u003e \u003cp\u003eFurther reading, 406\u003c\/p\u003e \u003cp\u003eWeb sites, 406\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Hormones and Endocrine Disorders, 407\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18.1 Endocrine physiology, 407\u003c\/p\u003e \u003cp\u003e18.2 The pathology of the endocrine system, 417\u003c\/p\u003e \u003cp\u003e18.3 Case studies, 434\u003c\/p\u003e \u003cp\u003eSummary, 435\u003c\/p\u003e \u003cp\u003eFurther reading, 435\u003c\/p\u003e \u003cp\u003eWeb sites, 436\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Cancer and Tumour Markers, 437\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19.1 General concepts in cancer biology, 437\u003c\/p\u003e \u003cp\u003e19.2 Blood science and cancer, 440\u003c\/p\u003e \u003cp\u003e19.3 Molecular genetics, 444\u003c\/p\u003e \u003cp\u003e19.4 Case studies, 445\u003c\/p\u003e \u003cp\u003eSummary, 446\u003c\/p\u003e \u003cp\u003eFurther reading, 446\u003c\/p\u003e \u003cp\u003eGuidelines, 447\u003c\/p\u003e \u003cp\u003eWeb sites, 447\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Inherited Metabolic Disorders, 449\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e20.1 The genetics of inheritance, 449\u003c\/p\u003e \u003cp\u003e20.2 Molecular inherited metabolic disorders, 451\u003c\/p\u003e \u003cp\u003e20.3 Organelle inherited metabolic disorders, 455\u003c\/p\u003e \u003cp\u003e20.4 Antenatal diagnosis and neonatal screening, 455\u003c\/p\u003e \u003cp\u003e20.5 Case studies, 456\u003c\/p\u003e \u003cp\u003eSummary, 457\u003c\/p\u003e \u003cp\u003eFurther reading, 457\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Drugs and Poisons, 459\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e21.1 Toxicology, 459\u003c\/p\u003e \u003cp\u003e21.2 Toxicology of specific compounds, 461\u003c\/p\u003e \u003cp\u003e21.3 Therapeutic drug monitoring, 465\u003c\/p\u003e \u003cp\u003e21.4 Case studies, 468\u003c\/p\u003e \u003cp\u003eSummary, 469\u003c\/p\u003e \u003cp\u003eReferences, 469\u003c\/p\u003e \u003cp\u003eFurther reading, 469\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 Case Reports in Blood Science, 471\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAbbreviations, 471\u003c\/p\u003e \u003cp\u003eCase report 1, 472\u003c\/p\u003e \u003cp\u003eAnaemia, hypercalcaemia, proteinuria, myeloma\u003cbr\u003e Case report 2, 473\u003c\/p\u003e \u003cp\u003eDiabetes, glycated haemoglobin, chronic renal failure\u003cbr\u003e Case report 3, 474\u003c\/p\u003e \u003cp\u003eAcute kidney injury, leucocytosis, neutrophilia, viruses\u003cbr\u003e Case report 4, 475\u003c\/p\u003e \u003cp\u003ePart 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols\u003cbr\u003e Case report 5, 477\u003c\/p\u003e \u003cp\u003ePart 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer\u003cbr\u003e Case report 6, 479\u003c\/p\u003e \u003cp\u003eHypothyroidism, marginally reduced haemoglobin\u003cbr\u003e Case report 7, 480\u003c\/p\u003e \u003cp\u003eRaised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus\u003cbr\u003e Case report 8, 481\u003c\/p\u003e \u003cp\u003eNormal blood results in renal transplantation\u003cbr\u003e Case report 9, 482\u003c\/p\u003e \u003cp\u003eFalling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia\u003cbr\u003e Case report 10, 484\u003c\/p\u003e \u003cp\u003eMicrocytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses\u003cbr\u003e Case report 11, 486\u003c\/p\u003e \u003cp\u003eAcidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine\u003cbr\u003e Case report 12, 487\u003c\/p\u003e \u003cp\u003eLow haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy\u003cbr\u003e Case report 13, 488\u003c\/p\u003e \u003cp\u003eRaised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome Case report 14, 489\u003c\/p\u003e \u003cp\u003ePaediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins\u003c\/p\u003e \u003cp\u003eReferences, 490\u003c\/p\u003e \u003cp\u003eAppendix: Reference Ranges, 491\u003c\/p\u003e \u003cp\u003e\u003ci\u003eFurther Reading, 493\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eGlossary, 495\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIndex, 519\u003c\/i\u003e\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49406855872855,"sku":"9781118351383","price":111.1,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118351383.jpg?v=1730497356","url":"https:\/\/bookcurl.com\/products\/blood-science-9781118351383","provider":"Book Curl","version":"1.0","type":"link"}