{"product_id":"biomechatronics-9780470573341","title":"Biomechatronics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003ea must-read for all modern bio-scientists and engineers working in the field of biotechnology.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003ea must-read for all modern bio-scientists and engineers working in the field of biotechnology. (Biotechnology Journal July 2012)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePREFACE xiii  \u003cp\u003e1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.1 Scope of Design \/ 1\u003c\/p\u003e \u003cp\u003e1.2 Definition of Biomechatronic Products \/ 3\u003c\/p\u003e \u003cp\u003e1.3 Principles of Biomechatronics \/ 4\u003c\/p\u003e \u003cp\u003e1.4 Brief History of the Development of Biomechatronic Products and Engineering \/ 7\u003c\/p\u003e \u003cp\u003e1.5 Aim of This Book \/ 9\u003c\/p\u003e \u003cp\u003eReferences \/ 10\u003c\/p\u003e \u003cp\u003ePART I FUNDAMENTALS 13\u003c\/p\u003e \u003cp\u003e2 Conceptual Design Theory 15\u003c\/p\u003e \u003cp\u003e2.1 Systematic Design \/ 15\u003c\/p\u003e \u003cp\u003e2.1.1 Design for Products \/ 15\u003c\/p\u003e \u003cp\u003e2.1.2 Origin of the Design Task \/ 18\u003c\/p\u003e \u003cp\u003e2.1.3 Development of Design Thinking \/ 18\u003c\/p\u003e \u003cp\u003e2.1.4 Recent Methods \/ 20\u003c\/p\u003e \u003cp\u003e2.2 Basics of Technical Systems \/ 21\u003c\/p\u003e \u003cp\u003e2.2.1 Energy, Material, and Signals and Their Conversion \/ 22\u003c\/p\u003e \u003cp\u003e2.2.2 Interrelationships of Functions \/ 22\u003c\/p\u003e \u003cp\u003e2.2.3 Interrelationship of Constructions \/ 25\u003c\/p\u003e \u003cp\u003e2.2.4 Interrelationship of Systems \/ 25\u003c\/p\u003e \u003cp\u003e2.3 Psychology in the Systematic Approach \/ 25\u003c\/p\u003e \u003cp\u003e2.4 A General Working Methodology \/ 26\u003c\/p\u003e \u003cp\u003e2.4.1 Analysis for Resolving Technical Problems \/ 27\u003c\/p\u003e \u003cp\u003e2.4.2 Abstraction of Interrelationships of Systems \/ 28\u003c\/p\u003e \u003cp\u003e2.4.3 Synthesis of the Technical System \/ 28\u003c\/p\u003e \u003cp\u003e2.5 Conceptual Design \/ 28\u003c\/p\u003e \u003cp\u003e2.6 Abstraction inOrder to Identify Essential Problems \/ 29\u003c\/p\u003e \u003cp\u003e2.7 Developing the Concepts \/ 31\u003c\/p\u003e \u003cp\u003e2.7.1 Organizing the Development Process \/ 33\u003c\/p\u003e \u003cp\u003e2.8 Concluding Remarks \/ 34\u003c\/p\u003e \u003cp\u003eReferences \/ 35\u003c\/p\u003e \u003cp\u003e3 Biotechnology and Mechatronic Design 37\u003c\/p\u003e \u003cp\u003e3.1 Transduction of the Biological Science into Biotechnology \/ 37\u003c\/p\u003e \u003cp\u003e3.2 Biological Sciences and Their Applications \/ 39\u003c\/p\u003e \u003cp\u003e3.3 Biotechnology and Bioengineering \/ 42\u003c\/p\u003e \u003cp\u003e3.4 Applying