{"product_id":"biostatistics-in-biopharmaceutical-research-and-development-9783031659478","title":"Biostatistics in Biopharmaceutical Research and Development","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eBias and Randomization in Clinical Trials: 1980s  2020s  2060s.- The Markov Model for Survival Trials at 35 Years-Old.- Absolute Power Corrupts Absolutely: A Review of the Use of Unconditional Probabilities in the Planning of Clinical Trials.- Design of Clinical Trials with the Desirability of Outcome Ranking Methodology.- Benefit:Risk Assessments during Clinical Trials: A Prediction Approach Using the Desirability of Outcome Ranking (DOOR).- The Power of Integration: How the 2-in-1 Clinical Trial Design is Changing the Future of Drug Development.- A Unified Bayesian Decision Rule-Based Approach for Bayesian Design of Clinical Trials Using Historical Data.- Group Sequential Design Under Non-proportional Hazards: Methodologies and Examples.- Multiple Testing in Group Sequential Design.- Plan per-protocol (PP) causal inference analysis addressing intercurrent events following the targeted learning roadmap.- Maximum Tolerated Imbalance Randomization: Theory and Practice.- Response-adaptive randomization designs based on optimal allocation proportion.\u003c\/p\u003e","brand":"Springer","offers":[{"title":"Default Title","offer_id":53195393040727,"sku":"9783031659478","price":170.99,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/bookcurl.com\/products\/biostatistics-in-biopharmaceutical-research-and-development-9783031659478","provider":"Book Curl","version":"1.0","type":"link"}