Mechatronic Theory to Biotechnology: Biomechatronics \/ 44\u003c\/p\u003e \u003cp\u003e3.5 Conclusions \/ 47\u003c\/p\u003e \u003cp\u003eReferences \/ 48\u003c\/p\u003e \u003cp\u003e4 Methodology for Utilization of Mechatronic Design Tools 49\u003c\/p\u003e \u003cp\u003e4.1 Idea of Applying the Mechatronic Design Tools \/ 49\u003c\/p\u003e \u003cp\u003e4.2 Table of User Needs \/ 51\u003c\/p\u003e \u003cp\u003e4.3 List of Target Specifications \/ 52\u003c\/p\u003e \u003cp\u003e4.4 Concept Generation Chart \/ 52\u003c\/p\u003e \u003cp\u003e4.4.1 Basic Concept Component Chart \/ 53\u003c\/p\u003e \u003cp\u003e4.4.2 Permutation Chart \/ 54\u003c\/p\u003e \u003cp\u003e4.5 Concept Screening Matrix \/ 55\u003c\/p\u003e \u003cp\u003e4.6 Concept Scoring Matrix \/ 56\u003c\/p\u003e \u003cp\u003e4.7 Hubka–Eder Mapping \/ 57\u003c\/p\u003e \u003cp\u003e4.7.1 Overview Hubka–Eder Map \/ 57\u003c\/p\u003e \u003cp\u003e4.7.2 Zoom-in Hubka–Eder Mapping \/ 59\u003c\/p\u003e \u003cp\u003e4.8 Functions Interaction Matrix \/ 60\u003c\/p\u003e \u003cp\u003e4.8.1 Functions Interaction Matrix for Systems and Subsystems \/ 60\u003c\/p\u003e \u003cp\u003e4.8.2 Functions Interaction Matrix for Systems and Transformation Process \/ 61\u003c\/p\u003e \u003cp\u003e4.8.3 Design Structure Matrix \/ 61\u003c\/p\u003e \u003cp\u003e4.9 Anatomical Blueprint \/ 62\u003c\/p\u003e \u003cp\u003e4.10 Conclusions \/ 63\u003c\/p\u003e \u003cp\u003eReferences \/ 63\u003c\/p\u003e \u003cp\u003ePART II APPLICATIONS 65\u003c\/p\u003e \u003cp\u003e5 Blood Glucose Sensors 67\u003c\/p\u003e \u003cp\u003e5.1 Background of Blood Glucose Analysis \/ 67\u003c\/p\u003e \u003cp\u003e5.2 Specification of Needs for Blood Glucose Analysis \/ 70\u003c\/p\u003e \u003cp\u003e5.3 Design of Blood Glucose Sensors \/ 71\u003c\/p\u003e \u003cp\u003e5.3.1 Generation of Sensor Concepts \/ 71\u003c\/p\u003e \u003cp\u003e5.4 Description of the Systems Involved in the Design Concepts for Glucose Blood Sensors \/ 76\u003c\/p\u003e \u003cp\u003e5.4.1 Biological Systems \/ 77\u003c\/p\u003e \u003cp\u003e5.4.2 Technical Systems \/ 77\u003c\/p\u003e \u003cp\u003e5.4.3 Information Systems \/ 78\u003c\/p\u003e \u003cp\u003e5.4.4 Management and Goal Systems \/ 78\u003c\/p\u003e \u003cp\u003e5.4.5 Human Systems \/ 79\u003c\/p\u003e \u003cp\u003e5.4.6 Active Environment \/ 79\u003c\/p\u003e \u003cp\u003e5.4.7 Interactions Between the Systems and Functions of the Design \/ 79\u003c\/p\u003e \u003cp\u003e5.4.8 Anatomical Blueprints from the Functions Interaction Matrix Analysis \/ 81\u003c\/p\u003e \u003cp\u003e5.5 Conclusions \/ 82\u003c\/p\u003e \u003cp\u003eReferences \/ 82\u003c\/p\u003e \u003cp\u003e6 Surface Plasmon Resonance Biosensor Devices 85\u003c\/p\u003e \u003cp\u003e6.1 Introduction \/ 85\u003c\/p\u003e \u003cp\u003e6.2 Design Requirements on SPR Systems \/ 88\u003c\/p\u003e \u003cp\u003e6.2.1 Needs and Specifications of an SPR Design \/ 88\u003c\/p\u003e \u003cp\u003e6.3 Mechatronic Design Approach of SPR Systems \/ 89\u003c\/p\u003e \u003cp\u003e6.3.1 Generation of Design Alternatives \/ 89\u003c\/p\u003e \u003cp\u003e6.3.2 Hubka–Eder Mapping of the Design Alternatives \/ 92\u003c\/p\u003e \u003cp\u003e6.4 Detailed Design of Critical SPR Subsystems \/ 99\u003c\/p\u003e \u003cp\u003e6.4.1 Design of the Sensor Surface \/ 100\u003c\/p\u003e \u003cp\u003e6.4.2 Design of the Fluidic System \/ 103\u003c\/p\u003e \u003cp\u003e6.5 Conclusions \/ 109\u003c\/p\u003e \u003cp\u003eReferences \/ 109\u003c\/p\u003e \u003cp\u003e7 A Diagnostic Device for Helicobacter pylori Infection 113\u003c\/p\u003e \u003cp\u003e7.1 Diagnostic Principle of Helicobacter Infection \/ 113\u003c\/p\u003e \u003cp\u003e7.2 Mechatronic Analysis of Urea Breath Test Systems \/ 117\u003c\/p\u003e \u003cp\u003e7.2.1 Mission and Specification for a Urea Breath Tests \/ 117\u003c\/p\u003e \u003cp\u003e7.2.2 Generation of UBT Design Concepts \/ 118\u003c\/p\u003e \u003cp\u003e7.2.3 Screening and Scoring of UBT Design Concepts \/ 119\u003c\/p\u003e \u003cp\u003e7.3 Description of the Systems Involved in the Design Concepts for the Urea Breath Tests \/ 124\u003c\/p\u003e \u003cp\u003e7.3.1 Biological Systems Involved \/ 124\u003c\/p\u003e \u003cp\u003e7.3.2 Technical Systems Alternatives \/ 126\u003c\/p\u003e \u003cp\u003e7.3.3 Information Systems (SIS) Required \/ 127\u003c\/p\u003e \u003cp\u003e7.3.4 Management and Goal Systems Required \/ 127\u003c\/p\u003e \u003cp\u003e7.3.5 Human Systems Involved in the Testing \/ 127\u003c\/p\u003e \u003cp\u003e7.3.6 Active Environment That Can Influence \/ 128\u003c\/p\u003e \u003cp\u003e7.4 Aspects of the Design for Efficient Manufacture \/ 128\u003c\/p\u003e \u003cp\u003e7.5 Conclusions \/ 131\u003c\/p\u003e \u003cp\u003eReferences \/ 131\u003c\/p\u003e \u003cp\u003e8 Microarray Devices 135\u003c\/p\u003e \u003cp\u003e8.1 Principles, Methods, and Applications of Microarrays \/ 135\u003c\/p\u003e \u003cp\u003e8.1.1 Principles and Technology \/ 135\u003c\/p\u003e \u003cp\u003e8.1.2 Fabrication Methods \/ 136\u003c\/p\u003e \u003cp\u003e8.1.3 Companies Developing Microarrays \/ 138\u003c\/p\u003e \u003cp\u003e8.1.4 Applications of DNA Microarrays \/ 139\u003c\/p\u003e \u003cp\u003e8.2 Specification of Needs \/ 141\u003c\/p\u003e \u003cp\u003e8.3 Design of Microarrays \/ 142\u003c\/p\u003e \u003cp\u003e8.3.1 Generation of cDNA Microarray Concepts \/ 142\u003c\/p\u003e \u003cp\u003e8.4 Description of the Systems Involved in the Design Concepts \/ 145\u003c\/p\u003e \u003cp\u003e8.4.1 Biological Systems \/ 146\u003c\/p\u003e \u003cp\u003e8.4.2 Technical Systems \/ 147\u003c\/p\u003e \u003cp\u003e8.4.3 Information System \/ 147\u003c\/p\u003e \u003cp\u003e8.4.4 Management and Goal Systems and the Human Systems \/ 147\u003c\/p\u003e \u003cp\u003e8.4.5 Active Environment \/ 147\u003c\/p\u003e \u003cp\u003e8.4.6 Interaction Analysis \/ 148\u003c\/p\u003e \u003cp\u003e8.5 Conclusions \/ 149\u003c\/p\u003e \u003cp\u003eReferences \/ 149\u003c\/p\u003e \u003cp\u003e9 Microbial and Cellular Bioreactors 153\u003c\/p\u003e \u003cp\u003e9.1 Bioreactor Development During the 1970s–1990s \/ 153\u003c\/p\u003e \u003cp\u003e9.2 Missions, User Needs, and Specifications for Bioreactors \/ 158\u003c\/p\u003e \u003cp\u003e9.2.1 Design Mission and User Needs \/ 158\u003c\/p\u003e \u003cp\u003e9.2.2 Target Specifications \/ 158\u003c\/p\u003e \u003cp\u003e9.3 Analysis of Systems for Conventional Bioreactors \/ 161\u003c\/p\u003e \u003cp\u003e9.3.1 Biological Systems in the Bioreactor \/ 161\u003c\/p\u003e \u003cp\u003e9.3.2 Technical Systems \/ 164\u003c\/p\u003e \u003cp\u003e9.3.3 Studying the Interactions of the Systems \/ 166\u003c\/p\u003e \u003cp\u003e9.3.4 Penicillin Production in a Metabolically Engineered Penicillium strain (Case 1) \/ 168\u003c\/p\u003e \u003cp\u003e9.3.5 A Bioreactor System Producing a Recombinant Protein in CHO Cell Culture (Case 2) \/ 171\u003c\/p\u003e \u003cp\u003e9.3.6 Information Systems \/ 173\u003c\/p\u003e \u003cp\u003e9.3.7 Management and Goal Systems \/ 177\u003c\/p\u003e \u003cp\u003e9.3.8 Human Systems \/ 179\u003c\/p\u003e \u003cp\u003e9.3.9 Active Environment \/ 179\u003c\/p\u003e \u003cp\u003e9.4 Novel Bioreactor Designs \/ 180\u003c\/p\u003e \u003cp\u003e9.4.1 Microbioreactors \/ 180\u003c\/p\u003e \u003cp\u003e9.4.2 Bioreactors with Immobilized Cells \/ 183\u003c\/p\u003e \u003cp\u003e9.4.3 Bioreactors for Tissue and Stem Cell Cultures \/ 185\u003c\/p\u003e \u003cp\u003e9.4.4 Bioreactors for Plant Cell Cultures \/ 186\u003c\/p\u003e \u003cp\u003e9.5 Conclusions \/ 187\u003c\/p\u003e \u003cp\u003eReferences \/ 187\u003c\/p\u003e \u003cp\u003e10 Chromatographic Protein Purification 193\u003c\/p\u003e \u003cp\u003e10.1 Background of Chromatographic Protein Purification \/ 193\u003c\/p\u003e \u003cp\u003e10.2 Specification of Needs for Protein Purification Systems \/ 197\u003c\/p\u003e \u003cp\u003e10.3 Design of Purification Systems \/ 199\u003c\/p\u003e \u003cp\u003e10.3.1 Generation of Design Alternatives \/ 199\u003c\/p\u003e \u003cp\u003e10.3.2 Screening the Design Alternatives \/ 201\u003c\/p\u003e \u003cp\u003e10.3.3 Analysis of the Generated Alternatives for a Chromatography System \/ 202\u003c\/p\u003e \u003cp\u003e10.3.4 Interactions Between Key Systems and the Transformation Process \/ 206\u003c\/p\u003e \u003cp\u003e10.4 Unit Operation Purification in a FVIII Production Process (Case 1) \/ 208\u003c\/p\u003e \u003cp\u003e10.5 Micropurification System Based on a Multichip Device (Case 2) \/ 209\u003c\/p\u003e \u003cp\u003e10.6 Conclusions \/ 211\u003c\/p\u003e \u003cp\u003eReferences \/ 212\u003c\/p\u003e \u003cp\u003e11 Stem Cell Manufacturing 215\u003c\/p\u003e \u003cp\u003e11.1 State of the Art of Stem Cell Manufacturing \/ 215\u003c\/p\u003e \u003cp\u003e11.2 Needs and Target Specifications for Scaled-Up Stem Cell Manufacturing \/ 218\u003c\/p\u003e \u003cp\u003e11.3 Setting Up an Efficient Manufacturing System by Using Biomechatronic Conceptual Design \/ 220\u003c\/p\u003e \u003cp\u003e11.3.1 Generating Process Alternatives \/ 220\u003c\/p\u003e \u003cp\u003e11.3.2 Hubka–Eder Map for a Human Embryonic Stem Cell Process \/ 220\u003c\/p\u003e \u003cp\u003e11.4 Conclusions \/ 225\u003c\/p\u003e \u003cp\u003eReferences \/ 226\u003c\/p\u003e \u003cp\u003e12 Bioartificial Organ-Simulating Devices 229\u003c\/p\u003e \u003cp\u003e12.1 Introduction \/ 229\u003c\/p\u003e \u003cp\u003e12.2 Design of Bioartificial Organ-Simulation Devices \/ 232\u003c\/p\u003e \u003cp\u003e12.2.1 Needs and Specifications \/ 232\u003c\/p\u003e \u003cp\u003e12.2.2 Evaluation of the Design Concepts \/ 236\u003c\/p\u003e \u003cp\u003e12.3 Analysis of Bioartificial Liver Systems \/ 239\u003c\/p\u003e \u003cp\u003e12.3.1 Biological Systems \/ 239\u003c\/p\u003e \u003cp\u003e12.3.2 Technical Systems \/ 241\u003c\/p\u003e \u003cp\u003e12.3.3 Information Systems \/ 242\u003c\/p\u003e \u003cp\u003e12.3.4 Management and Goals Systems \/ 243\u003c\/p\u003e \u003cp\u003e12.3.5 Human Systems \/ 243\u003c\/p\u003e \u003cp\u003e12.4 Conclusions \/ 244\u003c\/p\u003e \u003cp\u003eReferences \/ 244\u003c\/p\u003e \u003cp\u003e13 Applications to Process Analytical Technology and Quality by Design 249\u003c\/p\u003e \u003cp\u003e13.1 PAT and QbD Concepts \/ 249\u003c\/p\u003e \u003cp\u003e13.2 Needs of the PAT\/QbD Players and Resulting Specifications \/ 253\u003c\/p\u003e \u003cp\u003e13.3 Application of Design Methodology to PAT\/QbD \/ 255\u003c\/p\u003e \u003cp\u003e13.3.1 Concept Generation for a PAT\/QbD System Structure \/ 255\u003c\/p\u003e \u003cp\u003e13.3.2 Hubka–Eder Mapping of the PAT\/QbD Transformation Process for a Pharmaceutical\u003c\/p\u003e \u003cp\u003eProcess \/ 257\u003c\/p\u003e \u003cp\u003e13.3.3 Analysis of Effects \/ 259\u003c\/p\u003e \u003cp\u003e13.4 Applying Mechatronic Design on a PAT System for Online Software Sensing in a Bioprocess (Case) \/ 260\u003c\/p\u003e \u003cp\u003e13.5 Conclusions \/ 263\u003c\/p\u003e \u003cp\u003eReferences \/ 263\u003c\/p\u003e \u003cp\u003eGLOSSARY 267\u003c\/p\u003e \u003cp\u003eINDEX 275\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":53515417944407,"sku":"9780470573341","price":80.96,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/bookcurl.com\/products\/biomechatronics-9780470573341","provider":"Book Curl","version":"1.0","type":"link"}